Substrate recruitment mechanism by gram-negative type III, IV, and VI bacterial injectisomes

Trends Microbiol. 2023 Apr 19:S0966-842X(23)00084-7. doi: 10.1016/j.tim.2023.03.005. Online ahead of print.ABSTRACTBacteria use a wide arsenal of macromolecular substrates (DNA and proteins) to interact with or infect prokaryotic and eukaryotic cells. To do so, they utilize substrate-injecting secretion systems or injectisomes. However, prior to secretion, substrates must be recruited to specialized recruitment platforms and then handed over to the secretion apparatus for secretion. In this review, we provide an update on recent advances in substrate recruitment and delivery by gram-negative bacterial recruitment platforms associated with Type III, IV, and VI secretion systems.PMID:37085348 | DOI:10.1016/j.tim.2023.03.005

Source: Trends in Microbiology - April 19, 2023 Category: Microbiology Authors: Amit Meir K évin Macé Yogesh Vegunta Sunanda M Williams Gabriel Waksman Source Type: research