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Microangiopathic haemolytic anaemia: a rare first presentation of lung cancer
Med J Aust. 2022 Jul 18. doi: 10.5694/mja2.51659. Online ahead of print.NO ABSTRACTPMID:35851690 | DOI:10.5694/mja2.51659 (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - July 19, 2022 Category: General Medicine Authors: Nicholas M Stacey Martin Feddersen Source Type: research

Microangiopathic haemolytic anaemia: a rare first presentation of lung cancer
Med J Aust. 2022 Jul 18. doi: 10.5694/mja2.51659. Online ahead of print.NO ABSTRACTPMID:35851690 | DOI:10.5694/mja2.51659 (Source: Med J Aust)
Source: Med J Aust - July 19, 2022 Category: General Medicine Authors: Nicholas M Stacey Martin Feddersen Source Type: research

Recurrent microangiopathic hemolysis after recovery from complement-mediated hemolytic uremia syndrome during chemotherapy for a CFH-mutated patient with T-lymphoblastic lymphoma
We report the case of an 8-year-old boy with T-lymphoblastic lymphoma (T-LBL) who developed CM-HUS with complement factor H (CFH) mutations (S1191L, V1197A) during induction therapy. Safe administration of chemotherapy after CM-HUS recovery was challenging. By closely monitoring hemolytic and renal parameters during the 2-year treatment period, we observed four episodes of microangiopathic hemolytic anemia (MAHA) with hypocomplementemia and low haptoglobin but no renal dysfunction or thrombocytopenia. Here, we describe the MAHA and CM-HUS episodes in the hopes of elucidating the complex pathophysiology of disorders associa...
Source: International Journal of Hematology - July 5, 2022 Category: Hematology Authors: Fu-Shiuan Whitney Lee Chih-Ying Lee Giun-Yi Hung Min-Hua Tseng Hsin-Hui Wang Hsiu-Ju Yen Source Type: research

Hemophagocytic Lymphohistiocytosis Associated With Hemolytic Uremic Syndrome in a Child: A Case Report and Systematic Literature Review
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder resulting from excessive activation and nonmalignant proliferation of T-lymphocytes and macrophages. Hemolytic uremic syndrome (HUS) is a disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Reports pertaining to the association between HLH and HUS are rarely published; however, we report on a 4-year-old boy who was diagnosed with both conditions and treated successfully with high-dose steroid and intravenous immunoglobulin. Differentiating HUS from HLH can be challenging because of their clinical simil...
Source: Journal of Pediatric Hematology Oncology - June 30, 2022 Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research

A Comprehensive Review of Hepatic Hemangioma Management
ConclusionHHs are very common benign liver lesions. High-quality imaging is imperative to distinguish HHs from other liver lesions. Surgery is generally reserved for patients who present with symptoms such as pain, obstruction, or rarely Kasabach-Merritt syndrome. Surgery can involve either formal resection or, in most instances, simple enucleation. Patients generally have good outcomes following surgery with resolution of their symptoms. (Source: Journal of Gastrointestinal Surgery)
Source: Journal of Gastrointestinal Surgery - June 15, 2022 Category: Surgery Source Type: research

Thrombotic microangiopathies: An illustrated review
Res Pract Thromb Haemost. 2022 Apr 22;6(3):e12708. doi: 10.1002/rth2.12708. eCollection 2022 Mar.ABSTRACTThe thrombotic microangiopathies (TMAs) are a heterogenous group of disorders with distinct pathophysiologies that cause occlusive microvascular or macrovascular thrombosis, and are characterized by microangiopathic hemolytic anemia, thrombocytopenia, and/or end-organ ischemia. TMAs are associated with significant morbidity and mortality, and data on the management of certain TMAs are often lacking. The nomenclature, classification, and management of various TMAs is constantly evolving as we learn more about these rare ...
Source: Cell Research - May 26, 2022 Category: Cytology Authors: Mouhamed Yazan Abou-Ismail Sargam Kapoor Divyaswathi Citla Sridhar Lalitha Nayak Sanjay Ahuja Source Type: research

Thrombotic microangiopathies: An illustrated review
Res Pract Thromb Haemost. 2022 Apr 22;6(3):e12708. doi: 10.1002/rth2.12708. eCollection 2022 Mar.ABSTRACTThe thrombotic microangiopathies (TMAs) are a heterogenous group of disorders with distinct pathophysiologies that cause occlusive microvascular or macrovascular thrombosis, and are characterized by microangiopathic hemolytic anemia, thrombocytopenia, and/or end-organ ischemia. TMAs are associated with significant morbidity and mortality, and data on the management of certain TMAs are often lacking. The nomenclature, classification, and management of various TMAs is constantly evolving as we learn more about these rare ...
Source: Thrombosis and Haemostasis - May 26, 2022 Category: Hematology Authors: Mouhamed Yazan Abou-Ismail Sargam Kapoor Divyaswathi Citla Sridhar Lalitha Nayak Sanjay Ahuja Source Type: research

Copy number variation analysis using next-generation sequencing identifies the < em > CFHR < /em > 3/ < em > CFHR < /em > 1 deletion in atypical hemolytic uremic syndrome: a case report
CONCLUSION: We genetically diagnosed a Korean woman harboring a heterozygous CFHR3/CFHR1 deletion of a known causative gene for aHUS. Our report emphasizes the need for CNV analysis of NGS data and gene dosage assays, such as MLPA, to evaluate large-scale deletions or duplications and generate hybrid CFH genes in patients with suspected aHUS.PMID:35617302 | DOI:10.1080/16078454.2022.2075121 (Source: Hematology)
Source: Hematology - May 26, 2022 Category: Hematology Authors: Joonhong Park Ho-Young Yhim Kyung Pyo Kang Tae Won Bae Yong Gon Cho Source Type: research

Thrombotic microangiopathies: An illustrated review
Res Pract Thromb Haemost. 2022 Apr 22;6(3):e12708. doi: 10.1002/rth2.12708. eCollection 2022 Mar.ABSTRACTThe thrombotic microangiopathies (TMAs) are a heterogenous group of disorders with distinct pathophysiologies that cause occlusive microvascular or macrovascular thrombosis, and are characterized by microangiopathic hemolytic anemia, thrombocytopenia, and/or end-organ ischemia. TMAs are associated with significant morbidity and mortality, and data on the management of certain TMAs are often lacking. The nomenclature, classification, and management of various TMAs is constantly evolving as we learn more about these rare ...
Source: Thrombosis and Haemostasis - May 26, 2022 Category: Hematology Authors: Mouhamed Yazan Abou-Ismail Sargam Kapoor Divyaswathi Citla Sridhar Lalitha Nayak Sanjay Ahuja Source Type: research

Microangiopathic Hemolytic Anemia Is a Late and Fatal Complication of Gastric Signet Ring Cell Carcinoma: A Systematic Review and Case-Control Study
CONCLUSION: Microangiopathic hemolytic anemia is a rare, late-stage complication of metastatic gastric SRCC and is associated with significantly decreased survival compared with metastatic gastric SRCC alone.PMID:35589098 | DOI:10.1093/oncolo/oyac093 (Source: The Oncologist)
Source: The Oncologist - May 19, 2022 Category: Cancer & Oncology Authors: Robert Lam Nicholas Tarangelo Rong Wang Masayasu Horibe Alyssa A Grimshaw Dhanpat Jain Samir Haffar Fateh Bazerbachi Pamela L Kunz Darrick K Li Source Type: research

Cancer-related microangiopathic hemolytic anemia
Am J Med Sci. 2022 May 16:S0002-9629(22)00228-2. doi: 10.1016/j.amjms.2022.02.015. Online ahead of print.NO ABSTRACTPMID:35588891 | DOI:10.1016/j.amjms.2022.02.015 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - May 19, 2022 Category: General Medicine Authors: Yasuhiro Kano Kouichi Kajiwara Yasuji Kozai Source Type: research