GSE226959 CD4+ T cells select unique P65, IRF1 and FOS dependen responses in APC for integration into antiviral CD8+ T cell immunity
We describe gradual IFN-α/β-induced transcriptional adaptations that endowed APC with the capacity to rapidly activate the transcriptional regulators P65, IRF1 and FOS upon CD4+ T cell-mediated CD40 stimulation. While these res ponses operated through broadly utilized signaling components, they induced a unique set of costimulatory molecules and soluble mediators that could not be elicited by IFN-α/β or CD40 alone. This response was critical for the acquisition of antiviral CD8+ T cell effector function, and its activity in APC from patients infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) co...
Source: GEO: Gene Expression Omnibus - February 20, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
Selection of ethanol tolerant strains of < i > Candida albicans < /i > by repeated ethanol exposure results in strains with reduced susceptibility to fluconazole
This study identifies a selective pressure that can result in evolution of fluconazole tolerance and resistance without previous exposure to the drug. (Source: PLoS One)
Source: PLoS One - February 20, 2024 Category: Biomedical Science Authors: Andrew W. Day Source Type: research
Validation of a Design Architecture to Deliver Health Management and Behavior Change Evidence at Scale
Stud Health Technol Inform. 2024 Feb 19;312:112-117. doi: 10.3233/SHTI231323.ABSTRACTForty-four percent of Canadians over the age of 20 have a non-communicable disease (NCD). Millions of Canadians are at risk of developing the complications of NCDs; millions have already experienced those complications. Fortunately, the evidence base for NCD prevention and behavior change is large and growing and digital technologies can deliver them at scale and with high fidelity. However, the current model of in-person primary care is not designed nor capable of operationalizing that evidence. New developments in artificial intelligence...
Source: Studies in Health Technology and Informatics - February 19, 2024 Category: Information Technology Authors: Anson Li Mark Dayomi Pooyeh Graili Ali Balouchi Aziz Guergachi Karim Keshavjee Source Type: research
Role of aminopeptidase N ‐like in the acquisition of begomoviruses by Bemisia tabaci, the whitefly vector
In this study, we identified an aminopeptidase N-like protein (BtAPN) inB. tabaci Asia II 1, an efficient vector of SLCMV, which is involved in the SLCMV transmission process. Through the use of glutathione S-transferase pull-down assay and LC-MS/MS analysis, we demonstrated the interaction between BtAPN and the coat protein (CP) of SLCMV. This interaction was further confirmedin vitro, and we observed an induction ofBtAPN gene expression following SLCMV infection. By interfering with the function of BtAPN, the quantities of SLCMV were significantly reduced in various parts ofB. tabaci Asia II 1, including the wh...
Source: Insect Science - February 19, 2024 Category: Biology Authors: Yun ‐Yun Fan,
Yao Chi,
Na Chen,
Wilmer J. Cuellar,
Xiao‐Wei Wang Tags: ORIGINAL ARTICLE Source Type: research
Prevalence of chlamydia and gonorrhea in US Air Force male basic trainees
The incidence rates of Neisseria gonorrhoeae (GC) and Chlamydia trachomatis (CT) have been increasing over the past decade.1 Despite the increased burden of disease, current guidelines recommend only screening for GC and CT in select asymptomatic men, including those with HIV or at high risk of sexually transmitted infection (STI) acquisition.2 3 Due to these recommendations, most of the data in male asymptomatic GC and CT infection rates come from sexual health clinics with rates between 5% and 10%.4 The infection rate in other male populations is largely unknown. Service members who join the US Air Force (USAF) are appro...
Source: Sexually Transmitted Infections - February 19, 2024 Category: Sexual Medicine Authors: Wade, J. K., Marcus, J., Kieffer, J., Kasper, K., Smalley, J. Tags: PostScript Source Type: research
Role of zinc in health and disease
AbstractThis review provides a concise overview of the cellular and clinical aspects of the role of zinc, an essential micronutrient, in human physiology and discusses zinc-related pathological states. Zinc cannot be stored in significant amounts, so regular dietary intake is essential. ZIP4 and/or ZnT5B transport dietary zinc ions from the duodenum i nto the enterocyte, ZnT1 transports zinc ions from the enterocyte into the circulation, and ZnT5B (bidirectional zinc transporter) facilitates endogenous zinc secretion into the intestinal lumen. Putative promoters of zinc absorption that increase its bioavailability includ...
Source: Clinical and Experimental Medicine - February 17, 2024 Category: Research Source Type: research
