Percutaneous absorption and Skin accumulation of Lorazepam-Diphenhydramine- Haloperidol Carbopol gel in Porcine Ear Skin
In conclusion, the ABH Carbopol gel provides a promising alternative to the ABH PLO gel for treating CINV in hospice patients. Further studies are required to validate these findings in clinical settings.PMID:37700110 | DOI:10.1208/s12249-023-02608-6 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - September 12, 2023 Category: Drugs & Pharmacology Authors: Rabin Neupane Sai H S Boddu Moawia M Al-Tabakha Shery Jacob R Jayachandra Babu Amit K Tiwari Source Type: research
Percutaneous absorption and Skin accumulation of Lorazepam-Diphenhydramine- Haloperidol Carbopol gel in Porcine Ear Skin
In conclusion, the ABH Carbopol gel provides a promising alternative to the ABH PLO gel for treating CINV in hospice patients. Further studies are required to validate these findings in clinical settings.PMID:37700110 | DOI:10.1208/s12249-023-02608-6 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - September 12, 2023 Category: Drugs & Pharmacology Authors: Rabin Neupane Sai H S Boddu Moawia M Al-Tabakha Shery Jacob R Jayachandra Babu Amit K Tiwari Source Type: research
Comorbidities, symptoms and end-of-life medication use in hospitalised decedents before and during the COVID-19 pandemic: a retrospective regional cohort study in Ottawa, Canada
Conclusions
COVID-19 decedents, particularly those in ICU, required higher EoL opioid and sedating medication doses than matched prepandemic or intrapandemic controls. These findings should inform and guide clinical practice. (Source: BMJ Open)
Source: BMJ Open - September 5, 2023 Category: General Medicine Authors: Lawlor, P., Cohen, L., Adeli, S. R., Besserer, E., Gratton, V., Murphy, R., Warmels, G., Bruni, A., Kabir, M., Noel, C., Heidinger, B., Anderson, K., Arsenault-Mehta, K., Wooller, K., Lapenskie, J., Webber, C., Bedard, D., Enright, P., Desjardins, I., Bhi Tags: Open access, Palliative care, COVID-19 Source Type: research
Lorazepam/valproic-acid
(Source: Reactions Weekly)
Source: Reactions Weekly - September 1, 2023 Category: Drugs & Pharmacology Source Type: research
Beyond benzodiazepines: a meta-analysis and narrative synthesis of the efficacy and safety of alternative options for alcohol withdrawal syndrome management
ConclusionFor AWS treatments, non-BZDs are superior to or equally effective as BZDs. Non-BZD adverse events warrant further investigation. Agents that inhibit gated ion channels are promising candidates.Protocol registrationPROSPERO CRD42022384875. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - August 25, 2023 Category: Drugs & Pharmacology Source Type: research
A Comparison of Injectable Diazepam and Lorazepam in the Goal-Directed Management of Severe Alcohol Withdrawal
CONCLUSION AND RELEVANCE: DZP or LZP are equally efficacious for the treatment of severe AWS. LZP may be preferred due to cost but both medications can be used interchangeably based on availability.PMID:37606361 | DOI:10.1177/10600280231194790 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - August 22, 2023 Category: Drugs & Pharmacology Authors: Kendall H Brickel Emily K Hodge Daria Zavgorodnyaya John M Schroeder Lawrence H Brown Mitchell J Daley Source Type: research
A Comparison of Injectable Diazepam and Lorazepam in the Goal-Directed Management of Severe Alcohol Withdrawal
CONCLUSION AND RELEVANCE: DZP or LZP are equally efficacious for the treatment of severe AWS. LZP may be preferred due to cost but both medications can be used interchangeably based on availability.PMID:37606361 | DOI:10.1177/10600280231194790 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - August 22, 2023 Category: Drugs & Pharmacology Authors: Kendall H Brickel Emily K Hodge Daria Zavgorodnyaya John M Schroeder Lawrence H Brown Mitchell J Daley Source Type: research
Postictal Agitation to Lorazepam in Patient with Active Seizure
Nipun Gupta, Shalendra Singh, Beena Tiwari, Payal MaharanaNeurology India 2023 71(4):831-832 (Source: Neurology India)
Source: Neurology India - August 18, 2023 Category: Neurology Authors: Nipun Gupta Shalendra Singh Beena Tiwari Payal Maharana Source Type: research
Lorazepam Stimulates IL6 Production and Is Associated with Poor Survival Outcomes in Pancreatic Cancer
CONCLUSIONS: We demonstrate that LOR stimulates fibrosis and inflammatory signaling, promotes desmoplasia and ischemic necrosis, and is associated with decreased pancreatic cancer patient survival.PMID:37587561 | DOI:10.1158/1078-0432.CCR-23-0547 (Source: Cell Research)
Source: Cell Research - August 17, 2023 Category: Cytology Authors: Abigail C Cornwell Arwen A Tisdale Swati Venkat Kathryn E Maraszek Abdulrahman A Alahmari Anthony George Kristopher Attwood Madison George Donald Rempinski Janusz Franco-Barraza Mukund Seshadri Mark D Parker Eduardo Cortes Gomez Christos Fountzilas Edna C Source Type: research
Lorazepam Stimulates IL6 Production and Is Associated with Poor Survival Outcomes in Pancreatic Cancer
CONCLUSIONS: We demonstrate that LOR stimulates fibrosis and inflammatory signaling, promotes desmoplasia and ischemic necrosis, and is associated with decreased pancreatic cancer patient survival.PMID:37587561 | DOI:10.1158/1078-0432.CCR-23-0547 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - August 17, 2023 Category: Cancer & Oncology Authors: Abigail C Cornwell Arwen A Tisdale Swati Venkat Kathryn E Maraszek Abdulrahman A Alahmari Anthony George Kristopher Attwood Madison George Donald Rempinski Janusz Franco-Barraza Mukund Seshadri Mark D Parker Eduardo Cortes Gomez Christos Fountzilas Edna C Source Type: research
Lorazepam Stimulates IL6 Production and Is Associated with Poor Survival Outcomes in Pancreatic Cancer
CONCLUSIONS: We demonstrate that LOR stimulates fibrosis and inflammatory signaling, promotes desmoplasia and ischemic necrosis, and is associated with decreased pancreatic cancer patient survival.PMID:37587561 | DOI:10.1158/1078-0432.CCR-23-0547 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - August 17, 2023 Category: Cancer & Oncology Authors: Abigail C Cornwell Arwen A Tisdale Swati Venkat Kathryn E Maraszek Abdulrahman A Alahmari Anthony George Kristopher Attwood Madison George Donald Rempinski Janusz Franco-Barraza Mukund Seshadri Mark D Parker Eduardo Cortes Gomez Christos Fountzilas Edna C Source Type: research
The diagnostic dilemma in a patient with neuroleptic malignant syndrome during the COVID ‐19 pandemic: A significant increase in acute phase reactants
This article describes a woman treated with haloperidol, perphenazine, escitalopram, and alprazolam because she developed catatonic symptoms after psychological stress. She suffered from NMS symptoms and had elevated CRP and ESR levels, among other signs and symptoms. Given the COVID-19 pandemic and reports of co-occurrence of catatonia and NMS and COVID-19 and elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), this patient was a diagnostic dilemma. After consultation with the consultation-liaison psychiatry units, she was managed adequately with electroconvulsive therapy and lorazepam. (Source: Clinical Case Reports)
Source: Clinical Case Reports - August 3, 2023 Category: General Medicine Authors: Forouzan Elyasi,
Mehran Zarghami,
Arghavan Fariborzifar,
Hamed Cheraghmakani,
Mahboobeh Shirzad,
Feteme Kazempour Tags: CASE REPORT Source Type: research
Clozapine for treatment refractory catatonia in individuals with autism spectrum disorder: a retrospective chart review study
CONCLUSIONS: Overall, clozapine was associated with a high response rate for the treatment of catatonia in patients with ASD. These naturalistic data support the use of clozapine for the treatment of catatonia in patients with ASD for whom lorazepam is either ineffective or partially effective.PMID:37526285 | DOI:10.1080/17512433.2023.2243820 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - August 1, 2023 Category: Drugs & Pharmacology Authors: Robyn P Thom Michael Wu Caitlin Ravichandran Christopher J McDougle Source Type: research
Clozapine for treatment refractory catatonia in individuals with autism spectrum disorder: a retrospective chart review study
CONCLUSIONS: Overall, clozapine was associated with a high response rate for the treatment of catatonia in patients with ASD. These naturalistic data support the use of clozapine for the treatment of catatonia in patients with ASD for whom lorazepam is either ineffective or partially effective.PMID:37526285 | DOI:10.1080/17512433.2023.2243820 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - August 1, 2023 Category: Drugs & Pharmacology Authors: Robyn P Thom Michael Wu Caitlin Ravichandran Christopher J McDougle Source Type: research
Clozapine for treatment refractory catatonia in individuals with autism spectrum disorder: a retrospective chart review study
CONCLUSIONS: Overall, clozapine was associated with a high response rate for the treatment of catatonia in patients with ASD. These naturalistic data support the use of clozapine for the treatment of catatonia in patients with ASD for whom lorazepam is either ineffective or partially effective.PMID:37526285 | DOI:10.1080/17512433.2023.2243820 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - August 1, 2023 Category: Drugs & Pharmacology Authors: Robyn P Thom Michael Wu Caitlin Ravichandran Christopher J McDougle Source Type: research
