Sensors, Vol. 21, Pages 563: The Spectral X-ray Imaging Data Acquisition (SpeXIDAQ) Framework
. Boone Photon counting X-ray imagers have found their way into the mainstream scientific community in recent years, and have become important components in many scientific setups. These camera systems are in active development, with output data rates increasing significantly with every new generation of devices. A different class of PCD (Photon Counting Detector) devices has become generally available, where camera data output is no longer a matrix of photon counts but instead direct measurements of the deposited charge per pixel in every frame, which requires significant off-camera processing. This type of PCD, calle...
Source: Sensors - January 14, 2021 Category: Biotechnology Authors: Frederic Van Assche Sander Vanheule Luc Van Hoorebeke Matthieu N. Boone Tags: Article Source Type: research
Hadamard-transform spectral acquisition with an acousto-optic tunable filter in a broadband stimulated Raman scattering microscope
We present a novel configuration for high spectral resolution multiplexing acquisition based on the Hadamard transform in stimulated Raman ... (Source: Optics Express)
Source: Optics Express - January 13, 2021 Category: Physics Authors: Luca Genchi Andrea Bucci Sergey P. Laptenok Alessandro Giammona Carlo Liberale Source Type: research
Acquisition of Additional Nuclear Factor Kappa B Binding Sites in Long Terminal Repeat of Genetically Evolving HIV-1 Subtype C Viral Species in Host with Comorbidities
AIDS Research and Human Retroviruses, Ahead of Print. (Source: AIDS Research and Human Retroviruses)
Source: AIDS Research and Human Retroviruses - January 13, 2021 Category: Infectious Diseases Authors: Gurleen Aman Sharma Sunil K. Arora Source Type: research
Sensors, Vol. 21, Pages 513: Registering Unmanned Aerial Vehicle Videos in the Long Term
Tougne Unmanned aerial vehicles (UAVs) have become a very popular way of acquiring video within contexts such as remote data acquisition or surveillance. Unfortunately, their viewpoint is often unstable, which tends to impact the automatic processing of their video flux negatively. To counteract the effects of an inconsistent viewpoint, two video processing strategies are classically adopted, namely registration and stabilization, which tend to be affected by distinct issues, namely jitter and drifting. Following our prior work, we suggest that the motion estimators used in both situations can be modeled to take into ...
Source: Sensors - January 13, 2021 Category: Biotechnology Authors: Pierre Lemaire Carlos Fernando Crispim-Junior Lionel Robinault Laure Tougne Tags: Article Source Type: research
Infants ’ learning of non‐adjacent regularities from visual sequences
AbstractTracking adjacent (AD) and non ‐adjacent (NAD) dependencies in a sequence of elements is critical for the development of many complex abilities, such as language acquisition and social interaction. While learning of AD in infancy is a domain‐general ability that is functioning across different domains, infants’ processing o f NAD has been reported only for speech sequences. Here, we tested 9‐ to 12‐ and 13‐ to 15‐month‐olds’ ability to extract AxB grammars in visual sequences of unfamiliar elements. Infants were habituated to a series of 3‐visual arrays following an AxB grammar in which ...
Source: Infancy - January 13, 2021 Category: Child Development Authors: Roberta Bettoni, Hermann Bulf, Shannon Brady, Scott P. Johnson Tags: BRIEF REPORT Source Type: research
Daily briefing: Pulsars hint at sea of gravitational waves
Nature, Published online: 13 January 2021; doi:10.1038/d41586-021-00084-1Signs of ripples from supermassive black hole mergers in galaxies across the universe. Plus, the secret forces that squeeze and pull life into shape, and the questions around COVID vaccines and transmission. (Source: Nature AOP)
Source: Nature AOP - January 13, 2021 Category: Research Authors: Flora Graham Source Type: research
ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants
AbstractThe recent WHO classification of skin tumors has underscored the importance of acknowledging intermediate grade melanocytic proliferations. A multistep acquisition of oncogenic events drives the progressive transformation of nevi into melanomas. The various pathways described are modulated by the initial oncogenic drivers that define the common, blue, and Spitz nevi groups. Intermediate lesions are most often the result of a clonal evolution within such nevi. Based on this established classification, we have suggested for each pathway a practical diagnostic approach, benefiting from the recently developed molecular...
Source: Virchows Archiv - January 12, 2021 Category: Pathology Source Type: research
Sensors, Vol. 21, Pages 484: CIoTVID: Towards an Open IoT-Platform for Infective Pandemic Diseases such as COVID-19
nio F. Skarmeta The factors affecting the penetration of certain diseases such as COVID-19 in society are still unknown. Internet of Things (IoT) technologies can play a crucial role during the time of crisis and they can provide a more holistic view of the reasons that govern the outbreak of a contagious disease. The understanding of COVID-19 will be enriched by the analysis of data related to the phenomena, and this data can be collected using IoT sensors. In this paper, we show an integrated solution based on IoT technologies that can serve as opportunistic health data acquisition agents for combating the pandemic o...
Source: Sensors - January 12, 2021 Category: Biotechnology Authors: Alfonso P. Ramallo-Gonz ález Aurora Gonz ález-Vidal Antonio F. Skarmeta Tags: Technical Note Source Type: research
Cancers, Vol. 13, Pages 261: An Emerging Role for the Unfolded Protein Response in Pancreatic Cancer
shin Samali Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer and one of the leading causes of cancer-associated deaths in the world. It is characterised by dismal response rates to conventional therapies. A major challenge in treatment strategies for PDAC is the presence of a dense stroma that surrounds the tumour cells, shielding them from treatment. This unique tumour microenvironment is fuelled by paracrine signalling between pancreatic cancer cells and supporting stromal cell types including the pancreatic stellate cells (PSC). While our molecular understanding of PDAC is improvi...
Source: Cancers - January 12, 2021 Category: Cancer & Oncology Authors: Claire M. Robinson Aaron Talty Susan E. Logue Katarzyna Mnich Adrienne M. Gorman Afshin Samali Tags: Review Source Type: research
Multidrug Resistant Klebsiella pneumoniae ST101 Clone Survival Chain From Inpatients to Hospital Effluent After Chlorine Treatment
In this paper we describe the transmission of a multi-drug resistant Klebsiella pneumoniae ST101 clone from hospital to wastewater and its persistence after chlorine treatment. Water samples from influents and effluents of the sewage tank of an infectious diseases hospital and clinical strains collected from the intra-hospital infections, during a period of 10 days prior to wastewater sampling were analyzed. Antibiotic resistant K. pneumoniae strains from wastewaters were recovered on selective media. Based on antibiotic susceptibility profiles and PCR analyses of antibiotic resistance (AR) genetic background, as well as w...
Source: Frontiers in Microbiology - January 11, 2021 Category: Microbiology Source Type: research
Bioenergetic Inhibitors: Antibiotic Efficacy and Mechanisms of Action in Mycobacterium tuberculosis
Development of novel anti-tuberculosis combination regimens that increase efficacy and reduce treatment timelines will improve patient compliance, limit side-effects, reduce costs, and enhance cure rates. Such advancements would significantly improve the global TB burden and reduce drug resistance acquisition. Bioenergetics has received considerable attention in recent years as a fertile area for anti-tuberculosis drug discovery. Targeting the electron transport chain (ETC) and oxidative phosphorylation machinery promises not only to kill growing cells but also metabolically dormant bacilli that are inherently more drug to...
Source: Frontiers in cellular and infection microbiology - January 11, 2021 Category: Microbiology Source Type: research
Cancers, Vol. 13, Pages 247: FAM188B Downregulation Sensitizes Lung Cancer Cells to Anoikis via EGFR Downregulation and Inhibits Tumor Metastasis In Vivo
In this study, we demonstrated that FAM188B knockdown sensitized anoikis of lung cancer cell lines expressing WT-EGFR (A549 and H1299) or TKI-resistant EGFR mutant T790M/L858R (H1975). FAM188B knockdown using si-FAM188B inhibited the growth of all three human lung cancer cell lines cultured in both attachment and suspension conditions. FAM188B knockdown resulted in EGFR downregulation and thus decreased its activity. FAM188B knockdown decreased the activities of several oncogenic proteins downstream of EGFR that are involved in anoikis resistance, including pAkt, pSrc, and pSTAT3, with little changes to their protein level...
Source: Cancers - January 11, 2021 Category: Cancer & Oncology Authors: Eun-Ju Jang Jee Young Sung Ha-Eun Yoo Hyonchol Jang Jaegal Shim Eok-Soo Oh Sung-Ho Goh Yong-Nyun Kim Tags: Article Source Type: research
Advanced Imaging of the Forelimb: Use of Musculoskeletal Ultrasound and MRI of the Shoulder and Brachial Plexus
Advanced imaging (ultrasound, computed tomography, MRI) is a key component in defining and localizing the underlying cause of forelimb lameness. Given the propensity of soft tissue injury/disease of the shoulder and brachial plexus, ultrasound and MRI are of particular utility in defining tendinous, muscular, and nerve lesions. An advanced knowledge of shoulder and brachial plexus anatomy is necessary for both image acquisition and interpretation. To determine clinical significance, interpretation of both normal anatomy and suspected pathology must be correlated with clinical signs and orthopedic examination findings. (Sou...
Source: Veterinary Clinics of North America: Small Animal Practice - January 11, 2021 Category: Veterinary Research Authors: Ryan King Source Type: research
EHHADH contributes to cisplatin resistance through regulation by tumor-suppressive microRNAs in bladder cancer
Cisplatin-based chemotherapy is recommended as the primary treatment for advanced bladder cancer (BC) with unresectable or metastatic disease. However, the benefits are limited due to the acquisition of drug r... (Source: BMC Cancer)
Source: BMC Cancer - January 11, 2021 Category: Cancer & Oncology Authors: Shunsuke Okamura, Hirofumi Yoshino, Kazuki Kuroshima, Masafumi Tsuruda, Yoichi Osako, Takashi Sakaguchi, Masaya Yonemori, Yasutoshi Yamada, Shuichi Tatarano, Masayuki Nakagawa and Hideki Enokida Tags: Research article Source Type: research
Clinical Outcomes of Patients with Chronic Myeloid Leukemia with Concurrent Core Binding Factor Rearrangement and Philadelphia Chromosome
Acquisition of core binding factor (CBF) rearrangement is a rare additional cytogenetic abnormality in chronic myeloid leukemia (CML). We identified 11 patients (2 patients in chronic phase; 9 patients in blast phase) with CML with CBF rearrangements with a median survival of 6 months. The addition of CBF can be considered a high-risk additional cytogenetic abnormality. (Source: Clinical Lymphoma, Myeloma and Leukemia)
Source: Clinical Lymphoma, Myeloma and Leukemia - January 11, 2021 Category: Hematology Authors: Kiyomi Morita, Elias Jabbour, Farhad Ravandi, Gautam Borthakur, Joseph D. Khoury, Shimin Hu, Guillermo Garcia-Manero, William Wierda, Ghayas Issa, Naval Daver, Naveen Pemmaraju, Guillermo Montalban-Bravo, Kelly A. Soltysiak, Sherry Pierce, Carlos Bueso-Ra Tags: Original Study Source Type: research
Rewriting the playbook: infection prevention practices to mitigate nosocomial severe acute respiratory syndrome coronavirus 2 transmission
Purpose of review Given the limited evidence and experience with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), this novel pathogen has challenged the field of infection prevention. Despite uncertainty, infection prevention principles and experience with similar diseases have helped guide how to best protect providers and patients against disease acquisition. Recent findings Guidance to date has relied on data from SARS-CoV-1 and MERS-CoV to guide practices on patient isolation and personal protective equipment (PPE) use. Although a face mask and eye protection are likely adequate for most clinica...
Source: Current Opinion in Pediatrics - January 10, 2021 Category: Pediatrics Tags: INFECTIOUS DISEASES AND IMMUNIZATION: Edited by Robert Frenck Source Type: research
Sensors, Vol. 21, Pages 426: Hip Positioning and Sitting Posture Recognition Based on Human Sitting Pressure Image
Peng Xu Bad sitting posture is harmful to human health. Intelligent sitting posture recognition algorithm can remind people to correct their sitting posture. In this paper, a sitting pressure image acquisition system was designed. With the system, we innovatively proposed a hip positioning algorithm based on hip templates. The average deviation of the algorithm for hip positioning is 1.306 pixels (the equivalent distance is 1.50 cm), and the proportion of the maximum positioning deviation less than three pixels is 94.1%. Statistics show that the algorithm works relatively well for different subjects. At the same time, ...
Source: Sensors - January 9, 2021 Category: Biotechnology Authors: Qilong Wan Haiming Zhao Jie Li Peng Xu Tags: Article Source Type: research
Sensors, Vol. 21, Pages 422: Evaluation of a Dielectric-Only Transmitarray for Generating Multi-Focusing Near-Field Spots Using a Cluster of Feeds in the Ka-Band
Costa Carlos A. Fernandes A transmitarray antenna is evaluated to generate a multi-focusing spot area in the Fresnel region of the antenna in the Ka-band. The antenna is designed to focus the radiated field at a certain point using a central feeding configuration. The number of feeds is increased to create as many focusing spots as feeds. The feeds are placed along an arc defined in the principal planes of the transmitarray, radiating independent near-field spots and providing a solution with a wide-angle spot scanning without an antenna displacement and a high isolation between feeds. To validate this concept, a tra...
Source: Sensors - January 9, 2021 Category: Biotechnology Authors: Álvaro F. Vaquero Marcos Rodr íguez Pino Manuel Arrebola S érgio A. Matos Jorge R. Costa Carlos A. Fernandes Tags: Letter Source Type: research
Social Media and Your Cancer Patient
In an increasingly connected world, healthcare is rapidly evolving to meet the needs of a growing patient population seeking information online. In the past few years, social media has erupted as a means of dissemination of health-related information between patients and healthcare providers alike. Patients online have access to communities and expert-opinion previously inaccessible. Cancer patients especially are empowered through online knowledge acquisition and interactions with support groups or advocacy groups. (Source: Seminars in Thoracic and Cardiovascular Surgery)
Source: Seminars in Thoracic and Cardiovascular Surgery - January 9, 2021 Category: Cardiovascular & Thoracic Surgery Authors: Brendon M. Stiles, J. Nathan Mynard Tags: THORACIC – News and Views Source Type: research
Tumor microenvironment promotes breast cancer chemoresistance
AbstractBreast cancer is presently the most predominant tumor type and the second leading cause of tumor-related deaths among women. Although advancements in diagnosis and therapeutics have momentously improved, chemoresistance remains an important challenge. Tumors oppose chemotherapeutic agents through a variety of mechanisms, with studies revealing that the tumor microenvironment (TME) is central to this process. The components of TME including stromal cells, immune cells, and non-stromal factors on exposure to chemotherapy promote the acquisition of resistant phenotype. Consequently, limited targeting of tumor cells le...
Source: Cancer Chemotherapy and Pharmacology - January 9, 2021 Category: Cancer & Oncology Source Type: research
The likely association between wandering spleen and absent left kidney
AbstractWandering spleen is a cause of acute surgical abdomen with serious consequences. It arises from an absence or weakness of the supporting suspensory splenic ligaments. There is often a delayed diagnosis due to its non-specific clinical presentation. This leads to stalled acquisition of confirmatory diagnostic imaging with resultant increased morbidity and mortality. Congenital or acquired absence of the left kidney results in loss of the splenorenal ligament, a key ligament to maintain normal splenic position in the abdomen. Two patients, one with OHVIRA (obstructed hemivagina ipsilateral renal anomaly) syndrome and...
Source: Emergency Radiology - January 8, 2021 Category: Emergency Medicine Source Type: research
GSE164338 Hyperglycemic memory of innate immune cells promotes in vitro proinflammatory responses of human monocytes and murine macrophages
Contributors : Kathrin Thiem ; Rinke StienstraSeries Type : Expression profiling by arrayOrganism : Homo sapiensIt has been well established that the presence of diabetes is accompanied by a chronic inflammatory state promoting various diabetes-associated complications. One potential driver of this enhanced inflammatory state in patients with diabetes is hyperglycemia. Even after blood glucose control is achieved, diabetes-associated complications persist, suggesting the presence of a “hyperglycemic memory.” Innate immune cells, critically involved in various complications associated with diabetes, can build no...
Source: GEO: Gene Expression Omnibus - January 7, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Impaired Acquisition of Nicotine-Induced Conditioned Place Preference in Fatty Acid-Binding Protein 3 Null Mice
AbstractNicotine causes psychological dependence through its interactions with nicotinic acetylcholine receptors in the brain. We previously demonstrated that fatty acid-binding protein 3 (FABP3) colocalizes with dopamine D2 receptors (D2Rs) in the dorsal striatum, and FABP3 deficiency leads to impaired D2R function. Moreover, D2R null mice do not exhibit increased nicotine-induced conditioned place preference (CPP) following chronic nicotine administration. To investigate the role of FABP3 in nicotine-induced CPP, FABP3 knockout (FABP3−/−) mice were evaluated using a CPP apparatus following consecutive nicotin...
Source: Molecular Neurobiology - January 7, 2021 Category: Neurology Source Type: research
Pre-exposure prophylaxis makes it possible to better live one ’s sexuality and guide men who have sex with men towards a responsible approach to their health: a phenomenological qualitative study about primary motivations for PrEP
Pre-exposure prophylaxis (PrEP) for HIV is instrumental in the prevention of HIV for HIV-uninfected persons, by drastically reducing the risk of acquisition in the case of high-risk exposures. Despite its demo... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - January 7, 2021 Category: Infectious Diseases Authors: Marie Bistoquet, Alain Makinson, Vincent Tribout, Cyril Perrollaz, G érard Bourrel, Jacques Reynes and Agnès Oude Engberink Tags: Research Source Type: research
The thymus and the science of self
AbstractThe conventional perception asserts that immunology is the science of ‘discrimination’ between self and non-self. This concept is however no longer tenable as effector cells of the adaptive immune system are first conditioned to be tolerant to the body’s own antigens, collectively known as self until now. Only then attain these effectors the responsiveness to no n-self. The acquisition of this essential state of tolerance to self occurs for T cells in the thymus, the last major organ of our body that revealed its intricate function in health and disease. The ‘thymus’ as an anatomical n...
Source: Seminars in Immunopathology - January 7, 2021 Category: Pathology Source Type: research
The origins and consequences of < i > UPF1 < /i > variants in pancreatic adenosquamous carcinoma
Pancreatic adenosquamous carcinoma (PASC) is an aggressive cancer whose mutational origins are poorly understood. An early study reported high-frequency somatic mutations affecting UPF1, a nonsense-mediated mRNA decay (NMD) factor, in PASC, but subsequent studies did not observe these lesions. The corresponding controversy about whetherUPF1 mutations are important contributors to PASC has been exacerbated by a paucity of functional studies. Here, we modeled twoUPF1 mutations in human and mouse cells to find no significant effects on pancreatic cancer growth, acquisition of adenosquamous features,UPF1 splicing, UPF1 protein...
Source: eLife - January 6, 2021 Category: Biomedical Science Tags: Cancer Biology Source Type: research
Effects of acquisition device, sampling rate, and record length on kinocardiography during position-induced haemodynamic changes
Kinocardiography (KCG) is a promising new technique used to monitor cardiac mechanical function remotely. KCG is based on ballistocardiography (BCG) and seismocardiography (SCG), and measures 12 degrees-of-fre... (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - January 6, 2021 Category: Biomedical Engineering Authors: Amin Hossein, J érémy Rabineau, Damien Gorlier, Farhana Pinki, Philippe van de Borne, Antoine Nonclercq and Pierre-François Migeotte Tags: Research Source Type: research
Automatic, high-speed, high-precision acquisition scheme with QPD for the Taiji program
Most of the space gravitational wave detection missions, such as the Taiji program, use space-based laser interferometer to sense the ... (Source: Optics Express)
Source: Optics Express - January 5, 2021 Category: Physics Authors: Ruihong Gao Heshan Liu Ya Zhao Ziren Luo Gang Jin Source Type: research
Sensors, Vol. 21, Pages 300: SynPo-Net —Accurate and Fast CNN-Based 6DoF Object Pose Estimation Using Synthetic Training
Sensors, Vol. 21, Pages 300: SynPo-Net—Accurate and Fast CNN-Based 6DoF Object Pose Estimation Using Synthetic Training Sensors doi: 10.3390/s21010300 Authors: Yongzhi Su Jason Rambach Alain Pagani Didier Stricker Estimation and tracking of 6DoF poses of objects in images is a challenging problem of great importance for robotic interaction and augmented reality. Recent approaches applying deep neural networks for pose estimation have shown encouraging results. However, most of them rely on training with real images of objects with severe limitations concerning ground truth pose acquisition, full coverag...
Source: Sensors - January 5, 2021 Category: Biotechnology Authors: Yongzhi Su Jason Rambach Alain Pagani Didier Stricker Tags: Article Source Type: research
Can video games enhance surgical skills acquisition for medical students? A systematic review
To systematically assess literature examining the impact of being a gamer or participating in video-game –based training on surgical skills acquisition amongst medical students. (Source: Surgery)
Source: Surgery - January 5, 2021 Category: Surgery Authors: Arnav Gupta, Bishoy Lawendy, Mitchell G. Goldenberg, Ethan Grober, Jason Y. Lee, Nathan Perlis Source Type: research
Dentate gyrus development requires a cortical hem-derived astrocytic scaffold
During embryonic development, radial glial cells give rise to neurons, then to astrocytes following the gliogenic switch. Timely regulation of the switch, operated by several transcription factors, is fundamental for allowing coordinated interactions between neurons and glia. We deleted the gene for one such factor, SOX9, early during mouse brain development and observed a significantly compromised dentate gyrus (DG). We dissected the origin of the defect, targeting embryonicSox9 deletion to either the DG neuronal progenitor domain or the adjacent cortical hem (CH). We identified in the latter previously uncharacterized AL...
Source: eLife - January 4, 2021 Category: Biomedical Science Tags: Developmental Biology Neuroscience Source Type: research
Epidemiology of the Philadelphia Chromosome-Negative Classical Myeloproliferative Neoplasms
Polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) comprise the BCR-ABL-negative classical myeloproliferative neoplasms (MPNs). These clonal myeloid diseases are principally driven by well-described molecular events; however, factors leading to their acquisition are not well understood. Beyond increasing age, male sex, and race/ethnicity differences, few consistent risk factors for the MPNs are known. PV and ET have an incidence of 0.5 to 4.0 and 1.1 to 2.0 cases per 100,000 person-years, respectively, and predict similar survival. PMF, which has an incidence of about 0.3 to 2.0 cases p...
Source: Hematology/Oncology Clinics of North America - January 4, 2021 Category: Cancer & Oncology Authors: Rory M. Shallis, Amer M. Zeidan, Rong Wang, Nikolai A. Podoltsev Source Type: research
Brilliant X-rays reveal what might be a new type of star
Nature, Published online: 04 January 2021; doi:10.1038/d41586-020-03654-xA strange and unstable astronomical object seems to have formed from the merger of two white dwarfs. (Source: Nature AOP)
Source: Nature AOP - January 4, 2021 Category: Research Source Type: research
How Did She Get So Good? On Virtue and Skill
AbstractIn his recent book on skill and virtue, Matt Stichter provides an account based on work in empirical psychology, specifically on self-regulation. In this paper I wish to argue that while this account is novel and well informed, it falls short. I present several examples that I believe Stichter ’s view cannot explain and I try to identify the reasons for that. I argue that while trying to avoid the completely anti-intellectualist account of skill especially when it comes to virtue, Stichter may have inadvertently presented an account that is too intellectualist. To clarify my claims, I s tart with a brief expl...
Source: Ethical Theory and Moral Practice - January 3, 2021 Category: Medical Ethics Source Type: research
The Effect of Partnership Presence and Support on HIV Viral Suppression Among Serodiscordant Partnered and Single Heterosexual HIV-Positive Individuals in Brazil
This study aims to determine whether HIV viral suppression is associated with partnership status and partnership support among 201 HIV positive (HIV+ individuals in serodiscordant partnerships and 100 HIV+ unpartnered individuals receiving care at Hospital Nossa Senhora da Conceição in Porto Alegre, Brazil between 2014 and 2016. Clinical data and patient-reported questionnaire data were assessed, and propensity scores were used to control for confounding variables in adjusted logistic regression models. Viral suppression did not significantly differ between HIV+ partnered (78.5% virally suppres...
Source: AIDS and Behavior - January 2, 2021 Category: Infectious Diseases Source Type: research
Accelerated 3D bSSFP Using a Modified Wave-CAIPI Technique With Truncated Wave Gradients
In this study, we propose a 3D Wave-bSSFP scheme that adopts truncated wave gradients with zero 0th moment to avoid introducing additional banding artifacts and to maintain the advantages of wave encoding. The simulation results indicate that the number of wave cycles that are truncated and different options of applying wave gradients affect both the g-factor reduction and image quality, but the influence is limited. In phantom experiments, the proposed technique shows similar acceleration performance as the conventional Wave-CAIPI technique and effectively eliminates its introduced banding artifacts. Additionally, Wave-bS...
Source: IEE Transactions on Medical Imaging - January 1, 2021 Category: Biomedical Engineering Source Type: research
Uncertainty Quantification in Deep MRI Reconstruction
Reliable MRI is crucial for accurate interpretation in therapeutic and diagnostic tasks. However, undersampling during MRI acquisition as well as the overparameterized and non-transparent nature of deep learning (DL) leaves substantial uncertainty about the accuracy of DL reconstruction. With this in mind, this study aims to quantify the uncertainty in image recovery with DL models. To this end, we first leverage variational autoencoders (VAEs) to develop a probabilistic reconstruction scheme that maps out (low-quality) short scans with aliasing artifacts to the diagnostic-quality ones. The VAE encodes the acquisition unce...
Source: IEE Transactions on Medical Imaging - January 1, 2021 Category: Biomedical Engineering Source Type: research
Sensors, Vol. 21, Pages 246: Experimental Implementation and Performance Evaluation of an IoT Access Gateway for the Modbus Extension
gan This paper presents the relevant aspects regarding the experimental implementation and performance evaluation of an Internet of things (IoT) gateway for the Modbus extension. The proposed Modbus extension specifications are extended by defining the new optimized message format, and the structure of the acquisition cycle for obtaining a deterministic temporal behavior and solutions are presented for the description of devices at the MODBUS protocol level. Three different implementations are presented, and the Modbus extension&rsquo;s performance is validated regarding the efficiency in the use of the acquisi...
Source: Sensors - January 1, 2021 Category: Biotechnology Authors: G ăitan Zagan Tags: Article Source Type: research
GSE158904 Prox1 inhibits axon outgrowth during central nervous system development
Contributors : V Kaltezioti ; I Foskolou ; M.D Lavigne ; M Fousteri ; P PolitisSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDuring central nervous system (CNS) development, proper and timely induction of axon elongation is critical for generating functional, mature neurons and neuronal networks. Despite the wealth of information on the action of extracellular cues, little is known about the intrinsic gene regulatory factors that control this developmental decision. Here we report the identification of Prox1, a homeobox transcription factor, as a key player in inhibiting axon elonga...
Source: GEO: Gene Expression Omnibus - December 31, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Sensors, Vol. 21, Pages 214: Low-Cost IoT-Based Sensor System: A Case Study on Harsh Environmental Monitoring
kiliba Wireless Sensor Networks (WSNs) are promising technologies for exploiting in harsh environments such as can be found in the nuclear industry. Nuclear storage facilities can be considered harsh environments in that, amongst other variables, they can be dark, congested, and have high gamma radiation levels, which preclude operator access. These conditions represent significant challenges to sensor reliability, data acquisition and communications, power supplies, and longevity. Installed monitoring of parameters such as temperature, pressure, radiation, humidity, and hydrogen content within a nuclear facility may o...
Source: Sensors - December 31, 2020 Category: Biotechnology Authors: Ali Imam Sunny Aobo Zhao Li Li Sambu Kanteh Kanteh Sakiliba Tags: Communication Source Type: research
Acquisition set to help Newterra strengthen its position in the decentralised water-treatment market worldwide
Publication date: December 2020Source: Membrane Technology, Volume 2020, Issue 12Author(s): (Source: Membrane Technology)
Source: Membrane Technology - December 30, 2020 Category: Materials Science Source Type: research
Emx2 regulates hair cell rearrangement but not positional identity within neuromasts
Each hair cell (HC) precursor of zebrafish neuromasts divides to form two daughter HCs of opposite hair bundle orientations. Previously, we showed that transcription factor Emx2, expressed in only one of the daughter HCs, generates this bidirectional HC pattern (Jiang et al., 2017). Here, we asked whether Emx2 mediates this effect by changing location of hair bundle establishment or positions of HCs since daughter HCs are known to switch positions with each other. We showed this HC rearrangement, redefined as two processes named Rock& Roll, is required for positional acquisition of HCs. Apical protrusion formation of n...
Source: eLife - December 30, 2020 Category: Biomedical Science Tags: Developmental Biology Source Type: research
[ASAP] Rapid Sample Preparation Workflow for Serum Sample Analysis with Different Mass Spectrometry Acquisition Strategies
Analytical ChemistryDOI: 10.1021/acs.analchem.0c03985 (Source: Analytical Chemistry)
Source: Analytical Chemistry - December 29, 2020 Category: Chemistry Authors: Fenglin Shen, Yueting Xiong, Lei Zhang, Hengchao Li, Huanhuan Zhao, Xiaohui Liu, and Pengyuan Yang Source Type: research
GSE151368 MicroRNA and mRNA integrated transcriptional analysis in a Cx30-/- mouse model of non-syndromic hearing loss and deafness [miRNA]
Contributors : Giulia Gentile ; Antonio G Spampinato ; Maria Guarnaccia ; Sebastiano CavallaroSeries Type : Non-coding RNA profiling by arrayOrganism : Mus musculusThe GJB6 gene is located just 35 kb telomeric to GJB2 in the so-called nonsyndromic hearing loss and deafness locus 1 (DFNB1). Knock out mouse models confirmed that inner ear expression of their protein products, connexin 30 (Cx30) and connexin 26 (Cx26), is crucial for hearing acquisition and normal development of the organ of Corti, however the coordinated regulation mechanism of Cx26 and Cx30 expression in the cochlea remains unclear. To investigate the mecha...
Source: GEO: Gene Expression Omnibus - December 29, 2020 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Mus musculus Source Type: research
GSE151367 MicroRNA and mRNA integrated transcriptional analysis in a Cx30-/- mouse model of non-syndromic hearing loss and deafness [mRNA]
Contributors : Giulia Gentile ; Antonio G Spampinato ; Maria Guarnaccia ; Sebastiano CavallaroSeries Type : Expression profiling by arrayOrganism : Mus musculusThe GJB6 gene is located just 35 kb telomeric to GJB2 in the so-called nonsyndromic hearing loss and deafness locus 1 (DFNB1). Knock out mouse models confirmed that inner ear expression of their protein products, connexin 30 (Cx30) and connexin 26 (Cx26), is crucial for hearing acquisition and normal development of the organ of Corti, however the coordinated regulation mechanism of Cx26 and Cx30 expression in the cochlea remains unclear. To investigate the mechanism...
Source: GEO: Gene Expression Omnibus - December 29, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Seeing and Believing: The Relationship between Perception and Mental Verbs in Acquisition
. (Source: Language Learning and Development)
Source: Language Learning and Development - December 28, 2020 Category: Speech-Language Pathology Authors: E. Emory Davis Barbara Landau Source Type: research
Emergence of a novel urogenital-tropic Neisseria meningitidis
Purpose of review Neisseria meningitidis (Nm) is primarily associated with asymptomatic nasopharyngeal carriage and invasive meningococcal disease (sepsis and meningitis), but like N. gonorrhoea (Ng), Nm can colonize urogenital and rectal mucosal surfaces and cause disease. First noted in 2015, but with origins in 2011, male urethritis clusters caused by a novel Nm clade were reported in the USA (the US_NmUC). This review describes research developments that characterize this urogenital-tropic Nm. Recent findings The US_NmUC evolved from encapsulated Nm serogroup C strains. Loss of capsule expression, lipooligos...
Source: Current Opinion in Infectious Diseases - December 26, 2020 Category: Infectious Diseases Tags: STD: Edited by Joseph A. Duncan Source Type: research
Effects of HIV voluntary medical male circumcision programs on sexually transmitted infections
Purpose of review Evidence of the protective effect of voluntary medical male circumcision (VMMC) against HIV is well established. However, evidence of the protective effect of VMMC against other sexually transmitted infections (STIs) has been inconsistent or scarce across different populations and settings. This review summarizes the current evidence on the effect of VMMC for HIV prevention on acquisition and transmission of other STIs in heterosexual men, women, and men who have sex with men (MSM). Recent findings Recent findings continue to strongly support the protective effect of male medical circumcision a...
Source: Current Opinion in Infectious Diseases - December 26, 2020 Category: Infectious Diseases Tags: STD: Edited by Joseph A. Duncan Source Type: research
GSE163842 Transcriptome architecture and regulation at environmental transitions of the fish pathogen Flavobacterium psychrophilum
Contributors : Tatiana Rochat ; Cyprien Gu érinSeries Type : Expression profiling by arrayOrganism : Flavobacterium psychrophilumIn a context of fast development of aquaculture, infections by Flavobacterium psychrophilum, a member of the family Flavobacteriaceae, are a major sanitary concern for the salmonid farming industry worldwide. Several phenotypic traits related to pathogenesis have been documented for this bacterium, but molecular factors involved remain poorly characterized. Here, we conducted a global study of adaptation to outside- and within-host environments using a combination of in vitro transcriptomi...
Source: GEO: Gene Expression Omnibus - December 25, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Flavobacterium psychrophilum Source Type: research
GSE111686 DNA methylation dynamics of oocyte in follicular maturation (ChIP-Seq data set)
Contributors : Rui Gao ; Xiaolong Chen ; Chuan Chen ; Yuanlin He ; Xiaochen Kou ; Yanhong Zhao ; Jing Li ; Yawei Gao ; Cizhong Jiang ; Shaorong GaoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusFolliculogenesis in mammals is a cyclic and hierarchical process that the ovarian follicles undergo dramatic changes in the shape and number of granulosa cells accompanied by gradually enlarged immature oocyte. Here we show a thorough and high-resolution view of DNA methylation maps in oocyte free of somatic cells present at each distinct follicular development stages. We found t...
Source: GEO: Gene Expression Omnibus - December 25, 2020 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research