Identification of gravity ‐responsive serum proteins in spaceflight mice using a quantitative proteomic approach with data‐independent acquisition mass spectrometry
This study examined serum proteome profiles in response to gravity unloading, and may help deepen our understanding of microgravity adaptation mechanisms during prolonged spaceflight missions. (Source: Proteomics)
Source: Proteomics - March 13, 2024 Category: Biochemistry Authors: Yayoi Kimura,
Yusuke Nakai,
Yoko Ino,
Tomoko Akiyama,
Kayano Moriyama,
Takashi Ohira,
Tomoyuki Saito,
Yutaka Inaba,
Ken Kumagai,
Akihide Ryo,
Hisashi Hirano Tags: RESEARCH ARTICLE Source Type: research
Perspective: use and reuse of NMR-based metabolomics data: what works and what remains challenging
AbstractBackgroundThe National Cancer Institute issued a Request for Information (RFI; NOT-CA-23-007) in October 2022, soliciting input on using and reusing metabolomics data. This RFI aimed to gather input on best practices for metabolomics data storage, management, and use/reuse.Aim of reviewThe nuclear magnetic resonance (NMR) Interest Group within the Metabolomics Association of North America (MANA) prepared a set of recommendations regarding the deposition, archiving, use, and reuse of NMR-based and, to a lesser extent, mass spectrometry (MS)-based metabolomics datasets. These recommendations were built on the collect...
Source: Metabolomics - March 13, 2024 Category: Biology Source Type: research
Human vaccines and immunotherapeutics: News February 2024
Volume 20, Issue 1, December 2024 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - March 13, 2024 Category: Allergy & Immunology Authors: Ronald EllisAdam Weissa Editor-in-Chief, Jerusalem, Israelb Acquisitions Editor, Taylor & Francis Group Source Type: research
VPBrowse: Genome ‐based representation of MS/MS spectra to quantify 10,000 bovine proteins
AbstractSWATH is a data acquisition strategy acclaimed for generating quantitatively accurate and consistent measurements of proteins across multiple samples. Its utility for proteomics studies in nonlaboratory animals, however, is currently compromised by the lack of sufficiently comprehensive and reliable public libraries, either experimental or predicted, and relevant platforms that support their sharing and utilization in an intuitive manner. Here we describe the development of the Veterinary Proteome Browser, VPBrowse (http://browser.proteo.cloud/), an on-line platform for genome-based representation of theBos taurus ...
Source: Proteomics - March 12, 2024 Category: Biochemistry Authors: Selvam Paramasivan,
Mohamed Ashick,
Kevin J. Dudley,
Nana Satake,
Paul C. Mills,
Pawel Sadowski,
Shivashankar H. Nagaraj Tags: TECHNICAL BRIEF Source Type: research
GSE225437 Analysis of ΔcrcZ suppressor mutations
Contributors : F Corona ; J L MartinezSeries Type : Expression profiling by high throughput sequencingOrganism : Pseudomonas aeruginosa PAO1The ΔcrcZ mutant shows constitutive repression of all crc/Hfq target genes in the translation. Therefore, it presents a hyper‐repressed phenotype (more repressed than the parental strain) in the acquisition of secondary carbon sources, even though the preferred carbon source is not present.Δcrc is more sensitive to antibiotics, more susceptible to oxidative stress, and less motile than the parental strain.The ΔcrcZ strain is more motile and more resistant to antibiotics than the ...
Source: GEO: Gene Expression Omnibus - March 11, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Pseudomonas aeruginosa PAO1 Source Type: research
Osteocyte-mediated mechanical response controls osteoblast differentiation and function
Low bone mass is a pervasive global health concern, with implications for osteoporosis, frailty, disability, and mortality. Lifestyle factors, including sedentary habits, metabolic dysfunction, and an aging population, contribute to the escalating prevalence of osteopenia and osteoporosis. The application of mechanical load to bone through physical activity and exercise prevents bone loss, while sufficient mechanical load stimulates new bone mass acquisition. Osteocytes, cells embedded within the bone, receive mechanical signals and translate these mechanical cues into biological signals, termed mechano-transduction. Mecha...
Source: Frontiers in Physiology - March 11, 2024 Category: Physiology Source Type: research
Case report: accelerated cathodal HD-tDCS over the right dorsolateral prefrontal cortex in hoarding disorder
Hoarding disorder is an under-recognized condition characterized by the excessive acquisition of possessions and difficulty in disposing of them, which can have dramatic consequences. As hoarding disorder is difficult to treat and associated with high levels of disability in all areas of functioning, there appears to be a critical need to develop novel, tailored therapeutic strategies. Non-invasive brain stimulation techniques hold promise as potential therapeutic interventions for various psychiatric conditions and as a tool to modulate impulsivity when applied over the dorsolateral prefrontal cortex (DLPFC). Therefore, w...
Source: Frontiers in Human Neuroscience - March 11, 2024 Category: Neuroscience Source Type: research
GSE227072 Integrated transcriptomic analysis identifies coordinated responses to nitrogen and phosphate deficiency in rice
Contributors : Fei Wang ; Yan Wang ; Luying Ying ; Hong LuSeries Type : Expression profiling by high throughput sequencingOrganism : Oryza sativa Japonica GroupNitrogen (N) and phosphorus (P) are two primary components of fertilizers for crop production. Coordinated acquisition and utilization of N and P are crucial for plants to achieve nutrient balance and optimal growth in a changing rhizospheric nutrient environment. However, little is known about how N and P signaling pathways are integrated. We performed transcriptomic analyses and physiological experiments to explore gene expression profiles and physiological ho...
Source: GEO: Gene Expression Omnibus - March 10, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Oryza sativa Japonica Group Source Type: research
GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex virus type 1 infection
In this study, we investigated the role of the G protein-coupled receptors (GPR)41 and GPR43 that can bind microbiota-derived short chain fatty acids (SCFAs) in CD8+ T cell priming following epicutaneous herpes simplex virus type 1 (HSV-1) infection. We found that HSV-specific CD8+ T cells in GPR41/43-deficient mice were impaired in the antigen-elicited production of interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α), granzyme B and perforin, and failed to differentiate effectively into memory precursors. The defect in controlling HSV-1 at the site of infection could be restored when GPR41 and GPR43 were expr...
Source: Frontiers in Immunology - March 8, 2024 Category: Allergy & Immunology Source Type: research
Sensors, Vol. 24, Pages 1761: Self-Powered Intelligent Water Droplet Monitoring Sensor Based on Solid & ndash;Liquid Triboelectric Nanogenerator
Sensors, Vol. 24, Pages 1761: Self-Powered Intelligent Water Droplet Monitoring Sensor Based on Solid–Liquid Triboelectric Nanogenerator
Sensors doi: 10.3390/s24061761
Authors:
Zhu
Guo
Ding
Zhao
Liu
Che
Real-time monitoring of rainwater is a critical issue in the development of autonomous vehicles and smart homes, while the corresponding sensors play a pivotal role in ensuring their sensitivity. Here, we study a self-powered intelligent water droplet monitoring sensor based on a solid–liquid triboelectric nanogenerator (SL-TENG). The sensor comprises a SL-TENG, a signal acqui...
Source: Sensors - March 8, 2024 Category: Biotechnology Authors: Zhu Guo Ding Zhao Liu Che Tags: Article Source Type: research
Sensors, Vol. 24, Pages 1733: Autonomous Sensor System for Low-Capacity Wind Turbine Blade Vibration Measurement
odrigo Astroza
This paper presents the design, implementation, and validation of an on-blade sensor system for remote vibration measurement for low-capacity wind turbines. The autonomous sensor system was deployed on three wind turbines, with one of them operating in harsh weather conditions in the far south of Chile. The system recorded the acceleration response of the blades in the flapwise and edgewise directions, data that could be used for extracting the dynamic characteristics of the blades, information useful for damage diagnosis and prognosis. The proposed sensor system demonstrated reliable data acquisition an...
Source: Sensors - March 7, 2024 Category: Biotechnology Authors: Diego Muxica Sebastian Rivera Marcos E. Orchard Constanza Ahumada Francisco Jaramillo Felipe Bravo Jos é M. Gutiérrez Rodrigo Astroza Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1065: Correction: Gresseau et al. A Signaling Crosstalk Links SNAIL to the 37/67 kDa Laminin-1 Receptor Ribosomal Protein SA and Regulates the Acquisition of a Cancer Stem Cell Molecular Signature in U87 Glioblastoma Neurospheres. Cancers 2022, 14, 5944
Annabi
In the original publication [...] (Source: Cancers)
Source: Cancers - March 6, 2024 Category: Cancer & Oncology Authors: Loraine Gresseau Marie-Eve Roy St éphanie Duhamel Borhane Annabi Tags: Correction Source Type: research
