The Cutler-Beard flap for upper eyelid reconstruction: Surgical indications revisited
CONCLUSIONS: Although non-bridging techniques are usually favored to reconstruct large upper eyelid defects, the Cutler-Beard bridge flap is a valuable technique in case of large horizontal defects where the vertical gap is greater than 15 mm. Further surgical steps are rarely necessary; however, alternative techniques should be considered following excision of highly malignant tumors.PMID:38384118 | DOI:10.1177/11206721241234417 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 22, 2024 Category: Opthalmology Authors: Elia Franzolin Flavia Quaranta Leoni Francesco M Quaranta Leoni Source Type: research
The Cutler-Beard flap for upper eyelid reconstruction: Surgical indications revisited
CONCLUSIONS: Although non-bridging techniques are usually favored to reconstruct large upper eyelid defects, the Cutler-Beard bridge flap is a valuable technique in case of large horizontal defects where the vertical gap is greater than 15 mm. Further surgical steps are rarely necessary; however, alternative techniques should be considered following excision of highly malignant tumors.PMID:38384118 | DOI:10.1177/11206721241234417 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 22, 2024 Category: Opthalmology Authors: Elia Franzolin Flavia Quaranta Leoni Francesco M Quaranta Leoni Source Type: research
Cancers, Vol. 16, Pages 788: ATOH1, TFAP2B, and CEACAM6 as Immunohistochemical Markers to Distinguish Merkel Cell Carcinoma and Small Cell Lung Cancer
. Hewitt
Isaac Brownell
Merkel cell carcinoma (MCC) and small cell lung cancer (SCLC) can be histologically similar. Immunohistochemistry (IHC) for cytokeratin 20 (CK20) and thyroid transcription factor 1 (TTF-1) are commonly used to differentiate MCC from SCLC; however, these markers have limited sensitivity and specificity. To identify new diagnostic markers, we performed differential gene expression analysis on transcriptome data from MCC and SCLC tumors. Candidate markers included atonal BHLH transcription factor 1 (ATOH1) and transcription factor AP-2β (TFAP2B) for MCC, as well as carcinoembryonic a...
Source: Cancers - February 15, 2024 Category: Cancer & Oncology Authors: Serena M. Vilasi Jannett Nguyen Catherine J. Wang Lingling Miao Kenneth Daily Mary Eid Joon Seon Song Hong Jiang Kris Ylaya Klaus J. Busam Maria R. Gaiser Stephen M. Hewitt Isaac Brownell Tags: Article Source Type: research
High-volume facilities are significantly more likely to use guideline-adherent systemic immunotherapy for metastatic Merkel cell carcinoma: implications for cancer care regionalization
AbstractMerkel cell carcinoma (MCC) is a neuroendocrine skin cancer with a high rate of mortality. While still relatively rare, the incidence of MCC has been rapidly rising in the US and around the world. Since 2017, two immunotherapeutic drugs, avelumab and pembrolizumab, have been FDA-approved for the treatment of metastatic MCC and have revolutionized outcomes for MCC. However, real-world outcomes can differ from clinical trial data, and the adoption of novel therapeutics can be gradual. We aimed to characterize the treatment practices and outcomes of patients with metastatic MCC across the US. A retrospective cohort st...
Source: Archives of Dermatological Research - February 13, 2024 Category: Dermatology Source Type: research
Imaging of Merkel cell carcinoma of the eyelid: A case report
Oncol Lett. 2024 Jan 23;27(3):119. doi: 10.3892/ol.2024.14252. eCollection 2024 Mar.ABSTRACTMerkel cell carcinoma (MCC) is a rare primary neuroendocrine carcinoma commonly found in older adults in areas of the skin that are susceptible to ultraviolet ray damage. The current study reports the case of a 79-year-old woman who presented to the Affiliated Hospital of Zunyi Medical University (Zunyi, China) with a painless lump in the lower eyelid of the left eye accompanied by photophobic tears for 4 months. Head computed tomography (CT) and magnetic resonance imaging (MRI) showed a space-occupying lesion ~2.8×2.4 cm in size o...
Source: Oncology Letters - February 5, 2024 Category: Cancer & Oncology Authors: Guangwen Zhu Liting Xie Xianwen Hu Source Type: research
