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Semi-selective plasma filtration applied to the treatment of acquired thrombotic thrombocytopenic purpura following bnt162b2 administration
We report a case of a 63-year-old male who developed neurological symptoms after receiving the second dose of the bnt162b2 vaccine. Blood tests performed upon admission to the Emergency Department revealed severe thrombocytopenia and microangiopathic hemolytic anemia. ADAMTS13 activity was undetectable and antibody titer was high. Due to the rapid neurological deterioration, steroid therapy with prednisone was started at an initial dose of 1 mg/kg/day. Rituximab therapy was started to prevent the formation of new antibodies. Given the slow response to this therapy, we added Caplacizumab, (a monoclonal antibody anti-Von Wil...
Source: Journal of Nephrology - September 3, 2022 Category: Urology & Nephrology Authors: Roberta Fenoglio Martina Marchisio Alessandra Baffa Giacomo Quattrocchio Dario Roccatello Source Type: research

Concurrent thrombotic thrombocytopenic purpura and Guillian Barre Syndrome post infectious diarrhea
Ann Med Surg (Lond). 2022 Aug 5;80:104301. doi: 10.1016/j.amsu.2022.104301. eCollection 2022 Aug.ABSTRACTThrombotic thrombocytopenic purpura (TTP) characterized by microangiopathic hemolytic anemia, thrombocytopenia and signs of organ dysfunction, is due to either congenital or acquired deficiency of ADAMTS13 gene. Guillian Barre Syndrome (GBS) is a post infectious disorder, most commonly associated with C. jejuni infection. Both conditions have high mortality if untreated and have been reported with other comorbid conditions. We found only one case report of sequential TTP and GBS. However, we report the first case of con...
Source: Annals of Medicine - September 1, 2022 Category: Internal Medicine Authors: Taimoor Hussain Jasvindar Kumar Sarab Jeet Singh Anil Kumar Ihtisham Qayum Source Type: research

The Challenges in Diagnosis and Management of Acquired Thrombotic Thrombocytopenic Purpura: Consensus Report from Three Gulf Countries
Oman Med J. 2022 Jul 31;37(4):e407. doi: 10.5001/omj.2022.32. eCollection 2022 Jul.ABSTRACTAcquired thrombotic thrombocytopenic purpura (aTTP) is a rare hematological emergency characterized by microangiopathic hemolytic anemia, thrombocytopenia, fever, and multiorgan failure due to autoimmune-mediated deficiency in ADAMTS-13 activity. Currently, plasma exchange, with or without steroids, is the frontline option for the management of aTTP. The treatment should be started promptly once the disorder is clinically suspected. Besides, immunomodulators were studied in patients with aTTP to achieve stable remission and reduce th...
Source: Oman Medical Journal - August 11, 2022 Category: Middle East Health Authors: Murtadha Al-Khabori Faisal Alsayegh Hasan Al Yaseen Sabir Hussien Amar Lal Muna Al Rasheed Mohammad Al Bader Salam Al Kindi Mahmoud Marashi Source Type: research