The Cutler-Beard flap for upper eyelid reconstruction: Surgical indications revisited
CONCLUSIONS: Although non-bridging techniques are usually favored to reconstruct large upper eyelid defects, the Cutler-Beard bridge flap is a valuable technique in case of large horizontal defects where the vertical gap is greater than 15 mm. Further surgical steps are rarely necessary; however, alternative techniques should be considered following excision of highly malignant tumors.PMID:38384118 | DOI:10.1177/11206721241234417 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 22, 2024 Category: Opthalmology Authors: Elia Franzolin Flavia Quaranta Leoni Francesco M Quaranta Leoni Source Type: research
The Cutler-Beard flap for upper eyelid reconstruction: Surgical indications revisited
CONCLUSIONS: Although non-bridging techniques are usually favored to reconstruct large upper eyelid defects, the Cutler-Beard bridge flap is a valuable technique in case of large horizontal defects where the vertical gap is greater than 15 mm. Further surgical steps are rarely necessary; however, alternative techniques should be considered following excision of highly malignant tumors.PMID:38384118 | DOI:10.1177/11206721241234417 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 22, 2024 Category: Opthalmology Authors: Elia Franzolin Flavia Quaranta Leoni Francesco M Quaranta Leoni Source Type: research
Cancers, Vol. 16, Pages 788: ATOH1, TFAP2B, and CEACAM6 as Immunohistochemical Markers to Distinguish Merkel Cell Carcinoma and Small Cell Lung Cancer
. Hewitt
Isaac Brownell
Merkel cell carcinoma (MCC) and small cell lung cancer (SCLC) can be histologically similar. Immunohistochemistry (IHC) for cytokeratin 20 (CK20) and thyroid transcription factor 1 (TTF-1) are commonly used to differentiate MCC from SCLC; however, these markers have limited sensitivity and specificity. To identify new diagnostic markers, we performed differential gene expression analysis on transcriptome data from MCC and SCLC tumors. Candidate markers included atonal BHLH transcription factor 1 (ATOH1) and transcription factor AP-2β (TFAP2B) for MCC, as well as carcinoembryonic a...
Source: Cancers - February 15, 2024 Category: Cancer & Oncology Authors: Serena M. Vilasi Jannett Nguyen Catherine J. Wang Lingling Miao Kenneth Daily Mary Eid Joon Seon Song Hong Jiang Kris Ylaya Klaus J. Busam Maria R. Gaiser Stephen M. Hewitt Isaac Brownell Tags: Article Source Type: research
High-volume facilities are significantly more likely to use guideline-adherent systemic immunotherapy for metastatic Merkel cell carcinoma: implications for cancer care regionalization
AbstractMerkel cell carcinoma (MCC) is a neuroendocrine skin cancer with a high rate of mortality. While still relatively rare, the incidence of MCC has been rapidly rising in the US and around the world. Since 2017, two immunotherapeutic drugs, avelumab and pembrolizumab, have been FDA-approved for the treatment of metastatic MCC and have revolutionized outcomes for MCC. However, real-world outcomes can differ from clinical trial data, and the adoption of novel therapeutics can be gradual. We aimed to characterize the treatment practices and outcomes of patients with metastatic MCC across the US. A retrospective cohort st...
Source: Archives of Dermatological Research - February 13, 2024 Category: Dermatology Source Type: research
Imaging of Merkel cell carcinoma of the eyelid: A case report
Oncol Lett. 2024 Jan 23;27(3):119. doi: 10.3892/ol.2024.14252. eCollection 2024 Mar.ABSTRACTMerkel cell carcinoma (MCC) is a rare primary neuroendocrine carcinoma commonly found in older adults in areas of the skin that are susceptible to ultraviolet ray damage. The current study reports the case of a 79-year-old woman who presented to the Affiliated Hospital of Zunyi Medical University (Zunyi, China) with a painless lump in the lower eyelid of the left eye accompanied by photophobic tears for 4 months. Head computed tomography (CT) and magnetic resonance imaging (MRI) showed a space-occupying lesion ~2.8×2.4 cm in size o...
Source: Oncology Letters - February 5, 2024 Category: Cancer & Oncology Authors: Guangwen Zhu Liting Xie Xianwen Hu Source Type: research
Merkel Cell Carcinoma and the Eye
Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine tumor with a poor five year survival rate. Yearly cases have risen nearly 350% since the early 1980 ’s, and these are predicted to increase as the overall U.S. population ages. MCC of the eyelid is uncommon and can be misdiagnosed as other benign inflammatory and neoplastic eyelid disorders. While MCC of the head and neck is often more aggressive than other sites, eyelid MCC shows a lower diseas e specific mortality rate. A biopsy is essential for accurate diagnosis, including an immunohistochemical panel of CK20 and TTF-1, although other markers may be neces...
Source: Clinics in Dermatology - February 5, 2024 Category: Dermatology Authors: Rodolfo Valentini, Jane M. Grant-Kels, Madina Falcone, Campbell L. Stewart Source Type: research
LT and SOX9 expression are associated with gene sets that distinguish Merkel cell polyomavirus-positive and -negative Merkel cell carcinoma
CONCLUSIONS: Tumours with weak expression of LT tend to co-express genes related to squamous differentiation and cell cycle, and to have a higher mutational burden. These findings are congruent with those of earlier studies.PMID:38261397 | DOI:10.1093/bjd/ljae033 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 23, 2024 Category: Dermatology Authors: Juan Torre-Castro Marta Rodr íguez Ruth Alonso-Alonso Mar ía Dolores Mendoza Cembranos Jes ús Frutos Díaz-Alejo Marcos Rebollo-Gonz ález Jennifer Borreg ón Laura N ájera Botello Ignacio Mahillo-Fern ández Mathab Samimi Thibault Kervarrec Luis Requ Source Type: research
NCCN Guidelines ® Insights: Merkel Cell Carcinoma, Version 1.2024
J Natl Compr Canc Netw. 2024 Jan;22(1D):e240002. doi: 10.6004/jnccn.2024.0002.ABSTRACTThe NCCN Guidelines for Merkel Cell Carcinoma (MCC) provide recommendations for diagnostic workup, clinical stage, and treatment options for patients. The panel meets annually to discuss updates to the guidelines based on comments from expert review from panel members, institutional review, as well as submissions from within NCCN and external organizations. These NCCN Guidelines Insights focus on the introduction of a new page for locally advanced disease in the setting of clinical node negative status, entitled "Clinical N0 Disease, Loca...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 20, 2024 Category: Cancer & Oncology Authors: Chrysalyne D Schmults Rachel Blitzblau Sumaira Z Aasi Murad Alam Arya Amini Kristin Bibee Diana Bolotin Jeremy Bordeaux Pei-Ling Chen Carlo M Contreras Dominick DiMaio Jessica M Donigan Jeffrey M Farma Karthik Ghosh Kelly Harms Alan L Ho John Nicholas Luk Source Type: research
Cancers, Vol. 16, Pages 411: Combined Merkel Cell Carcinoma and Squamous Cell Carcinoma: A Systematic Review
z Llombart
Combined Merkel cell carcinoma (MCC) and squamous cell carcinoma (SCC) have classically been regarded as more aggressive than conventional, pure, Merkel cell polyomavirus (MCPyV)-positive MCC. It is still unknown whether combined MCC and SCC are more aggressive than pure, MCPyV-negative MCC, and the origin of both the SCC and MCC elements of these combined tumors has not been elucidated. The main objective of this systematic review was to assess whether combined MCC and SCC tumors are associated with a worse prognosis than pure MCC; the secondary goals were the characterization of the clinical and histopatho...
Source: Cancers - January 18, 2024 Category: Cancer & Oncology Authors: Elisa R íos-Viñuela Fatima Mayo-Mart ínez Eduardo Nagore David Millan-Esteban Celia Requena Onofre Sanmart ín Beatriz Llombart Tags: Systematic Review Source Type: research
