WALS- George Khoury Lecture: Coronavirus Activation and Antagonism of Interferon Signaling Pathways: from MHV to SARS-CoV-2
Coronavirus interactions with the interferon signaling response are crucial for antiviral defense especially at the early stages of infection. Murine coronavirus, MHV, has taught us a lot about the basic biology of this family of viruses as well as antagonism of innate immune response, a hallmark of coronavirus infection. Building on our MHV data, we have more recently worked with human coronaviruses. We have optimized methods for comparing human coronaviruses in a primary nasal cell air liquid interface (ALI) culture system, which models the initial site of respiratory virus infection. Common cold coronaviruses as well as...
Source: Videocast - All Events - March 6, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
WALS- George Khoury Lecture: Coronavirus Activation and Antagonism of Innate Immune Pathways
Our lab studies murine and human coronavirus pathogenesis, including MHV, MERS-CoV and SARS-CoV. We use MHV infection of mice as a model system for the study of:acute viral encephalitischronic demyelinating diseases such as Multiple Sclerosisvirus-induced hepatitissevere acute respiratory diseases.We have the important tools of a well-developed animal model system and reverse genetic systems with which to manipulate the viral genome. We also investigate pathogenesis of human coronaviruses both the lethal MERS-CoV and SARS-CoV-2 as well as the common cold viruses OC43 and 229E and NL63. We are investigating these both in ep...
Source: Videocast - All Events - October 4, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH – FDA COVID SIG Lecture with Malik Peiris
In 2003, Professor Peiris and his research team discovered SARS-CoV, a novel coronavirus, as the etiological agent for SARS. He joined The University of Hong Kong in 1995, and is now Chair of Virology at the School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China. He co-directs the WHO H5 Reference Laboratory and the WHO SARS-CoV-2 reference laboratory at The University of Hong Kong. Currently, he serves on many Hong Kong and WHO advisory committees, including the WHO International Health Regulations Emergency Committee on COVID-19.
He is a clinical and public health virologis...
Source: Videocast - All Events - February 10, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director's Seminar Series: The ecology of emerging coronaviruses, from host reservoir to disease
In the past two decades, three coronaviruses have emerged and caused widespread outbreaks in humans. The origin of these zoonotic viruses has been traced back to bats as natural reservoir. Since the SARS epidemic in 2002 – 2003, the appreciation of bats as key hosts of zoonotic coronaviruses has advanced rapidly, but data underlying key drivers of the epidemic and pandemic emergence of these viruses remain limited. Here we discuss the emergence of MERS-CoV and SARS-CoV-2. Highlighting the origin, genetic diversity, pandemic potential, transmission dynamics, pathogenicity, and development of countermeasure against these b...
Source: Videocast - All Events - July 6, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
COVID-19, International Law, and Data Governance
Speaker Alexandra L. Phelan is an Adjunct Professor in Global and Public Health Law and Ethics, Doctor of Juridical Science (SJD) candidate and General Sir John Monash Scholar at Georgetown University in Washington DC. Professor Phelan ’ s doctoral research examines the global governance of infectious diseases, with a focus on Australian, Chinese and US laws relating to the health and human rights of vulnerable population groups. Professor Phelan ’ s research explores the key legal issues of emerging and re-emerging infectious diseases – such as Ebola, Pandemic Influenza, MERS, and Zika Virus – in the face of press...
Source: Videocast - All Events - September 21, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
The RECOVERY Trial: Science in a Crisis
The speaker returned to Oxford in 2014 and established the Epidemic disease Research Group Oxford (ERGO). ERGO is engaged in an international program of clinical and epidemiological research to prepare for and respond to emerging infections that may develop into epidemics or pandemics. ERGO is involved in a number of international projects including the European Commission funded PREPARE project, and ISARIC (International Severe Acute Respiratory and Emerging Infection Consortium). The group is conducting research on a range of epidemic diseases including Ebola virus disease, bird flu (H5N1 and H7N9), MERS-CoV, and Enterov...
Source: Videocast - All Events - December 10, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Environmental engineers aim for an early indicator of an outbreak
Despite intensive study of SARS and MERS, we still lack a fundamental understanding of coronavirus behavior in the environment. Most importantly, we do not know how coronavirus spreads and how long it remains infective when exposed to sunlight. The goal of this RAPID research project is to address ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - May 18, 2020 Category: Science Source Type: video
Coronavirus, SARS-CoV-2, & Glycans
This workshop will focus on the roles of glycans in Coronavirus (CoV) infection, with emphasis on the Spike-glycoprotein of SARS-CoV-2, its host receptor(s) and it will introduce new research tools that can facilitate these studies and accelerate the development of therapeutics, vaccines and diagnostics.
Coronavirus ( α − , β − , γ − , and δ -CoVs) are single stranded RNA viruses that can infect the lung, gastrointestinal, and central nervous system of mammals ( α -, β -) and birds ( γ -, δ -). While both α and β -CoV strains can cause mild infections in humans, three β -CoV strains (SARS-CoV in 2003; MERS...
Source: Videocast - All Events - April 30, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Rapid COVID-19 Vaccine Development: An Example of the Prototype Pathogen Approach for Pandemic Preparedness
NIH COVID-19 SIG Lecture Series
The prototype pathogen approach for pandemic preparedness has been applied to the Middle East respiratory syndrome coronavirus (MERS CoV) over the last seven years. It was informed by structure-based immunogen-design concepts established for respiratory syncytial virus fusion (RSV F) subunit vacc ines, and focused on solving coronavirus spike structures, defining mechanisms of CoV neutralization, and evaluating MERS CoV vaccine candidates in collaboration with a commercial mRNA manufacturer. Prior spike protein engineering experience resulted in rapid sequence selection and using the mRNA m...
Source: Videocast - All Events - April 20, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Demystifying Medicine 2016: Ebola, MERS, and Likelihood of More Epidemics & Evolutionary Dynamics and Zoonotic and Cross-Species Transmission of Emerging Viruses
Presented by: Anthony Fauci, MD, NIAID, NIH and Vincent Munster, PhD, NIAID, NIHCategory: Demystifying MedicineAired date: 01/12/2016 (Source: Videocast - All Events)
Source: Videocast - All Events - January 13, 2016 Category: Journals (General) Tags: Past Events Source Type: video
Demystifying Medicine 2016: Ebola, MERS, and Likelihood of More Epidemics & Evolutionary Dynamics and Zoonotic and Cross-Species Transmission of Emerging Viruses
Demystifying Medicine is an annual course from January to May designed to help bridge the gap between advances in biology and their application to major human diseases. The course includes presentation of patients, pathology, diagnosis, and therapy in the context of major disease problems and current research, primarily directed toward Ph.D. students, fellows, and staff. All are invited.For more information go to https://demystifyingmedicine.od.nih.gov/
Air date: 1/12/2016 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 30, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
MERS-CoV Research: Current Status and Future Priorities Meeting
Presented by: NIAIDCategory: ConferencesAired date: 06/24/2013 (Source: Videocast - All Events)
Source: Videocast - All Events - June 26, 2013 Category: Journals (General) Tags: Past Events Source Type: video
MERS-CoV Research: Current Status and Future Priorities Meeting (HHS Only)
Presented by: NIAIDCategory: HHS OnlyAired date: 06/24/2013 (Source: Videocast - All Events)
Source: Videocast - All Events - June 26, 2013 Category: Journals (General) Tags: Past Events Source Type: video
MERS-CoV Research Current Topics and Future Priorities Meeting (HHS Only)
This meeting will bring together leading virologists to discuss the current status of the coronavirus field in the context of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). Air date: 6/24/2013 8:15:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - June 18, 2013 Category: Journals (General) Tags: Upcoming Events Source Type: video
