Fangchinoline inhibits SARS-CoV-2 and MERS-CoV entry
Antiviral Res. 2023 Nov 8:105743. doi: 10.1016/j.antiviral.2023.105743. Online ahead of print.ABSTRACTThe COVID-19 pandemic caused by SARS-CoV-2, lead to mild to severe respiratory illness and resulted in 6.9 million deaths worldwide. Although vaccines are effective in preventing COVID-19, they may not be sufficient to protect immunocompromised individuals from this respiratory illness. Moreover, novel emerging variants of SARS-CoV-2 pose a risk of new COVID-19 waves. Therefore, identification of effective antivirals is critical in controlling SARS and other coronaviruses, such as MERS-CoV. We show that Fangchinoline (Fcn)...
Source: Antiviral Research - November 10, 2023 Category: Virology Authors: Srikanth Sadhu Jyotsna Dandotiya Rajdeep Dalal Ritika Khatri Anna Z Mykytyn Aashima Batra Manpreet Kaur Rucha Chandwaskar Virendra Singh Aarzoo Kamboj Mitul Srivastava Shailendra Mani Shailendra Asthana Sweety Samal Zaigham Abbas Rizvi Deepak B Salunke Ba Source Type: research
Fangchinoline inhibits SARS-CoV-2 and MERS-CoV entry
Antiviral Res. 2023 Nov 8:105743. doi: 10.1016/j.antiviral.2023.105743. Online ahead of print.ABSTRACTThe COVID-19 pandemic caused by SARS-CoV-2, lead to mild to severe respiratory illness and resulted in 6.9 million deaths worldwide. Although vaccines are effective in preventing COVID-19, they may not be sufficient to protect immunocompromised individuals from this respiratory illness. Moreover, novel emerging variants of SARS-CoV-2 pose a risk of new COVID-19 waves. Therefore, identification of effective antivirals is critical in controlling SARS and other coronaviruses, such as MERS-CoV. We show that Fangchinoline (Fcn)...
Source: Antiviral Research - November 10, 2023 Category: Virology Authors: Srikanth Sadhu Jyotsna Dandotiya Rajdeep Dalal Ritika Khatri Anna Z Mykytyn Aashima Batra Manpreet Kaur Rucha Chandwaskar Virendra Singh Aarzoo Kamboj Mitul Srivastava Shailendra Mani Shailendra Asthana Sweety Samal Zaigham Abbas Rizvi Deepak B Salunke Ba Source Type: research
Fangchinoline inhibits SARS-CoV-2 and MERS-CoV entry
Antiviral Res. 2023 Nov 8:105743. doi: 10.1016/j.antiviral.2023.105743. Online ahead of print.ABSTRACTThe COVID-19 pandemic caused by SARS-CoV-2, lead to mild to severe respiratory illness and resulted in 6.9 million deaths worldwide. Although vaccines are effective in preventing COVID-19, they may not be sufficient to protect immunocompromised individuals from this respiratory illness. Moreover, novel emerging variants of SARS-CoV-2 pose a risk of new COVID-19 waves. Therefore, identification of effective antivirals is critical in controlling SARS and other coronaviruses, such as MERS-CoV. We show that Fangchinoline (Fcn)...
Source: Antiviral Research - November 10, 2023 Category: Virology Authors: Srikanth Sadhu Jyotsna Dandotiya Rajdeep Dalal Ritika Khatri Anna Z Mykytyn Aashima Batra Manpreet Kaur Rucha Chandwaskar Virendra Singh Aarzoo Kamboj Mitul Srivastava Shailendra Mani Shailendra Asthana Sweety Samal Zaigham Abbas Rizvi Deepak B Salunke Ba Source Type: research
Fangchinoline inhibits SARS-CoV-2 and MERS-CoV entry
Antiviral Res. 2023 Nov 8:105743. doi: 10.1016/j.antiviral.2023.105743. Online ahead of print.ABSTRACTThe COVID-19 pandemic caused by SARS-CoV-2, lead to mild to severe respiratory illness and resulted in 6.9 million deaths worldwide. Although vaccines are effective in preventing COVID-19, they may not be sufficient to protect immunocompromised individuals from this respiratory illness. Moreover, novel emerging variants of SARS-CoV-2 pose a risk of new COVID-19 waves. Therefore, identification of effective antivirals is critical in controlling SARS and other coronaviruses, such as MERS-CoV. We show that Fangchinoline (Fcn)...
Source: Antiviral Research - November 10, 2023 Category: Virology Authors: Srikanth Sadhu Jyotsna Dandotiya Rajdeep Dalal Ritika Khatri Anna Z Mykytyn Aashima Batra Manpreet Kaur Rucha Chandwaskar Virendra Singh Aarzoo Kamboj Mitul Srivastava Shailendra Mani Shailendra Asthana Sweety Samal Zaigham Abbas Rizvi Deepak B Salunke Ba Source Type: research
The KxGxYR and DxE motifs in the C-tail of the Middle East respiratory syndrome coronavirus membrane protein are crucial for infectious virus assembly
Cell Mol Life Sci. 2023 Nov 9;80(12):353. doi: 10.1007/s00018-023-05008-y.ABSTRACTThe coronavirus' (CoV) membrane (M) protein is the driving force during assembly, but this process remains poorly characterized. Previously, we described two motifs in the C-tail of the Middle East respiratory syndrome CoV (MERS-CoV) M protein involved in its endoplasmic reticulum (ER) exit (211DxE213) and trans-Golgi network (TGN) retention (199KxGxYR204). Here, their function in virus assembly was investigated by two different virus-like particle (VLP) assays and by mutating both motifs in an infectious MERS-CoV cDNA clone. It was shown tha...
Source: Cellular and Molecular Life Sciences : CMLS - November 8, 2023 Category: Cytology Authors: Lowiese Desmarets Adeline Danneels Julien Burlaud-Gaillard Emmanuelle Blanchard Jean Dubuisson Sandrine Belouzard Source Type: research
Localizing unmapped sequences with families to validate the Telomere-to-Telomere assembly and identify new hotspots for genetic diversity [METHODS]
Although it is ubiquitous in genomics, the current human reference genome (GRCh38) is incomplete: It is missing large sections of heterochromatic sequence, and as a singular, linear reference genome, it does not represent the full spectrum of human genetic diversity. To characterize gaps in GRCh38 and human genetic diversity, we developed an algorithm for sequence location approximation using nuclear families (ASLAN) to identify the region of origin of reads that do not align to GRCh38. Using unmapped reads and variant calls from whole-genome sequences (WGSs), ASLAN uses a maximum likelihood model to identify the most like...
Source: Genome Research - November 8, 2023 Category: Genetics & Stem Cells Authors: Chrisman, B., He, C., Jung, J.-Y., Stockham, N., Paskov, K., Washington, P., Petereit, J., Wall, D. P. Tags: METHODS Source Type: research
Symptomatic MERS-CoV infection reduces the risk of future COVID-19 disease; a retrospective cohort study
The general human immune responses similarity against different coronaviruses may reflect some degree of cross-immunity, whereby exposure to one coronavirus may confer partial immunity to another. The aim was ... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - November 3, 2023 Category: Infectious Diseases Authors: Aiman El-Saed, Fatmah Othman, Henry Baffoe-Bonnie, Rawabi Almulhem, Muayed Matalqah, Latifah Alshammari and Majid M. Alshamrani Tags: Research Source Type: research
Mental Health: Pandemics, Epidemics and Tau Protein
CONCLUSION: Future research on the underlying pathways may yield essential information for the treatment and prevention of prospective mental diseases in light of the ongoing decline in mental health during the past 10 years.PMID:37916210 | PMC:PMC10351338 | DOI:10.2174/17450179-v19-e230510-2022-51 (Source: Clinical Practice and Epidemiology in Mental Health)
Source: Clinical Practice and Epidemiology in Mental Health - November 2, 2023 Category: Psychiatry Authors: Ghinwa M Barakat Ghaith Assi Noura B El Khoury Source Type: research
What strengthens Protein-Protein Interactions: Analysis and Applications of Residue Correlation Networks
J Mol Biol. 2023 Oct 31:168337. doi: 10.1016/j.jmb.2023.168337. Online ahead of print.ABSTRACTIdentifying residues critical to protein-protein binding and efficient design of stable and specific protein binders are challenging tasks. Extending beyond the direct contacts in a protein-protein binding interface, our study employs computational modeling to reveal the essential network of residue interactions and dihedral angle correlations critical in protein-protein recognition. We hypothesized that mutating residues exhibiting highly correlated dynamic motion within the interaction network could efficiently optimize protein-...
Source: Mol Biol Cell - November 2, 2023 Category: Molecular Biology Authors: Ta I Hung Yun-Jung Hsieh Wei-Lin Lu Kuen-Phon Wu Chia-En A Chang Source Type: research
Mental Health: Pandemics, Epidemics and Tau Protein
CONCLUSION: Future research on the underlying pathways may yield essential information for the treatment and prevention of prospective mental diseases in light of the ongoing decline in mental health during the past 10 years.PMID:37916210 | PMC:PMC10351338 | DOI:10.2174/17450179-v19-e230510-2022-51 (Source: Clinical Practice and Epidemiology in Mental Health)
Source: Clinical Practice and Epidemiology in Mental Health - November 2, 2023 Category: Psychiatry Authors: Ghinwa M Barakat Ghaith Assi Noura B El Khoury Source Type: research
