Cancers, Vol. 15, Pages 4877: The Site of Origin of Medulloblastoma: Surgical Observations Correlated to Molecular Groups
This study aimed to analyze detailed intraoperative data with regard to the site of origin (STO) and compare these findings with the hypothesized regions of origin associated with the molecular group. A review of the institutional database identified 58 out of 72 pediatric patients who were operated for an MB at our department between 1996 and 2020 that had a detailed operative report and a surgical video as well as clinical and genetic classification data available for analysis. The STO was assessed based on intraoperative findings. Using the intraoperatively defined STO, “correct” prediction o...
Source: Cancers - October 7, 2023 Category: Cancer & Oncology Authors: Olga Ciobanu-Caraus Thomas Czech Andreas Peyrl Christine Haberler Gregor Kasprian Julia Furtner Marcel Kool Martin Sill Josa M. Frischer Anna Cho Irene Slavc Karl R össler Johannes Gojo Christian Dorfer Tags: Article Source Type: research
IFN- γ promotes radioresistant Nestin-expressing progenitor regeneration in the developing cerebellum by augmenting Shh ligand production
CONCLUSIONS: NEP was radioresistant and regenerative. IFN-γ was increased post irradiation to upregulate Shh ligand, contributing to NEP regeneration. Our study provides insight into the mechanisms of neural cell regeneration in irradiation injury of the developing cerebellum and will help to develop new therapeutic targets for minimizing the side effects of radiotherapy for brain tumors.PMID:37789668 | DOI:10.1111/cns.14485 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 4, 2023 Category: Neuroscience Authors: Jian Hu Zixuan Wang Biao Gong Liyuan Feng Yan Song Shuo Zhang Lin Wang Yanghui Qu Gen Li Li Zhang Chaonan Zheng Fang Du Peng Li Yuan Wang Source Type: research
IFN- γ promotes radioresistant Nestin-expressing progenitor regeneration in the developing cerebellum by augmenting Shh ligand production
CONCLUSIONS: NEP was radioresistant and regenerative. IFN-γ was increased post irradiation to upregulate Shh ligand, contributing to NEP regeneration. Our study provides insight into the mechanisms of neural cell regeneration in irradiation injury of the developing cerebellum and will help to develop new therapeutic targets for minimizing the side effects of radiotherapy for brain tumors.PMID:37789668 | DOI:10.1111/cns.14485 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 4, 2023 Category: Neuroscience Authors: Jian Hu Zixuan Wang Biao Gong Liyuan Feng Yan Song Shuo Zhang Lin Wang Yanghui Qu Gen Li Li Zhang Chaonan Zheng Fang Du Peng Li Yuan Wang Source Type: research
Class I HDAC inhibition reduces DNA damage repair capacity of MYC-amplified medulloblastoma cells
ConclusionOur study identifies the combination of entinostat with olaparib as a new potential therapeutic approach forMYC-driven Group 3 MB. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 3, 2023 Category: Cancer & Oncology Source Type: research
Design, synthesis and biological evaluation of novel 2,4-thiazolidinedione derivatives able to target the human BAG3 protein
In conclusion we have demonstrated that FB49 is a new derivative able to bind human BAG3 with high affinity and could be used as BAG3 modulator in cancers correlated with overexpression of this protein.PMID:37783101 | DOI:10.1016/j.ejmech.2023.115824 (Source: European Journal of Medicinal Chemistry)
Source: European Journal of Medicinal Chemistry - October 2, 2023 Category: Chemistry Authors: Federica Budassi Chiara Marchioro Martina Canton Annagiulia Favaro Mattia Sturlese Chiara Urbinati Marco Rusnati Romeo Romagnoli Giampietro Viola Elena Mariotto Source Type: research
Design, synthesis and biological evaluation of novel 2,4-thiazolidinedione derivatives able to target the human BAG3 protein
In conclusion we have demonstrated that FB49 is a new derivative able to bind human BAG3 with high affinity and could be used as BAG3 modulator in cancers correlated with overexpression of this protein.PMID:37783101 | DOI:10.1016/j.ejmech.2023.115824 (Source: European Journal of Medicinal Chemistry)
Source: European Journal of Medicinal Chemistry - October 2, 2023 Category: Chemistry Authors: Federica Budassi Chiara Marchioro Martina Canton Annagiulia Favaro Mattia Sturlese Chiara Urbinati Marco Rusnati Romeo Romagnoli Giampietro Viola Elena Mariotto Source Type: research
Meningeal macrophages inhibit chemokine signaling in pre-tumor cells to suppress mouse medulloblastoma initiation
Dev Cell. 2023 Sep 27:S1534-5807(23)00459-8. doi: 10.1016/j.devcel.2023.08.033. Online ahead of print.ABSTRACTThe microenvironment profoundly influences tumor initiation across numerous tissues but remains understudied in brain tumors. In the cerebellum, canonical Wnt signaling controlled by Norrin/Frizzled4 (Fzd4) activation in meningeal endothelial cells is a potent inhibitor of preneoplasia and tumor progression in mouse models of Sonic hedgehog medulloblastoma (Shh-MB). Single-cell transcriptome profiling and phenotyping of the meninges indicate that Norrin/Frizzled4 sustains the activation of meningeal macrophages (mM...
Source: Developmental Cell - September 29, 2023 Category: Cytology Authors: Nenad T Pokrajac Nicholas J A Tokarew Akshay Gurdita Arturo Ortin-Martinez Valerie A Wallace Source Type: research
Meningeal macrophages inhibit chemokine signaling in pre-tumor cells to suppress mouse medulloblastoma initiation
Dev Cell. 2023 Sep 27:S1534-5807(23)00459-8. doi: 10.1016/j.devcel.2023.08.033. Online ahead of print.ABSTRACTThe microenvironment profoundly influences tumor initiation across numerous tissues but remains understudied in brain tumors. In the cerebellum, canonical Wnt signaling controlled by Norrin/Frizzled4 (Fzd4) activation in meningeal endothelial cells is a potent inhibitor of preneoplasia and tumor progression in mouse models of Sonic hedgehog medulloblastoma (Shh-MB). Single-cell transcriptome profiling and phenotyping of the meninges indicate that Norrin/Frizzled4 sustains the activation of meningeal macrophages (mM...
Source: Cancer Control - September 29, 2023 Category: Cancer & Oncology Authors: Nenad T Pokrajac Nicholas J A Tokarew Akshay Gurdita Arturo Ortin-Martinez Valerie A Wallace Source Type: research
Meningeal macrophages inhibit chemokine signaling in pre-tumor cells to suppress mouse medulloblastoma initiation
Dev Cell. 2023 Sep 27:S1534-5807(23)00459-8. doi: 10.1016/j.devcel.2023.08.033. Online ahead of print.ABSTRACTThe microenvironment profoundly influences tumor initiation across numerous tissues but remains understudied in brain tumors. In the cerebellum, canonical Wnt signaling controlled by Norrin/Frizzled4 (Fzd4) activation in meningeal endothelial cells is a potent inhibitor of preneoplasia and tumor progression in mouse models of Sonic hedgehog medulloblastoma (Shh-MB). Single-cell transcriptome profiling and phenotyping of the meninges indicate that Norrin/Frizzled4 sustains the activation of meningeal macrophages (mM...
Source: Developmental Cell - September 29, 2023 Category: Cytology Authors: Nenad T Pokrajac Nicholas J A Tokarew Akshay Gurdita Arturo Ortin-Martinez Valerie A Wallace Source Type: research
Meningeal macrophages inhibit chemokine signaling in pre-tumor cells to suppress mouse medulloblastoma initiation
Dev Cell. 2023 Sep 27:S1534-5807(23)00459-8. doi: 10.1016/j.devcel.2023.08.033. Online ahead of print.ABSTRACTThe microenvironment profoundly influences tumor initiation across numerous tissues but remains understudied in brain tumors. In the cerebellum, canonical Wnt signaling controlled by Norrin/Frizzled4 (Fzd4) activation in meningeal endothelial cells is a potent inhibitor of preneoplasia and tumor progression in mouse models of Sonic hedgehog medulloblastoma (Shh-MB). Single-cell transcriptome profiling and phenotyping of the meninges indicate that Norrin/Frizzled4 sustains the activation of meningeal macrophages (mM...
Source: Developmental Cell - September 29, 2023 Category: Cytology Authors: Nenad T Pokrajac Nicholas J A Tokarew Akshay Gurdita Arturo Ortin-Martinez Valerie A Wallace Source Type: research
Meningeal macrophages inhibit chemokine signaling in pre-tumor cells to suppress mouse medulloblastoma initiation
Dev Cell. 2023 Sep 27:S1534-5807(23)00459-8. doi: 10.1016/j.devcel.2023.08.033. Online ahead of print.ABSTRACTThe microenvironment profoundly influences tumor initiation across numerous tissues but remains understudied in brain tumors. In the cerebellum, canonical Wnt signaling controlled by Norrin/Frizzled4 (Fzd4) activation in meningeal endothelial cells is a potent inhibitor of preneoplasia and tumor progression in mouse models of Sonic hedgehog medulloblastoma (Shh-MB). Single-cell transcriptome profiling and phenotyping of the meninges indicate that Norrin/Frizzled4 sustains the activation of meningeal macrophages (mM...
Source: Developmental Cell - September 29, 2023 Category: Cytology Authors: Nenad T Pokrajac Nicholas J A Tokarew Akshay Gurdita Arturo Ortin-Martinez Valerie A Wallace Source Type: research
Meningeal macrophages inhibit chemokine signaling in pre-tumor cells to suppress mouse medulloblastoma initiation
Dev Cell. 2023 Sep 27:S1534-5807(23)00459-8. doi: 10.1016/j.devcel.2023.08.033. Online ahead of print.ABSTRACTThe microenvironment profoundly influences tumor initiation across numerous tissues but remains understudied in brain tumors. In the cerebellum, canonical Wnt signaling controlled by Norrin/Frizzled4 (Fzd4) activation in meningeal endothelial cells is a potent inhibitor of preneoplasia and tumor progression in mouse models of Sonic hedgehog medulloblastoma (Shh-MB). Single-cell transcriptome profiling and phenotyping of the meninges indicate that Norrin/Frizzled4 sustains the activation of meningeal macrophages (mM...
Source: Developmental Cell - September 29, 2023 Category: Cytology Authors: Nenad T Pokrajac Nicholas J A Tokarew Akshay Gurdita Arturo Ortin-Martinez Valerie A Wallace Source Type: research
Meningeal macrophages inhibit chemokine signaling in pre-tumor cells to suppress mouse medulloblastoma initiation
Dev Cell. 2023 Sep 27:S1534-5807(23)00459-8. doi: 10.1016/j.devcel.2023.08.033. Online ahead of print.ABSTRACTThe microenvironment profoundly influences tumor initiation across numerous tissues but remains understudied in brain tumors. In the cerebellum, canonical Wnt signaling controlled by Norrin/Frizzled4 (Fzd4) activation in meningeal endothelial cells is a potent inhibitor of preneoplasia and tumor progression in mouse models of Sonic hedgehog medulloblastoma (Shh-MB). Single-cell transcriptome profiling and phenotyping of the meninges indicate that Norrin/Frizzled4 sustains the activation of meningeal macrophages (mM...
Source: Developmental Cell - September 29, 2023 Category: Cytology Authors: Nenad T Pokrajac Nicholas J A Tokarew Akshay Gurdita Arturo Ortin-Martinez Valerie A Wallace Source Type: research
Meningeal macrophages inhibit chemokine signaling in pre-tumor cells to suppress mouse medulloblastoma initiation
Dev Cell. 2023 Sep 27:S1534-5807(23)00459-8. doi: 10.1016/j.devcel.2023.08.033. Online ahead of print.ABSTRACTThe microenvironment profoundly influences tumor initiation across numerous tissues but remains understudied in brain tumors. In the cerebellum, canonical Wnt signaling controlled by Norrin/Frizzled4 (Fzd4) activation in meningeal endothelial cells is a potent inhibitor of preneoplasia and tumor progression in mouse models of Sonic hedgehog medulloblastoma (Shh-MB). Single-cell transcriptome profiling and phenotyping of the meninges indicate that Norrin/Frizzled4 sustains the activation of meningeal macrophages (mM...
Source: Developmental Cell - September 29, 2023 Category: Cytology Authors: Nenad T Pokrajac Nicholas J A Tokarew Akshay Gurdita Arturo Ortin-Martinez Valerie A Wallace Source Type: research
GSE235924 MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice
Contributors : Carolin G öbel ; Shweta Godbole ; Melanie Schoof ; Dörthe Holdhof ; Catena Kresbach ; Carolin Loose ; Ulrich SchüllerSeries Type : Methylation profiling by arrayOrganism : Mus musculusGroup 3 medulloblastoma is one of the most aggressive types of childhood brain tumors. Roughly 30% of cases carry genetic alterations in MYC, SMARCA4, or both genes combined. While overexpression of MYC has previously been shown to drive medulloblastoma formation in mice, the functional significance of SMARCA4 mutations and their suitability as a therapeutic target remain largely unclear. To address this issue, we com...
Source: GEO: Gene Expression Omnibus - September 26, 2023 Category: Genetics & Stem Cells Tags: Methylation profiling by array Mus musculus Source Type: research
