Kalman-Based Real-Time Functional Decomposition for the Spectral Calibration in Swept Source Optical Coherence Tomography
This paper presents a real-time functional decomposition adaptive algorithm for the optimal sampling of the interferometric signal in Swept-Source Optical Coherence Tomography imaging systems, which completely eliminates the input signal dependent nonlinearities that are problematic in current state-of-the-art OCT realizations that use interpolation and resampling. The proposed adaptive calibration algorithm uses the Kalman approach to estimate the wavenumber index parameter $k$ from the Mach-Zender Interferometer signal which is then applied to an adaptive level crossing sampler to generate a sampling clock that $k$-linea...
Source: IEEE Transactions on Biomedical Circuits and Systems - March 31, 2020 Category: Biomedical Engineering Source Type: research
Occupational leptospirosis as an underreported disease in high-risk groups: implications for prevention and control measures
Leptospirosis is a neglected zoonotic disease with no particular or verified symptoms, which has been underreported as an occupational infection. Leptospira interrogans serovar Icterohaemorrhagiae and L. interrogans serovar Grippotyphosa are the two major pathogenic serovars. Professionals who are in constant contact with animals and their residues, in water supply, rice mill, slaughtering houses, hospital sanitary places, strawberry picking, construction works, agriculture working, forest working and food industry are at highest risk. Factors related to occupational, environmental, and recreational aspects and the presenc...
Source: Reviews in Medical Microbiology - March 31, 2020 Category: Microbiology Tags: BACTERIOLOGY Source Type: research
Literacy as a Distinct Developmental Domain in Children
This Viewpoint characterizes literacy as a unique domain of child development separate from spoken language acquisition that can be promoted and monitored through early pediatric primary care intervention. (Source: JAMA Pediatrics)
Source: JAMA Pediatrics - March 30, 2020 Category: Pediatrics Source Type: research
Co-evolution within structured bacterial communities results in multiple expansion of CRISPR loci and enhanced immunity
Type II CRISPR-Cas systems provide immunity against phages and plasmids that infect bacteria through the insertion of a short sequence from the invader ’s genome, known as the ‘spacer’, into the CRISPR locus. Spacers are transcribed into guide RNAs that direct the Cas9 nuclease to its target on the invader. In liquid cultures, most bacteria acquire a single spacer. Multiple spacer integration is a rare event which significance for immunity is poorly understood. Here, we found that when phage infections occur on solid media, a high proportion of the surviving colonies display complex morphologies that cont...
Source: eLife - March 30, 2020 Category: Biomedical Science Tags: Microbiology and Infectious Disease Source Type: research
Cancers, Vol. 12, Pages 824: Chromosome Instability; Implications in Cancer Development, Progression, and Clinical Outcomes
nus Chromosome instability (CIN) refers to an ongoing rate of chromosomal changes and is a driver of genetic, cell-to-cell heterogeneity. It is an aberrant phenotype that is intimately associated with cancer development and progression. The presence, extent, and level of CIN has tremendous implications for the clinical management and outcomes of those living with cancer. Despite its relevance in cancer, there is still extensive misuse of the term CIN, and this has adversely impacted our ability to identify and characterize the molecular determinants of CIN. Though several decades of genetic research have provided insig...
Source: Cancers - March 29, 2020 Category: Cancer & Oncology Authors: Raghvendra Vishwakarma Kirk J. McManus Tags: Review Source Type: research
CT angiography of lower extremities from anatomy to traumatic and nontraumatic lesions: a pictorial review
AbstractAfter the introduction and the quick improvement of multidetector computed tomography technology, computed tomographic angiography (CTA) has become the imaging examination of choice for the first assessment of patients affected by lower extremities acute disorders. The widespread availability of CT equipment, the high temporal and spatial resolution with post-processing reformation possibilities represent the main advantages of this technique, which can reliably identify different findings related to arterial vessel pathology, such as occlusion, dissection, active bleeding, and pseudoaneurysm. Radiologists should k...
Source: Emergency Radiology - March 27, 2020 Category: Emergency Medicine Source Type: research
Activation and Inactivation of Nicotinic Receptnors in the Dorsal Hippocampal Region Restored Negative Effects of Total (TSD) and REM Sleep Deprivation (RSD) on Memory Acquisition, Locomotor Activity and Pain Perception
Publication date: Available online 19 March 2020Source: NeuroscienceAuthor(s): Bibi-Zahra Javad-Moosavi, Mohammad Nasehi, Salar Vaseghi, Seyed Hamid Jamaldini, Mohammad-Reza Zarrindast (Source: Neuroscience)
Source: Neuroscience - March 26, 2020 Category: Neuroscience Source Type: research
Prevalence of Mycoplasma genitalium infection in women with bacterial vaginosis
Bacterial vaginosis (BV) is a common condition in reproductive-age women and is known to be positively associated with risk of acquisition of sexually transmitted infections (STI) such as chlamydia and gonorrh... (Source: BMC Women's Health)
Source: BMC Women's Health - March 26, 2020 Category: OBGYN Authors: Melinda B. Nye, Ayla B. Harris, Amanda J. Pherson and Charles P. Cartwright Tags: Research article Source Type: research
Cancers, Vol. 12, Pages 797: Artificial Intelligence and Digital Microscopy Applications in Diagnostic Hematopathology
ury Digital Pathology is the process of converting histology glass slides to digital images using sophisticated computerized technology to facilitate acquisition, evaluation, storage, and portability of histologic information. By its nature, digitization of analog histology data renders it amenable to analysis using deep learning/artificial intelligence (DL/AI) techniques. The application of DL/AI to digital pathology data holds promise, even if the scope of use cases and regulatory framework for deploying such applications in the clinical environment remains in the early stages. Recent studies using whole-slide images...
Source: Cancers - March 26, 2020 Category: Cancer & Oncology Authors: Hanadi El El Achi Joseph D. Khoury Tags: Review Source Type: research
Response to MM Rojas-Rojas et al
We thank MM Rojas-Rojas et al. for their interest in our article investigating the role of multi-parametric MRI in squamous cell carcinoma of the anal canal (SCCAC) . They raise concerns regarding the variability of diffusion weighted image acquisition between centres and reference an editorial  citing two multi-centre studies that reported poor agreement of apparent diffusion coefficient values between sites [3,4]. Unfortunately, both of these studies failed to fully standardise MRI sequences between centres, which may explain the observed inconsistencies. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - March 26, 2020 Category: Radiology Authors: Michael Jones, Jarad Martin Tags: Letter to the Editor Source Type: research
Knowledge exchange, foster care and early education: Introducing treasure baskets to foster carers of young children
AbstractAll children have a right to early childhood education, but preschool ‐aged fostered children are less likely than others to access formal early childhood education and care (ECEC) services such as nurseries and playgroups. The home learning environment is crucial for this group. Building on an earlier pilot study where foster carers of young children saw education as something that largely happens outside the home, this paper presents a knowledge exchange project that aimed to build foster carers' self‐concept as educators. The design of the project aimed to exchange knowledge between academic researchers and ...
Source: Child and Family Social Work - March 25, 2020 Category: Child Development Authors: Claire Cameron, Veena Meetoo, Thure Johansen, Sonia Jackson Tags: ORIGINAL ARTICLE Source Type: research
Molecules, Vol. 25, Pages 1484: Green Tea Catechins Trigger Immediate-Early Genes in the Hippocampus and Prevent Cognitive Decline and Lifespan Shortening
Nakamura Senescence-accelerated mouse prone 10 (SAMP10) mice, after ingesting green tea catechins (GT-catechin, 60 mg/kg), were found to have suppressed aging-related decline in brain function. The dose dependence of brain function on GT-catechin indicated that intake of 1 mg/kg or more suppressed cognitive decline and a shortened lifespan. Mice that ingested 1 mg/kg GT-catechin had the longest median survival, but the dose was less effective at suppressing cognitive decline. The optimal dose for improving memory acquisition was 60 mg/kg, and memory retention was higher in mice that ingested 30 mg/kg or more. To eluci...
Source: Molecules - March 25, 2020 Category: Chemistry Authors: Keiko Unno Monira Pervin Kyoko Taguchi Tomokazu Konishi Yoriyuki Nakamura Tags: Article Source Type: research
Bacterial Membrane Vesicles as Mediators of Microbe – Microbe and Microbe – Host Community Interactions
Bacterial membrane vesicles are proteoliposomal nanoparticles produced by both Gram-negative and Gram-positive bacteria. As they originate from the outer surface of the bacteria, their composition and content is generally similar to the parent bacterium’s membrane and cytoplasm. However, there is ample evidence that preferential packaging of proteins, metabolites, and toxins into vesicles does occur. Incorporation into vesicles imparts a number of benefits to the cargo, including protection from degradation by other bacteria, the host organism, or environmental factors, maintenance of a favorable microenvironment for...
Source: Frontiers in Microbiology - March 24, 2020 Category: Microbiology Source Type: research
Developmental Dynamic Dysphasia: Are Bilateral Brain Abnormalities a Signature of Inefficient Neural Plasticity?
We describe, for the first time, a case of developmental dynamic dysphasia (DDD) in a right-handed adolescent boy (subject D) with cortical malformations involving language-eloquent regions (inferior frontal gyrus) in both the left and the right hemispheres. Language evaluation revealed a markedly reduced verbal output affecting phonemic and semantic fluency, phrase and sentence generation and verbal communication in everyday life. Auditory comprehension, repetition, naming, reading and spelling were relatively preserved, but executive function was impaired. Multimodal neuroimaging showed a malformed cerebral cortex with a...
Source: Frontiers in Human Neuroscience - March 24, 2020 Category: Neuroscience Source Type: research
ACR Advocates Against Payer Mandates on Specialty Pharmacy Acquisition of In-Office Treatments
In partnership with rheumatology and other specialty organizations, the ACR is working against payer and employer policies that mandate specialty pharmacy acquisition of in-office treatments. (Source: The Rheumatologist)
Source: The Rheumatologist - March 23, 2020 Category: Rheumatology Authors: From the College Tags: Legislation & Advocacy COVID-19 In-office treatment insurance pharmacy benefit managers specialty drug acquisition Source Type: research
Genes, Vol. 11, Pages 339: Experimental Evolution of Legume Symbionts: What Have We Learnt?
Capela Rhizobia, the nitrogen-fixing symbionts of legumes, are polyphyletic bacteria distributed in many alpha- and beta-proteobacterial genera. They likely emerged and diversified through independent horizontal transfers of key symbiotic genes. To replay the evolution of a new rhizobium genus under laboratory conditions, the symbiotic plasmid of Cupriavidus taiwanensis was introduced in the plant pathogen Ralstonia solanacearum, and the generated proto-rhizobium was submitted to repeated inoculations to the C. taiwanensis host, Mimosa pudica L.. This experiment validated a two-step evolutionary scenario of key symbi...
Source: Genes - March 23, 2020 Category: Genetics & Stem Cells Authors: Doin de Moura Remigi Masson-Boivin Capela Tags: Review Source Type: research
Parental Acculturation Attitudes: Direct and Indirect Impacts on Children ’s Second Language Acquisition
. (Source: Early Education and Development)
Source: Early Education and Development - March 23, 2020 Category: Child Development Authors: Larissa M. Troesch Robin Segerer Nina Claus-Pr östler Alexander Grob Source Type: research
Antibiotic Degradation by Commensal Microbes Shields Pathogens [Bacterial Infections]
The complex bacterial populations that constitute the gut microbiota can harbor antibiotic resistance genes (ARGs), including those encoding β-lactamase enzymes (BLA), which degrade commonly prescribed antibiotics such as ampicillin. The prevalence of such genes in commensal bacteria has been increased in recent years by the wide use of antibiotics in human populations and in livestock. While transfer of ARGs between bacterial species has well-established dramatic public health implications, these genes can also function in trans within bacterial consortia, where antibiotic-resistant bacteria can provide antibiotic-se...
Source: Infection and Immunity - March 23, 2020 Category: Infectious Diseases Authors: Gjonbalaj, M., Keith, J. W., Do, M. H., Hohl, T. M., Pamer, E. G., Becattini, S. Tags: Bacterial Infections Source Type: research
Matrix Metalloproteinases Expressed in Response to Bacterial Vaginosis Disrupt the Endocervical Epithelium, Increasing Transmigration of HIV [Host Response and Inflammation]
Bacterial vaginosis (BV), a disorder of the female reproductive tract (FRT) in which a healthy Lactobacillus-dominant microflora is replaced by BV-associated bacteria (BVAB), can significantly increase the incidence of human immunodeficiency virus (HIV) acquisition. Discerning the effect of BV on the mucosal epithelium of the FRT may yield novel preventatives and therapeutics for HIV infection. Here, we investigated barrier dysfunction of the endocervix by host-derived factors, secreted in response to BV, as a potential cause of HIV infection. Using a polarized endocervical cell culture system, we determined that condition...
Source: Infection and Immunity - March 23, 2020 Category: Infectious Diseases Authors: Cherne, M. D., Cole, A. L., Newberry, L., Schmidt-Owens, M., Deichen, M., Cole, A. M. Tags: Host Response and Inflammation Source Type: research
Neisseria meningitidis Induces Pathology-Associated Cellular and Molecular Changes in Trigeminal Schwann Cells [Bacterial Infections]
Neisseria meningitidis, a common cause of sepsis and bacterial meningitis, infects the meninges and central nervous system (CNS), primarily via paracellular traversal across the blood-brain barrier (BBB) or blood-cerebrospinal fluid barrier. N. meningitidis is often present asymptomatically in the nasopharynx, and the nerves extending between the nasal cavity and the brain constitute an alternative route by which the meningococci may reach the CNS. To date, the cellular mechanisms involved in nerve infection are not fully understood. Peripheral nerve glial cells are phagocytic and are capable of eliminating microorganisms,...
Source: Infection and Immunity - March 23, 2020 Category: Infectious Diseases Authors: Delbaz, A., Chen, M., Jen, F. E.- C., Schulz, B. L., Gorse, A.-D., Jennings, M. P., St John, J. A., Ekberg, J. A. K. Tags: Bacterial Infections Source Type: research
Developing a robust assay to monitor and quantify key players of metabolic pathways during adipogenesis by targeted proteomics
This article is protected by copyright. All rights reserved (Source: Proteomics)
Source: Proteomics - March 21, 2020 Category: Biochemistry Authors: Andreas Hentschel, Robert Ahrends Tags: Technical Brief Source Type: research
AGC to bolster drug services with MolMed acquisition
(Source: Chemical and Engineering News)
Source: Chemical and Engineering News - March 21, 2020 Category: Chemistry Authors: Rick Mullin Source Type: research
Image Acquisition and Quality Assurance in the Boston Adolescent Neuroimaging of Depression and Anxiety Study
Publication date: Available online 19 March 2020Source: NeuroImage: ClinicalAuthor(s): Viviana Siless, Nicholas A. Hubbard, Robert Jones, Jonathan Wang, Nicole Lo, Clemens C.C. Bauer, Mathias Goncalves, Isabelle Frosch, Daniel Norton, Genesis Vergara, Kristina Conroy, Flavia Vaz De Souza, Isabelle M. Rosso, Aleena Hay Wickham, Elizabeth Ann Cosby, Megan Pinaire, Dina Hirshfeld-Becker, Diego A. Pizzagalli, Aude Henin, Stefan G. Hofmann (Source: NeuroImage: Clinical)
Source: NeuroImage: Clinical - March 21, 2020 Category: Radiology Source Type: research
Phosphate transporters, PnPht1;1 and PnPht1;2 from Panax notoginseng enhance phosphate and arsenate acquisition
Panax notoginseng is a medicinally important Chinese herb with a long history of cultivation and clinical application. The planting area is mainly distributed in Wenshan Prefecture, where the quality and safety o... (Source: BMC Plant Biology)
Source: BMC Plant Biology - March 20, 2020 Category: Biology Authors: Guan-Hua Cao, Ze-Dong Li, Xi-Fu Wang, Xue Zhang, Rong-Hua Zhao, Wen Gu, Di Chen, Jie Yu and Sen He Tags: Research article Source Type: research
Viruses, Vol. 12, Pages 342: Structural Insight into Paramyxovirus and Pneumovirus Entry Inhibition
This article will summarize current mechanistic insight into F-mediated membrane fusion and examine the contribution of structural information to the development of small-molecule F inhibitors. Implications are outlined for future drug target selection and rational drug engineering strategies. (Source: Viruses)
Source: Viruses - March 20, 2020 Category: Virology Authors: Megha Aggarwal Richard K Plemper Tags: Review Source Type: research
The Challenge of Modeling the Acquisition of Mathematical Concepts
As a full-blown research topic, numerical cognition is investigated by a variety of disciplines including cognitive science, developmental and educational psychology, linguistics, anthropology and, more recently, biology and neuroscience. However, despite the great progress achieved by such a broad and diversified scientific inquiry, we are still lacking a comprehensive theory that could explain how numerical concepts are learned by the human brain. In this perspective, I argue that computer simulation should have a primary role in filling this gap because it allows identifying the finer-grained computational mechanisms un...
Source: Frontiers in Human Neuroscience - March 20, 2020 Category: Neuroscience Source Type: research
Effect of a Pediatric Mock Code Simulation Program on Resuscitation Skills and Team Performance
The timely delivery of high-quality cardiopulmonary resuscitation (CPR) is a key measure of quality life support and patient safety. Code simulation training facilitates the acquisition of resuscitation skills and improves team performance, which significantly improves cardiopulmonary arrest survival rates and improves patient safety. The purpose of this study was to explore the impact of simulation-based training on resuscitation skills and to provide evidence that code simulations can help improve team skills and the quality of team leadership. (Source: Clinical Simulation in Nursing)
Source: Clinical Simulation in Nursing - March 20, 2020 Category: Nursing Authors: Tarek R. Hazwani, Nicole Harder, Naila A. Shaheen, Zahra Al Hassan, Mohannad Antar, Ali Alshehri, Hamza Alali, Yasser M. Kazzaz Tags: Featured Article Source Type: research
E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish
by Haibo Xie, Yunsi Kang, Shuo Wang, Pengfei Zheng, Zhe Chen, Sudipto Roy, Chengtian Zhao E2f5 is a member of the E2f family of transcription factors that play essential roles during many cellular processes. E2f5 was initially characterized as a transcriptional repressor in cell proliferation studies through its interaction with the Retinoblastoma (Rb) protein for inhibition of target gene transcription. However, the precise roles of E2f5 during embryonic and post-embryonic development remain incompletely investigated. Here, we report that zebrafish E2f5 plays critical roles during spermatogenesis and multiciliated cell (...
Source: PLoS Genetics - March 20, 2020 Category: Genetics & Stem Cells Authors: Haibo Xie Source Type: research
Learning from Failure: Shame and Emotion Regulation in Virtue as Skill
AbstractOn an account of virtue as skill, virtues are acquired in the ways that skills are acquired. In this paper I focus on one implication of that account that is deserving of greater attention, which is that becoming more skillful requires learning from one ’s failures, but that turns out to be especially challenging when dealing with moral failures. In skill acquisition, skills are improved by deliberate practice, where you strive to correct past mistakes and learn how to overcome your current limitations. A similar story applies to virtue acquisiti on, as moral failures will be a part of anyone’s life, an...
Source: Ethical Theory and Moral Practice - March 20, 2020 Category: Medical Ethics Source Type: research
Activation and inactivation of nicotinic receptors in the dorsal hippocampal region restored negative effects of total (TSD) and REM sleep deprivation (RSD) on memory acquisition, locomotor activity and pain perception
Publication date: Available online 19 March 2020Source: NeuroscienceAuthor(s): Bibi-Zahra Javad-Moosavi, Mohammad Nasehi, Salar Vaseghi, Seyed Hamid Jamaldini, Mohammad-Reza Zarrindast (Source: Neuroscience)
Source: Neuroscience - March 19, 2020 Category: Neuroscience Source Type: research
Variational Learning in Child L2 Acquisition? Comprehension of Verbal Agreement in Spanish and English
. (Source: Language Learning and Development)
Source: Language Learning and Development - March 19, 2020 Category: Speech-Language Pathology Authors: Alexandra Morales Reyes Silvina Montrul Source Type: research
Travel, Diarrhea, Antibiotics, Antimicrobial Resistance and Practice Guidelines — a Holistic Approach to a Health Conundrum
AbstractPurpose of ReviewGiven the recent interest in the interface between travelers ’ diarrhea (TD) management guidelines and antimicrobial resistance from both the patient and population perspectives, we have undertaken a review of the evidence with an aim towards practical and pragmatic recommendations.Recent FindingsAntimicrobial resistance continues to be an existential threat. Therefore, an update is needed on the pathogens that cause TD, the role of antibiotics, the potential changes in microbiome and acquisiton of multi-drug resistant (MDR) bacteria, and lastly the impact of MDR acquisition of the traveler o...
Source: Current Infectious Disease Reports - March 18, 2020 Category: Infectious Diseases Source Type: research
Nonenzymatic function of Aldolase A downregulates miR-145 to promote the Oct4/DUSP4/TRAF4 axis and the acquisition of lung cancer stemness
Cell Death & Disease, Published online: 18 March 2020; doi:10.1038/s41419-020-2387-2Nonenzymatic function of Aldolase A downregulates miR-145 to promote the Oct4/DUSP4/TRAF4 axis and the acquisition of lung cancer stemness (Source: Cell death and disease)
Source: Cell death and disease - March 18, 2020 Category: Internal Medicine Authors: Yu-Chan Chang Yi-Fang Yang Jean Chiou Hsing-Fang Tsai Chih-Yeu Fang Chih-Jen Yang Chi-Long Chen Michael Hsiao Source Type: research
Carcinogenesis of Pancreatic Ductal Adenocarcinoma
Although the estimated time for development of pancreatic ductal adenocarcinoma (PDA) is more than 20 years, PDAs are usually detected at late, metastatic stages. PDAs develop from duct-like cells through a multistep carcinogenesis process, from low-grade dysplastic lesions to carcinoma in situ and eventually to metastatic disease. This process involves gradual acquisition of mutations in oncogenes and tumor suppressor genes, as well as changes in the pancreatic environment from a pro-inflammatory microenvironment that favors the development of early lesions, to a desmoplastic tumor microenvironment that is highly fibrotic...
Source: Gastroenterology - March 18, 2020 Category: Gastroenterology Authors: Peter Storz, Howard C. Crawford Source Type: research
Utilizing Transcranial Direct Current Stimulation to Enhance Laparoscopic Technical Skills Training: A Randomized Controlled Trial
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that delivers constant, low electrical current resulting in changes to cortical excitability. Prior work suggests it may enhance motor learning giving it the potential to augment surgical technical skill acquisition. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - March 18, 2020 Category: Neurology Authors: Morgan L. Cox, Zhi-De Deng, Hannah Palmer, Amanda Watts, Lysianne Beynel, Jonathan R. Young, Sarah H. Lisanby, John Migaly, Lawrence G. Appelbaum Source Type: research
[Reviews] Priorities for developing respiratory syncytial virus vaccines in different target populations
The development of an effective vaccine against respiratory syncytial virus (RSV) has been hampered by major difficulties that occurred in the 1960s when a formalin-inactivated vaccine led to increased severity of RSV disease after acquisition of the virus in the RSV season after vaccination. Recent renewed efforts to develop a vaccine have resulted in about 38 candidate vaccines and monoclonal antibodies now in clinical development. The target populations for effective vaccination are varied and include neonates, young children, pregnant women, and older adults. The reasons for susceptibility to infection in each of these...
Source: Science Translational Medicine - March 18, 2020 Category: Biomedical Science Authors: Drysdale, S. B., Barr, R. S., Rollier, C. S., Green, C. A., Pollard, A. J., Sande, C. J. Tags: Reviews Source Type: research
Sensors, Vol. 20, Pages 1668: Towards Safety Improvement of Measurement and Control Signals Transmission in Marine Environment
Grala This paper is dedicated to some aspects of maritime on-board safety improvement. The contribution of this article is a proposal to extend wireless communication on the ship, supported by examples of solutions that have not previously been used on board. Analyzed aspects concern the measurement and control signal transmission in hostile marine environment. A problem to solve is formulated, how to reduce a negative impact of this environment on effectiveness and reliability of maritime on board communication. The proposed ways for solving a problem under consideration cover recommendations concerning some aspects o...
Source: Sensors - March 17, 2020 Category: Biotechnology Authors: Romuald Masnicki Janusz Mindykowski Przemyslaw Grala Tags: Article Source Type: research
Effects of dose on acquisition and persistence of a new response for a remifentanil-associated stimulus
Previous research demonstrated that a remifentanil-associated stimulus facilitated the acquisition of a previously unlearned response; however, it is unclear how long a remifentanil-associated stimulus maintains conditioned reinforcing properties under conditions of daily testing. To address this gap, we exposed adult male rats to response-independent stimulus presentations and deliveries of remifentanil (1.0, 3.2, or 10.0 μg/kg/infusion). Rats either received the stimulus presentations and remifentanil deliveries together (Paired Pavlovian conditioning) or according to separate clocks (Random control group). In the ses...
Source: Behavioural Pharmacology - March 14, 2020 Category: Drugs & Pharmacology Tags: Research Reports Source Type: research
The acquisition of trisomy 8 associated with Behçet's-like disease in myelodysplastic syndrome
Publication date: Available online 12 March 2020Source: Leukemia Research ReportsAuthor(s): Satoko Oka, Kazuo Ono, Masaharu Nohgawa (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - March 14, 2020 Category: Hematology Source Type: research
GSE146910 Evolutionary selection of pestivirus variants with altered or no miRNA dependency
Contributors : Konstantinos G Kokkonos ; Nicolas Fossat ; Louise Nielsen ; Christina Holm ; Wytske M Hepkema ; Jens Bukh ; Troels K ScheelSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Bos taurusHost microRNA (miRNA) dependency is a hallmark of the human pathogen hepatitis C virus (HCV) and was recently also described for the related pestiviruses, which are important livestock pathogens. HCV critically depends on the liver-specific miR-122, whereas the broadly expressed let-7 and miR-17 families bind two sites (S1 and S2) in the pestiviral 3 ’ untranslated region (UTR). Here, we el...
Source: GEO: Gene Expression Omnibus - March 13, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Bos taurus Source Type: research
Neural Population Dynamics and Cognitive Function
This article attempts to provide an overview of PDP principles and applications that addresses a broader audience. (Source: Frontiers in Human Neuroscience)
Source: Frontiers in Human Neuroscience - March 12, 2020 Category: Neuroscience Source Type: research
Complexity Leadership in the Nursing Context
Consolidation through mergers and acquisitions is occurring across health care as a strategic move to address the disruptive forces of complexity. While consolidation is improving the overall fitness and viability of health care organizations, it is having the opposite effect on the professionals working within them who are reporting increasing rates of burnout from ongoing complexity in the health care environment. This happens in all organizations that try to respond to complexity with traditional bureaucratic leadership approaches. What is needed is to replace bureaucratic leadership with the networked approach of compl...
Source: Nursing Administration Quarterly - March 11, 2020 Category: Nursing Tags: Original Articles Source Type: research
[ASAP] Fourier Transform-Ion Mobility Linear Ion Trap Mass Spectrometer Using Frequency Encoding for Recognition of Related Compounds in a Single Acquisition
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05507 (Source: Analytical Chemistry)
Source: Analytical Chemistry - March 11, 2020 Category: Chemistry Authors: Robert L. Schrader, Brett M. Marsh, and R. Graham Cooks* Source Type: research
Enzyme ‐based detection of epoxides using colorimetric assay integrated with smartphone imaging
Schematic illustration of the enzyme ‐based epoxide detection. The detection scheme is based on the use of halohydrin dehalogenase that catalyzes epoxide substrate accompanying consumption of proton. The increase in pH is sensed by a pH sensitive dye. AbstractEpoxides are widely used chemicals, the determination of which is of paramount importance. Herein, we present an enzyme ‐based approach for noninstrumental detection of epoxides in standard solution and environmental samples. Halohydrin dehalogenase (HheC) as a biological recognition element and epichlorohydrin as a model analyte were evaluated for sensing. The de...
Source: Biotechnology and Applied Biochemistry - March 10, 2020 Category: Biochemistry Authors: Ijaz Gul, Tadesse Fantaye Bogale, Jiao Deng, Yong Chen, Ruiqin Fang, Juan Feng, Lixia Tang Tags: Original Article Source Type: research
Representation of visual landmarks in retrosplenial cortex
The process by which visual information is incorporated into the brain ’s spatial framework to represent landmarks is poorly understood. Studies in humans and rodents suggest that retrosplenial cortex (RSC) plays a key role in these computations. We developed an RSC-dependent behavioral task in which head-fixed mice learned the spatial relationship between visual lan dmark cues and hidden reward locations. Two-photon imaging revealed that these cues served as dominant reference points for most task-active neurons and anchored the spatial code in RSC. This encoding was more robust after task acquisition. Decoupling th...
Source: eLife - March 10, 2020 Category: Biomedical Science Tags: Neuroscience Source Type: research
Acquisition of Information About Innovative Practices in Outpatient Mental Health Clinics
This study uses qualitative interviews with leaders of 34 mental health clinics in the context of a statewide rollout of clinical and business innovations to explore how clinics first learn about innovations and which external sources of information they access. Clinic leaders reported accessing information about innovations mainly from government agencies, professional associations, peer organizations, and research literature. Leaders mentioned an average of two external sources of information. There was evidence of variation in how leaders accessed information and how information about innovations was communicated within...
Source: Administration and Policy in Mental Health and Mental Health Services Research - March 10, 2020 Category: Psychiatry Source Type: research
GSE146598 Hematopoietic stem cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia [Chip-Seq]
Contributors : Leanne Cooper ; Steven W Lane ; Megan Bywater ; Jasmin StraubeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe caudal-related homeobox transcription factor CDX2 is ectopically expressed in the majority of patients with acute myeloid leukemia (AML). We generated an inducible transgenic mouse model whereby Cdx2 was specifically activated in HSCs. Cdx2 mice developed myelodysplastic syndrome (MDS) with progression to acute leukemia associated with stepwise acquisition of additional driver mutations. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 9, 2020 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
Ebola Virus Glycoprotein-Specific Monoclonal Antibodies and Uses Thereof
Ebola virus is a large, negative-strand RNA virus composed of 7 genes encoding viral proteins, including a single glycoprotein (GP). The virus is responsible for causing Ebola virus disease (EVD), formerly known as Ebola hemorrhagic fever (EHF), in humans. In particular, Bundibugyo (BDBV), Zaire (EBOV), and Sudan (SUDV) species have been associated with large outbreaks of EVD in Africa and reported case fatality rates of up to 90%. Transmission of Ebola virus to humans is not yet fully understood but is likely due to incidental exposure to infected animals. EVD spreads through human-to-human transmission, with infection re...
Source: NIH OTT Licensing Opportunities - March 9, 2020 Category: Research Authors: ajoyprabhu3 Source Type: research
Acquisition of genetic mutations in group a streptococci at infection site and subsequent systemic dissemination of the mutants with lethal mutations in a streptococcal toxic shock syndrome mouse model
Publication date: Available online 3 March 2020Source: Microbial PathogenesisAuthor(s): Ken Otsuji, Kazumasa Fukuda, Tsukasa Maruoka, Midori Ogawa, Mitsumasa Saito (Source: Microbial Pathogenesis)
Source: Microbial Pathogenesis - March 6, 2020 Category: Infectious Diseases Source Type: research
Evidence to support the early introduction of laparoscopic suturing skills into the surgical training curriculum
The objectives of this study were to investigate the relationship between the acquisition of laparoscopic suturing skills and other operative laparoscopic skills and to provide evidence to determine ideal time... (Source: BMC Medical Education)
Source: BMC Medical Education - March 6, 2020 Category: Universities & Medical Training Authors: Benjie Tang, Lin Zhang and Afshin Alijani Tags: Research article Source Type: research