In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms
Cell Mol Immunol. 2023 Dec 26. doi: 10.1038/s41423-023-01116-8. Online ahead of print.ABSTRACTMembers of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent history. In this review, we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus family. We will detail the unmet clinical need associated with the continued transmission of SARS-CoV-2, MERS-CoV and the four seasonal coronaviruses (HCoV-OC43, NL63, HKU1 and 229E) in humans...
Source: Cellular and Molecular Immunology - December 26, 2023 Category: Molecular Biology Authors: S Cankat M U Demael L Swadling Source Type: research
Disease-Associated Streptococcus pneumoniae Genetic Variation
Emerg Infect Dis. 2024 Jan;30(1):39-49. doi: 10.3201/eid3001.221927.ABSTRACTStreptococcus pneumoniae is an opportunistic pathogen that causes substantial illness and death among children worldwide. The genetic backgrounds of pneumococci that cause infection versus asymptomatic carriage vary substantially. To determine the evolutionary mechanisms of opportunistic pathogenicity, we conducted a genomic surveillance study in China. We collected 783 S. pneumoniae isolates from infected and asymptomatic children. By using a 2-stage genomewide association study process, we compared genomic differences between infection and carria...
Source: Emerging Infectious Diseases - December 26, 2023 Category: Infectious Diseases Authors: Shimin Yang Jianyu Chen Jinjian Fu Jiayin Huang Ting Li Zhenjiang Yao Xiaohua Ye Source Type: research
In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms
Cell Mol Immunol. 2023 Dec 26. doi: 10.1038/s41423-023-01116-8. Online ahead of print.ABSTRACTMembers of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent history. In this review, we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus family. We will detail the unmet clinical need associated with the continued transmission of SARS-CoV-2, MERS-CoV and the four seasonal coronaviruses (HCoV-OC43, NL63, HKU1 and 229E) in humans...
Source: Cellular and Molecular Immunology - December 26, 2023 Category: Molecular Biology Authors: S Cankat M U Demael L Swadling Source Type: research
Disease-Associated Streptococcus pneumoniae Genetic Variation
Emerg Infect Dis. 2024 Jan;30(1):39-49. doi: 10.3201/eid3001.221927.ABSTRACTStreptococcus pneumoniae is an opportunistic pathogen that causes substantial illness and death among children worldwide. The genetic backgrounds of pneumococci that cause infection versus asymptomatic carriage vary substantially. To determine the evolutionary mechanisms of opportunistic pathogenicity, we conducted a genomic surveillance study in China. We collected 783 S. pneumoniae isolates from infected and asymptomatic children. By using a 2-stage genomewide association study process, we compared genomic differences between infection and carria...
Source: Emerging Infectious Diseases - December 26, 2023 Category: Infectious Diseases Authors: Shimin Yang Jianyu Chen Jinjian Fu Jiayin Huang Ting Li Zhenjiang Yao Xiaohua Ye Source Type: research
In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms
Cell Mol Immunol. 2023 Dec 26. doi: 10.1038/s41423-023-01116-8. Online ahead of print.ABSTRACTMembers of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent history. In this review, we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus family. We will detail the unmet clinical need associated with the continued transmission of SARS-CoV-2, MERS-CoV and the four seasonal coronaviruses (HCoV-OC43, NL63, HKU1 and 229E) in humans...
Source: Cellular and Molecular Immunology - December 26, 2023 Category: Molecular Biology Authors: S Cankat M U Demael L Swadling Source Type: research
Disease-Associated Streptococcus pneumoniae Genetic Variation
Emerg Infect Dis. 2024 Jan;30(1):39-49. doi: 10.3201/eid3001.221927.ABSTRACTStreptococcus pneumoniae is an opportunistic pathogen that causes substantial illness and death among children worldwide. The genetic backgrounds of pneumococci that cause infection versus asymptomatic carriage vary substantially. To determine the evolutionary mechanisms of opportunistic pathogenicity, we conducted a genomic surveillance study in China. We collected 783 S. pneumoniae isolates from infected and asymptomatic children. By using a 2-stage genomewide association study process, we compared genomic differences between infection and carria...
Source: Emerging Infectious Diseases - December 26, 2023 Category: Infectious Diseases Authors: Shimin Yang Jianyu Chen Jinjian Fu Jiayin Huang Ting Li Zhenjiang Yao Xiaohua Ye Source Type: research
In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms
Cell Mol Immunol. 2023 Dec 26. doi: 10.1038/s41423-023-01116-8. Online ahead of print.ABSTRACTMembers of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent history. In this review, we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus family. We will detail the unmet clinical need associated with the continued transmission of SARS-CoV-2, MERS-CoV and the four seasonal coronaviruses (HCoV-OC43, NL63, HKU1 and 229E) in humans...
Source: Cellular and Molecular Immunology - December 26, 2023 Category: Molecular Biology Authors: S Cankat M U Demael L Swadling Source Type: research
Disease-Associated Streptococcus pneumoniae Genetic Variation
Emerg Infect Dis. 2024 Jan;30(1):39-49. doi: 10.3201/eid3001.221927.ABSTRACTStreptococcus pneumoniae is an opportunistic pathogen that causes substantial illness and death among children worldwide. The genetic backgrounds of pneumococci that cause infection versus asymptomatic carriage vary substantially. To determine the evolutionary mechanisms of opportunistic pathogenicity, we conducted a genomic surveillance study in China. We collected 783 S. pneumoniae isolates from infected and asymptomatic children. By using a 2-stage genomewide association study process, we compared genomic differences between infection and carria...
Source: Emerging Infectious Diseases - December 26, 2023 Category: Infectious Diseases Authors: Shimin Yang Jianyu Chen Jinjian Fu Jiayin Huang Ting Li Zhenjiang Yao Xiaohua Ye Source Type: research
In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms
Cell Mol Immunol. 2023 Dec 26. doi: 10.1038/s41423-023-01116-8. Online ahead of print.ABSTRACTMembers of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent history. In this review, we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus family. We will detail the unmet clinical need associated with the continued transmission of SARS-CoV-2, MERS-CoV and the four seasonal coronaviruses (HCoV-OC43, NL63, HKU1 and 229E) in humans...
Source: Cellular and Molecular Immunology - December 26, 2023 Category: Molecular Biology Authors: S Cankat M U Demael L Swadling Source Type: research
Disease-Associated Streptococcus pneumoniae Genetic Variation
Emerg Infect Dis. 2024 Jan;30(1):39-49. doi: 10.3201/eid3001.221927.ABSTRACTStreptococcus pneumoniae is an opportunistic pathogen that causes substantial illness and death among children worldwide. The genetic backgrounds of pneumococci that cause infection versus asymptomatic carriage vary substantially. To determine the evolutionary mechanisms of opportunistic pathogenicity, we conducted a genomic surveillance study in China. We collected 783 S. pneumoniae isolates from infected and asymptomatic children. By using a 2-stage genomewide association study process, we compared genomic differences between infection and carria...
Source: Emerging Infectious Diseases - December 26, 2023 Category: Infectious Diseases Authors: Shimin Yang Jianyu Chen Jinjian Fu Jiayin Huang Ting Li Zhenjiang Yao Xiaohua Ye Source Type: research
In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms
Cell Mol Immunol. 2023 Dec 26. doi: 10.1038/s41423-023-01116-8. Online ahead of print.ABSTRACTMembers of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent history. In this review, we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus family. We will detail the unmet clinical need associated with the continued transmission of SARS-CoV-2, MERS-CoV and the four seasonal coronaviruses (HCoV-OC43, NL63, HKU1 and 229E) in humans...
Source: Cellular and Molecular Immunology - December 26, 2023 Category: Molecular Biology Authors: S Cankat M U Demael L Swadling Source Type: research
Unusual pediatric lung infections: imaging findings
AbstractPediatric lung infections continue to be a leading cause of pediatric morbidity and mortality. Although both pediatric and general radiologists are familiar with typical lung infections and their imaging findings in children, relatively rare lung infections continue to present a diagnostic challenge. In addition, the advances in radiological imaging and emergence of several new lung infections in recent years facilitated the need for up-to-date knowledge on this topic. In this review article, we discuss the imaging findings of pediatric lung infections caused by unusual/uncommon and new pathogens. We review the epi...
Source: Pediatric Radiology - December 14, 2023 Category: Radiology Source Type: research
Adolescent-Onset Multisystem Proteinopathy due to a Novel VCP Variant
Valosin-containing protein (VCP) is a protein of the AAA+ (ATPase Associated with diverse cellular Activities) family and is involved in various cellular mechanisms, including ubiquitin dependent cellular processes via ubiquitin-proteosome system, autophagy regulation and protein clearance [1 –3]. Pathogenic variants in VCP cause multisystem proteinopathy (MSP) manifesting with inclusion body myopathy (IBM), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Paget disease of bone (PDB) [4,5]. (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - December 8, 2023 Category: Neurology Authors: Pannathat Soontrapa, Nathan A. Seven, Teerin Liewluck, Gaofeng Cui, Georges Mers, Margherita Milone Tags: Case report Source Type: research
Broad-spectrum antiviral activity of two structurally analogous CYP3A inhibitors against pathogenic human coronaviruses in vitro
Antiviral Res. 2023 Nov 30:105766. doi: 10.1016/j.antiviral.2023.105766. Online ahead of print.ABSTRACTCoronaviruses pose a permanent risk of outbreaks, with three highly pathogenic species and strains (SARS-CoV, MERS-CoV, SARS-CoV-2) having emerged in the last twenty years. Limited antiviral therapies are currently available and their efficacy in randomized clinical trials enrolling SARS-CoV-2 patients has not been consistent, highlighting the need for more potent treatments. We previously showed that cobicistat, a clinically approved inhibitor of Cytochrome P450-3A (CYP3A), has direct antiviral activity against early cir...
Source: Antiviral Research - December 2, 2023 Category: Virology Authors: Lara Gallucci James Bazire Andrew D Davidson Iart Luca Shytaj Source Type: research
Broad-spectrum antiviral activity of two structurally analogous CYP3A inhibitors against pathogenic human coronaviruses in vitro
Antiviral Res. 2023 Nov 30:105766. doi: 10.1016/j.antiviral.2023.105766. Online ahead of print.ABSTRACTCoronaviruses pose a permanent risk of outbreaks, with three highly pathogenic species and strains (SARS-CoV, MERS-CoV, SARS-CoV-2) having emerged in the last twenty years. Limited antiviral therapies are currently available and their efficacy in randomized clinical trials enrolling SARS-CoV-2 patients has not been consistent, highlighting the need for more potent treatments. We previously showed that cobicistat, a clinically approved inhibitor of Cytochrome P450-3A (CYP3A), has direct antiviral activity against early cir...
Source: Antiviral Research - December 2, 2023 Category: Virology Authors: Lara Gallucci James Bazire Andrew D Davidson Iart Luca Shytaj Source Type: research
