EZH2 inhibition induces HLA class I re-expression in Merkel Cell Carcinoma
Merkel cell carcinoma (MCC) is a rare primary cutaneous neuroendocrine carcinoma with frequent metastases and poor outcome (Dellambra et al. 2021). MCC can be induced either by Merkel cell polyomavirus or by UV exposure both resulting in the expression of immunogenic proteins, i.e., viral antigens or neoantigens, respectively. Accordingly, immune escape mechanisms such as T-cell exhaustion through the expression of PD-1 (Afanasiev et al. 2013) and PD-L1 (Dellambra et al. 2021) in the tumor microenvironment are frequently observed in MCC tumors. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - December 2, 2023 Category: Dermatology Authors: Marie-Alice Durand, Aur élie Drouin, Kamel Bachiri, Laurine Durand, Patricia Berthon, Roland Houben, David Schrama, Etienne Coyaud, Mahtab Samimi, Antoine Touzé, Thibault Kervarrec Tags: Letters to the Editor Source Type: research
Enhancer of Zeste Homolog 2 Inhibition Induces HLA Class I Re-Expression in Merkel Cell Carcinoma
Merkel cell carcinoma (MCC) is a rare primary cutaneous neuroendocrine carcinoma with frequent metastases and poor outcomes (Dellambra et al, 2021). MCC can be induced either by Merkel cell polyomavirus or by UV exposure, both resulting in the expression of immunogenic proteins, that is, viral antigens or neoantigens, respectively. Accordingly, immune escape mechanisms such as T-cell exhaustion through the expression of PD-1 (Afanas iev et al, 2013) and PD-L1 (Dellambra et al, 2021) in the tumor microenvironment are frequently observed in MCC tumors. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - December 2, 2023 Category: Dermatology Authors: Marie-Alice Durand, Aur élie Drouin, Kamel Bachiri, Laurine Durand, Patricia Berthon, Roland Houben, David Schrama, Etienne Coyaud, Mahtab Samimi, Antoine Touzé, Thibault Kervarrec Tags: Letters to the Editor Source Type: research
Prevalence of viral DNA in high-grade serous epithelial ovarian cancer and correlation with clinical outcomes
CONCLUSIONS: The presence of a VOI was significantly associated with a lower OS. These findings may have implications for clinical management of ovarian cancer but require additional studies.PMID:38039311 | DOI:10.1371/journal.pone.0294448 (Source: Herpes)
Source: Herpes - December 1, 2023 Category: Infectious Diseases Authors: Sharon E Robertson Maya Yasukawa Douglas C Marchion Yin Xiong Syeda Mahrukh Hussnain Naqvi Tarik Gheit Massimo Tommasino Robert M Wenham Anna R Giuliano Johnathan M Lancaster Mian M K Shahzad Source Type: research
Prevalence of viral DNA in high-grade serous epithelial ovarian cancer and correlation with clinical outcomes
CONCLUSIONS: The presence of a VOI was significantly associated with a lower OS. These findings may have implications for clinical management of ovarian cancer but require additional studies.PMID:38039311 | PMC:PMC10691703 | DOI:10.1371/journal.pone.0294448 (Source: Herpes)
Source: Herpes - December 1, 2023 Category: Infectious Diseases Authors: Sharon E Robertson Maya Yasukawa Douglas C Marchion Yin Xiong Syeda Mahrukh Hussnain Naqvi Tarik Gheit Massimo Tommasino Robert M Wenham Anna R Giuliano Johnathan M Lancaster Mian M K Shahzad Source Type: research
RWD87 Retrospective Observational Study of Patients with Metastatic Merkel Cell Carcinoma (mMCC) Using the Caraderm Database Linked to the French National Health Data System (SNDS)
Avelumab, an anti –PD-L1 antibody, was granted marketing authorization in Europe in September 2017 for the treatment of mMCC, a rare and aggressive skin cancer, based on results from the pivotal phase 2 JAVELIN Merkel 200 trial (NCT02155647). Avelumab has been reimbursed in France since March 2019 in patients with mMCC with prior chemotherapy. In September 2018, the Transparency Committee requested collection of real-world data from a comprehensive registry. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: A. Blom, L. Mortier, I. Kachaner, L. Luciani, C. Cahuzac, B. Van Hille, M.N. Solbes, C. Maillard, S. Bahnini, H. Miotti, P. Saiag Source Type: research
EPH80 Survival and Best Recorded Response (BRR) in Patients With Advanced Merkel Cell Carcinoma (MCC): Analysis of a Prospective German MCC Registry Study (MCC TRIM) of the German Dermatologic Cooperative Oncology Group
This study aimed to describe real-world (RW) clinical outcomes with chemotherapy and immunotherapy as first- and second-line (1L, 2L) systemic treatment. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: S.H. Mahmoudpour, J.C. Backer, D. Schadendorf, U. Leiter, F. Meier, R. Herbst, S. Grabbe, P. Mohr, M.M. Sachse, C. Pf öhler, C. Gerbhardt, F. Ziller, L. Zimmer, E. Boutmy, S. Hoff, P. Verpillat, A.F. Milano, M. Shlaen, C. Fu, S. Ugurel Source Type: research
EE396 Economic Evaluation of PD-1 Blockers in Merkel Cell Carcinoma: A Systematic Literature Review
Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer, associated with ultraviolet exposure, immunosuppression, and Merkel cell polyomavirus infections. This systematic literature review assessed model-based economic evaluations of PD-1 inhibitors used to manage MCC. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: D. Ghoshal, T. Madan, A. Taneja Source Type: research
A SEER program study of survival trends in Merkel cell carcinoma of the eyelid: 2000-2019
CONCLUSIONS: Consistent with previous reports, most patients were white, female, and age 85+.Incidence correlated with metropolitan environments and median income. While most patients did not die from MCCE, majority of recorded deaths occurred within one year of diagnosis.PMID:38032687 | DOI:10.1080/01676830.2023.2286380 (Source: Orbit)
Source: Orbit - November 30, 2023 Category: Opthalmology Authors: Nicole T Nudelman Nehikhare Ekhator Michael Rothschild Edward J Wladis Source Type: research
A SEER program study of survival trends in Merkel cell carcinoma of the eyelid: 2000-2019
CONCLUSIONS: Consistent with previous reports, most patients were white, female, and age 85+.Incidence correlated with metropolitan environments and median income. While most patients did not die from MCCE, majority of recorded deaths occurred within one year of diagnosis.PMID:38032687 | DOI:10.1080/01676830.2023.2286380 (Source: Orbit)
Source: Orbit - November 30, 2023 Category: Opthalmology Authors: Nicole T Nudelman Nehikhare Ekhator Michael Rothschild Edward J Wladis Source Type: research
A SEER program study of survival trends in Merkel cell carcinoma of the eyelid: 2000-2019
CONCLUSIONS: Consistent with previous reports, most patients were white, female, and age 85+.Incidence correlated with metropolitan environments and median income. While most patients did not die from MCCE, majority of recorded deaths occurred within one year of diagnosis.PMID:38032687 | DOI:10.1080/01676830.2023.2286380 (Source: Orbit)
Source: Orbit - November 30, 2023 Category: Opthalmology Authors: Nicole T Nudelman Nehikhare Ekhator Michael Rothschild Edward J Wladis Source Type: research
A SEER program study of survival trends in Merkel cell carcinoma of the eyelid: 2000-2019
CONCLUSIONS: Consistent with previous reports, most patients were white, female, and age 85+.Incidence correlated with metropolitan environments and median income. While most patients did not die from MCCE, majority of recorded deaths occurred within one year of diagnosis.PMID:38032687 | DOI:10.1080/01676830.2023.2286380 (Source: Orbit)
Source: Orbit - November 30, 2023 Category: Opthalmology Authors: Nicole T Nudelman Nehikhare Ekhator Michael Rothschild Edward J Wladis Source Type: research
A SEER program study of survival trends in Merkel cell carcinoma of the eyelid: 2000-2019
CONCLUSIONS: Consistent with previous reports, most patients were white, female, and age 85+.Incidence correlated with metropolitan environments and median income. While most patients did not die from MCCE, majority of recorded deaths occurred within one year of diagnosis.PMID:38032687 | DOI:10.1080/01676830.2023.2286380 (Source: Orbit)
Source: Orbit - November 30, 2023 Category: Opthalmology Authors: Nicole T Nudelman Nehikhare Ekhator Michael Rothschild Edward J Wladis Source Type: research
A SEER program study of survival trends in Merkel cell carcinoma of the eyelid: 2000-2019
CONCLUSIONS: Consistent with previous reports, most patients were white, female, and age 85+.Incidence correlated with metropolitan environments and median income. While most patients did not die from MCCE, majority of recorded deaths occurred within one year of diagnosis.PMID:38032687 | DOI:10.1080/01676830.2023.2286380 (Source: Orbit)
Source: Orbit - November 30, 2023 Category: Opthalmology Authors: Nicole T Nudelman Nehikhare Ekhator Michael Rothschild Edward J Wladis Source Type: research
A SEER program study of survival trends in Merkel cell carcinoma of the eyelid: 2000-2019
CONCLUSIONS: Consistent with previous reports, most patients were white, female, and age 85+.Incidence correlated with metropolitan environments and median income. While most patients did not die from MCCE, majority of recorded deaths occurred within one year of diagnosis.PMID:38032687 | DOI:10.1080/01676830.2023.2286380 (Source: Orbit)
Source: Orbit - November 30, 2023 Category: Opthalmology Authors: Nicole T Nudelman Nehikhare Ekhator Michael Rothschild Edward J Wladis Source Type: research
A SEER program study of survival trends in Merkel cell carcinoma of the eyelid: 2000-2019
CONCLUSIONS: Consistent with previous reports, most patients were white, female, and age 85+.Incidence correlated with metropolitan environments and median income. While most patients did not die from MCCE, majority of recorded deaths occurred within one year of diagnosis.PMID:38032687 | DOI:10.1080/01676830.2023.2286380 (Source: Orbit)
Source: Orbit - November 30, 2023 Category: Opthalmology Authors: Nicole T Nudelman Nehikhare Ekhator Michael Rothschild Edward J Wladis Source Type: research
