Detailed preoperative lymphatic mapping by lymphoscintigraphy for sentinel node identification: a pictorial essay
AbstractPre-operative lymphatic mapping for sentinel node identification is essential for accurate staging in patients with several solid cancers and for important prognostic implications.99mTc-labelled colloid lymphoscintigraphy and intraoperative sentinel lymph node detection using a gamma probe represent a well-established nuclear medicine technique and a detailed imaging method thanks to the advent of hybrid multi-modality SPET/CT. Through the description of numerous clinical cases, different in terms of cancer type and fields of application, we aimed to bring out the strengths and advantages of pre-operative lymphosci...
Source: Clinical and Translational Imaging - May 6, 2023 Category: Radiology Source Type: research
Effects of an early intervention with Hyperbaric Oxygen Treatment on arm lymphedema and quality of life after breast cancer —an explorative clinical trial
ConclusionParticipants receiving HBOT experienced improved QOL without consistently significant changes in arm mass, volume or lymphatic drainage. These results call for studies into differential effect in patient sub-groups, and a large-scale, randomized placebo-controlled trial with long-term follow-up to assess the effect of HBOT in patients with soft tissue radiation injuries after breast cancer seems warranted.Trial registrationDanish Health and Medicines Authority, EUDRACT no. 2015 –000,604-25 Ethical committee of the Capitol Region, No. R96-A6604-14-S22. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - May 1, 2023 Category: Cancer & Oncology Source Type: research
1466 Lymphangiogenesis and lymphatic zippering in skin associated with the progression of lymphedema
In this study, we comprehensively analyzed the structural and functional alterations of dermal lymphatic vessels in patients with lower limb lymphedema classified as types 1-4 by lymphoscintigraphy. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: N. Itai, E. Gantumur, K. Tsujita, S. Akita, K. Kajiya Source Type: research
A hybrid radioactive and fluorescence approach is more than the sum of its parts; outcome of a phase II randomized sentinel node trial in prostate cancer patients
CONCLUSIONS: The hybrid tracer ICG-99mTc-nanocolloid improved the positive predictive value for tumor-bearing LNs while minimizing the number of fluorescent nodes compared to the sequential tracer approach. Consequently, the hybrid tracer ICG-99mTc-nanocolloid enables the most reliable and minimal invasive method for LN staging in PCa patients.PMID:37036490 | DOI:10.1007/s00259-023-06191-7 (Source: Molecular Medicine)
Source: Molecular Medicine - April 10, 2023 Category: Molecular Biology Authors: Esther M K Wit Gijs H KleinJan Anne-Claire Berrens Roos van Vliet Pim J van Leeuwen Tessa Buckle Maarten L Donswijk Elise M Bekers Fijs W B van Leeuwen Henk G van der Poel Source Type: research
Lymphoscintigraphic alterations in lower limbs in women with lipedema in comparison to women with overweight/obesity
Discussion: Our study indicates that lymphatic alterations are present before development to clinically visible secondary lymphedema in both conditions, lipedema and overweight/obesity. In majority of women from both study groups they indicate rather an overload of the lymphatic system than insufficiency. Lymphoscintigraphic alterations are similar in both groups, therefore, lymphoscintigraphy is not a diagnostic tool that might distinguish lipedema from overweight/obesity. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - April 10, 2023 Category: Physiology Source Type: research
A hybrid radioactive and fluorescence approach is more than the sum of its parts; outcome of a phase II randomized sentinel node trial in prostate cancer patients
ConclusionsThe hybrid tracer ICG-99mTc-nanocolloid improved the positive predictive value for tumor-bearing LNs while minimizing the number of fluorescent nodes compared to the sequential tracer approach. Consequently, the hybrid tracer ICG-99mTc-nanocolloid enables the most reliable and minimal invasive method for LN staging in PCa patients. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 10, 2023 Category: Nuclear Medicine Source Type: research
Summary: Appropriate Use Criteria for Lymphoscintigraphy in Sentinel Node Mapping and Lymphedema/Lipedema
Expert representatives from 11 professional societies, as part of an autonomous work group, researched and developed appropriate use criteria (AUC) for lymphoscintigraphy in sentinel lymph node mapping and lymphedema. The complete findings and discussions of the work group, including example clinical scenarios, were published on October 8, 2022, and are available at https://www.snmmi.org/ClinicalPractice/content.aspx?ItemNumber=42021. The complete AUC document includes clinical scenarios for scintigraphy in patients with breast, cutaneous, and other cancers, as well as for mapping lymphatic flow in lymphedema. Pediatric co...
Source: Journal of Nuclear Medicine - April 3, 2023 Category: Nuclear Medicine Authors: Donohoe, K. J., Carroll, B. J., Chung, D. K. V., Dibble, E. H., Diego, E., Giammarile, F., Grant, F. D., Lai, S. Y., Linden, H., Miller, M. E., Pandit-Taskar, N., Tawa, N. E., Vidal-Sicart, S. Tags: Appropriate Use Criteria Source Type: research
Measures of performance for sentinel lymph node biopsy in oro-oropharyngeal squamous cell carcinoma: a systematic review and meta-analysis
ConclusionsThe superiority of SPECT/CT over planar methods has been reported for providing identification of SLNs by aberrant lymphatic drainage. The additional contribution of optical tracers (mainly represented by blue dye) to the radiocolloid-based techniques did not improve significantly the measures of performance. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - March 29, 2023 Category: Radiology Source Type: research
Comparison of two hybrid sentinel node tracers: indocyanine green (ICG)- < sup > 99m < /sup > Tc-nanocolloid vs. ICG- < sup > 99m < /sup > Tc-nanoscan from a nuclear medicine and surgical perspective
CONCLUSIONS: Based on this retrospective analysis, we can conclude that ICG-99mTc-nanoscan has similar capacity for SN identification as ICG-99mTc-nanocolloid and can safely be implemented in SN procedures.PMID:36929210 | DOI:10.1007/s00259-023-06157-9 (Source: Molecular Medicine)
Source: Molecular Medicine - March 17, 2023 Category: Molecular Biology Authors: Manon T A Vreeburg Samaneh Azargoshasb Danny van Willigen Tom Molenaar Matthias N van Oosterom Tessa Buckle Leon J Slof Martin Klop Baris Karakullukcu Maarten Donswijk Henk G van der Poel Fijs W B van Leeuwen Oscar R Brouwer Daphne D D Rietbergen Source Type: research
Comparison of two hybrid sentinel node tracers: indocyanine green (ICG)- < sup > 99m < /sup > Tc-nanocolloid vs. ICG- < sup > 99m < /sup > Tc-nanoscan from a nuclear medicine and surgical perspective
CONCLUSIONS: Based on this retrospective analysis, we can conclude that ICG-99mTc-nanoscan has similar capacity for SN identification as ICG-99mTc-nanocolloid and can safely be implemented in SN procedures.PMID:36929210 | DOI:10.1007/s00259-023-06157-9 (Source: Molecular Medicine)
Source: Molecular Medicine - March 17, 2023 Category: Molecular Biology Authors: Manon T A Vreeburg Samaneh Azargoshasb Danny van Willigen Tom Molenaar Matthias N van Oosterom Tessa Buckle Leon J Slof Martin Klop Baris Karakullukcu Maarten Donswijk Henk G van der Poel Fijs W B van Leeuwen Oscar R Brouwer Daphne D D Rietbergen Source Type: research
Comparison of two hybrid sentinel node tracers: indocyanine green (ICG)-99mTc-nanocolloid vs. ICG-99mTc-nanoscan from a nuclear medicine and surgical perspective
ConclusionsBased on this retrospective analysis, we can conclude that ICG-99mTc-nanoscan has similar capacity for SN identification as ICG-99mTc-nanocolloid and can safely be implemented in SN procedures. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 17, 2023 Category: Nuclear Medicine Source Type: research
99mTc-Rituximab sentinel lymph node mapping and biopsy, the effective technique avoids axillary dissection and predicts prognosis in 533 cutaneous melanoma
ConclusionThe novel radiotracer99mTc-rituximab could identify SLNs specifically in SLN lymphoscintigraphy and SLNB in CMM patients, and the pathology obtained from SLNB rather than from RLND better indicated the staging and long-term prognosis. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 1, 2023 Category: Nuclear Medicine Source Type: research
Nonvisualized sentinel node on preoperative lymphoscintigraphy in primary cutaneous melanoma: an 11-year retrospective survey
CONCLUSIONS: The nonvisualization of regional lymph nodes by lymphoscintigraphy is more frequent in older patients with head and neck melanomas. From the clinical point of view, no specific recommendation emerged for patients' management because the nonvisualization of the SLN did not show a significant influence on DFS and OS rates. However, lack of knowledge of lymph node status suggests performing a tighter follow-up eventually by ultrasound evaluation of all potential lymph node drainage basins.PMID:36826418 | DOI:10.1097/MNM.0000000000001671 (Source: Cancer Control)
Source: Cancer Control - February 24, 2023 Category: Cancer & Oncology Authors: Tiziano Pallara Alessio Annovazzi Renzo Cristiani Federica Vinci Ettore Bertozzi Antonio Bonadies Claudia Romani Marinella Tedesco Barbara Bellei Federica Papaccio Silvia Caputo Carlo Cota Isabella Sperduti Flavio Andrea Govoni Aldo Morrone Emilia Miglian Source Type: research
Pneumatic compression therapy using the EQ Press accelerates lymphatic flow in healthy equine forelimbs as determined by lymphoscintigraphy
The objective of this study was to determine the effect of a novel, equine-specific pneumatic compression device on the lymphatic flow of healthy horse forelimbs as determined by Tc-99m sulfur colloid lymphoscintigraphy.ANIMALS: 6 healthy Thoroughbreds.PROCEDURES: In a randomized crossover design, horses underwent bilateral forelimb lymphoscintigraphy following subcutaneous injection of Tc-99m sulfur colloid at the coronary band as untreated control or with pneumatic compression therapy using the EQ Press. Lateral, static images were obtained of the distal limb (time 0 to 60 minutes) and proximal limb (time 30 to 60 minute...
Source: American Journal of Veterinary Research - February 17, 2023 Category: Veterinary Research Authors: Drew W Koch Lauren V Schnabel Justin Reynolds Clifford R Berry Source Type: research
