GSE264574 Understanding resistance to polymyxin and amikacin in Klebsiella pneumoniae

Contributors : Camila de Souza ; Octavio FrancoSeries Type : Expression profiling by high throughput sequencingOrganism : Klebsiella pneumoniaeKlebsiella pneumoniae poses a significant global health threat primarily attributable to its pronounced resistance. Here, we report an in vitro acquired resistance analyses of K. pneumoniae to the combination of amikacin and polymyxin B. We found some differentially expressed genes associated with the resistome of K. pneumoniae. The main differences were found in the genes aphA, asmA, phoP, and in the arn operon. Once these genes are related to modification in lipopolysaccharides, aminoglycosides and in the membrane structure, the mechanisms associated with them can justify the resistance acquisition to amikacin and polymyxin b.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Klebsiella pneumoniae Source Type: research