Intracellular signaling in proto-eukaryotes evolves to alleviate regulatory conflicts of endosymbiosis
by Samuel H. A. von der Dunk, Paulien Hogeweg, Berend Snel
The complex eukaryotic cell resulted from a merger between simpler prokaryotic cells, yet the role of the mitochondrial endosymbiosis with respect to other eukaryotic innovations has remained under dispute. To investigate how the regulatory challenges associated with the endosymbiotic state impacted genome and network evolution during eukaryogenesis, we study a constructive computational model where two simple cells are forced into an obligate endosymbiosis. Across multiplein silico evolutionary replicates, we observe the emergence of different mechanisms for the ...
Source: PLoS Computational Biology - February 9, 2024 Category: Biology Authors: Samuel H. A. von der Dunk Source Type: research
GSE227907 Identification of PSMB4 and PSMD4 as novel target correlated with 1q21 amp in patients with smoldering myeloma and multiple myeloma.
In this study, we analyzed purified CD138+ bone marrow PCs from 11 SMM and 18 NDMM patients to identify genes whose expressions are deregulated in patients with 1q21+ in correlation with the number of copies and their putative role in drug response. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - February 7, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Source Type: research
Children ’s Acquisition of Morphosyntactic Variation: A Reply to Commentaries
Volume 20, Issue 1, January-March 2024, Page 83-96 . (Source: Language Learning and Development)
Source: Language Learning and Development - February 7, 2024 Category: Speech-Language Pathology Authors: Naomi ShinKaren Lynn Millera Linguistics and Spanish & Portuguese, University of New Mexico, Albuquerque, New Mexico, USAb Department of Spanish, Italian, and Portuguese, Penn State University, University Park, Pennsylvania, USA Source Type: research
Models of Variable Form Acquisition Should Be Informed by Cross-Dialect Studies of Children with and without Developmental Language Disorder (DLD)
Volume 20, Issue 1, January-March 2024, Page 79-82 . (Source: Language Learning and Development)
Source: Language Learning and Development - February 7, 2024 Category: Speech-Language Pathology Authors: Janna B. OettingDepartment of Communication Sciences & Disorders, Louisiana State University, Baton Rouge, Louisiana, USA Source Type: research
Sensors, Vol. 24, Pages 1083: A Novel Framework for Image Matching and Stitching for Moving Car Inspection under Illumination Challenges
In this study, we introduce an innovative end-to-end pipeline tailored for efficient image matching and stitching, specifically addressing the challenges posed by moving objects in static uncalibrated camera setups. Extracting features from moving objects with strong reflections presents significant difficulties, beyond the capabilities of current image matching algorithms. To tackle this, we introduce a novel filtering scheme that can be applied to every image matching process, provided that the input features are sufficient. A critical aspect of this module involves the exclusion of points located in the background, effe...
Source: Sensors - February 7, 2024 Category: Biotechnology Authors: Andreas El Saer Lazaros Grammatikopoulos Giorgos Sfikas George Karras Elli Petsa Tags: Article Source Type: research
The Role of Artificial Intelligence in Cardiac Imaging
Artificial intelligence (AI) is having a significant impact in medical imaging, advancing almost every aspect of the field, from image acquisition and postprocessing to automated image analysis with outreach toward supporting decision making. Noninvasive cardiac imaging is one of the main and most exciting fields for AI development. The aim of this review is to describe the main applications of AI in cardiac imaging, including CT and MR imaging, and provide an overview of recent advancements and available clinical applications that can improve clinical workflow, disease detection, and prognostication in cardiac disease. (S...
Source: Radiologic Clinics of North America - February 7, 2024 Category: Radiology Authors: Carlotta Onnis, Marly van Assen, Emanuele Muscogiuri, Giuseppe Muscogiuri, Gabrielle Gershon, Luca Saba, Carlo N. De Cecco Source Type: research
Human vaccines and immunotherapeutics: News January 2024
Volume 20, Issue 1, December 2024 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - February 7, 2024 Category: Allergy & Immunology Authors: Ronald EllisAdam Weissa Editor-in-Chief, Jerusalem, Israelb Acquisitions Editor, Taylor & Francis Group Source Type: research
The Effect of Mixing Iodinated Contrast Media and Ultrasound Contrast Agents on Subharmonic Signals
This study aims to elucidate the effects of iodinated contrast (Visipaque, GE HealthCare) on subharmonic signal amplitude from contrast microbubbles (Definity, Lantheus Medical Imaging, Inc.). In an acrylic water tank, 0.06 mL of Definity and varied amounts of Visipaque (0.14, 0.43, 0.85, and 1.70 mL) were added to 425 mL of deionized water. Ultrasound scanning was performed with a SonixTablet scanner (BK Medical Systems) using optimized parameters for SHAPE with Definity (ftransmit/receive = 3.0/1.5 MHz; chirp down pulse). Subharmonic data was acquired and analyzed at 9 different incident acoustic outputs (n = 3). Results...
Source: Ultrasonic Imaging - February 6, 2024 Category: Radiology Authors: Cara Esposito Kenneth Tzan Priscilla Machado Flemming Forsberg Jaydev K Dave Source Type: research
Cancers, Vol. 16, Pages 694: Cancer Cell Biomechanical Properties Accompany Tspan8-Dependent Cutaneous Melanoma Invasion
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Ingrid Masse
The intrinsic biomechanical properties of cancer cells remain poorly understood. To decipher whether cell stiffness modulation could increase melanoma cells’ invasive capacity, we performed both in vitro and in vivo experiments exploring cell stiffness by atomic force microscopy (AFM). We correlated stiffness properties with cell morphology adaptation and the molecular mechanisms underlying epithelial-to-mesenchymal (EMT)-like phenotype switching. We found that melanoma cell stiffness reduction was systematically associated with the acquisition of invasive properties in cutaneous melano...
Source: Cancers - February 6, 2024 Category: Cancer & Oncology Authors: Ga ël Runel No émie Lopez-Ramirez Laetitia Barbollat-Boutrand Muriel Cario Simon Durand Maxime Grimont Manfred Schartl St éphane Dalle Julie Caramel Julien Chlasta Ingrid Masse Tags: Article Source Type: research
Spatial perception in stereoscopic augmented reality based on multifocus sensing
In many areas ranging from medical imaging to visual entertainment, 3D information acquisition and display is a key task. In this regard, ... (Source: Optics Express)
Source: Optics Express - February 5, 2024 Category: Physics Authors: Julia R. Alonso Ariel Fern á ndez Bahram Javidi Source Type: research
Sensors, Vol. 24, Pages 1040: Multi-Stage Learning Framework Using Convolutional Neural Network and Decision Tree-Based Classification for Detection of DDoS Pandemic Attacks in SDN-Based SCADA Systems
This study proposes a multi-stage learning model using a 1-dimensional convolutional neural network (1D-CNN) and decision tree-based classification to detect DDoS attacks in SDN-based SCADA systems effectively. A new dataset containing various attack scenarios on a specific experimental network topology was created to be used in the training and testing phases of this model. According to the experimental results of this study, the proposed model achieved a 97.8% accuracy rate in DDoS-attack detection. The proposed multi-stage learning model shows that high-performance results can be achieved in detecting DDoS attacks again...
Source: Sensors - February 5, 2024 Category: Biotechnology Authors: Onur Polat Muammer T ürkoğlu H üseyin Polat Saadin Oyucu H üseyin Üzen Fahri Yard ımcı Ahmet Aks öz Tags: Article Source Type: research
Sensors, Vol. 24, Pages 1027: Examination of Traditional Botnet Detection on IoT-Based Bots
wland
A botnet is a collection of Internet-connected computers that have been suborned and are controlled externally for malicious purposes. Concomitant with the growth of the Internet of Things (IoT), botnets have been expanding to use IoT devices as their attack vectors. IoT devices utilise specific protocols and network topologies distinct from conventional computers that may render detection techniques ineffective on compromised IoT devices. This paper describes experiments involving the acquisition of several traditional botnet detection techniques, BotMiner, BotProbe, and BotHunter, to evaluate their capabilities...
Source: Sensors - February 5, 2024 Category: Biotechnology Authors: Ashley Woodiss-Field Michael N. Johnstone Paul Haskell-Dowland Tags: Article Source Type: research
Addressing Parental Gatekeeping in Early-Intervention Services: Engaging all Caregivers
This article examines parental gatekeeping—a concept from the family science literature that can have a significant impact on services provided by speech language pathologists (SLPs). We outline and provide examples of family dynamics that may pose challenges to SLPs working with young children and their families as well as provide strategies for effectively navigating and working within these dynamics. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Seminars in Speech and Language)
Source: Seminars in Speech and Language - February 5, 2024 Category: Speech-Language Pathology Authors: Puhlman, Daniel J. Puhlman, Jane Tags: Clinical Seminar: Pediatric Source Type: research
Using the Structural Influence Model to Explore U.S. Latina/O/X/E Undocumented Immigrants ’ COVID-19 Information Acquisition, Perceptions, and Prevention Behaviors
. (Source: Health Communication)
Source: Health Communication - February 5, 2024 Category: Health Management Authors: Nancy Molina-RogersJennifer A. KamMonica CornejoRoselia Mendez Murilloa Department of Communication, University of Californiab Department of Communication, Cornell Universityc Department of Communication Studies, University of Texas Source Type: research
Genomic analysis of Ralstonia pickettii reveals the genetic features for potential pathogenicity and adaptive evolution in drinking water
This study provides comprehensive insights into the potential pathogenicity and adaptive evolution of Ralstonia pickettii in drinking water environments from a genomic perspective. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - February 2, 2024 Category: Microbiology Source Type: research
