The Cancer-Protective Potential of Protocatechuic Acid: A Narrative Review
Molecules. 2024 Mar 23;29(7):1439. doi: 10.3390/molecules29071439.ABSTRACTCancer is one of the leading causes of death worldwide, making the search for alternatives for its control a critical issue. In this context, exploring alternatives from natural sources, such as certain vegetables containing a variety of secondary metabolites with beneficial effects on the body and that play a crucial role in the fight against cancer, is essential. Among the compounds with the greatest efficacy in controlling this disease, those with antioxidant activity, particularly phenolic com-pounds, stand out. A remarkable example of this group...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Jorge Cadena-I ñiguez Edelmiro Santiago-Osorio Nancy S ánchez-Flores Sandra Salazar-Aguilar Ram ón Marcos Soto-Hernández Mar ía de la Luz Riviello-Flores V íctor Manuel Macías-Zaragoza Itzen Agui ñiga-Sánchez Source Type: research
Association between oral health-related quality of life and symptoms of temporomandibular disorder among older adults: A cross-sectional study
. (Source: Cranio - Journal of Craniomandibular and Sleep Practice)
Source: Cranio - Journal of Craniomandibular and Sleep Practice - April 4, 2024 Category: Sleep Medicine Authors: Larissa Viana de OliveiraPedro Paulo de Almeida DantasJos é Wittor de Macêdo SantosPaulo Roberto Grafitti ColussiMyrna Maria Arcanjo Frota BarrosFrancisco Wilker Mustafa Gomes Muniza School of Dentistry, Federal University of Pelotas, Pelotas, BR-RS, Br Source Type: research
Molecules, Vol. 29, Pages 1439: The Cancer-Protective Potential of Protocatechuic Acid: A Narrative Review
-Sánchez
Cancer is one of the leading causes of death worldwide, making the search for alternatives for its control a critical issue. In this context, exploring alternatives from natural sources, such as certain vegetables containing a variety of secondary metabolites with beneficial effects on the body and that play a crucial role in the fight against cancer, is essential. Among the compounds with the greatest efficacy in controlling this disease, those with antioxidant activity, particularly phenolic com-pounds, stand out. A remarkable example of this group is protocatechuic acid (PCA), which has been the subject of...
Source: Molecules - March 23, 2024 Category: Chemistry Authors: Jorge Cadena-I ñiguez Edelmiro Santiago-Osorio Nancy S ánchez-Flores Sandra Salazar-Aguilar Ram ón Marcos Soto-Hernández Mar ía de la Luz Riviello-Flores V íctor Manuel Macías-Zaragoza Itzen Agui ñiga-Sánchez Tags: Review Source Type: research
A novel approach of using Maca root as a radioprotector in a rat testicular damage model focusing on GRP78/CHOP/Caspase-3 pathway
CONCLUSION: Our findings show for the first time that Maca has a protective effect on male reproductive damage induced by radiotherapy. Maca root reveals anti-apoptotic effect and protection against testicular damage via GRP78/CHOP/caspase-3 pathway.PMID:38518815 | DOI:10.1016/j.abb.2024.109963 (Source: Archives of Biochemistry and Biophysics)
Source: Archives of Biochemistry and Biophysics - March 22, 2024 Category: Biochemistry Authors: Mai H Mekkawy Fatma Y Abdou Maha M Ali Amira Abd-ElRaouf Source Type: research
A novel approach of using Maca root as a radioprotector in a rat testicular damage model focusing on GRP78/CHOP/Caspase-3 pathway
CONCLUSION: Our findings show for the first time that Maca has a protective effect on male reproductive damage induced by radiotherapy. Maca root reveals anti-apoptotic effect and protection against testicular damage via GRP78/CHOP/caspase-3 pathway.PMID:38518815 | DOI:10.1016/j.abb.2024.109963 (Source: Archives of Biochemistry and Biophysics)
Source: Archives of Biochemistry and Biophysics - March 22, 2024 Category: Biochemistry Authors: Mai H Mekkawy Fatma Y Abdou Maha M Ali Amira Abd-ElRaouf Source Type: research
A novel approach of using Maca root as a radioprotector in a rat testicular damage model focusing on GRP78/CHOP/Caspase-3 pathway
CONCLUSION: Our findings show for the first time that Maca has a protective effect on male reproductive damage induced by radiotherapy. Maca root reveals anti-apoptotic effect and protection against testicular damage via GRP78/CHOP/caspase-3 pathway.PMID:38518815 | DOI:10.1016/j.abb.2024.109963 (Source: Archives of Biochemistry and Biophysics)
Source: Archives of Biochemistry and Biophysics - March 22, 2024 Category: Biochemistry Authors: Mai H Mekkawy Fatma Y Abdou Maha M Ali Amira Abd-ElRaouf Source Type: research
Viruses, Vol. 16, Pages 467: Assessing the Clinical Impact of the SARS-CoV-2 Gamma Variant on Intensive Care Unit Admissions: Insights from a Reference Hospital in Northeastern Brazil
a Ferreira Costa
Zaquer Suzana Costa-Ferro
Clarissa Araújo Gurgel Rocha
Silvia Inês Sardi
Gúbio Soares
Ana Verena Almeida Mendes
Bruno Solano de Freitas Souza
The global challenge posed by the prolonged COVID-19 pandemic underscores the critical need for ongoing genomic surveillance to identify emerging variants and formulate effective public health strategies. This retrospective observational study, conducted in a reference hospital in Northeast Brazil and comprising 2116 cases, employed PCR genotyping together with epidemiological data to elucidate the impact of the Gamma variant during its emergence, ...
Source: Viruses - March 20, 2024 Category: Virology Authors: Carolina Kymie Vasques Nonaka Adlas Michel de Jesus Ribeiro Gisele Vieira Rocha Helena Souza da Hora Ant ônio Augusto Fonseca Junior Fernanda de Mac êdo Lima Iasmin Nogueira Bastos Samara Alves Sa Teles Thamires Gomes Lopes Weber Vanessa Ferreira Costa Tags: Article Source Type: research
Extracellular Kir2.1 < sup > C122Y < /sup > Mutant Upsets Kir2.1-PIP2 Bonds and Is Arrhythmogenic in Andersen-Tawil Syndrome
CONCLUSIONS: The extracellular Cys122-to-Cys154 disulfide bond in the tridimensional Kir2.1 channel structure is essential for the channel function. We demonstrate that breaking disulfide bonds in the extracellular domain disrupts phosphatidylinositol 4,5-bisphosphate-dependent regulation, leading to channel dysfunction and defects in Kir2.1 energetic stability. The mutation also alters functional expression of the NaV1.5 channel and ultimately leads to conduction disturbances and life-threatening arrhythmia characteristic of Andersen-Tawil syndrome type 1.PMID:38497220 | DOI:10.1161/CIRCRESAHA.123.323895 (Source: Circulation Research)
Source: Circulation Research - March 18, 2024 Category: Cardiology Authors: Francisco M Cruz Álvaro Macías Ana I Moreno-Manuel Lilian K Guti érrez Mar ía Linarejos Vera-Pedrosa Isabel Mart ínez-Carrascoso Patricia S ánchez Pérez Juan Manuel Ruiz Robles Francisco J Berm údez-Jiménez Aitor D íaz-Agustín Fernando Mart ín Source Type: research
Extracellular Kir2.1 < sup > C122Y < /sup > Mutant Upsets Kir2.1-PIP2 Bonds and Is Arrhythmogenic in Andersen-Tawil Syndrome
CONCLUSIONS: The extracellular Cys122-to-Cys154 disulfide bond in the tridimensional Kir2.1 channel structure is essential for the channel function. We demonstrate that breaking disulfide bonds in the extracellular domain disrupts phosphatidylinositol 4,5-bisphosphate-dependent regulation, leading to channel dysfunction and defects in Kir2.1 energetic stability. The mutation also alters functional expression of the NaV1.5 channel and ultimately leads to conduction disturbances and life-threatening arrhythmia characteristic of Andersen-Tawil syndrome type 1.PMID:38497220 | DOI:10.1161/CIRCRESAHA.123.323895 (Source: Circulation Research)
Source: Circulation Research - March 18, 2024 Category: Cardiology Authors: Francisco M Cruz Álvaro Macías Ana I Moreno-Manuel Lilian K Guti érrez Mar ía Linarejos Vera-Pedrosa Isabel Mart ínez-Carrascoso Patricia S ánchez Pérez Juan Manuel Ruiz Robles Francisco J Berm údez-Jiménez Aitor D íaz-Agustín Fernando Mart ín Source Type: research
Hasta la Raiz: Cultivating racial ‐ethnic socialization in Latine families
AbstractFamilial racial-ethnic socialization (RES) helps youth build tools of cultural resilience by providing messages regarding race and ethnicity that enable them to negotiate and survive the demands of a racialized society. Thus, RES is an important caregiving task for historically minoritized families, including Latine families in the United States. In this article, we review research on RES in Latine families, which has focused primarily on RES processes in middle childhood to adolescence, to provide an evidence-informed conceptual model delineating the youth, parental, dyadic/familial, and sociohistorical factors th...
Source: Child Development Perspectives - March 13, 2024 Category: Child Development Authors: Norma J. Perez ‐Brena,
Mayra Y. Bámaca,
Gabriela Livas Stein,
Elisa Gomez Tags: ARTICLE Source Type: research
Molecules, Vol. 29, Pages 1226: Structure, Absolute Configuration, Antiproliferative and Phytotoxic Activities of Icetexane and Abietane Diterpenoids from Salvia carranzae and Chemotaxonomic Implications
ero Esquivel
From the aerial parts of Salvia carranzae Zamudio and Bedolla, three new icetexane-type diterpenoids were isolated. Their structures were established through spectroscopic methods and named the following: salvicarranzanolide (1), 19-deoxo-salvicarranzanolide (2) and 19-deoxo-20-deoxy-salvicarranzanolide (3). In addition, the known icetexane-type diterpenoids, 6,7,11,14-tetrahydro-7-oxo-icetexone (4), iso-icetexone (5), 19-deoxo-iso-icetexone (6), icetexone (7), 19-deoxo-icetexone (8) and 7&alpha;-acetoxy-6,7-dihydroicetexone (9), were also isolated, along with the abietanes sessein (10) and ferrugi...
Source: Molecules - March 9, 2024 Category: Chemistry Authors: Celia Bustos-Brito Juan Pablo Torres-Medicis Brenda Y. Bedolla-Garc ía Sergio Zamudio Teresa Ram írez-Apan Martha Lydia Mac ías-Rubalcava Leovigildo Quijano Baldomero Esquivel Tags: Article Source Type: research
Deregulation of interferon-gamma receptor 1 expression and its implications for lung adenocarcinoma progression
World J Clin Oncol. 2024 Feb 24;15(2):195-207. doi: 10.5306/wjco.v15.i2.195.ABSTRACTInterferon-gamma (IFN-γ) plays a dual role in cancer; it is both a pro- and an antitumorigenic cytokine, depending on the type of cancer. The deregulation of the IFN-γ canonic pathway is associated with several disorders, including vulnerability to viral infections, inflammation, and cancer progression. In particular, the interplay between lung adenocarcinoma (LUAD) and viral infections appears to exist in association with the deregulation of IFN-γ signaling. In this mini-review, we investigated the status of the IFN-γ signaling pathway...
Source: Clinical Lung Cancer - March 8, 2024 Category: Cancer & Oncology Authors: Angeles C Tecalco-Cruz Karen H Medina-Abreu Enrique Oropeza-Mart ínez Jesus Zepeda-Cervantes Aleida V ázquez-Macías Marina Mac ías-Silva Source Type: research
Deregulation of interferon-gamma receptor 1 expression and its implications for lung adenocarcinoma progression
World J Clin Oncol. 2024 Feb 24;15(2):195-207. doi: 10.5306/wjco.v15.i2.195.ABSTRACTInterferon-gamma (IFN-γ) plays a dual role in cancer; it is both a pro- and an antitumorigenic cytokine, depending on the type of cancer. The deregulation of the IFN-γ canonic pathway is associated with several disorders, including vulnerability to viral infections, inflammation, and cancer progression. In particular, the interplay between lung adenocarcinoma (LUAD) and viral infections appears to exist in association with the deregulation of IFN-γ signaling. In this mini-review, we investigated the status of the IFN-γ signaling pathway...
Source: Clinical Lung Cancer - March 8, 2024 Category: Cancer & Oncology Authors: Angeles C Tecalco-Cruz Karen H Medina-Abreu Enrique Oropeza-Mart ínez Jesus Zepeda-Cervantes Aleida V ázquez-Macías Marina Mac ías-Silva Source Type: research
Deregulation of interferon-gamma receptor 1 expression and its implications for lung adenocarcinoma progression
World J Clin Oncol. 2024 Feb 24;15(2):195-207. doi: 10.5306/wjco.v15.i2.195.ABSTRACTInterferon-gamma (IFN-γ) plays a dual role in cancer; it is both a pro- and an antitumorigenic cytokine, depending on the type of cancer. The deregulation of the IFN-γ canonic pathway is associated with several disorders, including vulnerability to viral infections, inflammation, and cancer progression. In particular, the interplay between lung adenocarcinoma (LUAD) and viral infections appears to exist in association with the deregulation of IFN-γ signaling. In this mini-review, we investigated the status of the IFN-γ signaling pathway...
Source: Clinical Lung Cancer - March 8, 2024 Category: Cancer & Oncology Authors: Angeles C Tecalco-Cruz Karen H Medina-Abreu Enrique Oropeza-Mart ínez Jesus Zepeda-Cervantes Aleida V ázquez-Macías Marina Mac ías-Silva Source Type: research
Bilateral primary motor area intermittent theta-burst stimulation may alleviate gait and postural disturbances in Parkinson's disease patients by astrocytic modulation, caudate volume changes, and increased functional neuroplasticity
Axial signs, such as gait disturbances and postural abnormalities, are common symptoms in advanced Parkinson's disease (PD). Postural instability is closely linked with both gait and balance dysfunction, and these conditions are directly related to the risk of falls. Compared to dyskinesia and motor complications, gait and postural dysfunctions are some of the most disabling symptoms for individuals with PD and are a major contributor to loss of autonomy and diminished quality of life. In addition, debilitating axial symptoms are common as the condition progresses, result in a substantial reduction in the therapeutic respo...
Source: Parkinsonism and Related Disorders - March 6, 2024 Category: Neurology Authors: Ra úl Rashid-López, Paloma Macías-García, Álvaro J. Cruz-Gómez, Francisco L. Sánchez-Fernández, Fátima Cano-Cano, Florencia Sanmartino, Esteban Sarrias-Arrabal, Elena Lozano-Soto, Constantino Méndez-Bértolo, Fernando López-Sosa, Álvaro Gonzá Tags: Correspondence Source Type: research
