Molecules, Vol. 28, Pages 4064: UPLC-QE-Orbitrap-Based Cell Metabolomics and Network Pharmacology to Reveal the Mechanism of N-Benzylhexadecanamide Isolated from Maca (Lepidium meyenii Walp.) against Testicular Dysfunction
This study examined the effects of H2O2 on cell viability and testosterone levels in mouse Leydig cells (TM3) under oxidative stress. In addition, cell metabolomics analysis based on UPLC-Q-Exactive-MS/MS showed that NBH was mainly involved in arginine biosynthesis, aminoacyl-tRNA biosynthesis, phenylalanine, tyrosine and tryptophan biosynthesis, the TCA cycle and other metabolic pathways by affecting 23 differential metabolites, including arginine and phenylalanine. Furthermore, we also performed network pharmacological analysis to observe the key protein targets in NBH treatment. The results showed that its role was to u...
Source: Molecules - May 12, 2023 Category: Chemistry Authors: Kai-Yue Zhang Chun-Nan Li Nan-Xi Zhang Xiao-Chen Gao Jia-Ming Shen Duan-Duan Cheng Yue-Long Wang Hui Zhang Jing-Wei Lv Jia-Ming Sun Tags: Article Source Type: research
A novel aminotransferase gene and its regulator acquired in Saccharomyces by a horizontal gene transfer event
Horizontal gene transfer (HGT) is an evolutionary mechanism of adaptive importance, which has been deeply studied in wine S. cerevisiae strains, where those acquired genes conferred improved traits related to bot... (Source: BMC Biology)
Source: BMC Biology - May 8, 2023 Category: Biology Authors: Sebasti án M. Tapia, Laura G. Macías, Roberto Pérez-Torrado, Noemi Daroqui, Paloma Manzanares, Amparo Querol and Eladio Barrio Tags: Research article Source Type: research
Molecules, Vol. 28, Pages 3943: The Efficient Synthesis and Anti-Fatigue Activity Evaluation of Macamides: The Unique Bioactive Compounds in Maca
Xiaobao Jin
Hui Yin
Macamides are a class of amide alkaloids that are only found in maca and are widely considered to be its bioactive marker compounds. More than thirty macamide monomers have been identified in recent years; however, it is difficult to obtain a single macamide monomer from the maca plant because of their similar structures and characteristics. We used the carbodiimide condensation method (CCM) to efficiently synthesize five typical macamides, including N-benzyl-hexadecanamide (NBH), N-benzyl-9Z,12Z,15Z-octadecenamide, N-(3-methoxybenzyl)-9Z,12Z-octadecenamide, N-benzyl-9Z,12Z-octadecenamide, and N-(...
Source: Molecules - May 7, 2023 Category: Chemistry Authors: Tao Liu Ziyan Peng Wei Lai Yan Shao Qing Gao Miaoxin He Wan Zhou Lirong Guo Jiyao Kang Xiaobao Jin Hui Yin Tags: Article Source Type: research
Molecules, Vol. 28, Pages 3932: Determining the Photoelectrical Behavior and Photocatalytic Activity of an h-YMnO3 New Type of Obelisk-Like Perovskite in the Degradation of Malachite Green Dye
pez de Alba Carlos Alberto
Reynoso-García César Alberto
YMnO3 is a P-type semiconductor with a perovskite-type structure (ABO3). It presents two crystalline systems: rhombohedral and hexagonal, the latter being the most stable and studied. In the hexagonal system, Mn3+ ions are coordinated by five oxygen ions forming a trigonal bipyramid, and the Y3+ ions are coordinated by five oxygen ions. This arrangement favors its ferroelectric and ferromagnetic properties, which have been widely studied since 1963. However, applications based on their optical properties have yet to be explored. This work evaluates the photoe...
Source: Molecules - May 6, 2023 Category: Chemistry Authors: L ópez-Alvarez Miguel Ángel Silva-Jara Jorge Manuel Silva-Galindo Jazm ín Guadalupe Reyes-Becerril Martha Vel ázquez-Carriles Carlos Arnulfo Mac ías-Rodríguez María Esther Mac ías-Lamas Adriana Macaria Garc ía-Ramírez Mario Alberto L ópez de Al Tags: Article Source Type: research
Macathioureas A-D, four new thiourea analogues from the roots of Lepidium meyenii
Fitoterapia. 2023 May 3:105521. doi: 10.1016/j.fitote.2023.105521. Online ahead of print.ABSTRACTMacathioureas A-D (1-4), four new thiourea derivatives with a carbamothioylpyrrolidine-2-carboxamide framework, were isolated from the roots of Lepidium meyenii (Maca) collected from Qujing, Yunnan Province of China. Their structures were identified based on extensive spectroscopic data, including 1D NMR, 2D NMR, and HRESIMS techniques. Their absolute configurations were assigned as 7S by the comparison of the experimental and predicted electronic circular dichroism (ECD) spectra. All the thiourea analogues were tested for thei...
Source: Fitoterapia - May 5, 2023 Category: Biochemistry Authors: Hui-Chun Geng Xue-Song Wang Ning Chen Jun-Jiang Lv Min Zhou Source Type: research
Macathioureas A-D, four new thiourea analogues from the roots of Lepidium meyenii
Fitoterapia. 2023 May 3:105521. doi: 10.1016/j.fitote.2023.105521. Online ahead of print.ABSTRACTMacathioureas A-D (1-4), four new thiourea derivatives with a carbamothioylpyrrolidine-2-carboxamide framework, were isolated from the roots of Lepidium meyenii (Maca) collected from Qujing, Yunnan Province of China. Their structures were identified based on extensive spectroscopic data, including 1D NMR, 2D NMR, and HRESIMS techniques. Their absolute configurations were assigned as 7S by the comparison of the experimental and predicted electronic circular dichroism (ECD) spectra. All the thiourea analogues were tested for thei...
Source: Fitoterapia - May 5, 2023 Category: Biochemistry Authors: Hui-Chun Geng Xue-Song Wang Ning Chen Jun-Jiang Lv Min Zhou Source Type: research
Substrate recruitment mechanism by gram-negative type III, IV, and VI bacterial injectisomes
Trends Microbiol. 2023 Apr 19:S0966-842X(23)00084-7. doi: 10.1016/j.tim.2023.03.005. Online ahead of print.ABSTRACTBacteria use a wide arsenal of macromolecular substrates (DNA and proteins) to interact with or infect prokaryotic and eukaryotic cells. To do so, they utilize substrate-injecting secretion systems or injectisomes. However, prior to secretion, substrates must be recruited to specialized recruitment platforms and then handed over to the secretion apparatus for secretion. In this review, we provide an update on recent advances in substrate recruitment and delivery by gram-negative bacterial recruitment platforms...
Source: Trends in Microbiology - April 21, 2023 Category: Microbiology Authors: Amit Meir K évin Macé Yogesh Vegunta Sunanda M Williams Gabriel Waksman Source Type: research
Substrate recruitment mechanism by gram-negative type III, IV, and VI bacterial injectisomes
Trends Microbiol. 2023 Apr 19:S0966-842X(23)00084-7. doi: 10.1016/j.tim.2023.03.005. Online ahead of print.ABSTRACTBacteria use a wide arsenal of macromolecular substrates (DNA and proteins) to interact with or infect prokaryotic and eukaryotic cells. To do so, they utilize substrate-injecting secretion systems or injectisomes. However, prior to secretion, substrates must be recruited to specialized recruitment platforms and then handed over to the secretion apparatus for secretion. In this review, we provide an update on recent advances in substrate recruitment and delivery by gram-negative bacterial recruitment platforms...
Source: Trends in Microbiology - April 21, 2023 Category: Microbiology Authors: Amit Meir K évin Macé Yogesh Vegunta Sunanda M Williams Gabriel Waksman Source Type: research
Substrate recruitment mechanism by gram-negative type III, IV, and VI bacterial injectisomes
Trends Microbiol. 2023 Apr 19:S0966-842X(23)00084-7. doi: 10.1016/j.tim.2023.03.005. Online ahead of print.ABSTRACTBacteria use a wide arsenal of macromolecular substrates (DNA and proteins) to interact with or infect prokaryotic and eukaryotic cells. To do so, they utilize substrate-injecting secretion systems or injectisomes. However, prior to secretion, substrates must be recruited to specialized recruitment platforms and then handed over to the secretion apparatus for secretion. In this review, we provide an update on recent advances in substrate recruitment and delivery by gram-negative bacterial recruitment platforms...
Source: Trends in Microbiology - April 19, 2023 Category: Microbiology Authors: Amit Meir K évin Macé Yogesh Vegunta Sunanda M Williams Gabriel Waksman Source Type: research
Substrate recruitment mechanism by gram-negative type III, IV, and VI bacterial injectisomes
Trends Microbiol. 2023 Apr 19:S0966-842X(23)00084-7. doi: 10.1016/j.tim.2023.03.005. Online ahead of print.ABSTRACTBacteria use a wide arsenal of macromolecular substrates (DNA and proteins) to interact with or infect prokaryotic and eukaryotic cells. To do so, they utilize substrate-injecting secretion systems or injectisomes. However, prior to secretion, substrates must be recruited to specialized recruitment platforms and then handed over to the secretion apparatus for secretion. In this review, we provide an update on recent advances in substrate recruitment and delivery by gram-negative bacterial recruitment platforms...
Source: Trends in Microbiology - April 19, 2023 Category: Microbiology Authors: Amit Meir K évin Macé Yogesh Vegunta Sunanda M Williams Gabriel Waksman Source Type: research
Evaluation of quality of life (QOL) of young patients with primary hyperhidrosis (PH) before and after endoscopic thoracic sympathectomy (ETS)
Primary hyperhidrosis (PH) affects young patients and may cause emotional distress and a negative quality of life (QOL). (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 14, 2023 Category: Dermatology Authors: Sonia Oliveira Lima, Jos é Machado Neto, Letícia Moreira Fontes, Maria Bernadete Galrão de Almeida Figueiredo, Jéssica Macêdo Santos, Vanessa Rocha Santana Tags: Online-only original articles Source Type: research
The impact of Parkinson's disease severity on performance of activities of daily living: an observational study
CONCLUSIONS: The severity of PD is closely related to the impairment of functional skills measured with the AMPS scale in non-demented PD patients. A strong correlation was found with the motor skills. A strong correlation was found between the AMPS process skills scale and Schwab and England ADL scale. A weak correlation was found between the AMPS motor scale and disease duration. The AMPS scale might be a useful tool to monitoring the PD progression through the observation of ADL performance.PMID:37046393 | DOI:10.33588/rn.7608.2022263 (Source: Revista de Neurologia)
Source: Revista de Neurologia - April 13, 2023 Category: Neurology Authors: J Alegre-Ayala L Vela D Fern ández-Vázquez V Navarro-L ópez Y Mac ías-Macías R Cano-de-la-Cuerda Source Type: research
The impact of Parkinson's disease severity on performance of activities of daily living: an observational study
CONCLUSIONS: The severity of PD is closely related to the impairment of functional skills measured with the AMPS scale in non-demented PD patients. A strong correlation was found with the motor skills. A strong correlation was found between the AMPS process skills scale and Schwab and England ADL scale. A weak correlation was found between the AMPS motor scale and disease duration. The AMPS scale might be a useful tool to monitoring the PD progression through the observation of ADL performance.PMID:37046393 | DOI:10.33588/rn.7608.2022263 (Source: Revista de Neurologia)
Source: Revista de Neurologia - April 13, 2023 Category: Neurology Authors: J Alegre-Ayala L Vela D Fern ández-Vázquez V Navarro-L ópez Y Mac ías-Macías R Cano-de-la-Cuerda Source Type: research
The impact of Parkinson's disease severity on performance of activities of daily living: an observational study
CONCLUSIONS: The severity of PD is closely related to the impairment of functional skills measured with the AMPS scale in non-demented PD patients. A strong correlation was found with the motor skills. A strong correlation was found between the AMPS process skills scale and Schwab and England ADL scale. A weak correlation was found between the AMPS motor scale and disease duration. The AMPS scale might be a useful tool to monitoring the PD progression through the observation of ADL performance.PMID:37046393 | DOI:10.33588/rn.7608.2022263 (Source: Revista de Neurologia)
Source: Revista de Neurologia - April 13, 2023 Category: Neurology Authors: J Alegre-Ayala L Vela D Fern ández-Vázquez V Navarro-L ópez Y Mac ías-Macías R Cano-de-la-Cuerda Source Type: research
The impact of Parkinson's disease severity on performance of activities of daily living: an observational study
CONCLUSIONS: The severity of PD is closely related to the impairment of functional skills measured with the AMPS scale in non-demented PD patients. A strong correlation was found with the motor skills. A strong correlation was found between the AMPS process skills scale and Schwab and England ADL scale. A weak correlation was found between the AMPS motor scale and disease duration. The AMPS scale might be a useful tool to monitoring the PD progression through the observation of ADL performance.PMID:37046393 | DOI:10.33588/rn.7608.2022263 (Source: Revista de Neurologia)
Source: Revista de Neurologia - April 13, 2023 Category: Neurology Authors: J Alegre-Ayala L Vela D Fern ández-Vázquez V Navarro-L ópez Y Mac ías-Macías R Cano-de-la-Cuerda Source Type: research
