Clinical characteristics of anti-GBM disease with thrombotic microangiopathy: a case report and literature review
AbstractThe coexistence of anti-glomerular basement membrane (anti-GBM) disease with thrombotic microangiopathy (TMA) is rarely encountered, and the clinical characteristics of this phenomenon are not well known.A 76-year-old Japanese woman with a history of idiopathic pulmonary disease was diagnosed with anti-GBM disease due to rapidly progressive glomerulonephritis and a positive anti-GBM antibody test result. We treated the patient with hemodialysis, glucocorticoids, and plasmapheresis. During treatment, the patient suddenly became comatose. TMA was then diagnosed because of thrombocytopenia and microangiopathic hemolyt...
Source: CEN Case Reports - May 22, 2023 Category: Urology & Nephrology Source Type: research

Congenital Thrombotic Thrombocytopenic Purpura Masquerading As Vitamin B12 Deficiency
Congenital thrombotic thrombocytopenic purpura (CTTP), also called Upshaw-Schulman syndrome (USS), is a rare autosomal recessive disorder resulting from the deficiency of the ADAMTS13. CTTP is characterized by the formation of platelet-rich thrombi in small vessels of multiple organs, resulting in thrombocytopenia and microangiopathic hemolytic anemia, eventually leading to organ failure. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - May 15, 2023 Category: Hematology Authors: Deedar Nanjiani, Sohail Kumar, Nitik Sharma, Sundus Nasim, Dua Azim, Oam Parkash Source Type: research

A case of infection-induced thrombotic thrombocytopenic purpura
CONCLUSION: TTP is an acute severe disease with complex etiology, abrupt onset, and dangerous conditions. In this patient with TTP, an important cause of the disease may have been an acute gastrointestinal infection. The plasma examination in another hospital revealed positive results for ADAMTS13 inhibitors, providing strong evidence for the diagnosis of this case. Multiple plasma exchanges and glucocorticoids yielded favorable treatment results and were critical measures of successful treatment of TTP.PMID:37182863 | DOI:10.3233/CH-231784 (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - May 14, 2023 Category: Hematology Authors: Shaohua Cui Chaoyue Liang Lixia Geng Source Type: research

A case of infection-induced thrombotic thrombocytopenic purpura
CONCLUSION: TTP is an acute severe disease with complex etiology, abrupt onset, and dangerous conditions. In this patient with TTP, an important cause of the disease may have been an acute gastrointestinal infection. The plasma examination in another hospital revealed positive results for ADAMTS13 inhibitors, providing strong evidence for the diagnosis of this case. Multiple plasma exchanges and glucocorticoids yielded favorable treatment results and were critical measures of successful treatment of TTP.PMID:37182863 | DOI:10.3233/CH-231784 (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - May 14, 2023 Category: Hematology Authors: Shaohua Cui Chaoyue Liang Lixia Geng Source Type: research

A case of infection-induced thrombotic thrombocytopenic purpura
CONCLUSION: TTP is an acute severe disease with complex etiology, abrupt onset, and dangerous conditions. In this patient with TTP, an important cause of the disease may have been an acute gastrointestinal infection. The plasma examination in another hospital revealed positive results for ADAMTS13 inhibitors, providing strong evidence for the diagnosis of this case. Multiple plasma exchanges and glucocorticoids yielded favorable treatment results and were critical measures of successful treatment of TTP.PMID:37182863 | DOI:10.3233/CH-231784 (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - May 14, 2023 Category: Hematology Authors: Shaohua Cui Chaoyue Liang Lixia Geng Source Type: research

A case of infection-induced thrombotic thrombocytopenic purpura
CONCLUSION: TTP is an acute severe disease with complex etiology, abrupt onset, and dangerous conditions. In this patient with TTP, an important cause of the disease may have been an acute gastrointestinal infection. The plasma examination in another hospital revealed positive results for ADAMTS13 inhibitors, providing strong evidence for the diagnosis of this case. Multiple plasma exchanges and glucocorticoids yielded favorable treatment results and were critical measures of successful treatment of TTP.PMID:37182863 | DOI:10.3233/CH-231784 (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - May 14, 2023 Category: Hematology Authors: Shaohua Cui Chaoyue Liang Lixia Geng Source Type: research

A case of infection-induced thrombotic thrombocytopenic purpura
CONCLUSION: TTP is an acute severe disease with complex etiology, abrupt onset, and dangerous conditions. In this patient with TTP, an important cause of the disease may have been an acute gastrointestinal infection. The plasma examination in another hospital revealed positive results for ADAMTS13 inhibitors, providing strong evidence for the diagnosis of this case. Multiple plasma exchanges and glucocorticoids yielded favorable treatment results and were critical measures of successful treatment of TTP.PMID:37182863 | DOI:10.3233/CH-231784 (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - May 14, 2023 Category: Hematology Authors: Shaohua Cui Chaoyue Liang Lixia Geng Source Type: research

A case of infection-induced thrombotic thrombocytopenic purpura
CONCLUSION: TTP is an acute severe disease with complex etiology, abrupt onset, and dangerous conditions. In this patient with TTP, an important cause of the disease may have been an acute gastrointestinal infection. The plasma examination in another hospital revealed positive results for ADAMTS13 inhibitors, providing strong evidence for the diagnosis of this case. Multiple plasma exchanges and glucocorticoids yielded favorable treatment results and were critical measures of successful treatment of TTP.PMID:37182863 | DOI:10.3233/CH-231784 (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - May 14, 2023 Category: Hematology Authors: Shaohua Cui Chaoyue Liang Lixia Geng Source Type: research

A case of infection-induced thrombotic thrombocytopenic purpura
CONCLUSION: TTP is an acute severe disease with complex etiology, abrupt onset, and dangerous conditions. In this patient with TTP, an important cause of the disease may have been an acute gastrointestinal infection. The plasma examination in another hospital revealed positive results for ADAMTS13 inhibitors, providing strong evidence for the diagnosis of this case. Multiple plasma exchanges and glucocorticoids yielded favorable treatment results and were critical measures of successful treatment of TTP.PMID:37182863 | DOI:10.3233/CH-231784 (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - May 14, 2023 Category: Hematology Authors: Shaohua Cui Chaoyue Liang Lixia Geng Source Type: research

P95 Plasma exchange for HELLP syndrome complicated by persistent microangiopathic haemolytic anaemia resulting in a rapid recovery of renal function
(Source: International Journal of Obstetric Anesthesia)
Source: International Journal of Obstetric Anesthesia - May 1, 2023 Category: Anesthesiology Authors: P. Wyatt, M. Aukland, B. Anderson, S. Fletcher Source Type: research

Better late than never: Diagnosis of recurrent atypical hemolytic uremic syndrome
We present a case of a 50-year-old female who received her first kidney transplant from her mother at the age of 9 years. She experienced recurrent losses of transplants, and only after the loss of her fourth transplant did the diagnosis of aHUS become evident.PMID:37114491 | DOI:10.5414/CN111047 (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 28, 2023 Category: Urology & Nephrology Authors: Sari Aaltonen Anne R äisänen-Sokolowski Kati Kaartinen Source Type: research

Better late than never: Diagnosis of recurrent atypical hemolytic uremic syndrome
We present a case of a 50-year-old female who received her first kidney transplant from her mother at the age of 9 years. She experienced recurrent losses of transplants, and only after the loss of her fourth transplant did the diagnosis of aHUS become evident.PMID:37114491 | DOI:10.5414/CN111047 (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 28, 2023 Category: Urology & Nephrology Authors: Sari Aaltonen Anne R äisänen-Sokolowski Kati Kaartinen Source Type: research

Better late than never: Diagnosis of recurrent atypical hemolytic uremic syndrome
We present a case of a 50-year-old female who received her first kidney transplant from her mother at the age of 9 years. She experienced recurrent losses of transplants, and only after the loss of her fourth transplant did the diagnosis of aHUS become evident.PMID:37114491 | DOI:10.5414/CN111047 (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 28, 2023 Category: Urology & Nephrology Authors: Sari Aaltonen Anne R äisänen-Sokolowski Kati Kaartinen Source Type: research

Better late than never: Diagnosis of recurrent atypical hemolytic uremic syndrome
We present a case of a 50-year-old female who received her first kidney transplant from her mother at the age of 9 years. She experienced recurrent losses of transplants, and only after the loss of her fourth transplant did the diagnosis of aHUS become evident.PMID:37114491 | DOI:10.5414/CN111047 (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 28, 2023 Category: Urology & Nephrology Authors: Sari Aaltonen Anne R äisänen-Sokolowski Kati Kaartinen Source Type: research

A multicenter evaluation of the Technoscreen ADAMTS13 activity semi-quantitative screening test for thrombotic thrombocytopenic purpura diagnosis and exclusion
CONCLUSION: The Technoscreen assay appears to be a reliable screening test for ADAMTS13 activity to exclude TTP in routine clinical practice. However, the assay falsely identified ADAMTS13 deficiency in many cases, partially batch related, which mandates confirmation with a quantitative assay, as well as initial assessment of kits as 'fit for purpose' prior to use for patient testing.PMID:37078536 | DOI:10.1111/ijlh.14077 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - April 20, 2023 Category: Hematology Authors: Jared Stephenson Kent Chapman Soma Mohammed Diane Zebeljan Monica Ahuja Dea Donikian Leonardo Pasalic Penelope Motum Danny Hsu Timothy Brighton Emmanuel J Favaloro Source Type: research