Guardian of the Genome: An Alternative RAG/Transib Co-Evolution Hypothesis for the Origin of V(D)J Recombination
The appearance of adaptive immunity in jawed vertebrates is termed the immunological ‘Big Bang’ because of the short evolutionary time over which it developed. Underlying it is the recombination activating gene (RAG)-based V(D)J recombination system, which initiates the sequence diversification of the immunoglobulins and lymphocyte antigen receptors. It was convincingly argued that the RAG1 and RAG2 genes originated from a single transposon. The current dogma postulates that the V(D)J recombination system was established by the split of a primordial vertebrate immune receptor gene into V and J segments by a RAG...
Source: Frontiers in Immunology - July 28, 2021 Category: Allergy & Immunology Source Type: research

Cancers, Vol. 13, Pages 3801: Functional Analysis of Non-Genetic Resistance to Platinum in Epithelial Ovarian Cancer Reveals a Role for the MBD3-NuRD Complex in Resistance Development
Zuber Udo Jeschke Fabian Trillsch Philipp Rathert Epithelial ovarian cancer (EOC) is the most lethal disease of the female reproductive tract, and although most patients respond to the initial treatment with platinum (cPt)-based compounds, relapse is very common. We investigated the role of epigenetic changes in cPt-sensitive and -resistant EOC cell lines and found distinct differences in their enhancer landscape. Clinical data revealed that two genes (JAK1 and FGF10), which gained large enhancer clusters in resistant EOC cell lines, could provide novel biomarkers for early patient stratification with statistica...
Source: Cancers - July 28, 2021 Category: Cancer & Oncology Authors: Tabea L. Bauer Katrin Collmar Till Kaltofen Ann-Katrin Loeffler Lorena Decker Jan Mueller Sabine Pinter Stephan A. Eisler Sven Mahner Patricia Fraungruber Stefan Kommoss Annette Staebler Lewis Francis R. Steven Conlan Johannes Zuber Udo Jeschke Fabian Tri Tags: Article Source Type: research

Cancers, Vol. 13, Pages 3804: Comprehensive Library Generation for Identification and Quantification of Endometrial Cancer Protein Biomarkers in Cervico-Vaginal Fluid
ton Crosbie Endometrial cancer is the most common gynaecological malignancy in high-income countries and its incidence is rising. Early detection, aided by highly sensitive and specific biomarkers, has the potential to improve outcomes as treatment can be provided when it is most likely to effect a cure. Sequential window acquisition of all theoretical mass spectra (SWATH-MS), an accurate and reproducible platform for analysing biological samples, offers a technological advance for biomarker discovery due to its reproducibility, sensitivity and potential for data re-interrogation. SWATH-MS requires a spectral librar...
Source: Cancers - July 28, 2021 Category: Cancer & Oncology Authors: Njoku Chiasserini Geary Pierce Jones Whetton Crosbie Tags: Article Source Type: research

Write this way: examining teachers ’ supportive strategies to facilitate children’s early writing in preschool
In this study, we applied a fine-grained approach to examine preschool teachers’ instructional practices for supporting children’s early writing skills in a dyadic (i.e., one-on-one) context. The key aims were: (1) to describe teachers’ supportiv e strategies for handwriting, spelling, and composing within a dyadic writing task; and (2) to determine whether teachers’ supportive strategies varied according to the domain of writing they addressed. We asked thirty teacher–child dyads to complete a picture description writing task, and used a researcher-developed coding scheme to document teachers...
Source: Reading and Writing - July 27, 2021 Category: Child Development Source Type: research

Congenital muscular dystrophies: what is new?
The congenital muscular dystrophies (CMDs) are inherited disorders primarily affecting the skeletal muscle and defined by hypotonia and weakness occurring before the achievement of independent ambulation, delay or arrest in the attainment of gross motor milestones, and dystrophic muscle pathology. Allelic mutations in several genes can cause onset either before or after the acquisition of ambulation, providing a pragmatic boundary between CMDs and limb girdle muscular dystrophies (LGMD) (Table 1). (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - July 27, 2021 Category: Neurology Authors: Alberto A. Zambon, Francesco Muntoni Source Type: research

Integrated Tapping Mode Kelvin Probe Force Microscopy with Photoinduced Force Microscopy for Correlative Chemical and Surface Potential Mapping
Herein, a novel approach to signal generation in tapping-mode Kelvin probe force microscopy (KPFM) is explored. A home-built field-effect transistor circuit bypasses the necessity for an AC voltage to generate KPFM signal, allowing for imaging with ≈25 nm spatial resolution. The resulting technique is compatible with photoinduced force microscopy, allowing for single-pass imaging of electrical and chemical domains simultaneously. AbstractKelvin probe force microscopy (KPFM) is a popular technique for mapping the surface potential at the nanoscale through measurement of the Coulombic force between an atomic force...
Source: Small - July 26, 2021 Category: Nanotechnology Authors: Devon S. Jakob, Nengxu Li, Huanping Zhou, Xiaoji G. Xu Tags: Research Article Source Type: research

GSE180677 Microarray analysis of correlates of vaccine immunogenecity following ALVAC vaccination in NHP in Study 36
Contributors : Jeffrey A Tomalka ; Adam-Nicolas Pelletier ; Slim Fourati ; Muhammad B Latif ; Ashish Sharma ; Kathryn Furr ; Kevin Carlson ; Michelle Lifton ; Ana Gonzalez ; Peter Wilkinson ; Genoveffa Franchini ; Robert Parks ; Norman Letvin ; Nicole L Yates ; Kelly E Seaton ; Georgia Tomaras ; Jim Tartaglia ; Merlin Robb ; Nelson Michael ; Richard Koup ; Barton Haynes ; Sampa Santra ; Rafick-Pierre S ékalySeries Type : Expression profiling by arrayOrganism : Homo sapiens ; Macaca mulattaThe RV144 HIV vaccine trial remains the only study to demonstrate significant protection from future HIV-1 acquisition. One of th...
Source: GEO: Gene Expression Omnibus - July 26, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Macaca mulatta Source Type: research

Impact of a restrictive antibiotic policy on the acquisition of extended-spectrum beta-lactamase-producing Enterobacteriaceae in an endemic region: a before-and-after, propensity-matched cohort study in a Caribbean intensive care unit
High-level antibiotic consumption plays a critical role in the selection and spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) in the ICU. Implementation of a stewardship program in... (Source: Critical Care)
Source: Critical Care - July 26, 2021 Category: Intensive Care Authors: Christophe Le Terrier, Marco Vinetti, Paul Bonjean, R égine Richard, Bruno Jarrige, Bertrand Pons, Benjamin Madeux, Pascale Piednoir, Fanny Ardisson, Elain Elie, Frédéric Martino, Marc Valette, Edouard Ollier, Sébastien Breurec, Michel Carles and Guil Tags: Research Source Type: research

Cancers, Vol. 13, Pages 3737: Targeting RB1 Loss in Cancers
Chiaki Takahashi Retinoblastoma protein 1 (RB1) is encoded by a tumor suppressor gene that was discovered more than 30 years ago. Almost all mitogenic signals promote cell cycle progression by braking on the function of RB1 protein through mono- and subsequent hyper-phosphorylation mediated by cyclin-CDK complexes. The loss of RB1 function drives tumorigenesis in limited types of malignancies including retinoblastoma and small cell lung cancer. In a majority of human cancers, RB1 function is suppressed during tumor progression through various mechanisms. The latter gives rise to the acquisition of various phenotypes t...
Source: Cancers - July 25, 2021 Category: Cancer & Oncology Authors: Paing Linn Susumu Kohno Jindan Sheng Nilakshi Kulathunga Hai Yu Zhiheng Zhang Dominic Voon Yoshihiro Watanabe Chiaki Takahashi Tags: Review Source Type: research

Molecules, Vol. 26, Pages 4480: Lipidomics of the Edible Brown Alga Wakame (Undaria pinnatifida) by Liquid Chromatography Coupled to Electrospray Ionization and Tandem Mass Spectrometry
I. Cataldi The lipidome of a brown seaweed commonly known as wakame (Undaria pinnatifida), which is grown and consumed around the world, including Western countries, as a healthy nutraceutical food or supplement, was here extensively examined. The study was focused on the characterization of phospholipids (PL) and glycolipids (GL) by liquid chromatography (LC), either hydrophilic interaction LC (HILIC) or reversed-phase LC (RPLC), coupled to electrospray ionization (ESI) and mass spectrometry (MS), operated both in high and in low-resolution mode. Through the acquisition of single (MS) and tandem (MS/MS) mass spectra ...
Source: Molecules - July 24, 2021 Category: Chemistry Authors: Davide Coniglio Mariachiara Bianco Giovanni Ventura Cosima D. Calvano Ilario Losito Tommaso R. I. Cataldi Tags: Article Source Type: research

AMRI, now Curia, expands in biologics with two acquisitions
(Source: Chemical and Engineering News)
Source: Chemical and Engineering News - July 23, 2021 Category: Chemistry Source Type: research

Spatiotemporal expression of Rap1 and Ras mediates the acquisition and reinstatement of methamphetamine-induced conditioned place preference in mice via extracellular signal-regulated kinase activation
Drug addiction is a chronic recurrent brain disease characterized by compulsive drug use and a high tendency to relapse. We previously reported that the Ras-extracellular signal-regulated kinase (ERK)-ΔFosB pathway in the caudate putamen (CPu) was involved in methamphetamine-induced behavioral sensitization. Rap1, as an antagonist of Ras originally, was found to participate in neuronal synaptic plasticity recently, but the role of Rap1 in methamphetamine addiction is unclear. First, in this study, we constructed the acquisition, extinction and reinstatement of methamphetamine-induced conditioned place preference (CPP...
Source: NeuroReport - July 23, 2021 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research

Symbolic play provides a fertile context for language development
In this study, we test the hypothesis that symbolic play represents a fertile context for language acquisition because its inherent ambiguity elicits communicative behaviors that positively influence development. Infant –caregiver dyads (N = 54) participated in two 20-minute play sessions six months apart (Time 1 = 18 months, Time 2 = 24 months). During each session, the dyads played with two sets of toys that elicited either symbolic or functional play. The sessions were transcribed and coded for several features of dyadic inter action and language; infants’ linguistic proficiency was measu...
Source: Infancy - July 23, 2021 Category: Child Development Authors: No ëlie Creaghe, Sara Quinn, Evan Kidd Tags: RESEARCH ARTICLE Source Type: research

Cancers, Vol. 13, Pages 3717: The DNA Damage Response Is Differentially Involved in HPV-Positive and HPV-Negative Radioresistant Head and Neck Squamous Cell Carcinoma
ra Nuyts Radioresistance is a major cause of recurrences and radiotherapy (RT) failure in head and neck squamous cell carcinoma (HNSCC). DNA damage response (DDR) is known to be important for RT response, but its role in radioresistance is not fully understood. Here, we assessed the role of DDR in the radioresistance process of HNSCC by generating radioresistant clones from both HPV-positive SCC154 and HPV-negative SCC61 cells. We show that fractionated RT decreased RT response of HPV-positive and HPV-negative radioresistant clones in vitro and in vivo. Moreover, HPV-positive and HPV-negative radioresistant clones were...
Source: Cancers - July 23, 2021 Category: Cancer & Oncology Authors: Marieke Bamps R üveyda Dok Sandra Nuyts Tags: Article Source Type: research

Liver Imaging Reporting and Data System: Review of Pros and Cons
Semin Liver Dis DOI: 10.1055/s-0041-1732356The American College of Radiology has released the Liver Imaging Reporting and Data System (LI-RADS) scheme which categorizes focal liver lesions (FLLs) in patients at risk for hepatocellular carcinoma (HCC) according to the degree of risk of nodules to be HCC. It subgroups FLL in LR-1 (definitely benign), LR-2 (probably benign), LR-3 (intermediate probability of malignancy), LR-4 (probably HCC), LR-5 (definitely HCC), and LR-M (probable malignancy not specific for HCC). Computed tomography/magnetic resonance imaging (CT/MRI) and contrast enhanced ultrasound (CEUS) LI-RADS diagnos...
Source: Seminars in Liver Disease - July 23, 2021 Category: Gastroenterology Authors: Terzi, Eleonora Ayuso, Carmen Piscaglia, Fabio Bruix, Jordi Tags: Review Article Source Type: research

[ASAP] Strategy for Nontargeted Metabolomic Annotation and Quantitation Using a High-Resolution Spectral-Stitching Nanoelectrospray Direct-Infusion Mass Spectrometry with Data-Independent Acquisition
Analytical ChemistryDOI: 10.1021/acs.analchem.1c01480 (Source: Analytical Chemistry)
Source: Analytical Chemistry - July 22, 2021 Category: Chemistry Authors: Lichao Wang, Wangjie Lv, Xiaoshan Sun, Fujian Zheng, Tianrun Xu, Xinyu Liu, Hang Li, Xin Lu, Xiaojun Peng, Chunxiu Hu, and Guowang Xu Source Type: research

Analysis of Adaptive Olaparib Resistance Effects on Cisplatin Sensitivity in Triple Negative Breast Cancer Cells
Poly-(ADP)-ribose polymerase inhibitors (PARPi) and platinum-based drugs are promising therapies for triple negative breast cancers (TNBC) with BRCA1 or BRCA2 loss. PARPi(s) show better efficacies when combined with platinum-based therapy, however, acquisition of PARPi resistance has been linked with co-resistance to platinum-based drugs. Here, we show that TNBCs with constitutively hyperactivated PARP-1 display greater tolerances for the PARPi olaparib and cisplatin, and respond synergistically to olaparib/cisplatin combinations with increased cytotoxicity. Regardless of BRCA1 and PARP-1 activity status, upon gaining olap...
Source: Frontiers in Oncology - July 22, 2021 Category: Cancer & Oncology Source Type: research

Magnetic resonance imaging for deep infiltrating endometriosis: current concepts, imaging technique and key findings
AbstractEndometriosis is an estrogen-dependent chronic disease affecting about 10% of reproductive-age women with symptoms like pelvic pain and infertility. Pathologically, it is defined by the presence of endometrial tissue outside the uterine cavity responsible for a chronic inflammatory process. For decades the diagnosis of endometriosis was based on surgical exploration and biopsy of pelvic lesions. However, laparoscopy is not a risk-free procedure with possible false negative diagnosis due to an underestimate of retroperitoneal structures such as ureters and nerves. For these reasons nowadays, the diagnosis of endomet...
Source: Insights into Imaging - July 22, 2021 Category: Radiology Source Type: research

Genes, Vol. 12, Pages 1112: In Prototypical Autism, the Genetic Ability to Learn Language Is Triggered by Structured Information, Not Only by Exposure to Oral Language
agnon What does the way that autistic individuals bypass, learn, and eventually master language tell us about humans’ genetically encoded linguistic ability? In this theoretical review, we argue that autistic non-social acquisition of language and autistic savant abilities provide a strong argument for an innate, human-specific orientation towards (and mastery of) complex embedded structures. Autistic non-social language learning may represent a widening of the material processed during development beyond oral language. The structure detection and manipulation and generative production of non-linguistic embedded ...
Source: Genes - July 22, 2021 Category: Genetics & Stem Cells Authors: Laurent Mottron Alexia Ostrolenk David Gagnon Tags: Review Source Type: research

Multimodality Imaging for the Staging of Pancreatic Cancer
This article reviews key principles of the acquisition, interpretation, and reporting of pancreatic ductal adenocarcinoma imaging with computed tomography scanning and highlights potential roles for newer and supplemental imaging technologies. We discuss the importance of structured interpretation and reporting for providing the most complete and accurate assessment of tumor stage and resectability. (Source: Surgical Oncology Clinics of North America)
Source: Surgical Oncology Clinics of North America - July 22, 2021 Category: Surgery Authors: Martin McKinney, Michael O. Griffin, Parag P. Tolat Source Type: research

Long-term trends of BMI and cardiometabolic risk factors among adults with type 1 diabetes: an observational study from the German/Austrian DPV registry
The prevalence of overweight and obesity is increasing globally and has reached epidemic proportions. Since 1975, global age-standardized mean BMI increased by about 0.6 kg/m2 per decade in adults and by about 0.36 kg/m2 per decade in children aged 5-19 years [1,2]. Excess weight is an important risk factor for many chronic conditions such as cardiovascular disease (CVD), type 2 diabetes (T2DM) and certain types of cancer [3]. Likewise, overweight and obesity are associated with significantly higher all-cause mortality, particularly at higher BMI levels [4]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 21, 2021 Category: Endocrinology Authors: Alena Welters, Sascha R Tittel, Katharina Laubner, Markus Laimer, Diethelm Tsch öpe, Julia K Mader, Sigrun Merger, Susanne Milek, Sebastian Kummer, Reinhard W Holl Source Type: research

Tricks and tips for target volume definition and delineation in breast cancer: lessons learned from ESTRO breast courses
Delineation of target and ‘organ at risk (OAR)’ volumes is a critical part of modern radiation therapy planning, the next essential step after deciding the indication, patient discussion and image acquisition. Adoption of volume-based treatment planning for non-metastatic breast cancer has increased greatly along with th e use of improved planning techniques, essential for modern therapy. However, identifying the volumes on a planning CT is no easy task. The current paper is written by ESTRO’s breast course faculty, providing tricks and tips for target volume definition and delineation for optimal postope...
Source: Radiotherapy and Oncology - July 21, 2021 Category: Radiology Authors: O. Kaidar-Person, B.V. Offersen, L. Boersma, I. Meattini, D. Dodwell, L. Wyld, M. Aznar, T. Major, T. Kuehn, V. Strand, M. Palmu, S. Hol, P. Poortmans Tags: Review Article Source Type: research

Update on neuroimaging in brain tumours
Purpose of review To highlight some of the recent advances in magnetic resonance imaging (MRI), in terms of acquisition, analysis, and interpretation for primary diagnosis, treatment planning, and surveillance of patients with a brain tumour. Recent findings The rapidly emerging field of radiomics associates large numbers of imaging features with clinical characteristics. In the context of glioma, attempts are made to correlate such imaging features with the tumour genotype, using so-called radiogenomics. The T2-fluid attenuated inversion recovery (FLAIR) mismatch sign is an easy to apply imaging feature for ide...
Source: Current Opinion in Neurology - July 20, 2021 Category: Neurology Tags: NEUROIMAGING: Edited by Massimo Filippi Source Type: research

Estradiol Alters the Virulence Traits of Uropathogenic Escherichia coli
Uropathogenic Escherichia coli (UPEC) is the most common bacteria to cause urinary tract infection (UTI). Postmenopausal women have an increased risk of recurrent UTI. This is partly explained by estrogenic effects on host defenses against UTI. Current research is mostly focused on how UPEC affects host factors, but not so much is known about how host factors like hormones affect UPEC virulence. The aim of the present study was to investigate the impact of estradiol exposure on the virulence of UPEC. We found that a postmenopausal concentration of estradiol increased CFT073 growth and biofilm formation, but not the premeno...
Source: Frontiers in Microbiology - July 20, 2021 Category: Microbiology Source Type: research

Prevalence and Characteristic of Swine-Origin mcr-1-Positive Escherichia coli in Northeastern China
The emergence of the plasmid-mediated colistin resistance gene mcr-1 is threatening the last-line role of colistin in human medicine. With mcr-1-positive Escherichia coli (E. coli) isolated from food animal being frequently reported in China, the prevalence of mcr-1 in food animal has attracted public attention. In the present study, a total of 105 colistin-resistant E. coli strains were isolated from 200 fecal samples collected from six swine farms in northeastern China. mcr-PCR revealed that the prevalence of mcr-1 in colistin-resistant E. coli was 53.33% (56/105). mcr-1-positive E. coli showed extensive antimicrobial re...
Source: Frontiers in Microbiology - July 20, 2021 Category: Microbiology Source Type: research

Employing Broadly Neutralizing Antibodies as a Human Immunodeficiency Virus Prophylactic & Therapeutic Application
Despite the discovery that the human immunodeficiency virus 1 (HIV-1) is the pathogen of acquired immunodeficiency syndrome (AIDS) in 1983, there is still no effective anti-HIV-1 vaccine. The major obstacle to the development of HIV-1 vaccine is the extreme diversity of viral genome sequences. Nonetheless, a number of broadly neutralizing antibodies (bNAbs) against HIV-1 have been made and identified in this area. Novel strategies based on using these bNAbs as an efficacious preventive and/or therapeutic intervention have been applied in clinical. In this review, we summarize the recent development of bNAbs and its applica...
Source: Frontiers in Immunology - July 20, 2021 Category: Allergy & Immunology Source Type: research

Broadly Neutralizing Antibodies for HIV-1 Prevention
Given the absence of an effective vaccine for protection against HIV-1 infection, passive immunization strategies that utilize potent broadly neutralizing antibodies (bnAbs) to block acquisition of HIV-1 are being rigorously pursued in the clinical setting. bnAbs have demonstrated robust protection in preclinical animal models, and several leading bnAb candidates have shown favorable safety and pharmacokinetic profiles when tested individually or in combinations in early phase human clinical trials. Furthermore, passive administration of bnAbs in HIV-1 infected individuals has resulted in prolonged suppression of viral reb...
Source: Frontiers in Immunology - July 20, 2021 Category: Allergy & Immunology Source Type: research

Strategies to Overcome the Market Dominance of Hospitals
To the Editor In their recent Viewpoint, Dr Kocher and colleagues illuminated the concerning trend of hospital-dominated markets that has contributed to unsustainable growth in US health care costs. However, by focusing on managing vertical and horizontal consolidation, they addressed the symptom rather than the underlying disease. Through acquisition and organic growth, hospitals now employ more than one-third of physicians, driven largely by an economic model whereby the razor-thin profit margins of hospitals depend on highly reimbursed elective procedures to cross-subsidize essential but poorly reimbursed services, such...
Source: JAMA - July 20, 2021 Category: General Medicine Source Type: research

Heteroresistance to beta-lactam antibiotics may often be  a stage in the progression to antibiotic resistance
by Victor I. Band, David S. Weiss Antibiotic resistance is a growing crisis that threatens many aspects of modern healthcare. Dogma is that resistance often develops due to acquisition of a resistance gene or mutation and that when this occurs, all the cells in the bacterial population are phenotypically resistant. In contrast, he teroresistance (HR) is a form of antibiotic resistance where only a subset of cells within a bacterial population are resistant to a given drug. These resistant cells can rapidly replicate in the presence of the antibiotic and cause treatment failures. If and how HR and resistance are related is...
Source: PLoS Biology: Archived Table of Contents - July 20, 2021 Category: Biology Authors: Victor I. Band Source Type: research

Endoscopic Supply Chain Management and Optimization
Endoscopy is a procedural specialty that incurs significant cost through its high usage of consumables. Thus, supply chain management and optimization in endoscopy can improve value-based care, by identifying areas of cost saving in device procurement. Creating a multidisciplinary supply chain management team, such as multidisciplinary endoscopic device committee (MEDC), suggests a way to optimize supply chain. The essential components of MEDC are physicians, clinical administration, and institutional supply chain. The physicians in the committee identify new products, define the value of products, lead the product acquisi...
Source: Gastrointestinal Endoscopy Clinics of North America - July 20, 2021 Category: Gastroenterology Authors: Ji Seok Park, Sunguk Jang Source Type: research

Salbutamol and salt-sensitive hypertension
Salbutamol activates the NaCl cotransporter of the distal convoluted tubule. Salbutamol, in conjunction with high salt intake, induced hypertension in mice, rescued by thiazide therapy. Phosphoproteomics identified protein phosphatase 1/inhibitor 1 as a distinct regulatory node for NaCl cotransporter activation by salbutamol, which did not activate the transporter in inhibitor 1 knockout mice. Salbutamol is widely used in respiratory medicine, and the acquisition of salt sensitivity may be relevant to understanding cardiovascular risk in certain patients. (Source: Kidney International)
Source: Kidney International - July 19, 2021 Category: Urology & Nephrology Authors: Matthew A. Bailey Tags: Commentary Source Type: research

Beyond McDonald: updated perspectives on the MRI diagnosis for multiple sclerosis
The objective of this article is to analyse, based on publicly available database since the publication of the 2017 McDonald diagnostic criteria, the clinical impact of these criteria, to discuss the potential inclusion within these criteria of the optic nerve to demonstrate dissemination in space, and to guide the acquisition and interpretation of MRI scans for diagnostic purposes. Finally, the authors will review emerging MRI features that could improve the specificity of MRI in the diagnosis of MS and consequently minimize the misdiagnosis of this disease.EXPERT OPINION: Although the optic nerve has not been included as...
Source: Expert Review of Neurotherapeutics - July 19, 2021 Category: Neurology Authors: Àlex Rovira Cristina Auger Source Type: research

Tumorigenic effect of < em > TERT < /em > and its potential therapeutic target in NSCLC (Review)
Oncol Rep. 2021 Aug;46(2):182. doi: 10.3892/or.2021.8133. Epub 2021 Jul 19.ABSTRACTNon‑small cell lung cancer (NSCLC), which accounts for ~85% of all lung cancer cases, is commonly diagnosed at an advanced stage and has a high patient mortality rate. Despite the increasing availability of treatment strategies, the prognosis of patients with NSCLC remains poor, with a low 5‑year survival rate. This poor prognosis may be associated with the tumor heterogeneity of NSCLC, as well as its acquisition and intrinsic resistance to therapeutic drugs. It has been suggested that combination therapy with telomerase inhibition may b...
Source: Oncology Reports - July 19, 2021 Category: Cancer & Oncology Authors: Liu Yang Na Li Meng Wang Yan-Hua Zhang Lu-Da Yan Wen Zhou Zhi-Qiong Yu Xiao-Chun Peng Jun Cai Source Type: research

Beyond McDonald: updated perspectives on the MRI diagnosis for multiple sclerosis
The objective of this article is to analyse, based on publicly available database since the publication of the 2017 McDonald diagnostic criteria, the clinical impact of these criteria, to discuss the potential inclusion within these criteria of the optic nerve to demonstrate dissemination in space, and to guide the acquisition and interpretation of MRI scans for diagnostic purposes. Finally, the authors will review emerging MRI features that could improve the specificity of MRI in the diagnosis of MS and consequently minimize the misdiagnosis of this disease.EXPERT OPINION: Although the optic nerve has not been included as...
Source: Expert Review of Neurotherapeutics - July 19, 2021 Category: Neurology Authors: Àlex Rovira Cristina Auger Source Type: research

Tumorigenic effect of < em > TERT < /em > and its potential therapeutic target in NSCLC (Review)
Oncol Rep. 2021 Aug;46(2):182. doi: 10.3892/or.2021.8133. Epub 2021 Jul 19.ABSTRACTNon‑small cell lung cancer (NSCLC), which accounts for ~85% of all lung cancer cases, is commonly diagnosed at an advanced stage and has a high patient mortality rate. Despite the increasing availability of treatment strategies, the prognosis of patients with NSCLC remains poor, with a low 5‑year survival rate. This poor prognosis may be associated with the tumor heterogeneity of NSCLC, as well as its acquisition and intrinsic resistance to therapeutic drugs. It has been suggested that combination therapy with telomerase inhibition may b...
Source: Oncology Reports - July 19, 2021 Category: Cancer & Oncology Authors: Liu Yang Na Li Meng Wang Yan-Hua Zhang Lu-Da Yan Wen Zhou Zhi-Qiong Yu Xiao-Chun Peng Jun Cai Source Type: research

Beyond McDonald: updated perspectives on the MRI diagnosis for multiple sclerosis
The objective of this article is to analyse, based on publicly available database since the publication of the 2017 McDonald diagnostic criteria, the clinical impact of these criteria, to discuss the potential inclusion within these criteria of the optic nerve to demonstrate dissemination in space, and to guide the acquisition and interpretation of MRI scans for diagnostic purposes. Finally, the authors will review emerging MRI features that could improve the specificity of MRI in the diagnosis of MS and consequently minimize the misdiagnosis of this disease.EXPERT OPINION: Although the optic nerve has not been included as...
Source: Expert Review of Neurotherapeutics - July 19, 2021 Category: Neurology Authors: Àlex Rovira Cristina Auger Source Type: research

Tumorigenic effect of < em > TERT < /em > and its potential therapeutic target in NSCLC (Review)
Oncol Rep. 2021 Aug;46(2):182. doi: 10.3892/or.2021.8133. Epub 2021 Jul 19.ABSTRACTNon‑small cell lung cancer (NSCLC), which accounts for ~85% of all lung cancer cases, is commonly diagnosed at an advanced stage and has a high patient mortality rate. Despite the increasing availability of treatment strategies, the prognosis of patients with NSCLC remains poor, with a low 5‑year survival rate. This poor prognosis may be associated with the tumor heterogeneity of NSCLC, as well as its acquisition and intrinsic resistance to therapeutic drugs. It has been suggested that combination therapy with telomerase inhibition may b...
Source: Oncology Reports - July 19, 2021 Category: Cancer & Oncology Authors: Liu Yang Na Li Meng Wang Yan-Hua Zhang Lu-Da Yan Wen Zhou Zhi-Qiong Yu Xiao-Chun Peng Jun Cai Source Type: research

Beyond McDonald: updated perspectives on the MRI diagnosis for multiple sclerosis
The objective of this article is to analyse, based on publicly available database since the publication of the 2017 McDonald diagnostic criteria, the clinical impact of these criteria, to discuss the potential inclusion within these criteria of the optic nerve to demonstrate dissemination in space, and to guide the acquisition and interpretation of MRI scans for diagnostic purposes. Finally, the authors will review emerging MRI features that could improve the specificity of MRI in the diagnosis of MS and consequently minimize the misdiagnosis of this disease.EXPERT OPINION: Although the optic nerve has not been included as...
Source: Expert Review of Neurotherapeutics - July 19, 2021 Category: Neurology Authors: Àlex Rovira Cristina Auger Source Type: research

Beyond McDonald: updated perspectives on MRI diagnosis of multiple sclerosis
The objective of this article is to analyze, based on publicly available database since the publication of the 2017 McDonald diagnostic criteria, the clinical impact of these criteria, to discuss the potential inclusion within these criteria of the optic nerve to demonstrate dissemination in space, and to guide the acquisition and interpretation of MRI scans for diagnostic purposes. Finally, the authors will review emerging MRI features that could improve the specificity of MRI in the diagnosis of MS and consequently minimize the misdiagnosis of this disease.EXPERT OPINION: Although the optic nerve has not been included as...
Source: Expert Review of Neurotherapeutics - July 19, 2021 Category: Neurology Authors: Àlex Rovira Cristina Auger Source Type: research