Die interdisziplin äre Behandlung von HautkrebsInterdisciplinary management of skin cancer
Laryngorhinootologie 2024; 103: S100-S124 DOI: 10.1055/a-2171-4570Die interdisziplinäre Behandlung von Hautkrebs im Kopf-Halsbereich erfordert die
enge Zusammenarbeit zwischen verschiedenen Fachdisziplinen. Die häufigsten
nicht-melanozytären Tumorentitäten sind das kutane Plattenepithelkarzinom und
das Basalzellkarzinom sowie deren Vorläuferläsionen. Zu den eher selteneren
Tumoren gehört das Merkelzellkarzinom, welches ebenfalls vornehmlich an den
lichtexponierten Arealen auftritt und im Gegensatz zum Platten- und
Basalzellkarzinom häufiger eine Metastasie...
Source: Laryngo- Rhino- Otologie - May 2, 2024 Category: ENT & OMF Authors: Rudolph, Victoria Leven, Anna-Sophia Eisenburger, Robin Schadendorf, Dirk Wiegand, Susanne Tags: Referat Source Type: research
Merkel cell carcinoma overlapping Bowen's disease: two cases report and literature review
CONCLUSIONS: MCC overlapping BD is a very rare skin tumor mainly predisposed on the faces, with high misdiagnosis rate and recurrence rate. Advanced disease at diagnosis is a poor prognostic factor, suggesting that earlier detection may improve outcome. The acronym, AEIOUN, has been proposed to aid in clinical identification. Our reports and the literature review can provide a better awareness and management of it.PMID:38668799 | DOI:10.1007/s00432-024-05743-0 (Source: Cell Research)
Source: Cell Research - April 26, 2024 Category: Cytology Authors: Xueqin Chen Xiao Song Hui Huang Lian Zhang Zhiqiang Song Xichuan Yang Shanchuan Lei Zhifang Zhai Source Type: research
Merkel cell carcinoma overlapping Bowen ’s disease: two cases report and literature review
ConclusionsMCC overlapping BD is a very rare skin tumor mainly predisposed on the faces, with high misdiagnosis rate and recurrence rate. Advanced disease at diagnosis is a poor prognostic factor, suggesting that earlier detection may improve outcome. The acronym, AEIOUN, has been proposed to aid in clinical identification. Our reports and the literature review can provide a better awareness and management of it. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 26, 2024 Category: Cancer & Oncology Source Type: research
Systematic evaluation of Merkel cell carcinoma clinical practice guidelines using the AGREE II instrument
The objective of this study was to appraise such CPGs via the Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument. Eight CPGs were identified via systematic literature search following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. Four appraisers trained in AGREE II protocols evaluated each CPG and deemed two CPGs as high quality, five as moderate quality, and one as low quality. Intraclass correlation coefficients (ICCs) were calculated to verify reviewer consistency as excellent, good, and moderate across four, one, and one domain, respectively. The majority o...
Source: Cell Research - April 25, 2024 Category: Cytology Authors: Deepak Lakshmipathy Christian Fritz Jacob Harris Tejas Athni Beatrice Go Alvaro Moreira Cerrene Giordano Karthik Rajasekaran Source Type: research
Systematic evaluation of Merkel cell carcinoma clinical practice guidelines using the AGREE II instrument
The objective of this study was to appraise such CPGs via the Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument. Eight CPGs were identified via systematic literature search following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. Four appraisers trained in AGREE II protocols evaluated each CPG and deemed two CPGs as high quality, five as moderate quality, and one as low quality. Intraclass correlation coefficients (ICCs) were calculated to verify reviewer consistency as excellent, good, and moderate across four, one, and one domain, respectively. The majority o...
Source: Archives of Dermatological Research - April 25, 2024 Category: Dermatology Source Type: research
Merkel Cell Carcinoma: Integrating Epidemiology, Immunology, and Therapeutic Updates
AbstractMerkel cell carcinoma (MCC) is a rare skin cancer characterized by neuroendocrine differentiation. Its carcinogenesis is based either on the integration of the Merkel cell polyomavirus or on ultraviolet (UV) mutagenesis, both of which lead to high immunogenicity either through the expression of viral proteins or neoantigens. Despite this immunogenicity resulting from viral or UV-associated carcinogenesis, it exhibits highly aggressive behavior. However, owing to the rarity of MCC and the lack of epidemiologic registries with detailed clinical data, there is some uncertainty regarding the spontaneous course of the d...
Source: American Journal of Clinical Dermatology - April 22, 2024 Category: Dermatology Source Type: research
T antigen–specific CD8+ T cells associate with PD-1 blockade response in virus-positive Merkel cell carcinoma
Merkel cell carcinoma (MCC) is a highly immunogenic skin cancer primarily induced by Merkel cell polyomavirus, which is driven by the expression of the oncogenic T antigens (T-Ags). Blockade of the programmed cell death protein-1 (PD-1) pathway has shown remarkable response rates, but evidence for therapy-associated T-Ag–specific immune response and therapeutic strategies for the nonresponding fraction are both limited. We tracked T-Ag–reactive CD8+ T cells in peripheral blood of 26 MCC patients under anti-PD1 therapy, using DNA-barcoded pMHC multimers, displaying all peptides from the predicted HLA ligandome of the on...
Source: Journal of Clinical Investigation - April 15, 2024 Category: Biomedical Science Authors: Ulla Kring Hansen, Candice D. Church, Ana Micaela Carnaz Simões, Marcus Svensson Frej, Amalie Kai Bentzen, Siri A. Tvingsholm, Jürgen C. Becker, Steven P. Fling, Nirasha Ramchurren, Suzanne L. Topalian, Paul T. Nghiem, Sine Reker Hadrup Source Type: research
Polyomavirus-positive Merkel cell carcinoma: the beginning of the beginning
Merkel cell carcinoma (MCC) is an aggressive, fast-growing, highly metastatic neuroendocrine skin cancer. The Merkel cell polyomavirus (MCPyV) is an oncogenic driver in the majority of MCC tumors. In this issue of the JCI, Hansen and authors report on their tracking of CD8+ T cells reactive to MCPyV T antigen (T-Ag) in the peripheral blood of 26 patients with MCC who were undergoing frontline anti–programmed cell death protein-1 (anti–PD-1) immunotherapy. They discovered unique T cell epitopes and used the power of bar-coded tetramers to portray immune checkpoint inhibitor–induced immunogenicity as a predictor of cli...
Source: Journal of Clinical Investigation - April 15, 2024 Category: Biomedical Science Authors: Michael K. Wong, Cassian Yee Source Type: research
Personalized treatment concepts in extraocular cancer
CONCLUSIONS: The optimal treatment for periocular skin cancer depends on the type and size of the tumor and whether it involves orbital and adnexal structures. Adjuvant and neoadjuvant therapy with chemotherapy-targeted therapies and immune checkpoint inhibitors should be considered based on tumor type, tumor molecular profile, expected response rate, and candidacy for systemic treatment.PMID:38590555 | PMC:PMC10999489 | DOI:10.1016/j.aopr.2024.02.003 (Source: Cell Research)
Source: Cell Research - April 9, 2024 Category: Cytology Authors: Sitong Ju Alexander C Rokohl Yongwei Guo Ke Yao Wanlin Fan Ludwig M Heindl Source Type: research
GSE230760 Merkel cell polyomavirus small tumor antigen contributes to immune evasion by interfering with type I interferon signaling
Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 4, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE230758 Merkel cell polyomavirus small tumor antigen contributes to immune evasion by interfering with type I interferon signaling [ChIP-Seq]
This study investigated the influence of MCPyV T antigens on the host genome using transcriptomics and epigenomics. Results revealed a role for the small Tumor (sT) antigen in subverting type I interferon response and immune evasion, contributing to persistent infection and tumor progression. These findings enhance our understanding of MCPyV pathogenesis and may inform new therapeutic strategies. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 4, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE229019 Merkel cell polyomavirus small tumor antigen contributes to immune evasion by interfering with type I interferon signaling [RNA-Seq]
This study investigated the influence of MCPyV T antigens on the host genome using transcriptomics and epigenomics. Results revealed a role for the small Tumor (sT) antigen in subverting type I interferon response and immune evasion, contributing to persistent infection and tumor progression. These findings enhance our understanding of MCPyV pathogenesis and may inform new therapeutic strategies. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 4, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Nationwide Case-Control Analysis of Merkel Cell Carcinoma and Associated Skin Cancer Comorbidities: An Examination of the All of Us Database
Conclusion The study examines the link between merkel cell carcinoma and other skin malignancies, underscoring the need for more national research to better understand the underlying causes that contribute to this link. The findings also indicate the possibility of sample bias in the All of Us database, emphasizing the need to assess the patient population's representativeness in such investigations.PMID:38510898 | PMC:PMC10951432 | DOI:10.7759/cureus.54426 (Source: Cancer Control)
Source: Cancer Control - March 21, 2024 Category: Cancer & Oncology Authors: Kritin K Verma Travis S Dowdle Sumoni Verma Tejas P Joshi Richard F Wagner Source Type: research
No detectable truncating mutations in large T antigen (LT-Ag) sequence of Merkel cell polyomavirus (MCPyV) DNA obtained from porocarcinomas
Merkel cell polyomavirus (MCPyV) is associated with Merkel cell carcinoma (MCC). In tumor cells the MCPyV large T antigen (LT-Ag) is frequently found truncated and this is considered a m... (Source: Infectious Agents and Cancer)
Source: Infectious Agents and Cancer - March 21, 2024 Category: Cancer & Oncology Authors: Rosaria Arvia, Mauro Sollai, Daniela Massi, Patricia Asensio-Calavia, Carmelo Urso and Krystyna Zakrzewska Tags: Correspondence Source Type: research
Considerations Regarding Mohs Surgery for Early-Stage Merkel Cell Carcinoma
To the Editor I read with interest the recent article by Cheraghlou and colleagues regarding primary tumor excision techniques in Merkel cell carcinoma (MCC). The article ’s central observation, an association between the use of Mohs surgery and improved overall survival (OS) compared with wide excision, appears to be accurate. However, the assertion that Mohs surgery provides a “more effective treatment for MCC primary tumors than conventional” wide local exci sion does not appear to be supported by the presented data. (Source: JAMA Dermatology)
Source: JAMA Dermatology - March 20, 2024 Category: Dermatology Source Type: research
