Brief Report: HIV Testing and Risk Among Justice-Involved Youth
AbstractJustice-involved youth have a number of risk factors for HIV infection, including high rates of substance use, psychiatric comorbidities, and risky sexual behaviors. Although detained youth are likely to receive health care —which may include HIV testing—court-involved, non-incarcerated (CINI) youth may be unlikely to receive HIV testing services either before or during their justice involvement. However, the relationship between risk factors and HIV testing among CINI youth is largely unknown. We explored the asso ciation between HIV testing and factors commonly associated with both HIV testing and HIV...
Source: AIDS and Behavior - April 16, 2021 Category: Infectious Diseases Source Type: research

Cancers, Vol. 13, Pages 1939: Age- and Intravenous Methotrexate-Associated Leukoencephalopathy and Its Neurological Impact in Pediatric Patients with Lymphoblastic Leukemia
This study suggests leukoencephalopathy frequently occurs in both symptomatic and asymptomatic leukemia patients. Younger children and patients treated with higher cumulative IV-MTX doses might need more regular screening for early detection and follow-up of associated sequelae. (Source: Cancers)
Source: Cancers - April 16, 2021 Category: Cancer & Oncology Authors: Ilona Rijmenams Daan Moechars Anne Uyttebroeck Ahmed Radwan Jeroen Blommaert Sabine Deprez Stefan Sunaert Heidi Segers C éline R. Gillebert Jurgen Lemiere Charlotte Sleurs Tags: Article Source Type: research

Cancers, Vol. 13, Pages 1928: Assessment of Resistance Mechanisms and Clinical Implications in Patients with KRAS Mutated-Metastatic Breast Cancer and Resistance to CDK4/6 Inhibitors
This study was conducted in order to understand the molecular mechanisms of resistance to palbociclib, and to identify biomarkers to predict who will take advantage from cyclin-dependent kinase 4/6 inhibitors (CDK4/6i). A total of about a thousand blood samples were collected from 106 patients with hormone receptor positive (HR+) human epidermal growth factor receptor 2 (HER2) negative metastatic breast cancer who received palbociclib in combination with fulvestrant as the first-line metastatic therapy enrolled in this study. The genotyping of their plasma cell-free DNA was studied, including serial plasma samples. Collect...
Source: Cancers - April 16, 2021 Category: Cancer & Oncology Authors: Lucrezia Raimondi Filippo Maria Raimondi Marta Pietranera Arianna Di Rocco Laura Di Benedetto Evelina Miele Rachele Lazzeroni Giuseppe Cimino Gian Paolo Spinelli Tags: Article Source Type: research

Smoking and Risk of COVID-19 Hospitalization
All authors have contributed to the current manuscript in the following manner: Substantial contribution to the conception, design, data acquisition, analysis and interpretation of the manuscript. Drafted and/or revised the manuscript for important intellectual content. Approved the final version to be submitted for publication. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 16, 2021 Category: Respiratory Medicine Authors: Daniel Puebla Neira, Abigail Watts, Justin Seashore, Efstathia Polychronopoulou, Yong-Fang Kuo, Gulshan Sharma Source Type: research

Sensors, Vol. 21, Pages 2779: A Raspberry Pi-Based Traumatic Brain Injury Detection System for Single-Channel Electroencephalogram
o Dong Si Traumatic Brain Injury (TBI) is a common cause of death and disability. However, existing tools for TBI diagnosis are either subjective or require extensive clinical setup and expertise. The increasing affordability and reduction in the size of relatively high-performance computing systems combined with promising results from TBI related machine learning research make it possible to create compact and portable systems for early detection of TBI. This work describes a Raspberry Pi based portable, real-time data acquisition, and automated processing system that uses machine learning to efficiently identify TB...
Source: Sensors - April 15, 2021 Category: Biotechnology Authors: Navjodh Singh Dhillon Agustinus Sutandi Manoj Vishwanath Miranda M. Lim Hung Cao Dong Si Tags: Article Source Type: research

Molecules, Vol. 26, Pages 2298: NMR-Based Metabolomic Analyses to Identify the Effect of Harvesting Frequencies on the Leaf Metabolite Profile of a Moringa oleifera Cultivar Grown in an Open Hydroponic System
nsloo Moringa oleifera Lam. is one of the world’s most useful medicinal plants. Different parts of the M. oleifera tree contain a rich profile of important minerals, proteins, vitamins, and various important bioactive compounds. However, there are differences in the phytochemical composition of the medicinal plant’s raw materials due to seasonal variation, cultivation practices, and post-harvest processing. The main objective of this study was therefore to determine the effect of harvesting frequencies on selected bioactive compounds of a M. oleifera cultivar (PKM1) grown in a hydroponic system under a shad...
Source: Molecules - April 15, 2021 Category: Chemistry Authors: Lavhelesani R. Managa Elsa S. du Toit Gerhard Prinsloo Tags: Article Source Type: research

Omics in Seminal Plasma: An Effective Strategy for Predicting Sperm Retrieval Outcome in Non-obstructive Azoospermia
AbstractNon-obstructive azoospermia (NOA) is a severe form of male factor infertility resulting from the impairment of sperm production. Surgical sperm retrieval followed by intracytoplasmic sperm injection (ICSI) is the only alternative for NOA patients to have their own genetic children. Nevertheless, due to an approximately 50% chance of success, harvesting sperm from these patients remains challenging. Thus, discovering noninvasive biomarkers, which are able to reliably predict the probability of sperm acquisition, not only can eliminate the risk of surgery but also can lower the costs of NOA diagnosis and treatment. S...
Source: Molecular Diagnosis and Therapy - April 15, 2021 Category: Molecular Biology Source Type: research

Sensors, Vol. 21, Pages 2762: Sensors Data Analysis in Supervisory Control and Data Acquisition (SCADA) Systems to Foresee Failures with an Undetermined Origin
Izaskun Garrido This paper presents the design and implementation of a supervisory control and data acquisition (SCADA) system for automatic fault detection. The proposed system offers advantages in three areas: the prognostic capacity for preventive and predictive maintenance, improvement in the quality of the machined product and a reduction in breakdown times. The complementary technologies, the Industrial Internet of Things (IIoT) and various machine learning (ML) techniques, are employed with SCADA systems to obtain the objectives. The analysis of different data sources and the replacement of specific digital sen...
Source: Sensors - April 14, 2021 Category: Biotechnology Authors: F. Javier Maseda Iker L ópez Itziar Martija Patxi Alkorta Aitor J. Garrido Izaskun Garrido Tags: Article Source Type: research

Evolution of pathogen-specific improved survivorship post-infection in populations of < i > Drosophila melanogaster < /i > adapted to larval crowding
In this study, we report the co-related evolution of pathogen-specific increased survivorship post-infection in populations ofDrosophila melanogaster as a result of adaptation to larval crowding environment. (Source: PLoS One)
Source: PLoS One - April 14, 2021 Category: Biomedical Science Authors: Rohit Kapila Source Type: research

[ASAP] Comprehensive Analysis of DNA Adducts Using Data-Independent wSIM/MS < sup > 2 < /sup > Acquisition and wSIM-City
Analytical ChemistryDOI: 10.1021/acs.analchem.1c00362 (Source: Analytical Chemistry)
Source: Analytical Chemistry - April 12, 2021 Category: Chemistry Authors: Scott J. Walmsley, Jingshu Guo, Paari Murugan, Christopher J. Weight, Jinhua Wang, Peter W. Villalta, and Robert J. Turesky Source Type: research

Molecular tracking devices quantify antigen distribution and archiving in the murine lymph node
The detection of foreign antigensin vivo has relied on fluorescent conjugation or indirect read-outs such as antigen presentation. In our studies, we found that these widely used techniques had several technical limitations that have precluded a complete picture of antigen trafficking or retention across lymph node cell types. To address these limitations, we developed a 'molecular tracking device' to follow the distribution, acquisition, and retention of antigen in the lymph node. Utilizing an antigen conjugated to a nuclease-resistant DNA tag, acting as a combined antigen-adjuvant conjugate, and single-cell mRNA sequenci...
Source: eLife - April 12, 2021 Category: Biomedical Science Tags: Cell Biology Immunology and Inflammation Source Type: research

Sensors, Vol. 21, Pages 2685: TTAS: Trusted Token Authentication Service of Securing SCADA Network in Energy Management System for Industrial Internet of Things
ing-Wei Hou The vigorous development of the Industrial Internet of Things brings the advanced connection function of the new generation of industrial automation and control systems. The Supervisory Control and Data Acquisition (SCADA) network is converted into an open and highly interconnected network, where the equipment connections between industrial electronic devices are integrated with a SCADA system through a Modbus protocol. As SCADA and Modbus are easily used for control and monitoring, the interconnection and operational efficiency between systems are highly improved; however, such connectivity inevitably expo...
Source: Sensors - April 11, 2021 Category: Biotechnology Authors: Yu-Sheng Yang Shih-Hsiung Lee Wei-Che Chen Chu-Sing Yang Yuen-Min Huang Ting-Wei Hou Tags: Article Source Type: research

Atypical mycobacterial infections – management and when to treat
Purpose of review Infections caused by nontuberculous mycobacteria (NTM) are increasing for several reasons, including diagnostic advances, increased awareness and a larger at-risk population. NTM pulmonary disease is surpassing tuberculosis (TB) in some low incidence areas. This review summarizes the latest literature and guidelines and aims to be a concise source outlining treatment and management of NTM lung infections, integrating established treatment paradigms with novel pharmacological interventions. Recent findings Recent additions to NTM treatment are inhaled liposomal amikacin and the anti-TB drug beda...
Source: Current Opinion in Pulmonary Medicine - April 10, 2021 Category: Respiratory Medicine Tags: INFECTIOUS DISEASES: Edited by Michael S. Niederman and Alimuddin Zumla Source Type: research

Sensors, Vol. 21, Pages 2679: Real-Time and Efficient Traffic Information Acquisition via Pavement Vibration IoT Monitoring System
Linbing Wang Traditional road-embedded monitoring systems for traffic monitoring have the disadvantages of a short life, high energy consumption and data redundancy, resulting in insufficient durability and high cost. In order to improve the durability and efficiency of the road-embedded monitoring system, a pavement vibration monitoring system is developed based on the Internet of things (IoT). The system includes multi-acceleration sensing nodes, a gateway, and a cloud platform. The key design principles and technologies of each part of the system are proposed, which provides valuable experience for the application ...
Source: Sensors - April 10, 2021 Category: Biotechnology Authors: Zhoujing Ye Guannan Yan Ya Wei Bin Zhou Ning Li Shihui Shen Linbing Wang Tags: Article Source Type: research

China's State Council approves ChemChina-Sinochem merger
(Source: Chemical and Engineering News)
Source: Chemical and Engineering News - April 9, 2021 Category: Chemistry Source Type: research

Imaging Motion: A Comprehensive Review of Optical Coherence Tomography Angiography
Adv Exp Med Biol. 2021;1310:343-365. doi: 10.1007/978-981-33-6064-8_12.ABSTRACTOptical coherence tomography (OCT) is a three-dimensional (3-D) optical imaging technology that provides noninvasive, micrometer resolution images of structural interiors within biological samples with an approximately 1 ~ 2 mm penetration depth. Over the last decades, advances in OCT have revolutionized biomedical imaging by demonstrating a potential of optical biopsy in preclinical and clinical settings. Recently, functional OCT imaging has shown a promise as angiography to visualize cell-perfused vasculatures in the tissue bed in vivo without...
Source: Advances in Experimental Medicine and Biology - April 9, 2021 Category: Research Authors: Woo June Choi Source Type: research

Small bowel radiology
Purpose of review Recent advances in computed tomography (CT), ultrasound (US), magnetic resonance imaging (MRI), and nuclear radiology have improved the diagnosis and characterization of small bowel pathology. Our purpose is to highlight the current status and recent advances in multimodality noninvasive imaging of the small bowel. Recent findings CT and MR enterography are established techniques for small bowel evaluation. Dual-energy CT is a novel technique that has shown promise for the mesenteric ischemia and small bowel bleeding. Advanced US techniques and MRI sequences are being investigated to improve as...
Source: Current Opinion in Gastroenterology - April 9, 2021 Category: Gastroenterology Tags: SMALL INTESTINE: Edited by Reena Sidhu Source Type: research

Cancers, Vol. 13, Pages 1792: Multifunctional Role of Astrocyte Elevated Gene-1 (AEG-1) in Cancer: Focus on Drug Resistance
kar Cancer development results from the acquisition of numerous genetic and epigenetic alterations in cancer cells themselves, as well as continuous changes in their microenvironment. The plasticity of cancer cells allows them to continuously adapt to selective pressures brought forth by exogenous environmental stresses, the internal milieu of the tumor and cancer treatment itself. Resistance to treatment, either inherent or acquired after the commencement of treatment, is a major obstacle an oncologist confronts in an endeavor to efficiently manage the disease. Resistance to chemotherapy, chemoresistance, is an import...
Source: Cancers - April 9, 2021 Category: Cancer & Oncology Authors: Debashri Manna Devanand Sarkar Tags: Review Source Type: research

Disrupting Reconsolidation by Systemic Inhibition of mTOR Kinase via Rapamycin Reduces Cocaine-Seeking Behavior
Drug addiction is considered maladaptive learning, and drug-related memories aroused by the presence of drug related stimuli (drug context or drug-associated cues) promote recurring craving and reinstatement of drug seeking. The mammalian target of rapamycin signaling pathway is involved in reconsolidation of drug memories in conditioned place preference and alcohol self-administration (SA) paradigms. Here, we explored the effect of mTOR inhibition on reconsolidation of addiction memory using cocaine self-administration paradigm. Rats received intravenous cocaine self-administration training for 10 consecutive days, during...
Source: Frontiers in Pharmacology - April 9, 2021 Category: Drugs & Pharmacology Source Type: research

Sensors, Vol. 21, Pages 2656: An Open Source Low-Cost Device Coupled with an Adaptative Time-Lag Time-Series Linear Forecasting Modeling for Apple Trentino (Italy) Precision Irrigation
This study described the development of an open source soil moisture LoRa (long-range) device and analysis of the data collected and updated directly in the field (i.e., weather station and ground sensor). The work produced adaptive supervised predictive models to optimize the management of agricultural precision irrigation practices and for an effective calibration of other agronomic interventions. These approaches are defined as adaptive because they self-learn with the acquisition of new data, updating the on-the-go model over time. The location chosen for the experimental setup is a cultivated area in the municipality ...
Source: Sensors - April 9, 2021 Category: Biotechnology Authors: Figorilli Pallottino Colle Spada Beni Tocci Vasta Antonucci Pagano Fedrizzi Costa Tags: Article Source Type: research

18F-FDG PET/CT Detection of a Popliteal Mycotic Aneurysm Complicating Staphylococcus aureus Bacteremia
A 75-year-old man presented with Staphylococcus aureus bacteremia, fever, and right posterior knee pain. Venous Doppler ultrasound of the lower extremity showed an isolated right calf muscle vein thrombosis, without any sign of deep vein thrombosis. 18F-FDG PET/CT revealed an intense focal uptake on the right popliteal artery, suggesting a mycotic aneurysm (MA). Lower limb CT angiography confirmed an MA of the right popliteal artery. The patient underwent surgical procedure with excision of the MA, whose cultures grew methicillin-sensitive S. aureus. Our case highlights the importance of including lower limbs in 18F-FDG PE...
Source: Clinical Nuclear Medicine - April 7, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Viruses, Vol. 13, Pages 634: Full-Genome Sequences and Phylogenetic Analysis of Archived Danish European Bat Lyssavirus 1 (EBLV-1) Emphasize a Higher Genetic Resolution and Spatial Segregation for Sublineage 1a
In this study, a set of 21 archived Danish EBLV-1 samples from the years 1985 to 2009 was processed for the acquisition of full-genome sequences using a high-throughput sequencing approach. Subsequent phylogenetic analysis encompassing all available EBLV-1 full genomes from databases revealed the Danish sequences belong to the EBLV-1a subtype and further highlighted the distinct, close phylogenetic relationship of Danish, Dutch and German isolates in this region. In addition, the formation of five putative groups nearly exclusively formed by Danish isolates and the overall increased resolution of the EBLV-1a branch indicat...
Source: Viruses - April 7, 2021 Category: Virology Authors: Sten Calvelage Conrad M. Freuling Anthony R. Fooks Dirk H öper Denise A. Marston Lorraine McElhinney Thomas Bruun Rasmussen Stefan Finke Martin Beer Thomas M üller Tags: Communication Source Type: research

< i > Aedes aegypti dyspepsia < /i > encodes a novel member of the SLC16 family of transporters and is critical for reproductive fitness
In this study, we performed an RNAseq-based screen in anAe.aegypti cell line cultured under iron-deficient and iron-excess conditions. A subset of differentially expressed genes were analyzed via a cytosolic iron-sensitive dual-luciferase reporter assay with several gene candidates potentially involved in iron transport.In vivo gene silencing resulted in significant reduction of fecundity (egg number) and fertility (hatch rate) for one gene, termeddyspepsia. Silencing ofdyspepsia reduced the induction of ferritin expression in the midgut and also resulted in delayed/impaired excretion and digestion. Further characterizatio...
Source: PLoS Neglected Tropical Diseases - April 7, 2021 Category: Tropical Medicine Authors: Hitoshi Tsujimoto Source Type: research

Cancers, Vol. 13, Pages 1742: Roles of microRNAs in Regulating Cancer Stemness in Head and Neck Cancers
Tsen Liao Head and neck squamous cell carcinomas (HNSCCs) are epithelial malignancies with 5-year overall survival rates of approximately 40–50%. Emerging evidence indicates that a small population of cells in HNSCC patients, named cancer stem cells (CSCs), play vital roles in the processes of tumor initiation, progression, metastasis, immune evasion, chemo-/radioresistance, and recurrence. The acquisition of stem-like properties of cancer cells further provides cellular plasticity for stress adaptation and contributes to therapeutic resistance, resulting in a worse clinical outcome. Thus, targeting cancer stemne...
Source: Cancers - April 6, 2021 Category: Cancer & Oncology Authors: Melysa Fitriana Wei-Lun Hwang Chan Tai-Yuan Hsueh Tsai-Tsen Liao Tags: Review Source Type: research

The role of activity, scan duration and patient ’s body mass index in the optimization of FDG imaging protocols on a TOF-PET/CT scanner
Time-of-flight (TOF) PET technology determines a reduction in the noise and improves the reconstructed image quality in low count acquisitions, such as in overweight patients, allowing a reduction of administe... (Source: EJNMMI Physics)
Source: EJNMMI Physics - April 6, 2021 Category: Radiology Authors: Roberta Matheoud, Naema Al-Maymani, Alessia Oldani, Gian Mauro Sacchetti, Marco Brambilla and Alessandro Carriero Tags: Original research Source Type: research

Assessment of operator performance during oocyte retrievals: residents ’ learning curve and continuous monitoring of senior physicians
The learning curve cumulative summation test (LC CUSUM test) allows to define an individualized learning curve and determine the moment when clinical proficiency is attained. After acquisition of the skills, t... (Source: BMC Medical Education)
Source: BMC Medical Education - April 6, 2021 Category: Universities & Medical Training Authors: C. Verhaeghe, H. El Hachem, L. Inchboard, R. Corroenne, C. Dreux, P. Jeanneteau, G. Legendre, P. Descamps, P. Saulnier, P. May-Panloup and P. E. Bouet Tags: Research article Source Type: research

Psychotherapy Aimed at Social Engagement Reduces Depression Associated With Loneliness
A form of psychotherapy aimed at helping older adults feel more connected to other people reduced depression and improved quality of life for those who had reported they felt lonely and/or were a burden to people around them, according to astudy in theJournal of Geriatric Psychiatry.“Social connection is essential for health and quality of life at all ages and may be an especially useful intervention target for promoting mental health in later life,” wrote Kimberly Van Orden, Ph.D., an associate professor of psychiatry at the University of Rochester, and colleagues.The researchers adapted a manualized form of b...
Source: Psychiatr News - April 5, 2021 Category: Psychiatry Source Type: research

Calcinosis in systemic sclerosis
Publication date: Available online 31 March 2021Source: Joint Bone SpineAuthor(s): Mohammad Ryadh Pokeerbux, Meryem Maud Farhat, Marguerite Merger, David Launay, Eric Hachulla (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 2, 2021 Category: Orthopaedics Source Type: research

The Linguistically Informed Virtue-Novice as Precocious: a Reply to Stichter ’s The Skillfulness of Virtue
AbstractStichter ’sThe Skillfulness of Virtue provides an original and contemporary discussion of virtue-acquisition from an interdisciplinary standpoint. By equating virtues to skills, he offers an empirically informed progression towards virtue expertise. With the focus on gaining proficiency, there is little room to analyse the status of the virtue-novice, who is equated to a novice in any other skill: an agent consciously following simple rules, gaining experience in order to respond to normatively-laden situations with more automaticity in the following stages of skill-acquisition. This paper argues for a disana...
Source: Ethical Theory and Moral Practice - April 2, 2021 Category: Medical Ethics Source Type: research

Cancers, Vol. 13, Pages 1686: Emerging Therapeutic Strategies to Overcome Drug Resistance in Multiple Myeloma
nou Multiple myeloma is a malignant plasma cell neoplasm that remains incurable and is ultimately fatal when patients acquire multi-drug resistance. Thus, advancing our understanding of the mechanisms behind drug resistance in multi-relapsed patients is critical for developing better strategies to extend their lifespan. Here, we review the understanding of resistance to the three key drug classes approved for multiple myeloma treatment: immunomodulatory drugs, proteasome inhibitors, and monoclonal antibodies. We consider how the complex, heterogenous biology of multiple myeloma may influence the acquisition of drug res...
Source: Cancers - April 2, 2021 Category: Cancer & Oncology Authors: Lorraine N. Davis Daniel W. Sherbenou Tags: Review Source Type: research

Primary Care Providers ’ Perspectives on Using Automated HIV Risk Prediction Models to Identify Potential Candidates for Pre-exposure Prophylaxis
AbstractIdentifying patients at increased risk for HIV acquisition can be challenging. Primary care providers (PCPs) may benefit from tools that help them identify appropriate candidates for HIV pre-exposure prophylaxis (PrEP). We and others have previously developed and validated HIV risk prediction models to identify PrEP candidates using electronic health records data. In the current study, we convened focus groups with PCPs to elicit their perspectives on using prediction models to identify PrEP candidates in clinical practice. PCPs were receptive to using prediction models to identify PrEP candidates. PCPs believed th...
Source: AIDS and Behavior - April 2, 2021 Category: Infectious Diseases Source Type: research

GSE160498 Ae. aegypti dyspepsia (AAEL000471) is involved in mosquito iron homeostasis and is critical for reproductive fitness
In this study, we performed an RNAseq-based screen in an Ae. aegypti cell line cultured under iron-deficient and iron-excess conditions. A subset of differentially expressed genes were analyzed via a cytosolic iron-sensitive dual-luciferase reporter assay with several gene candidates potentially involved in iron transport. In vivo gene silencing resulted in significant reduction of fecundity (egg number) and fertility (hatch rate) for one gene, AAEL000471. Consistent with a role in iron homeostasis, ferritin expression in the midgut was reduced upon silencing of AAEL000471. Silencing of AAEL000471 also resulted in delayed/...
Source: GEO: Gene Expression Omnibus - April 1, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Aedes aegypti Source Type: research

Compressed ultrafast tomographic imaging by passive spatiotemporal projections
Existing streak-camera-based two-dimensional (2D) ultrafast imaging techniques are limited by long acquisition time, the trade-off between ... (Source: Optics Letters)
Source: Optics Letters - April 1, 2021 Category: Physics Authors: Yingming Lai Ruibo Shang Christian-Yves C ô t é Xianglei Liu Antoine Laram é e Fran ç ois L é gar é Geoffrey P. Luke Jinyang Liang Source Type: research

New Insights Into Biomphalysin Gene Family Diversification in the Vector Snail Biomphalaria glabrata
Aerolysins initially characterized as virulence factors in bacteria are increasingly found in massive genome and transcriptome sequencing data from metazoans. Horizontal gene transfer has been demonstrated as the main way of aerolysin-related toxins acquisition in metazoans. However, only few studies have focused on their potential biological functions in such organisms. Herein, we present an extensive characterization of a multigene family encoding aerolysins - named biomphalysin - in Biomphalaria glabrata snail, the intermediate host of the trematode Schistosoma mansoni. Our results highlight that duplication and domesti...
Source: Frontiers in Immunology - April 1, 2021 Category: Allergy & Immunology Source Type: research

Viruses, Vol. 13, Pages 601: Phylogenetic Clustering among Asylum Seekers with New HIV-1 Diagnoses in Montreal, QC, Canada
er Nadine Kronfli Migrants are at an increased risk of HIV acquisition. We aimed to use phylogenetics to characterize transmission clusters among newly-diagnosed asylum seekers and to understand the role of networks in local HIV transmission. Retrospective chart reviews of asylum seekers linked to HIV care between 1 June 2017 and 31 December 2018 at the McGill University Health Centre and the Jewish General Hospital in Montreal were performed. HIV-1 partial pol sequences were analyzed among study participants and individuals in the provincial genotyping database. Trees were reconstructed using MEGA10 neighbor-joining...
Source: Viruses - April 1, 2021 Category: Virology Authors: Hyejin Park Bluma Brenner Ruxandra-Ilinca Ibanescu Joseph Cox Karl Weiss Marina B. Klein Isabelle Hardy Lavanya Narasiah Michel Roger Nadine Kronfli Tags: Article Source Type: research

Cancers, Vol. 13, Pages 1662: Myc-Related Mitochondrial Activity as a Novel Target for Multiple Myeloma
z Miguel Ángel Navarro-Aguadero María Velasco-Estevez Eva Lospitao María Teresa Cedena Santiago Barrio Joaquín Martínez-López María Linares Miguel Gallardo Mitochondria are involved in the development and acquisition of a malignant phenotype in hematological cancers. Recently, their role in the pathogenesis of multiple myeloma (MM) has been suggested to be therapeutically explored. MYC is a master regulator of b-cell malignancies such as multiple myeloma, and its activation is known to deregulate mitochondrial function. We investigated the impact of mitoc...
Source: Cancers - April 1, 2021 Category: Cancer & Oncology Authors: Alejandra Ortiz-Ruiz Yanira Ruiz-Heredia Mar ía Luz Morales Pedro Aguilar-Garrido Almudena Garc ía-Ortiz Antonio Valeri Carmen B árcena Rosa Mar ía García-Martin Vanesa Garrido Laura Moreno Alicia Gimenez Miguel Ángel Navarro-Aguadero Mar ía Velasc Tags: Article Source Type: research

Whole Brain Myelin Water Mapping in One Minute Using Tensor Dictionary Learning With Low-Rank Plus Sparse Regularization
The quantification of myelin water content in the brain can be obtained by the multi-echo $text{T}2^ast $ weighted images ( $text{T}2^ast $ WIs). To accelerate the long acquisition, a novel tensor dictionary learning algorithm with low-rank and sparse regularization (TDLLS) is proposed to reconstruct the $text{T}2^ast $ WIs from the undersampled data. The proposed algorithm explores the local and nonlocal similarity and the global temporal redundancy in the real and imaginary parts of the complex relaxation signals. The joint application of the low-rank constraints on the dictionaries and the sparse constraints on the core...
Source: IEE Transactions on Medical Imaging - April 1, 2021 Category: Biomedical Engineering Source Type: research

Effect of quantitative values on shortened acquisition duration in brain tumor 11C-methionine PET/CT
This study aims to clarify the effect of acquisition time shortenin... (Source: EJNMMI Physics)
Source: EJNMMI Physics - March 31, 2021 Category: Radiology Authors: Masatoshi Morimoto, Nobuyuki Kudomi, Yukito Maeda, Takuya Kobata, Akihiro Oishi, Keisuke Matsumoto, Toshihide Monden, Takanobu Iwasaki, Katsuya Mitamura, Takashi Norikane, Yuka Yamamoto and Yoshihiro Nishiyama Tags: Original research Source Type: research

Creating clear and informative image-based figures for scientific publications
We present detailed descriptions and visual examples to help scientists avoid common pitfalls when publishing images. Our recommendations address image magnification, scale information, insets, annotation, and color and may encourage discussion about quality standards for bioimage publishing. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - March 31, 2021 Category: Biology Authors: Helena Jambor Source Type: research

Evidence for human diabetic cardiomyopathy
AbstractGrowing interest has been accumulated in the definition of worsening effects of diabetes in the cardiovascular system. This is associated with epidemiological data regarding the high incidence of heart failure (HF) in diabetic patients. To investigate the detrimental effects both of hyperglycemia and insulin resistance, a lot of preclinical models were developed. However, the evidence of pathogenic and histological alterations of the so-called diabetic cardiomyopathy (DCM) is still poorly understood in humans. Here, we provide a stringent literature analysis to investigate unique data regarding human DCM. This appr...
Source: Acta Diabetologica - March 31, 2021 Category: Endocrinology Source Type: research

[ASAP] Rapid Development of Improved Data-Dependent Acquisition Strategies
Analytical ChemistryDOI: 10.1021/acs.analchem.0c03895 (Source: Analytical Chemistry)
Source: Analytical Chemistry - March 30, 2021 Category: Chemistry Authors: Vinny Davies, Joe Wandy, Stefan Weidt, Justin J. J. van der Hooft, Alice Miller, Ro ́nán Daly, and Simon Rogers Source Type: research

Reproducing GW150914: The First Observation of Gravitational Waves From a Binary Black Hole Merger
In 2016, LIGO and Virgo announced the first observation of gravitational waves from a binary black hole merger, known as GW150914. To establish the confidence of this detection, large-scale scientific workflows were used to measure the event’s statistical significance. They used code written by the LIGO/Virgo and were executed on the LIGO Data Grid. The codes are publicly available, but there has not yet been an attempt to directly reproduce the results, although several analyses have replicated the analysis, confirming the detection. We attempt to reproduce the result presented in the GW150914 discovery paper using ...
Source: Computing in Science and Engineering - March 30, 2021 Category: Information Technology Source Type: research

Concurrent and longitudinal predictors of beginning writing in Chinese: the unique role of copying skills
This study highlights the importance of copying for Chinese dictation/spelling acquisition. (Source: Reading and Writing)
Source: Reading and Writing - March 30, 2021 Category: Child Development Source Type: research

Current Challenges for Education and Training in Transanal Surgery
Clin Colon Rectal Surg 2021; 34: 151-154 DOI: 10.1055/s-0040-1718684Transanal endoscopic microsurgery (TEM) is a technique that was introduced in the 1980s for improved exposure to upper rectal polyps. This technique, though initially difficult to master due to new skill acquisition for surgeons, has spared many patients proctectomy. There are many benign indications for transanal endoscopic surgery which has led to in vivo operating room training with fewer undesirable effects to the patient. With the explosion of laparoscopic technology this transanal technique is no longer limited to intraluminal pathology, but is now b...
Source: Clinics in Colon and Rectal Surgery - March 29, 2021 Category: Surgery Authors: Costedio, Meagan Tags: Review Article Source Type: research

Distant activation of Notch signaling induces stem cell niche assembly
by Andriy S. Yatsenko, Halyna R. Shcherbata Here we show that multiple modes of Notch signaling activation specify the complexity of spatial cellular interactions necessary for stem cell niche assembly. In particular, we studied the formation of the germline stem cell niche inDrosophila ovaries, which is a two-step process whereby terminal filaments are formed first. Then, terminal filaments signal to the adjacent cap cell precursors, resulting in Notch signaling activation, which is necessary for the lifelong acquisition of stem cell niche cell fate. The genetic data suggest that in order to initiate the process of stem ...
Source: PLoS Genetics - March 29, 2021 Category: Genetics & Stem Cells Authors: Andriy S. Yatsenko Source Type: research

Population structure and uropathogenic potential of extended-spectrum cephalosporin-resistant Escherichia coli from retail chicken meat
Food-producing animals and their products are considered a source for human acquisition of antimicrobial resistant (AMR) bacteria, and poultry are suggested to be a reservoir for Escherichia coli resistant to ext... (Source: BMC Microbiology)
Source: BMC Microbiology - March 29, 2021 Category: Microbiology Authors: May Linn Buberg, Solveig S ølverød Mo, Camilla Sekse, Marianne Sunde, Yngvild Wasteson and Ingun Lund Witsø Tags: Research article Source Type: research

Single-Scan Measurements of Nuclear Spin Singlet Order Decay Rates
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Giulia Melchiorre, Ciara Nelder, Lynda Jane Brown, Jean-Nicolas Dumez, Giuseppe Pileio Measurement of singlet spin order decay rates are time consuming due to the long-lived nature of this form of order and the typical pseudo-2D mode of acquisition. Additionally, this acquisition... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - March 27, 2021 Category: Chemistry Authors: Giulia Melchiorre Source Type: research