A multicenter evaluation of the Technoscreen ADAMTS13 activity semi-quantitative screening test for thrombotic thrombocytopenic purpura diagnosis and exclusion

CONCLUSION: The Technoscreen assay appears to be a reliable screening test for ADAMTS13 activity to exclude TTP in routine clinical practice. However, the assay falsely identified ADAMTS13 deficiency in many cases, partially batch related, which mandates confirmation with a quantitative assay, as well as initial assessment of kits as 'fit for purpose' prior to use for patient testing.PMID:37078536 | DOI:10.1111/ijlh.14077

Source: International Journal of Laboratory Hematology - April 20, 2023 Category: Hematology Authors: Jared Stephenson Kent Chapman Soma Mohammed Diane Zebeljan Monica Ahuja Dea Donikian Leonardo Pasalic Penelope Motum Danny Hsu Timothy Brighton Emmanuel J Favaloro Source Type: research