Broad-spectrum antiviral activity of two structurally analogous CYP3A inhibitors against pathogenic human coronaviruses in vitro
Antiviral Res. 2023 Nov 30;221:105766. doi: 10.1016/j.antiviral.2023.105766. Online ahead of print.ABSTRACTCoronaviruses pose a permanent risk of outbreaks, with three highly pathogenic species and strains (SARS-CoV, MERS-CoV, SARS-CoV-2) having emerged in the last twenty years. Limited antiviral therapies are currently available and their efficacy in randomized clinical trials enrolling SARS-CoV-2 patients has not been consistent, highlighting the need for more potent treatments. We previously showed that cobicistat, a clinically approved inhibitor of Cytochrome P450-3A (CYP3A), has direct antiviral activity against early...
Source: Antiviral Research - December 2, 2023 Category: Virology Authors: Lara Gallucci James Bazire Andrew D Davidson Iart Luca Shytaj Source Type: research
Enumeration of olive derived lignan, pinoresinol for activity against recent Omicron variant spike protein for structure-based drug design, DFT, molecular dynamics simulations, and MMGBSA studies
This study focuses on virtual screening, docking, and molecular dynamic analysis; we aimed to identify therapeutic candidates for the SARS-CoV-2 variant Omicron based on their ability to inhibit non-structural proteins. We investigate the prediction of the properties of a substantial database of drug molecules obtained from the OliveNet™ database. Compounds that did not exhibit adequate gastrointestinal absorption and failed the Lipinski test are not considered for further research. The filtered compounds were coupled with our primary target, SARS-CoV-2 Omicron spike protein. We focused on SARS-CoV-2 Omicron spike protei...
Source: J Appl Genet - November 29, 2023 Category: Genetics & Stem Cells Authors: Samia S Alkhalil Shoruq E Alosaimi Manal E Alosaimi Zuhair M Mohammedsaleh Waleed Al Abdulmonem Abdullah Saleh Alkhamiss Ruqaih S Alghsham Abdullah S M Aljohani Abdullah F Shater Fayez M Saleh Hailah M Almohaimeed Mona H Soliman Source Type: research
Viruses, Vol. 15, Pages 2342: Bats & mdash;The Magnificent Virus Player: SARS, MERS, COVID-19 and Beyond
Viruses, Vol. 15, Pages 2342: Bats—The Magnificent Virus Player: SARS, MERS, COVID-19 and Beyond
Viruses doi: 10.3390/v15122342
Authors:
Kenneth S. M. Li
Susanna K. P. Lau
Patrick C. Y. Woo
Irrespective of whether COVID-19 originated from a natural or a genetically engineered virus, the ultimate source of Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) is bats [...] (Source: Viruses)
Source: Viruses - November 29, 2023 Category: Virology Authors: Kenneth S. M. Li Susanna K. P. Lau Patrick C. Y. Woo Tags: Editorial Source Type: research
Boosting the Electrical Performance of PLA ‐Based Triboelectric Nanogenerators for Sustainable Power Sources and Self‐Powered Sensing
A flexible TENG with high output is fabricated by assembling mPEG-modified PLA and P(VDF –TrFE) electrospun films. The optimized TENG achieves significant performance improvements by tuning the crystallinity and molecular dynamics of PLA fibers. This work provides new insights into tuning the structures and properties of electrospun polymers to reinforce the TENG output and self-power ed systems. AbstractTriboelectric nanogenerators (TENGs) have emerged as a promising technology for harvesting mechanical energy from the ambient environment. However, developing tribopositive materials with strong piezoelectric effects and...
Source: Small - November 27, 2023 Category: Nanotechnology Authors: Xingxing Shi,
Wanjie Si,
Jingyi Zhu,
Shuidong Zhang Tags: Research Article Source Type: research
Design of MERS-CoV entry inhibitory short peptides based on helix-stabilizing strategies
Bioorg Med Chem Lett. 2023 Nov 24;97:129569. doi: 10.1016/j.bmcl.2023.129569. Online ahead of print.ABSTRACTInteraction between Middle East respiratory syndrome coronavirus (MERS-CoV) spike (S) protein heptad repeat-1 domain (HR1) and heptad repeat-2 domain (HR2) is critical for the MERS-CoV fusion process. This interaction is mediated by the α-helical region from HR2 and the hydrophobic groove in a central HR1 trimeric coiled coil. We sought to develop a short peptidomimetic to act as a MERS-CoV fusion inhibitor by reproducing the key recognition features of HR2 helix. This was achieved by the use of helix-stabilizing st...
Source: Bioorganic and Medicinal Chemistry Letters - November 26, 2023 Category: Chemistry Authors: Jichun Li Qing Li Shuai Xia Jiahuang Tu Longbo Zheng Qian Wang Shibo Jiang Chao Wang Source Type: research
Design of MERS-CoV entry inhibitory short peptides based on helix-stabilizing strategies
Bioorg Med Chem Lett. 2023 Nov 24;97:129569. doi: 10.1016/j.bmcl.2023.129569. Online ahead of print.ABSTRACTInteraction between Middle East respiratory syndrome coronavirus (MERS-CoV) spike (S) protein heptad repeat-1 domain (HR1) and heptad repeat-2 domain (HR2) is critical for the MERS-CoV fusion process. This interaction is mediated by the α-helical region from HR2 and the hydrophobic groove in a central HR1 trimeric coiled coil. We sought to develop a short peptidomimetic to act as a MERS-CoV fusion inhibitor by reproducing the key recognition features of HR2 helix. This was achieved by the use of helix-stabilizing st...
Source: Bioorganic and Medicinal Chemistry Letters - November 26, 2023 Category: Chemistry Authors: Jichun Li Qing Li Shuai Xia Jiahuang Tu Longbo Zheng Qian Wang Shibo Jiang Chao Wang Source Type: research
Design of MERS-CoV entry inhibitory short peptides based on helix-stabilizing strategies
Bioorg Med Chem Lett. 2023 Nov 24;97:129569. doi: 10.1016/j.bmcl.2023.129569. Online ahead of print.ABSTRACTInteraction between Middle East respiratory syndrome coronavirus (MERS-CoV) spike (S) protein heptad repeat-1 domain (HR1) and heptad repeat-2 domain (HR2) is critical for the MERS-CoV fusion process. This interaction is mediated by the α-helical region from HR2 and the hydrophobic groove in a central HR1 trimeric coiled coil. We sought to develop a short peptidomimetic to act as a MERS-CoV fusion inhibitor by reproducing the key recognition features of HR2 helix. This was achieved by the use of helix-stabilizing st...
Source: Bioorganic and Medicinal Chemistry Letters - November 26, 2023 Category: Chemistry Authors: Jichun Li Qing Li Shuai Xia Jiahuang Tu Longbo Zheng Qian Wang Shibo Jiang Chao Wang Source Type: research
Type of delivery and perinatal outcomes in pregnant women diagnosed with COVID-19: A Systematic review and Meta-analysis
Pregnant women diagnosed with COVID-19 are less likely to have vaginal delivery with approximately two-thirds of deliveries in this population being caesarean sections.1,2 In women with severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), caesarean section is also more commonly indicated due to complications such as maternal hypoxemia. With evidence suggesting that pregnant women with COVID-19 were not as severely affected as pregnant women infected during other epidemics, this may explain the high rate of caesarean sections observed in the literature for this patient population. (Source: E...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - November 17, 2023 Category: OBGYN Authors: Alana S. Villar da Motta, Yangmyung Ma, Amanda V. Sardeli, Luciane Velasque Tags: Full length article Source Type: research
Effective Vaccination and Education Strategies for Emerging Infectious Diseases Such as COVID-19
This study aimed to establish vaccine strategies and vaccination education plans for new infectious diseases that may occur in the future. Many ways to promote vaccination to the general public and healthcare workers should be prepared to ensure that the latest vaccines against new infectious diseases are administered safely. Thus, education and promotion of vaccine efficacy and safety based on specific data from clinical studies are necessary.PMID:37967881 | DOI:10.3346/jkms.2023.38.e371 (Source: J Korean Med Sci)
Source: J Korean Med Sci - November 15, 2023 Category: General Medicine Authors: Seong-Heon Wie Jaehun Jung Woo Joo Kim Source Type: research
Effective Vaccination and Education Strategies for Emerging Infectious Diseases Such as COVID-19
This study aimed to establish vaccine strategies and vaccination education plans for new infectious diseases that may occur in the future. Many ways to promote vaccination to the general public and healthcare workers should be prepared to ensure that the latest vaccines against new infectious diseases are administered safely. Thus, education and promotion of vaccine efficacy and safety based on specific data from clinical studies are necessary.PMID:37967881 | DOI:10.3346/jkms.2023.38.e371 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - November 15, 2023 Category: Biomedical Science Authors: Seong-Heon Wie Jaehun Jung Woo Joo Kim Source Type: research
Effective Vaccination and Education Strategies for Emerging Infectious Diseases Such as COVID-19
This study aimed to establish vaccine strategies and vaccination education plans for new infectious diseases that may occur in the future. Many ways to promote vaccination to the general public and healthcare workers should be prepared to ensure that the latest vaccines against new infectious diseases are administered safely. Thus, education and promotion of vaccine efficacy and safety based on specific data from clinical studies are necessary.PMID:37967881 | DOI:10.3346/jkms.2023.38.e371 (Source: J Korean Med Sci)
Source: J Korean Med Sci - November 15, 2023 Category: General Medicine Authors: Seong-Heon Wie Jaehun Jung Woo Joo Kim Source Type: research
Effective Vaccination and Education Strategies for Emerging Infectious Diseases Such as COVID-19
This study aimed to establish vaccine strategies and vaccination education plans for new infectious diseases that may occur in the future. Many ways to promote vaccination to the general public and healthcare workers should be prepared to ensure that the latest vaccines against new infectious diseases are administered safely. Thus, education and promotion of vaccine efficacy and safety based on specific data from clinical studies are necessary.PMID:37967881 | PMC:PMC10643251 | DOI:10.3346/jkms.2023.38.e371 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - November 15, 2023 Category: Biomedical Science Authors: Seong-Heon Wie Jaehun Jung Woo Joo Kim Source Type: research
Effective Vaccination and Education Strategies for Emerging Infectious Diseases Such as COVID-19
This study aimed to establish vaccine strategies and vaccination education plans for new infectious diseases that may occur in the future. Many ways to promote vaccination to the general public and healthcare workers should be prepared to ensure that the latest vaccines against new infectious diseases are administered safely. Thus, education and promotion of vaccine efficacy and safety based on specific data from clinical studies are necessary.PMID:37967881 | PMC:PMC10643251 | DOI:10.3346/jkms.2023.38.e371 (Source: J Korean Med Sci)
Source: J Korean Med Sci - November 15, 2023 Category: General Medicine Authors: Seong-Heon Wie Jaehun Jung Woo Joo Kim Source Type: research
Effective Vaccination and Education Strategies for Emerging Infectious Diseases Such as COVID-19
This study aimed to establish vaccine strategies and vaccination education plans for new infectious diseases that may occur in the future. Many ways to promote vaccination to the general public and healthcare workers should be prepared to ensure that the latest vaccines against new infectious diseases are administered safely. Thus, education and promotion of vaccine efficacy and safety based on specific data from clinical studies are necessary.PMID:37967881 | PMC:PMC10643251 | DOI:10.3346/jkms.2023.38.e371 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - November 15, 2023 Category: Biomedical Science Authors: Seong-Heon Wie Jaehun Jung Woo Joo Kim Source Type: research
Effective Vaccination and Education Strategies for Emerging Infectious Diseases Such as COVID-19
This study aimed to establish vaccine strategies and vaccination education plans for new infectious diseases that may occur in the future. Many ways to promote vaccination to the general public and healthcare workers should be prepared to ensure that the latest vaccines against new infectious diseases are administered safely. Thus, education and promotion of vaccine efficacy and safety based on specific data from clinical studies are necessary.PMID:37967881 | PMC:PMC10643251 | DOI:10.3346/jkms.2023.38.e371 (Source: J Korean Med Sci)
Source: J Korean Med Sci - November 15, 2023 Category: General Medicine Authors: Seong-Heon Wie Jaehun Jung Woo Joo Kim Source Type: research
