Metabolism-mediated thrombotic microangiopathy and B12
Vitam Horm. 2022;119:441-455. doi: 10.1016/bs.vh.2022.01.002. Epub 2022 Feb 25.ABSTRACTThrombotic microangiopathies (TMAs) are a group of life-threatening conditions requiring urgent management and characterized by a clinical triad of microangiopathic hemolytic anemia, thrombocytopenia, and ischemic tissue injury. Severe vitamin B12 (Cobalamin-Cbl) deficiency or defective cobalamin metabolism, particularly defects in intracellular B12 metabolism, may lead to a TMA-like picture. The latter has been termed metabolism-mediated TMA (MM-TMA). This confusing picture is mediated partly by ineffective erythropoiesis with significa...
Source: Vitamins and Hormones - March 26, 2022 Category: Endocrinology Authors: Hadi Goubran Gaafar Ragab Waleed Sabry Source Type: research

Metabolism-mediated thrombotic microangiopathy and B12
Vitam Horm. 2022;119:441-455. doi: 10.1016/bs.vh.2022.01.002. Epub 2022 Feb 25.ABSTRACTThrombotic microangiopathies (TMAs) are a group of life-threatening conditions requiring urgent management and characterized by a clinical triad of microangiopathic hemolytic anemia, thrombocytopenia, and ischemic tissue injury. Severe vitamin B12 (Cobalamin-Cbl) deficiency or defective cobalamin metabolism, particularly defects in intracellular B12 metabolism, may lead to a TMA-like picture. The latter has been termed metabolism-mediated TMA (MM-TMA). This confusing picture is mediated partly by ineffective erythropoiesis with significa...
Source: Vitamins and Hormones - March 26, 2022 Category: Endocrinology Authors: Hadi Goubran Gaafar Ragab Waleed Sabry Source Type: research

Metabolism-mediated thrombotic microangiopathy and B12
Vitam Horm. 2022;119:441-455. doi: 10.1016/bs.vh.2022.01.002. Epub 2022 Feb 25.ABSTRACTThrombotic microangiopathies (TMAs) are a group of life-threatening conditions requiring urgent management and characterized by a clinical triad of microangiopathic hemolytic anemia, thrombocytopenia, and ischemic tissue injury. Severe vitamin B12 (Cobalamin-Cbl) deficiency or defective cobalamin metabolism, particularly defects in intracellular B12 metabolism, may lead to a TMA-like picture. The latter has been termed metabolism-mediated TMA (MM-TMA). This confusing picture is mediated partly by ineffective erythropoiesis with significa...
Source: Vitamins and Hormones - March 26, 2022 Category: Endocrinology Authors: Hadi Goubran Gaafar Ragab Waleed Sabry Source Type: research

Metabolism-mediated thrombotic microangiopathy and B12
Vitam Horm. 2022;119:441-455. doi: 10.1016/bs.vh.2022.01.002. Epub 2022 Feb 25.ABSTRACTThrombotic microangiopathies (TMAs) are a group of life-threatening conditions requiring urgent management and characterized by a clinical triad of microangiopathic hemolytic anemia, thrombocytopenia, and ischemic tissue injury. Severe vitamin B12 (Cobalamin-Cbl) deficiency or defective cobalamin metabolism, particularly defects in intracellular B12 metabolism, may lead to a TMA-like picture. The latter has been termed metabolism-mediated TMA (MM-TMA). This confusing picture is mediated partly by ineffective erythropoiesis with significa...
Source: Vitamins and Hormones - March 26, 2022 Category: Endocrinology Authors: Hadi Goubran Gaafar Ragab Waleed Sabry Source Type: research

Metabolism-mediated thrombotic microangiopathy and B12
Vitam Horm. 2022;119:441-455. doi: 10.1016/bs.vh.2022.01.002. Epub 2022 Feb 25.ABSTRACTThrombotic microangiopathies (TMAs) are a group of life-threatening conditions requiring urgent management and characterized by a clinical triad of microangiopathic hemolytic anemia, thrombocytopenia, and ischemic tissue injury. Severe vitamin B12 (Cobalamin-Cbl) deficiency or defective cobalamin metabolism, particularly defects in intracellular B12 metabolism, may lead to a TMA-like picture. The latter has been termed metabolism-mediated TMA (MM-TMA). This confusing picture is mediated partly by ineffective erythropoiesis with significa...
Source: Vitamins and Hormones - March 26, 2022 Category: Endocrinology Authors: Hadi Goubran Gaafar Ragab Waleed Sabry Source Type: research