Knockdown of nicotinamide N-methyltransferase suppresses proliferation, migration, and chemoresistance of Merkel cell carcinoma cells in vitro
In this study, we investigated the possible involvement of this enzyme in MCC. Preliminary immunohistochemical analyses were performed to evaluate NNMT expression in MCC tissue specimens. To explore the enzyme function in tumor cell metabolism, MCC cell lines have been transfected with plasmids encoding for short hairpin RNAs (shRNAs) targeting NNMT mRNA. Preliminary immunohistochemical analyses showed elevated NNMT expression in MCC tissue specimens. The effect of enzyme downregulation on cell proliferation, migration, and chemosensitivity was then evaluated through MTT, trypan blue, and wound healing assays. Data obtaine...
Source: Human Cell - March 19, 2024 Category: Cytology Source Type: research
Paraneoplastic neurologic manifestations of neuroendocrine tumors
Handb Clin Neurol. 2024;200:397-407. doi: 10.1016/B978-0-12-823912-4.00023-2.ABSTRACTNeuroendocrine neoplasms (NENs) are a heterogeneous group of tumors arising from the transformation of neuroendocrine cells in several organs, most notably the gastro-entero-pancreatic system and respiratory tract. The classification was recently revised in the 5th Edition of the WHO Classification of Endocrine and Neuroendocrine Tumors. NENs can rarely spread to the central or peripheral nervous systems. Neurologic involvement is determined by the rare development of paraneoplastic syndromes, which are remote effects of cancer. Mechanisms...
Source: Clinical Lung Cancer - March 17, 2024 Category: Cancer & Oncology Authors: Marco Zoccarato Wolfgang Grisold Source Type: research
Hypofractionated Radiotherapy for Merkel Cell Carcinoma
Merkel cell carcinoma (MCC) is a radiosensitive skin cancer. Historically, radiation treatment for MCC has involved standard 1.8-2 Gy fractions treated daily over 4-6 weeks. For other cutaneous malignancies, radiation treatment with daily doses>2 Gy has increased in prevalence in order to reduce treatment time and increase patient convenience. The equivalence of such hypofractionated treatment regimens to standard fractionation regimens for tumor control and skin toxicity has been shown for common cutaneous malignancies such as basal cell and squamous cell carcinomas. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: L. Gonzalez, S. Yarlagadda, M. Rubens, N.S. Kalman Tags: 251 Source Type: research
Combination of Upfront Systemic Therapy and Radiation in Advanced Non-Melanoma Skin Cancer
Checkpoint inhibitors and hedgehog inhibitors have shown promising results for treatment of locally advanced cutaneous squamous cell carcinoma (cSCC), Merkel cell carcinoma (MCC), and basal cell carcinoma (BCC) in the neoadjuvant setting. Given high clinical response rates to systemic therapy, we evaluated the role of upfront systemic therapy followed by consolidative radiation as a potential treatment strategy for those anticipated to suffer significant surgically-related morbidity. Herein, we describe our experience using upfront systemic therapy in combination with radiation in advanced non-melanoma skin cancer (NMSC) w...
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: M.T. Victor, P. Vaidya, J. Chang, J. Bliamptis, A. Dornisch, P. Sanghvi, T. Guo, S. Park Tags: 235 Source Type: research
Tumor Mutational Burden Predicts Survival in Merkel Cell Carcinoma
In Merkel cell carcinoma (MCC), clinical factors, including advanced age and immunosuppression, are variably prognostic and poorly predictive of treatment response. There is a clear need for robust genetic markers of aggressive disease to inform treatment selection and prognostication. In a cohort of 54 MCC patients, we assessed the impact of tumor mutational burden (TMB), single nucleotide (SNV) and copy number variations (CNV), and Merkel Cell Polyomavirus (MCPyV) integration on MCC-specific survival outcomes. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: J.D. Smith, A. Bhangale, W. Gu, E. Gensterblum-Miller, C. Brummel, M.E. Spector, R. Mills, C. Brenner Tags: 229 Source Type: research
Neurological autoimmunity in patients with non-pulmonary neuroendocrine neoplasms: clinical manifestations and neural autoantibody profiles
DISCUSSION: Neurological autoimmunity associated with non-pulmonary NENs is often multifocal and can be treatment responsive, underscoring the importance of rapid recognition and early treatment.PMID:38466015 | DOI:10.1111/ene.16273 (Source: Cancer Control)
Source: Cancer Control - March 11, 2024 Category: Cancer & Oncology Authors: Georgios Mangioris Thorvardur R Halfdanarson Vanda A Lennon Bryce K Chang Divyanshu Dubey P James B Dyck Eoin P Flanagan Andrew McKeon John R Mills Sean J Pittock Anastasia Zekeridou Source Type: research
Viruses, Vol. 16, Pages 416: Human Oncogenic Viruses: Characteristics and Prevention Strategies & mdash;Lessons Learned from Human Papillomaviruses
Viruses, Vol. 16, Pages 416: Human Oncogenic Viruses: Characteristics and Prevention Strategies—Lessons Learned from Human Papillomaviruses
Viruses doi: 10.3390/v16030416
Authors:
Luisa Galati
Maria Vincenza Chiantore
Mariarosaria Marinaro
Paola Di Bonito
Approximately 12% of human cancers worldwide are associated with infectious agents, which are classified by the International Agency for Research on Cancer (IARC) as Group 1 within the agents that are carcinogenic to humans. Most of these agents are viruses. Group 1 oncogenic viruses include hepatitis C virus, hepatitis B virus (HBV), human T-cell ...
Source: Viruses - March 8, 2024 Category: Virology Authors: Luisa Galati Maria Vincenza Chiantore Mariarosaria Marinaro Paola Di Bonito Tags: Review Source Type: research
Medicamentous Therapy of Malignant Eyelid Tumors
CONCLUSION: Even though the data on these eye tumors is still limited, the reported case studies using systemic therapies for malignant eyelid tumors demonstrate the potential of this treatment modality. However, the need for further research is high especially concerning the combination of different therapy principles for increasing the effectiveness of eyelid tumor therapy.PMID:38413000 | DOI:10.1055/a-2255-5937 (Source: Klinische Monatsblatter fur Augenheilkunde)
Source: Klinische Monatsblatter fur Augenheilkunde - February 27, 2024 Category: Opthalmology Authors: Daniel Walsch Olga Furashova Steffen Emmert Vinodh Kakkassery Source Type: research
