Government Initiatives for Research Ethics During COVID-19 Pandemic in Korea
CONCLUSION: As a result of South Korea's commitment to ethical principles in their pandemic response, the medical system did not experience collapses due to the pandemic, and pandemic research was conducted with careful ethical considerations. The pandemic ethics immunization during the Middle East respiratory syndrome epidemic in 2015 laid the foundation for prompt government initiatives that ensured both pandemic research ethics and pandemic response ethics.PMID:38565174 | PMC:PMC10985498 | DOI:10.3346/jkms.2024.39.e116 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - April 2, 2024 Category: Biomedical Science Authors: Young Su Park Ock-Joo Kim Source Type: research
Government Initiatives for Research Ethics During COVID-19 Pandemic in Korea
CONCLUSION: As a result of South Korea's commitment to ethical principles in their pandemic response, the medical system did not experience collapses due to the pandemic, and pandemic research was conducted with careful ethical considerations. The pandemic ethics immunization during the Middle East respiratory syndrome epidemic in 2015 laid the foundation for prompt government initiatives that ensured both pandemic research ethics and pandemic response ethics.PMID:38565174 | PMC:PMC10985498 | DOI:10.3346/jkms.2024.39.e116 (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 2, 2024 Category: General Medicine Authors: Young Su Park Ock-Joo Kim Source Type: research
Government Initiatives for Research Ethics During COVID-19 Pandemic in Korea
CONCLUSION: As a result of South Korea's commitment to ethical principles in their pandemic response, the medical system did not experience collapses due to the pandemic, and pandemic research was conducted with careful ethical considerations. The pandemic ethics immunization during the Middle East respiratory syndrome epidemic in 2015 laid the foundation for prompt government initiatives that ensured both pandemic research ethics and pandemic response ethics.PMID:38565174 | PMC:PMC10985498 | DOI:10.3346/jkms.2024.39.e116 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - April 2, 2024 Category: Biomedical Science Authors: Young Su Park Ock-Joo Kim Source Type: research
Government Initiatives for Research Ethics During COVID-19 Pandemic in Korea
CONCLUSION: As a result of South Korea's commitment to ethical principles in their pandemic response, the medical system did not experience collapses due to the pandemic, and pandemic research was conducted with careful ethical considerations. The pandemic ethics immunization during the Middle East respiratory syndrome epidemic in 2015 laid the foundation for prompt government initiatives that ensured both pandemic research ethics and pandemic response ethics.PMID:38565174 | PMC:PMC10985498 | DOI:10.3346/jkms.2024.39.e116 (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 2, 2024 Category: General Medicine Authors: Young Su Park Ock-Joo Kim Source Type: research
Government Initiatives for Research Ethics During COVID-19 Pandemic in Korea
CONCLUSION: As a result of South Korea's commitment to ethical principles in their pandemic response, the medical system did not experience collapses due to the pandemic, and pandemic research was conducted with careful ethical considerations. The pandemic ethics immunization during the Middle East respiratory syndrome epidemic in 2015 laid the foundation for prompt government initiatives that ensured both pandemic research ethics and pandemic response ethics.PMID:38565174 | PMC:PMC10985498 | DOI:10.3346/jkms.2024.39.e116 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - April 2, 2024 Category: Biomedical Science Authors: Young Su Park Ock-Joo Kim Source Type: research
Development and preliminary validation of a MERS-CoV ELISA for serological testing of camels and alpacas
This study describes the development and preliminary validation of a new serological assay using MERS-CoV S1 protein in an indirect enzyme-linked immunosorbent assay (ELISA) format. This assay has the advantage of being able to test MERS-CoV serum samples in a PC2 laboratory without the need for a high-level biocontainment laboratory (PC3 or PC4), which requires highly trained and skilled staff and a high level of resources and equipment. Furthermore, this MERS-CoV S1 ELISA enables a larger number of samples to be tested quickly, with results obtained in approximately five hours. The MERS-CoV S1 ELISA demonstrated high ana...
Source: Journal of Virological Methods - April 1, 2024 Category: Virology Authors: Leanne McNabb Peter A Durr Ross Lunt Jennifer Barr Timothy E Adams Lesley Pearce Leo L M Poon Ranawaka A P M Perera Getnet Fekadu Demissie Timothy R Bowden Source Type: research
Development and preliminary validation of a MERS-CoV ELISA for serological testing of camels and alpacas
This study describes the development and preliminary validation of a new serological assay using MERS-CoV S1 protein in an indirect enzyme-linked immunosorbent assay (ELISA) format. This assay has the advantage of being able to test MERS-CoV serum samples in a PC2 laboratory without the need for a high-level biocontainment laboratory (PC3 or PC4), which requires highly trained and skilled staff and a high level of resources and equipment. Furthermore, this MERS-CoV S1 ELISA enables a larger number of samples to be tested quickly, with results obtained in approximately five hours. The MERS-CoV S1 ELISA demonstrated high ana...
Source: Journal of Virological Methods - April 1, 2024 Category: Virology Authors: Leanne McNabb Peter A Durr Ross Lunt Jennifer Barr Timothy E Adams Lesley Pearce Leo L M Poon Ranawaka A P M Perera Getnet Fekadu Demissie Timothy R Bowden Source Type: research
Development and preliminary validation of a MERS-CoV ELISA for serological testing of camels and alpacas
This study describes the development and preliminary validation of a new serological assay using MERS-CoV S1 protein in an indirect enzyme-linked immunosorbent assay (ELISA) format. This assay has the advantage of being able to test MERS-CoV serum samples in a PC2 laboratory without the need for a high-level biocontainment laboratory (PC3 or PC4), which requires highly trained and skilled staff and a high level of resources and equipment. Furthermore, this MERS-CoV S1 ELISA enables a larger number of samples to be tested quickly, with results obtained in approximately five hours. The MERS-CoV S1 ELISA demonstrated high ana...
Source: Journal of Virological Methods - April 1, 2024 Category: Virology Authors: Leanne McNabb Peter A Durr Ross Lunt Jennifer Barr Timothy E Adams Lesley Pearce Leo L M Poon Ranawaka Ap M Perera Getnet Fekadu Demissie Timothy R Bowden Source Type: research
Development and preliminary validation of a MERS-CoV ELISA for serological testing of camels and alpacas
This study describes the development and preliminary validation of a new serological assay using MERS-CoV S1 protein in an indirect enzyme-linked immunosorbent assay (ELISA) format. This assay has the advantage of being able to test MERS-CoV serum samples in a PC2 laboratory without the need for a high-level biocontainment laboratory (PC3 or PC4), which requires highly trained and skilled staff and a high level of resources and equipment. Furthermore, this MERS-CoV S1 ELISA enables a larger number of samples to be tested quickly, with results obtained in approximately five hours. The MERS-CoV S1 ELISA demonstrated high ana...
Source: Journal of Virological Methods - April 1, 2024 Category: Virology Authors: Leanne McNabb Peter A Durr Ross Lunt Jennifer Barr Timothy E Adams Lesley Pearce Leo L M Poon Ranawaka Ap M Perera Getnet Fekadu Demissie Timothy R Bowden Source Type: research
Differences and similarities between innate immune evasion strategies of human coronaviruses
Curr Opin Microbiol. 2024 Mar 30;79:102466. doi: 10.1016/j.mib.2024.102466. Online ahead of print.ABSTRACTSo far, seven coronaviruses have emerged in humans. Four recurring endemic coronaviruses cause mild respiratory symptoms. Infections with epidemic Middle East respiratory syndrome-related coronavirus or severe acute respiratory syndrome coronavirus (SARS-CoV)-1 are associated with high mortality rates. SARS-CoV-2 is the causative agent of the coronavirus disease 2019 pandemic. To establish an infection, coronaviruses evade restriction by human innate immune defenses, such as the interferon system, autophagy and the inf...
Source: Current Opinion in Microbiology - March 31, 2024 Category: Microbiology Authors: Helene Hoenigsperger Rinu Sivarajan Konstantin Mj Sparrer Source Type: research
Differences and similarities between innate immune evasion strategies of human coronaviruses
Curr Opin Microbiol. 2024 Mar 30;79:102466. doi: 10.1016/j.mib.2024.102466. Online ahead of print.ABSTRACTSo far, seven coronaviruses have emerged in humans. Four recurring endemic coronaviruses cause mild respiratory symptoms. Infections with epidemic Middle East respiratory syndrome-related coronavirus or severe acute respiratory syndrome coronavirus (SARS-CoV)-1 are associated with high mortality rates. SARS-CoV-2 is the causative agent of the coronavirus disease 2019 pandemic. To establish an infection, coronaviruses evade restriction by human innate immune defenses, such as the interferon system, autophagy and the inf...
Source: Current Opinion in Microbiology - March 31, 2024 Category: Microbiology Authors: Helene Hoenigsperger Rinu Sivarajan Konstantin Mj Sparrer Source Type: research
Differences and similarities between innate immune evasion strategies of human coronaviruses
Curr Opin Microbiol. 2024 Mar 30;79:102466. doi: 10.1016/j.mib.2024.102466. Online ahead of print.ABSTRACTSo far, seven coronaviruses have emerged in humans. Four recurring endemic coronaviruses cause mild respiratory symptoms. Infections with epidemic Middle East respiratory syndrome-related coronavirus or severe acute respiratory syndrome coronavirus (SARS-CoV)-1 are associated with high mortality rates. SARS-CoV-2 is the causative agent of the coronavirus disease 2019 pandemic. To establish an infection, coronaviruses evade restriction by human innate immune defenses, such as the interferon system, autophagy and the inf...
Source: Current Opinion in Microbiology - March 31, 2024 Category: Microbiology Authors: Helene Hoenigsperger Rinu Sivarajan Konstantin Mj Sparrer Source Type: research
New conjugates based on N4-hydroxycytidine with more potent antiviral efficacy in vitro than EIDD-2801 against SARS-CoV-2 and other human coronaviruses
Antiviral Res. 2024 Mar 28:105871. doi: 10.1016/j.antiviral.2024.105871. Online ahead of print.ABSTRACTThe spread of COVID-19 continues due to genetic variation in SARS-CoV-2. Highly mutated variants of SARS-CoV-2 have an increased transmissibility and immune evasion. Due to the emergence of various new variants of the virus, there is an urgent need to develop broadly effective specific drugs for therapeutic strategies for the prevention and treatment of COVID-19. Molnupiravir (EIDD-2801, MK-4482), is an orally bioavailable ribonucleoside analogue of β-D-N4-hydroxycytidine (NHC), has demonstrated efficacy against SARS-CoV...
Source: Antiviral Research - March 30, 2024 Category: Virology Authors: Andrei E Siniavin Vladimir A Gushchin Natal'ya S Shastina Elizaveta S Darnotuk Sergey I Luyksaar Leonid I Russu Anna M Inshakova Elena V Shidlovskaya Daria V Vasina Nadezhda A Kuznetsova Daria M Savina Ilya D Zorkov Inna V Dolzhikova Anna B Sheremet Denis Source Type: research
New conjugates based on N4-hydroxycytidine with more potent antiviral efficacy in vitro than EIDD-2801 against SARS-CoV-2 and other human coronaviruses
Antiviral Res. 2024 Mar 28:105871. doi: 10.1016/j.antiviral.2024.105871. Online ahead of print.ABSTRACTThe spread of COVID-19 continues due to genetic variation in SARS-CoV-2. Highly mutated variants of SARS-CoV-2 have an increased transmissibility and immune evasion. Due to the emergence of various new variants of the virus, there is an urgent need to develop broadly effective specific drugs for therapeutic strategies for the prevention and treatment of COVID-19. Molnupiravir (EIDD-2801, MK-4482), is an orally bioavailable ribonucleoside analogue of β-D-N4-hydroxycytidine (NHC), has demonstrated efficacy against SARS-CoV...
Source: Antiviral Research - March 30, 2024 Category: Virology Authors: Andrei E Siniavin Vladimir A Gushchin Natal'ya S Shastina Elizaveta S Darnotuk Sergey I Luyksaar Leonid I Russu Anna M Inshakova Elena V Shidlovskaya Daria V Vasina Nadezhda A Kuznetsova Daria M Savina Ilya D Zorkov Inna V Dolzhikova Anna B Sheremet Denis Source Type: research
Kinetics of Hepatitis E Virus Infections in Asymptomatic Persons
R. Pl ümers et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - March 29, 2024 Category: Infectious Diseases Source Type: research
