TWiV 1089: Shoot out at the Circle-T ranch
TWiV reviews a fatal Alaskapox case, MERS in Kenya, diagnostic tests for Nipah and Lassa diseases, HPV vaccination rates in the US, cases of measles in Arizona and Minnesota, hepatitis C virus-derived RNA circles in infected cells, and prevention of respiratory virus transmission by resident memory CD8+ T cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in ...
Source: This Week in Virology - MP3 Edition - February 18, 2024 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 968: A spillover waiting in the wings
TWiV reviews eukaryotic viruses recovered from ancient permafrost, a mistake made by scientists on Omicron origins, and close relatives of MERS-CoV from bats that bind ACE2 for entry into cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV Positions with the Mosquito and Vector Control Division in Harris County Public Health (one and two) Ancient eukaryotic viruses from permaf...
Source: This Week in Virology - MP3 Edition - December 25, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

X-ray analysis hints at answers to fossil mystery
00:45 The puzzle of PalaeospondylusOver a hundred years ago, archaeologists discovered fossils of the aquatic animal Palaeospondylus. But since then researchers have been unable to place where this animal sits on the tree of life. Now, new analysis of Palaeospondylus’s anatomy might help to solve this mystery.Research article: Hirasawa et al.News and Views: Clues to the identity of the fossil fish Palaeospondylus08:18 Research HighlightsA strong, silk-based version of mother of pearl, and the parrots that use their heads when climbing.Research Highlight: Silk imitates mother of pearl for a tough, eco-friendly materialRes...
Source: Nature Podcast - May 25, 2022 Category: Science Authors: Springer Nature Limited Source Type: podcasts

TWiV 729: A floret of spikes with Matt Frieman
Matt Frieman returns to TWiV to discuss the COVID-19 pandemic from the point of view of a coronavirologist, including his work with Novavax on their spike protein-based vaccine. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Matt Frieman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Phase 1-2 trial of Novavax protein vaccine (NEJM) MERS-CoV spike nanoparticle vaccine in mice (Vaccine) Novavax phase 3 press release When you’ve been fully vaccinated (CDC) Letters read on TWiV 729 Timestamps by Jolene. Than...
Source: This Week in Virology - MP3 Edition - March 11, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 674: In the company of coronaviruses with Lisa Gralinski
Lisa joins TWiV to discuss her research on the pathogenesis of SARS-CoV, MERS-CoV, and SARS-CoV-2, including work on vaccines and an antiviral, then we review the SARS-CoV-2 spike protein as a potential analgesic, and listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: Lisa Gralinski Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-like bat CoV with potential for human emergence (Nat Med) SARS-CoV susceptibility loci in CC mice (PLoS Genetics) Combination attenuation for SARS-CoV vaccine (J Virol) Orally admin...
Source: This Week in Virology - MP3 Edition - October 22, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 668: Mice, bats, and coronaviruses with Tony Schountz
Tony Schountz joins TWiV to explain the work of his laboratory showing that deer mice can be infected with and transmit SARS-CoV-2, and how his colony of Jamaican fruit bats is being used to understand their response to virus infections. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: Tony Schountz Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 infection of deer mice (bioRxiv) Infection of Jamaican fruit bats with MERS-CoV (Sci Rep) Immunological control of virus infections in bats (Front Immunol) Transmission of bat ...
Source: This Week in Virology - MP3 Edition - October 1, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 640: Test often, fast turnaround, with Michael Mina
Michael Mina joins TWiV to reveal why frequent and rapid SARS-CoV-2 testing is more important than accuracy, how a daily $1 rapid test could control the pandemic, and why group testing works. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guests: Michael Mina Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Michael Mina on Immune 26 White House bypasses CDC (NY Times) Test sensitivity is secondary to frequency and turnaround time (medRxiv) Group testing for SARS-CoV-2 (medRxiv) Consider the cycle threshold value (Clin Inf Dis) MERS-CoV...
Source: This Week in Virology - MP3 Edition - July 16, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 622: Nonhuman primate model for COVID-19 with Emmie de Wit
Emmie de Wit joins TWiV to explain her work on the pathogenesis of infection with SARS-CoV-2 in rhesus macaques, including studies on remdesivir and vaccine candidate. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Emmie de Wit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Respiratory disease in macaques inoculated with SARS-CoV-2 (Nature) Clinical benefit of remdesivir in SARS-CoV-2 infected macaques (bioRxiv) Remdesivir for MERS-CoV infection in macaques (PNAS) ChAdOX1 vaccination for SARS-CoV-2 in macaques (bioRxiv) Image credit Timestamp...
Source: This Week in Virology - MP3 Edition - June 2, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 613: Jenner, vaccines, and COVID-19
Vincent, Kathy and Rich explain the Jenner Institute's SARS-CoV-2 vaccine, the NIH decision to stop the Remdesivir study, and answer listener questions. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 brings out dark side of science (Mother Jones, Wired) Jenner Institute COVID-19 vaccine (BioSpace) Recombineering (Nucleic Acids Res) Vaccines lecture (YouTube) ChAdOx1 MERS vaccines protects NHP (Lancet Inf Dis) Chimpanzee adenovirus vector (PLoS One) Ad-MERS vaccine protects monkeys (NIH) Rapid C...
Source: This Week in Virology - MP3 Edition - May 14, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 614: Jenner, vaccines, and COVID-19
Vincent, Kathy and Rich explain the Jenner Institute's SARS-CoV-2 vaccine, the NIH decision to stop the Remdesivir study, and answer listener questions. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 brings out dark side of science (Mother Jones, Wired) Jenner Institute COVID-19 vaccine (BioSpace) Recombineering (Nucleic Acids Res) Vaccines lecture (YouTube) ChAdOx1 MERS vaccines protects NHP (Lancet Inf Dis) Chimpanzee adenovirus vector (PLoS One) Ad-MERS vaccine protects monkeys (NIH) Rapid C...
Source: This Week in Virology - MP3 Edition - May 14, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 609: A coronavirus chronology with Susan Weiss
Susan Weiss recalls some of her 40 years of research on coronaviruses, including mouse hepatitis virus, MERS-CoV, and now SARS-CoV-2. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Susan Weiss Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Coronaviruses by Susan Weiss (YouTube) Forty years with coronaviruses (JEM) No credible evidence that SARS-CoV-2 came from a lab (Emerg Micr Infect) CoV and antagonism of RNAse L (mBio) Exoribonuclease needed for MHV innate antagonism (J Virol) RNAse L and ADAR...
Source: This Week in Virology - MP3 Edition - May 3, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 602: Coronavirus immunology with Stanley Perlman
Stanley Perlman joins TWiV to discuss immune responses to coronaviruses, including seasonal CoV, MERS, SARS, and SARS-CoV-2, including prospects for a vaccine. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Stanley Perlman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Perlman Laboratory An Iowa Caucus of Viruses (TWiV 538) Anti-SARS-CoV spike IgG and acute lung injury (JCI Insight) T cell responses to respiratory CoV (Immunol Res) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions an...
Source: This Week in Virology - MP3 Edition - April 16, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 585: The coronavirus epidemic
The TWiVerers continue their coverage of the new coronavirus outbreak in China, as the number of cases increase dramatically and the virus begins person-to-person transmission in other countries. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2020 Real time tracking of 2019-nCoV (JHU) Estimation of 2019-nCoV R0 (Int J Inf Dis) WHO Sitreps on 2019-nCoV Coronavirus overtakes SARS (SCMP) HHS press conference Discovery of 2019-nCoV (bioRxiv) Rich CoV genes ...
Source: This Week in Virology - MP3 Edition - February 2, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

Nudging the calories off your order
There has been a lot of noise made about calorie counts on labels - the idea being it ’s one of those things that might nudge people to make healthier choices. So much so that in 2018, in the USA, it became mandatory for food chains with more than 20 outlets to label the calories in their food. But the effectiveness of that is hard to gauge - it’s relied on reporting from custo mers, which leads to an incomplete picture. The really killer data would be from the chains themselves, but they’re reluctant to share that widely. That's where new research comes in - and we're joined in the podcast by Joshua Petimar, post...
Source: The BMJ Podcast - October 31, 2019 Category: General Medicine Authors: BMJ talk medicine Source Type: podcasts