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The Role of Complement in Autoimmune Disease-Associated Thrombotic Microangiopathy and the Potential for Therapeutics
J Rheumatol. 2023 Jan 15:jrheum.220752. doi: 10.3899/jrheum.220752. Online ahead of print.ABSTRACTThe complement system is a tightly regulated, cascading protein network representing a key component linking the innate and humoral immune systems. However, if misdirected or dysregulated, it can be similarly damaging to host-tissue. The role of complement dysregulation on vascular endothelial cells has been well established in atypical hemolytic uremic syndrome (aHUS), a thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and target organ injury. Yet a great deal of complexit...
Source: J Rheumatol - January 15, 2023 Category: Rheumatology Authors: Anuja Java Alfred H J Kim Source Type: research

The Role of Complement in Autoimmune Disease-Associated Thrombotic Microangiopathy and the Potential for Therapeutics
J Rheumatol. 2023 Jan 15:jrheum.220752. doi: 10.3899/jrheum.220752. Online ahead of print.ABSTRACTThe complement system is a tightly regulated, cascading protein network representing a key component linking the innate and humoral immune systems. However, if misdirected or dysregulated, it can be similarly damaging to host-tissue. The role of complement dysregulation on vascular endothelial cells has been well established in atypical hemolytic uremic syndrome (aHUS), a thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and target organ injury. Yet a great deal of complexit...
Source: Journal of Rheumatology - January 15, 2023 Category: Rheumatology Authors: Anuja Java Alfred H J Kim Source Type: research

The Role of Complement in Autoimmune Disease-Associated Thrombotic Microangiopathy and the Potential for Therapeutics
J Rheumatol. 2023 Jan 15:jrheum.220752. doi: 10.3899/jrheum.220752. Online ahead of print.ABSTRACTThe complement system is a tightly regulated, cascading protein network representing a key component linking the innate and humoral immune systems. However, if misdirected or dysregulated, it can be similarly damaging to host-tissue. The role of complement dysregulation on vascular endothelial cells has been well established in atypical hemolytic uremic syndrome (aHUS), a thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and target organ injury. Yet, a great deal of complexi...
Source: Journal of Rheumatology - January 15, 2023 Category: Rheumatology Authors: Anuja Java Alfred H J Kim Source Type: research

The Role of Complement in Autoimmune Disease-Associated Thrombotic Microangiopathy and the Potential for Therapeutics
J Rheumatol. 2023 Jan 15:jrheum.220752. doi: 10.3899/jrheum.220752. Online ahead of print.ABSTRACTThe complement system is a tightly regulated, cascading protein network representing a key component linking the innate and humoral immune systems. However, if misdirected or dysregulated, it can be similarly damaging to host-tissue. The role of complement dysregulation on vascular endothelial cells has been well established in atypical hemolytic uremic syndrome (aHUS), a thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and target organ injury. Yet, a great deal of complexi...
Source: J Rheumatol - January 15, 2023 Category: Rheumatology Authors: Anuja Java Alfred H J Kim Source Type: research