Genes, Vol. 15, Pages 22: Rare Deletions or Large Duplications Contribute to Genetic Variation in Patients with Severe Tinnitus and Meniere Disease
In this study, we analyzed exome sequencing data from 310 MD Spanish patients and selected 75 patients with severe tinnitus based on a Tinnitus Handicap Inventory (THI) score > 68. Three rare deletions were identified in two unrelated individuals overlapping the ERBB3 gene in the positions: NC_000012.12:g.56100028_56100172del, NC_000012.12:g.56100243_56101058del, and NC_000012.12:g.56101359_56101526del. Moreover, an ultra-rare large duplication was found covering the AP4M1, COPS6, MCM7, TAF6, MIR106B, MIR25, and MIR93 genes in another two patients in the NC_000007.14:g.100089053_100112257dup region. All the codi...
Source: Genes - December 22, 2023 Category: Genetics & Stem Cells Authors: Alba Escalera-Balsera Alberto M. Parra-Perez Alvaro Gallego-Martinez Lidia Frejo Juan Martin-Lagos Victoria Rivero de Jesus Paz P érez-Vázquez Patricia Perez-Carpena Jose A. Lopez-Escamez Tags: Article Source Type: research
Endolymphatic hydrops asymmetry distinguishes patients with Meniere ’s disease from normal controls with high sensitivity and specificity
ConclusionCompared to conventional semiquantitative grading or quantitative EH% analysis, EH asymmetry may better distinguish MD patients from normal controls. Quantitative hydrops volumetric analysis yields clinically relevant information on inner ear function. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - December 21, 2023 Category: Neurology Source Type: research
Trends in the incidence of peripheral vestibular disorders: a Nationwide population-based study
ConclusionThe incidence of peripheral vestibular disorders, overall, and the four major subgroups, benign paroxysmal positional vertigo, Meniere’s disease, vestibular neuritis, and other peripheral vestibular dizziness, all decreased substantially, year by year within the 2010–2018 period. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - December 12, 2023 Category: Neurology Source Type: research
Redox Modulation of Meniere Disease by Coriolus Versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential
CONCLUSIONS: Our study suggests MD as a model of cochlear neurodegenerative disease for the identification of potent inducers of the Nrf2-vitagene pathway, able to reduce the deleterious consequences associated with neurodegenerative damage, probably by indirectly acting on α-synuclein expression and on inflammatory processes NF- kB-mediated.PMID:38073105 | DOI:10.2174/1570159X22666231206153936 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Rosanna Di Paola Rosalba Siracusa Roberta Fusco Marialaura Ontario Gaetano Cammilleri Licia Pantano Maria Scuto Mario Tomasello Sestina Span ò Angela Trovato Salinaro Ali S Abdelhameed Vincenzo Ferrantelli Antonio Arcidiacono Tilman Fritsch Gabriella Lup Source Type: research
Redox Modulation of Meniere Disease by Coriolus Versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential
CONCLUSIONS: Our study suggests MD as a model of cochlear neurodegenerative disease for the identification of potent inducers of the Nrf2-vitagene pathway, able to reduce the deleterious consequences associated with neurodegenerative damage, probably by indirectly acting on α-synuclein expression and on inflammatory processes NF- kB-mediated.PMID:38073105 | DOI:10.2174/1570159X22666231206153936 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Rosanna Di Paola Rosalba Siracusa Roberta Fusco Marialaura Ontario Gaetano Cammilleri Licia Pantano Maria Scuto Mario Tomasello Sestina Span ò Angela Trovato Salinaro Ali S Abdelhameed Vincenzo Ferrantelli Antonio Arcidiacono Tilman Fritsch Gabriella Lup Source Type: research
Redox Modulation of Meniere Disease by Coriolus Versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential
CONCLUSIONS: Our study suggests MD as a model of cochlear neurodegenerative disease for the identification of potent inducers of the Nrf2-vitagene pathway, able to reduce the deleterious consequences associated with neurodegenerative damage, probably by indirectly acting on α-synuclein expression and on inflammatory processes NF- kB-mediated.PMID:38073105 | DOI:10.2174/1570159X22666231206153936 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Rosanna Di Paola Rosalba Siracusa Roberta Fusco Marialaura Ontario Gaetano Cammilleri Licia Pantano Maria Scuto Mario Tomasello Sestina Span ò Angela Trovato Salinaro Ali S Abdelhameed Vincenzo Ferrantelli Antonio Arcidiacono Tilman Fritsch Gabriella Lup Source Type: research
Redox Modulation of Meniere Disease by Coriolus Versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential
CONCLUSIONS: Our study suggests MD as a model of cochlear neurodegenerative disease for the identification of potent inducers of the Nrf2-vitagene pathway, able to reduce the deleterious consequences associated with neurodegenerative damage, probably by indirectly acting on α-synuclein expression and on inflammatory processes NF- kB-mediated.PMID:38073105 | DOI:10.2174/1570159X22666231206153936 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Rosanna Di Paola Rosalba Siracusa Roberta Fusco Marialaura Ontario Gaetano Cammilleri Licia Pantano Maria Scuto Mario Tomasello Sestina Span ò Angela Trovato Salinaro Ali S Abdelhameed Vincenzo Ferrantelli Antonio Arcidiacono Tilman Fritsch Gabriella Lup Source Type: research
Redox Modulation of Meniere Disease by Coriolus Versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential
CONCLUSIONS: Our study suggests MD as a model of cochlear neurodegenerative disease for the identification of potent inducers of the Nrf2-vitagene pathway, able to reduce the deleterious consequences associated with neurodegenerative damage, probably by indirectly acting on α-synuclein expression and on inflammatory processes NF- kB-mediated.PMID:38073105 | DOI:10.2174/1570159X22666231206153936 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Rosanna Di Paola Rosalba Siracusa Roberta Fusco Marialaura Ontario Gaetano Cammilleri Licia Pantano Maria Scuto Mario Tomasello Sestina Span ò Angela Trovato Salinaro Ali S Abdelhameed Vincenzo Ferrantelli Antonio Arcidiacono Tilman Fritsch Gabriella Lup Source Type: research
Redox Modulation of Meniere Disease by Coriolus Versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential
CONCLUSIONS: Our study suggests MD as a model of cochlear neurodegenerative disease for the identification of potent inducers of the Nrf2-vitagene pathway, able to reduce the deleterious consequences associated with neurodegenerative damage, probably by indirectly acting on α-synuclein expression and on inflammatory processes NF- kB-mediated.PMID:38073105 | DOI:10.2174/1570159X22666231206153936 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Rosanna Di Paola Rosalba Siracusa Roberta Fusco Marialaura Ontario Gaetano Cammilleri Licia Pantano Maria Scuto Mario Tomasello Sestina Span ò Angela Trovato Salinaro Ali S Abdelhameed Vincenzo Ferrantelli Antonio Arcidiacono Tilman Fritsch Gabriella Lup Source Type: research
Redox Modulation of Meniere Disease by Coriolus Versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential
CONCLUSIONS: Our study suggests MD as a model of cochlear neurodegenerative disease for the identification of potent inducers of the Nrf2-vitagene pathway, able to reduce the deleterious consequences associated with neurodegenerative damage, probably by indirectly acting on α-synuclein expression and on inflammatory processes NF- kB-mediated.PMID:38073105 | DOI:10.2174/1570159X22666231206153936 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Rosanna Di Paola Rosalba Siracusa Roberta Fusco Marialaura Ontario Gaetano Cammilleri Licia Pantano Maria Scuto Mario Tomasello Sestina Span ò Angela Trovato Salinaro Ali S Abdelhameed Vincenzo Ferrantelli Antonio Arcidiacono Tilman Fritsch Gabriella Lup Source Type: research
Redox Modulation of Meniere Disease by Coriolus Versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential
CONCLUSIONS: Our study suggests MD as a model of cochlear neurodegenerative disease for the identification of potent inducers of the Nrf2-vitagene pathway, able to reduce the deleterious consequences associated with neurodegenerative damage, probably by indirectly acting on α-synuclein expression and on inflammatory processes NF- kB-mediated.PMID:38073105 | DOI:10.2174/1570159X22666231206153936 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Rosanna Di Paola Rosalba Siracusa Roberta Fusco Marialaura Ontario Gaetano Cammilleri Licia Pantano Maria Scuto Mario Tomasello Sestina Span ò Angela Trovato Salinaro Ali S Abdelhameed Vincenzo Ferrantelli Antonio Arcidiacono Tilman Fritsch Gabriella Lup Source Type: research
Redox Modulation of Meniere Disease by Coriolus Versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential
CONCLUSIONS: Our study suggests MD as a model of cochlear neurodegenerative disease for the identification of potent inducers of the Nrf2-vitagene pathway, able to reduce the deleterious consequences associated with neurodegenerative damage, probably by indirectly acting on α-synuclein expression and on inflammatory processes NF- kB-mediated.PMID:38073105 | DOI:10.2174/1570159X22666231206153936 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Rosanna Di Paola Rosalba Siracusa Roberta Fusco Marialaura Ontario Gaetano Cammilleri Licia Pantano Maria Scuto Mario Tomasello Sestina Span ò Angela Trovato Salinaro Ali S Abdelhameed Vincenzo Ferrantelli Antonio Arcidiacono Tilman Fritsch Gabriella Lup Source Type: research
Redox Modulation of Meniere Disease by Coriolus Versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential
CONCLUSIONS: Our study suggests MD as a model of cochlear neurodegenerative disease for the identification of potent inducers of the Nrf2-vitagene pathway, able to reduce the deleterious consequences associated with neurodegenerative damage, probably by indirectly acting on α-synuclein expression and on inflammatory processes NF- kB-mediated.PMID:38073105 | DOI:10.2174/1570159X22666231206153936 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Rosanna Di Paola Rosalba Siracusa Roberta Fusco Marialaura Ontario Gaetano Cammilleri Licia Pantano Maria Scuto Mario Tomasello Sestina Span ò Angela Trovato Salinaro Ali S Abdelhameed Vincenzo Ferrantelli Antonio Arcidiacono Tilman Fritsch Gabriella Lup Source Type: research
Redox Modulation of Meniere Disease by Coriolus Versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential
CONCLUSIONS: Our study suggests MD as a model of cochlear neurodegenerative disease for the identification of potent inducers of the Nrf2-vitagene pathway, able to reduce the deleterious consequences associated with neurodegenerative damage, probably by indirectly acting on α-synuclein expression and on inflammatory processes NF- kB-mediated.PMID:38073105 | DOI:10.2174/1570159X22666231206153936 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Rosanna Di Paola Rosalba Siracusa Roberta Fusco Marialaura Ontario Gaetano Cammilleri Licia Pantano Maria Scuto Mario Tomasello Sestina Span ò Angela Trovato Salinaro Ali S Abdelhameed Vincenzo Ferrantelli Antonio Arcidiacono Tilman Fritsch Gabriella Lup Source Type: research
Redox Modulation of Meniere Disease by Coriolus Versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential
CONCLUSIONS: Our study suggests MD as a model of cochlear neurodegenerative disease for the identification of potent inducers of the Nrf2-vitagene pathway, able to reduce the deleterious consequences associated with neurodegenerative damage, probably by indirectly acting on α-synuclein expression and on inflammatory processes NF- kB-mediated.PMID:38073105 | DOI:10.2174/1570159X22666231206153936 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Rosanna Di Paola Rosalba Siracusa Roberta Fusco Marialaura Ontario Gaetano Cammilleri Licia Pantano Maria Scuto Mario Tomasello Sestina Span ò Angela Trovato Salinaro Ali S Abdelhameed Vincenzo Ferrantelli Antonio Arcidiacono Tilman Fritsch Gabriella Lup Source Type: research
