Brain Tumors in Adolescents and Young Adults: A Review
Semin Neurol DOI: 10.1055/s-0043-1776775Brain tumors account for the majority of cancer-related deaths in adolescents and young adults (AYAs), defined as individuals aged 15 to 39. AYAs constitute a distinct population in which both pediatric- and adult-type central nervous system (CNS) tumors can be observed. Clinical manifestations vary depending on tumor location and often include headaches, seizures, focal neurological deficits, and signs of increased intracranial pressure. With the publication of the updated World Health Organization CNS tumor classification in 2021, diagnoses have been redefined to emphasize key mole...
Source: Seminars in Neurology - November 10, 2023 Category: Neurology Authors: Rousseau, Julien Bennett, Julie Lim-Fat, Mary Jane Tags: Review Article Source Type: research
Recent Advances in Pediatric Medulloblastoma
AbstractPurpose of ReviewReview recent advances in the understanding of pediatric medulloblastoma including etiology, biology, radiology, and management of pediatric medulloblastoma.Recent FindingsThe classic four subgroups have been reclassified and further subdivided based on new molecular findings. Research is revealing the cell origins of the different subtypes of medulloblastoma. There has been continued personalization of management based on molecular parameters.SummaryWhile many advances have been made in the knowledge base of this most common malignant pediatric brain tumor, there has not yet been translation into ...
Source: Current Neurology and Neuroscience Reports - November 9, 2023 Category: Neuroscience Source Type: research
Dosimetric impact of adding non-coplanar arcs for scalp-avoidance whole-brain irradiation with volumetric-modulated arc radiotherapy on scalp dose reduction in pediatric patients with medulloblastomas
CONCLUSION: NcVMAT could reduce the EQD50%scalp of the top area below the cut-off dose of 19.9 Gy. NcVMAT appears to be a promising treatment technique for SAWB-VMAT.PMID:37917885 | DOI:10.1002/acm2.14189 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - November 2, 2023 Category: Physics Authors: Daichi Torizuka Megumi Uto Takashi Mizowaki Source Type: research
Dosimetric impact of adding non-coplanar arcs for scalp-avoidance whole-brain irradiation with volumetric-modulated arc radiotherapy on scalp dose reduction in pediatric patients with medulloblastomas
CONCLUSION: NcVMAT could reduce the EQD50%scalp of the top area below the cut-off dose of 19.9 Gy. NcVMAT appears to be a promising treatment technique for SAWB-VMAT.PMID:37917885 | DOI:10.1002/acm2.14189 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - November 2, 2023 Category: Physics Authors: Daichi Torizuka Megumi Uto Takashi Mizowaki Source Type: research
Survival nomogram for medulloblastoma and multi-center external validation cohort
Conclusion: This study developed a nomogram that incorporates clinical and molecular factors to predict OS prognosis in medulloblastoma patients. The nomogram exhibited improved predictive accuracy compared to previous studies and demonstrated good performance in the external validation cohort. By considering multiple factors, clinicians can utilize this nomogram as a valuable tool for individualized prognosis prediction and treatment decision-making in medulloblastoma patients. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 2, 2023 Category: Drugs & Pharmacology Source Type: research
GSE188813 RNA sequencing analysis of stable medulloblastoma DAOY, D425, and CHLA01 cells expressing vector only (V/O) or miR-211
Contributors : Menglang Yuan ; Keisuke Katsushma ; Rudramani Pokhrel ; Bongyong Lee ; Ranjan J PereraSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the role of miR-211 in medulloblastoma, next-generation sequencing analysis of RNA extracted from DAOY, D425, and CHLA01 cells expressing vector only (V/O) or miR-211 were performed. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - November 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE232749 Genomic maps of lnc-HLX-2-7 occupancy in human medulloblastoma cell line.
Contributors : Keisuke Katsushma ; Rabi Murad ; Kandarp Joshi ; Menglang Yuan ; Ranjan J PereraSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo gain more insights into the functional significance of lnc-HLX-2-7 in human medulloblastoma, genomic mapping of lnc-HLX-2-7 occupancy were analyzied by ChIRP DNA sequencing. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - November 1, 2023 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
Pediatric neurosurgical-oncology scope and management paradigms in Sub-Saharan Africa: a collaboration among 7 referral hospitals on the subcontinent
ConclusionThe histopathologic variety of pediatric brain and spinal tumors managed across 7 SSA referral hospitals was similar to published accounts from other parts of the world. About two-thirds of patients received a tumor-directed surgery with significant inter-institutional variability. Less than a third of patients received adjuvant therapy when indicated. Multi-dimensional capacity building efforts in neuro-oncology are necessary to approach parity in the management of children with brain and spinal tumors in SSA. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - November 1, 2023 Category: Cancer & Oncology Source Type: research
Clinical implementation of robust vmat treatment workflow for cranio-spinal radiotherapy in medulloblastoma patients
(Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - November 1, 2023 Category: General Medicine Authors: E. De Martin, M. Stroppi, F. Puglia, M.L. Fumagalli, F. Ghielmetti, S. Morlino, R. Pellegrini, L. Fariselli Tags: ORAL COMMUNICATIONS Source Type: research
The identification of BCL-XL and MCL-1 as key anti-apoptotic proteins in medulloblastoma that mediate distinct roles in chemotherapy resistance
Cell Death & Disease, Published online: 28 October 2023; doi:10.1038/s41419-023-06231-yThe identification of BCL-XL and MCL-1 as key anti-apoptotic proteins in medulloblastoma that mediate distinct roles in chemotherapy resistance (Source: Cell death and disease)
Source: Cell death and disease - October 28, 2023 Category: Internal Medicine Authors: Marie-Claire Fitzgerald Philip J. O ’Halloran Sean A. Kerrane Triona N í Chonghaile Niamh M. C. Connolly Brona M. Murphy Source Type: research
Mitochondrial subtype < em > MB-G3 < /em > contains potential novel biomarkers and therapeutic targets associated with prognosis of medulloblastoma
CONCLUSIONS: We show the importance of mitochondria and compare their role in the four different medulloblastoma groups.PMID:37886818 | DOI:10.1080/1354750X.2023.2276670 (Source: Biomarkers)
Source: Biomarkers - October 27, 2023 Category: Research Authors: Qiang Li Yanfei Jia Bo Tang Hu Yang Qiang Yang Xiaodong Luo Yawen Pan Source Type: research
GSE239854 Single nuclei RNA-seq profiles from medulloblastoma tumors with extensive nodularity
Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - October 26, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE239853 Single nuclei RNA-seq profiles from medulloblastoma tumors with extensive nodularity [bulk RNA-Seq]
Contributors : David R Ghasemi ; Konstantin OkonechnikovSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMedulloblastoma with extensive nodularity (MBEN) are cerebellar tumors with two histologically distinct compartments and varying disease course. We invetiagated this tumor class in detail with single cell transcriptome analysis confirmed with inter-nodular microdissected bulk profiles. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - October 26, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
