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Clinical Profile, Treatment and Outcome of Thrombotic Thrombocytopenia Purpura (TTP) in Rituximab Era- an Experience from Tertiary Care Centre from North India
AbstractThrombotic thrombocytopenic purpura (TTP) is a microangiopathic hemolytic anemia (MAHA) resulting from severe deficiency of ADAMTS13. TTP is an acute medical emergency which requires early treatment with therapeutic plasma exchange. With the early use of Rituximab along with PLEX, early response is achieved and relapse rate has gone down. There is lack of published data from India regarding treatment and outcome of TTP. We retrospectively analyzed our data of 21 patients of TTP including 4 patients who had TA-TMA. TTP patients were treated with TPE, pulse methylprednisolone and rituximab. After a median follow up o...
Source: Indian Journal of Hematology and Blood Transfusion - April 20, 2024 Category: Hematology Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research