Current understanding of pathogenetic mechanisms in neuroendocrine neoplasms
Expert Rev Endocrinol Metab. 2023 Nov 3:1-13. doi: 10.1080/17446651.2023.2279540. Online ahead of print.ABSTRACTINTRODUCTION: Despite the fact that important advances in research on neuroendocrine neoplasms (NENs) have been made, consistent data about their pathogenetic mechanism are still lacking. Furthermore, different primary sites may recognize different pathogenetic mechanisms.AREAS COVERED: This review analyzes the possible biological and molecular mechanisms that may lead to NEN onset and progression in different organs. Through extensive research of the literature, risk factors including hypercholesterolemia, infla...
Source: Expert Review of Endocrinology and Metabolism - November 8, 2023 Category: Endocrinology Authors: Roberta Modica Alessia Liccardi Roberto Minotta Giuseppe Cannavale Elio Benevento Annamaria Colao Source Type: research
Interplay between the DNA damage response and the life cycle of DNA tumor viruses
Tumour Virus Res. 2023 Oct 31:200272. doi: 10.1016/j.tvr.2023.200272. Online ahead of print.ABSTRACTApproximately 20 % of human cancers are associated with virus infection. DNA tumor viruses can induce tumor formation in host cells by disrupting the cell's DNA replication and repair mechanisms. Specifically, these viruses interfere with the host cell's DNA damage response (DDR), which is a complex network of signaling pathways that is essential for maintaining the integrity of the genome. DNA tumor viruses can disrupt these pathways by expressing oncoproteins that mimic or inhibit various DDR components, thereby promoting ...
Source: Cell Research - November 2, 2023 Category: Cytology Authors: Caleb J Studstill Michelle Mac Cary A Moody Source Type: research
Interplay between the DNA damage response and the life cycle of DNA tumor viruses
Tumour Virus Res. 2023 Oct 31:200272. doi: 10.1016/j.tvr.2023.200272. Online ahead of print.ABSTRACTApproximately 20 % of human cancers are associated with virus infection. DNA tumor viruses can induce tumor formation in host cells by disrupting the cell's DNA replication and repair mechanisms. Specifically, these viruses interfere with the host cell's DNA damage response (DDR), which is a complex network of signaling pathways that is essential for maintaining the integrity of the genome. DNA tumor viruses can disrupt these pathways by expressing oncoproteins that mimic or inhibit various DDR components, thereby promoting ...
Source: Cell Research - November 2, 2023 Category: Cytology Authors: Caleb J Studstill Michelle Mac Cary A Moody Source Type: research
A retrospective study of sentinel lymph node biopsy for skin cancer in Japan: Comparison with breast cancer and evaluation of factors related to its use
ConclusionsSLNB is underutilized for skin cancer. Further investigation is required to explore the reasons for its underutilization so that it may be implemented more universally. (Source: Cancer Medicine)
Source: Cancer Medicine - October 30, 2023 Category: Cancer & Oncology Authors: Shogo Wada,
Tomone Watanabe,
Taisuke Ishii,
Yuichi Ichinose,
Ryoko Rikitake,
Dai Ogata,
Eiji Nakano,
Kenjiro Namikawa,
Naoya Yamazaki,
Takahiro Higashi Tags: RESEARCH ARTICLE Source Type: research
A retrospective study of sentinel lymph node biopsy for skin cancer in Japan: Comparison with breast cancer and evaluation of factors related to its use
CONCLUSIONS: SLNB is underutilized for skin cancer. Further investigation is required to explore the reasons for its underutilization so that it may be implemented more universally.PMID:37902245 | DOI:10.1002/cam4.6677 (Source: Cancer Control)
Source: Cancer Control - October 30, 2023 Category: Cancer & Oncology Authors: Shogo Wada Tomone Watanabe Taisuke Ishii Yuichi Ichinose Ryoko Rikitake Dai Ogata Eiji Nakano Kenjiro Namikawa Naoya Yamazaki Takahiro Higashi Source Type: research
Palliative radiotherapy is effective for both well ‐ and poorly differentiated neuroendocrine neoplasms
ConclusionPalliative RT is an appropriate option for management of symptoms in patients with both well- and poorly differentiated metastatic NEN. (Source: Journal of Medical Imaging and Radiation Oncology)
Source: Journal of Medical Imaging and Radiation Oncology - October 30, 2023 Category: Radiology Authors: Eileen O'Reilly,
Louis Lao,
Braden Woodhouse,
Katrina Sharples,
Cris Print,
Ben Lawrence Tags: Radiation Oncology —Original Article Source Type: research
Incidence, Mortality, and Survival of Merkel Cell Carcinoma: A Systematic Review of Population Based-Studies
CONCLUSIONS: MCC is increasing in incidence and may increase further given the ageing population of many countries. The prognosis of MCC is poor, particularly for males, those who are immunosuppressed, and patients diagnosed at higher stages or at an older age.PMID:37874770 | DOI:10.1093/bjd/ljad404 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 24, 2023 Category: Dermatology Authors: Samiha T Mohsen Emma L Price An-Wen Chan Timothy P Hanna James J Limacher Carolyn Nessim Jessica E Shiers Victor Tron Frances C Wright Aaron M Drucker Source Type: research
Cancers, Vol. 15, Pages 5084: An Updated Review of the Biomarkers of Response to Immune Checkpoint Inhibitors in Merkel Cell Carcinoma: Merkel Cell Carcinoma and Immunotherapy
ir Vranic
Merkel cell carcinoma (MCC) is primarily a disease of the elderly Caucasian, with most cases occurring in individuals over 50. Immune checkpoint inhibitors (ICI) treatment has shown promising results in MCC patients. Although ~34% of MCC patients are expected to exhibit at least one of the predictive biomarkers (PD-L1, high tumor mutational burden/TMB-H/, and microsatellite instability), their clinical significance in MCC is not fully understood. PD-L1 expression has been variably described in MCC, but its predictive value has not been established yet. Our literature survey indicates conflicting results regar...
Source: Cancers - October 20, 2023 Category: Cancer & Oncology Authors: Adnan Fojnica Kenana Ljuca Saghir Akhtar Zoran Gatalica Semir Vranic Tags: Review Source Type: research
Characterization of immunosuppressive myeloid cells in Merkel cell carcinoma: correlation with resistance to PD-1 pathway blockade
CONCLUSIONS: This study further characterizes TAMs in MCC tumors and provides insights into their possible immunosuppressive mechanism. TAMs may reduce the likelihood of treatment response in MCC by counteracting the benefit of CD8 T-cell infiltration.PMID:37851052 | DOI:10.1158/1078-0432.CCR-23-1957 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - October 18, 2023 Category: Cancer & Oncology Authors: Paul Nghiem Shira Tabachnick-Cherny Thomas Pulliam Haroldo J Rodriguez Xinyi Fan Daniel S Hippe Daniel C Jones Ata S Moshiri Kimberly S Smythe Rima M Kulikauskas Lisa Zaba Kelly G Paulson Source Type: research
Cabozantinib for different endocrine tumours: killing two birds with one stone. A systematic review of the literature
CONCLUSION: Promising data on cabozantinib treatment for endocrine and neuroendocrine neoplasms is recently emerging in the literature. In our clinical case, we reported that, besides the good response for the MTC, cabozantinib also seems to effectively control metastatic MCC, along with efficient surgery and adjuvant radiotherapy. Further investigations are needed to determine the efficacy and safety of cabozantinib in MCC patients and in off-label endocrine tumours.PMID:37851242 | DOI:10.1007/s12020-023-03526-0 (Source: Cancer Control)
Source: Cancer Control - October 18, 2023 Category: Cancer & Oncology Authors: Elena Zago Antonio Galluzzo Silvia Pradella Lorenzo Antonuzzo Mario Maggi Luisa Petrone Clotilde Sparano Source Type: research
Characterization of immunosuppressive myeloid cells in Merkel cell carcinoma: correlation with resistance to PD-1 pathway blockade
CONCLUSIONS: This study further characterizes TAMs in MCC tumors and provides insights into their possible immunosuppressive mechanism. TAMs may reduce the likelihood of treatment response in MCC by counteracting the benefit of CD8 T-cell infiltration.PMID:37851052 | DOI:10.1158/1078-0432.CCR-23-1957 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - October 18, 2023 Category: Cancer & Oncology Authors: Shira Tabachnick-Cherny Thomas Pulliam Haroldo J Rodriguez Xinyi Fan Daniel S Hippe Daniel C Jones Ata S Moshiri Kimberly S Smythe Rima M Kulikauskas Lisa Zaba Kelly G Paulson Paul Nghiem Source Type: research
Salivary Duct Carcinoma Arising in a Warthin Tumor of the Parotid Gland: A Rare Case Report with Review of Literature and PD-L1 Expression
We describe an extremely rare case of salivary duct carcinoma arising in a Warthin tumo r in a 64-year-old male. Patient presented with an enlarging left parotid mass, biopsy of which showed salivary duct carcinoma. He subsequently underwent left parotidectomy along with left level II–IV lymph node dissection. Histology revealed both in situ as well as invasive salivary duct carcinom a arising from Warthin tumor. Immunohistochemistry showed tumor cells positive for CK7, AR, and GATA3, while p63 highlighted the myoepithelial cell layer in the in situ component. Her2 was 2+ by immunohistochemistry. In addition, PD-L1 IHC...
Source: Head and Neck Pathology - October 13, 2023 Category: Pathology Source Type: research
BK polyomavirus: latency, reactivation, diseases and tumorigenesis
Front Cell Infect Microbiol. 2023 Sep 13;13:1263983. doi: 10.3389/fcimb.2023.1263983. eCollection 2023.ABSTRACTThe identification of the first human polyomavirus BK (BKV) has been over half century, The previous epidemiological and phylogenetic studies suggest that BKV prevailed and co-evolved with humans, leading to high seroprevalence all over the world. In general, BKV stays latent and symptomless reactivation in healthy individuals. BKV has been mainly interlinked with BKV-associated nephropathy (BKVAN) in kidney-transplant recipients and hemorrhagic cystitis (HC) in hematopoietic stem cell transplant recipients (HSCTR...
Source: Cancer Control - September 29, 2023 Category: Cancer & Oncology Authors: Xianfeng Zhou Chunlong Zhu Hui Li Source Type: research
Extended duration of treatment using reduced-frequency dosing of anti-PD-1 therapy in patients with advanced melanoma and Merkel cell carcinoma
CONCLUSIONS: ICI administration at RFD can allow extension of treatment duration, while preserving efficacy and reducing logistical and financial burden. RFD approach deserves further exploration in prospective clinical trials.PMID:37733060 | DOI:10.1007/s00262-023-03539-8 (Source: Cancer Control)
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Lisa May Ling Tachiki Daniel S Hippe Karly Williams Silva Evan Thomas Hall William McCamy Dane Fritzsche Andrea Perdue Julia Majovski Thomas Pulliam Daniel A Goldstein Joshua Veatch Joel Ho Paul T Nghiem John A Thompson Shailender Bhatia Source Type: research
