Tumour follower cells: A novel driver of leader cells in collective invasion (Review)
Int J Oncol. 2023 Oct;63(4):115. doi: 10.3892/ijo.2023.5563. Epub 2023 Aug 24.ABSTRACTCollective cellular invasion in malignant tumours is typically characterized by the cooperative migration of multiple cells in close proximity to each other. Follower cells are led away from the tumour by specialized leader cells, and both cell populations play a crucial role in collective invasion. Follower cells form the main body of the migration system and depend on intercellular contact for migration, whereas leader cells indicate the direction for the entire cell population. Although collective invasion can occur in epithelial and n...
Source: International Journal of Oncology - August 24, 2023 Category: Cancer & Oncology Authors: Xiao-Chen Wang Ya-Ling Tang Xin-Hua Liang Source Type: research
Tumour follower cells: A novel driver of leader cells in collective invasion (Review)
Int J Oncol. 2023 Oct;63(4):115. doi: 10.3892/ijo.2023.5563. Epub 2023 Aug 24.ABSTRACTCollective cellular invasion in malignant tumours is typically characterized by the cooperative migration of multiple cells in close proximity to each other. Follower cells are led away from the tumour by specialized leader cells, and both cell populations play a crucial role in collective invasion. Follower cells form the main body of the migration system and depend on intercellular contact for migration, whereas leader cells indicate the direction for the entire cell population. Although collective invasion can occur in epithelial and n...
Source: International Journal of Oncology - August 24, 2023 Category: Cancer & Oncology Authors: Xiao-Chen Wang Ya-Ling Tang Xin-Hua Liang Source Type: research
Tumour follower cells: A novel driver of leader cells in collective invasion (Review)
Int J Oncol. 2023 Oct;63(4):115. doi: 10.3892/ijo.2023.5563. Epub 2023 Aug 24.ABSTRACTCollective cellular invasion in malignant tumours is typically characterized by the cooperative migration of multiple cells in close proximity to each other. Follower cells are led away from the tumour by specialized leader cells, and both cell populations play a crucial role in collective invasion. Follower cells form the main body of the migration system and depend on intercellular contact for migration, whereas leader cells indicate the direction for the entire cell population. Although collective invasion can occur in epithelial and n...
Source: International Journal of Oncology - August 24, 2023 Category: Cancer & Oncology Authors: Xiao-Chen Wang Ya-Ling Tang Xin-Hua Liang Source Type: research
Tumour follower cells: A novel driver of leader cells in collective invasion (Review)
Int J Oncol. 2023 Oct;63(4):115. doi: 10.3892/ijo.2023.5563. Epub 2023 Aug 24.ABSTRACTCollective cellular invasion in malignant tumours is typically characterized by the cooperative migration of multiple cells in close proximity to each other. Follower cells are led away from the tumour by specialized leader cells, and both cell populations play a crucial role in collective invasion. Follower cells form the main body of the migration system and depend on intercellular contact for migration, whereas leader cells indicate the direction for the entire cell population. Although collective invasion can occur in epithelial and n...
Source: International Journal of Oncology - August 24, 2023 Category: Cancer & Oncology Authors: Xiao-Chen Wang Ya-Ling Tang Xin-Hua Liang Source Type: research
Tumour follower cells: A novel driver of leader cells in collective invasion (Review)
Int J Oncol. 2023 Oct;63(4):115. doi: 10.3892/ijo.2023.5563. Epub 2023 Aug 24.ABSTRACTCollective cellular invasion in malignant tumours is typically characterized by the cooperative migration of multiple cells in close proximity to each other. Follower cells are led away from the tumour by specialized leader cells, and both cell populations play a crucial role in collective invasion. Follower cells form the main body of the migration system and depend on intercellular contact for migration, whereas leader cells indicate the direction for the entire cell population. Although collective invasion can occur in epithelial and n...
Source: International Journal of Oncology - August 24, 2023 Category: Cancer & Oncology Authors: Xiao-Chen Wang Ya-Ling Tang Xin-Hua Liang Source Type: research
Tumour follower cells: A novel driver of leader cells in collective invasion (Review)
Int J Oncol. 2023 Oct;63(4):115. doi: 10.3892/ijo.2023.5563. Epub 2023 Aug 24.ABSTRACTCollective cellular invasion in malignant tumours is typically characterized by the cooperative migration of multiple cells in close proximity to each other. Follower cells are led away from the tumour by specialized leader cells, and both cell populations play a crucial role in collective invasion. Follower cells form the main body of the migration system and depend on intercellular contact for migration, whereas leader cells indicate the direction for the entire cell population. Although collective invasion can occur in epithelial and n...
Source: International Journal of Oncology - August 24, 2023 Category: Cancer & Oncology Authors: Xiao-Chen Wang Ya-Ling Tang Xin-Hua Liang Source Type: research
Genes, Vol. 14, Pages 1670: Simultaneous Occurrence of Multiple Neoplasms in Children with Cancer Predisposition Syndromes: Collaborating with Abnormal Genes
This article aims to provide a comprehensive analysis of three unique cases involving pediatric patients with CPS who were diagnosed with multiple simultaneous or metachronous cancers. The first case involves a child with embryonal rhabdomyosarcoma, nephroblastoma, glioma, and subsequent medulloblastoma. Genetic analysis identified two pathogenic variants in the BRCA2 gene. The second case involves a child with alveolar rhabdomyosarcoma, juvenile xanthogranuloma, gliomas, and subsequent JMML/MDS/MPS. A pathogenic variant in the NF1 gene was identified. The third case involves a child with pleuropulmonary blastoma and pedia...
Source: Genes - August 24, 2023 Category: Genetics & Stem Cells Authors: Gabriela Telman Ewa Strauss Patrycja Sosnowska-Sienkiewicz Magdalena Halasz Danuta Januszkiewicz-Lewandowska Tags: Article Source Type: research
< em > hGFAP < /em > -mediated < em > GLI2 < /em > overexpression leads to early death and severe cerebellar malformations with rare tumor formation
iScience. 2023 Jul 28;26(9):107501. doi: 10.1016/j.isci.2023.107501. eCollection 2023 Sep 15.ABSTRACTThe zinc-finger transcription factor GLI2 is frequently amplified in childhood medulloblastoma of the Sonic-hedgehog type (SHH-MB), with or without amplification of NMYC or deletion of TP53. Despite the aggressive tumor behavior, tumorigenesis is not well understood, and adequate mouse models are lacking. Therefore, we generated mice with a GLI2 overexpression under control of the hGFAP-promoter. These mice died within 150 days. The majority only survived until postnatal day 40. They displayed severe cerebellar hypoplasia, ...
Source: Cancer Control - August 23, 2023 Category: Cancer & Oncology Authors: Judith Niesen Irm Hermans-Borgmeyer Christina Kr üger Melanie Schoof Franziska Modemann Ulrich Sch üller Source Type: research
GSE210723 EpiGe: A cytosine methyl-genotyping PCR-based machine-learning tool for rapid classification of medulloblastoma
Contributors : Cinzia Lavarino ; Soledad G ómez-GonzálezSeries Type : Methylation profiling by arrayOrganism : Homo sapiensMolecular classification of medulloblastoma is critical for the correct treatment of this malignant paediatric brain tumour. The analysis of genome-wide DNA methylation patterns has profoundly improved diagnostic precision and classification of brain tumours. However, the implementation of DNA methylation microarrays in daily clinical practice can be time-consuming, costly and inaccessible for many centres worldwide. We aimed to develop a machine-learning decision support system for rapid and cost-...
Source: GEO: Gene Expression Omnibus - August 23, 2023 Category: Genetics & Stem Cells Tags: Methylation profiling by array Homo sapiens Source Type: research
Cancer data quality and harmonization in Europe: the experience of the BENCHISTA Project – international benchmarking of childhood cancer survival by stage
ConclusionDifferences in interpretation and processes required to harmonize general data protection regulations across countries were encountered causing delays in data transfer. Despite challenges, the BENCHISTA Project has established a large collaboration between PBCRs and clinicians to collect detailed and standardised TG at a population-level enhancing the understanding of the reasons for variation in overall survival rates for CC, stimulate research and improve national/regional child health plans. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - August 22, 2023 Category: Cancer & Oncology Source Type: research
Research of Pesticide Metabolites in Human Brain Tumor Tissues by Chemometrics-Based Gas Chromatography-Mass Spectrometry Analysis for a Hypothetical Correlation between Pesticide Exposure and Risk Factor of Central Nervous System Tumors
ACS Omega. 2023 Aug 3;8(32):29812-29835. doi: 10.1021/acsomega.3c04592. eCollection 2023 Aug 15.ABSTRACTPesticides are widely used, resulting in continuing human exposure with potential health impacts. Some exposures related to agricultural works have been associated with neurological disorders. Since the 2000s, the hypothesis of the role of pesticides in the occurrence of central nervous system (CNS) tumors has been better documented in the literature. However, the etiology of childhood brain cancers still remains largely unknown. The major objective of this work was to assess the potential role of pesticide exposure as a...
Source: Cancer Control - August 21, 2023 Category: Cancer & Oncology Authors: Kaouthar Louati Fatma Kolsi Rim Kallel Yassine Gdoura Mahdi Borni Leila Sellami Hakim Rania Zribi Sirine Choura Amina Maalej Sami Sayadi Mohamed Chamkha Basma Mnif Zouheir Khemakhem Tahya Sellami Boudawara Mohamed Zaher Boudawara Fathi Safta Source Type: research
MYC up-regulation confers vulnerability to dual inhibition of CDK12 and CDK13 in high-risk Group 3 medulloblastoma
Medulloblastoma (MB) is the most common cerebellar malignancy during childhood. Among MB, MYC-amplified Group 3 tumors display the worst prognosis. MYC is an oncogenic transcription factor currently thought to... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - August 21, 2023 Category: Cancer & Oncology Authors: Consuelo Pitolli, Alberto Marini, Marika Guerra, Marco Pieraccioli, Veronica Marabitti, Fernando Palluzzi, Luciano Giac ò, Gianpiero Tamburrini, Francesco Cecconi, Francesca Nazio, Claudio Sette and Vittoria Pagliarini Tags: Research Source Type: research
KCTD1 is a new modulator of the KCASH family of Hedgehog suppressors
Neoplasia. 2023 Aug 17;43:100926. doi: 10.1016/j.neo.2023.100926. Online ahead of print.ABSTRACTThe Sonic Hedgehog (Hh) signal transduction pathway plays a critical role in many developmental processes and, when deregulated, may contribute to several cancers, including basal cell carcinoma, medulloblastoma, colorectal, prostate, and pancreatic cancer. In recent years, several Hh inhibitors have been developed, mainly acting on the Smo receptor. However, drug resistance due to Smo mutations or non-canonical Hh pathway activation highlights the need to identify further mechanisms of Hh pathway modulation. Among these, deacet...
Source: Neoplasia - August 19, 2023 Category: Cancer & Oncology Authors: A Di Fiore S Bellardinelli L Pirone R Russo A Angrisani G Terriaca M Bowen F Bordin Z M Besharat G Canettieri F Fabretti S Di Gaetano L Di Marcotullio E Pedone M Moretti E De Smaele Source Type: research
KCTD1 is a new modulator of the KCASH family of Hedgehog suppressors
Neoplasia. 2023 Aug 17;43:100926. doi: 10.1016/j.neo.2023.100926. Online ahead of print.ABSTRACTThe Sonic Hedgehog (Hh) signal transduction pathway plays a critical role in many developmental processes and, when deregulated, may contribute to several cancers, including basal cell carcinoma, medulloblastoma, colorectal, prostate, and pancreatic cancer. In recent years, several Hh inhibitors have been developed, mainly acting on the Smo receptor. However, drug resistance due to Smo mutations or non-canonical Hh pathway activation highlights the need to identify further mechanisms of Hh pathway modulation. Among these, deacet...
Source: Neoplasia - August 19, 2023 Category: Cancer & Oncology Authors: A Di Fiore S Bellardinelli L Pirone R Russo A Angrisani G Terriaca M Bowen F Bordin Z M Besharat G Canettieri F Fabretti S Di Gaetano L Di Marcotullio E Pedone M Moretti E De Smaele Source Type: research
Oncolytic virus-driven immune remodeling revealed in mouse medulloblastomas at single cell resolution
Mol Ther Oncolytics. 2023 Jul 19;30:39-55. doi: 10.1016/j.omto.2023.07.006. eCollection 2023 Sep 21.ABSTRACTOncolytic viruses, modified for tumor-restricted infection, are a promising cancer immunotherapeutic, yet much remains to be understood about factors driving their activity and outcome in the tumor microenvironment. Here, we report that oncolytic herpes simplex virus C134, previously found to exert T cell-dependent efficacy in mouse models of glioblastoma, exerts T cell-independent efficacy in mouse models of medulloblastoma, indicating this oncolytic virus uses different mechanisms in different tumors. We investigat...
Source: Herpes - August 16, 2023 Category: Infectious Diseases Authors: Jack Hedberg Adam Studebaker Luke Smith Chun-Yu Chen Jesse J Westfall Maren Cam Amy Gross Ilse Hernandez-Aguirre Alexia Martin Doyeon Kim Ravi Dhital Yeaseul Kim Ryan D Roberts Timothy P Cripe Elaine R Mardis Kevin A Cassady Jeffrey Leonard Katherine E Mi Source Type: research
