Design, synthesis and biological evaluation of novel 2,4-thiazolidinedione derivatives able to target the human BAG3 protein

In conclusion we have demonstrated that FB49 is a new derivative able to bind human BAG3 with high affinity and could be used as BAG3 modulator in cancers correlated with overexpression of this protein.PMID:37783101 | DOI:10.1016/j.ejmech.2023.115824

Source: European Journal of Medicinal Chemistry - October 2, 2023 Category: Chemistry Authors: Federica Budassi Chiara Marchioro Martina Canton Annagiulia Favaro Mattia Sturlese Chiara Urbinati Marco Rusnati Romeo Romagnoli Giampietro Viola Elena Mariotto Source Type: research