LC-Q-TOF/MS-based Fragmentation Behavior Study and In vitro Metabolites Identification of Nine Benzodiazepines
CONCLUSION: These experimental data add to our knowledge of the nine benzodiazepine drugs and their metabolism study, which could provide useful information and evidence of their in vivo metabolic profile prediction and help promote their monitoring in both clinical use and social/illegal abuse.PMID:37114779 | DOI:10.2174/1389200224666230419090733 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 28, 2023 Category: Drugs & Pharmacology Authors: Shuhan Zhou Xiaoting Song Pengkai Fang Jingyi Xu Siqi Liu Tian Zheng Guoping Wu Liang Wu Source Type: research
Elucidation of Degradation Behavior of Hydroxy Group-Containing Benzodiazepines in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (III)
Chem Pharm Bull (Tokyo). 2023;71(4):312-317. doi: 10.1248/cpb.c22-00911.ABSTRACTThe degradation behavior of three benzodiazepines (BZPs)-lormetazepam (LMZ), lorazepam, and oxazepam-with hydroxy groups on the diazepine ring in artificial gastric juice and the effect of storage pH conditions on drug degradability were monitored using an LC/photodiode array detector (PDA) to estimate their pharmacokinetics in the stomach. Although the three BZPs degraded in artificial gastric juice, none could be restored, despite increasing the storage pH, implying that the degradation reaction was irreversible. As for LMZ, we discussed the ...
Source: Chemical and Pharmaceutical Bulletin - April 2, 2023 Category: Drugs & Pharmacology Authors: Rie Ito Chisa Takemura Hiroshi Akiyama Koichi Saito Source Type: research
Elucidation of Degradation Behavior of Hydroxy Group-Containing Benzodiazepines in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (III)
Chem Pharm Bull (Tokyo). 2023;71(4):312-317. doi: 10.1248/cpb.c22-00911.ABSTRACTThe degradation behavior of three benzodiazepines (BZPs)-lormetazepam (LMZ), lorazepam, and oxazepam-with hydroxy groups on the diazepine ring in artificial gastric juice and the effect of storage pH conditions on drug degradability were monitored using an LC/photodiode array detector (PDA) to estimate their pharmacokinetics in the stomach. Although the three BZPs degraded in artificial gastric juice, none could be restored, despite increasing the storage pH, implying that the degradation reaction was irreversible. As for LMZ, we discussed the ...
Source: Chemical and Pharmaceutical Bulletin - April 2, 2023 Category: Drugs & Pharmacology Authors: Rie Ito Chisa Takemura Hiroshi Akiyama Koichi Saito Source Type: research
Elucidation of Degradation Behavior of Hydroxy Group-Containing Benzodiazepines in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (III)
Chem Pharm Bull (Tokyo). 2023;71(4):312-317. doi: 10.1248/cpb.c22-00911.ABSTRACTThe degradation behavior of three benzodiazepines (BZPs)-lormetazepam (LMZ), lorazepam, and oxazepam-with hydroxy groups on the diazepine ring in artificial gastric juice and the effect of storage pH conditions on drug degradability were monitored using an LC/photodiode array detector (PDA) to estimate their pharmacokinetics in the stomach. Although the three BZPs degraded in artificial gastric juice, none could be restored, despite increasing the storage pH, implying that the degradation reaction was irreversible. As for LMZ, we discussed the ...
Source: Chemical and Pharmaceutical Bulletin - April 2, 2023 Category: Drugs & Pharmacology Authors: Rie Ito Chisa Takemura Hiroshi Akiyama Koichi Saito Source Type: research
Elucidation of Degradation Behavior of Hydroxy Group-Containing Benzodiazepines in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (III)
Chem Pharm Bull (Tokyo). 2023;71(4):312-317. doi: 10.1248/cpb.c22-00911.ABSTRACTThe degradation behavior of three benzodiazepines (BZPs)-lormetazepam (LMZ), lorazepam, and oxazepam-with hydroxy groups on the diazepine ring in artificial gastric juice and the effect of storage pH conditions on drug degradability were monitored using an LC/photodiode array detector (PDA) to estimate their pharmacokinetics in the stomach. Although the three BZPs degraded in artificial gastric juice, none could be restored, despite increasing the storage pH, implying that the degradation reaction was irreversible. As for LMZ, we discussed the ...
Source: Chemical and Pharmaceutical Bulletin - April 2, 2023 Category: Drugs & Pharmacology Authors: Rie Ito Chisa Takemura Hiroshi Akiyama Koichi Saito Source Type: research
Elucidation of Degradation Behavior of Hydroxy Group-Containing Benzodiazepines in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (III)
Chem Pharm Bull (Tokyo). 2023;71(4):312-317. doi: 10.1248/cpb.c22-00911.ABSTRACTThe degradation behavior of three benzodiazepines (BZPs)-lormetazepam (LMZ), lorazepam, and oxazepam-with hydroxy groups on the diazepine ring in artificial gastric juice and the effect of storage pH conditions on drug degradability were monitored using an LC/photodiode array detector (PDA) to estimate their pharmacokinetics in the stomach. Although the three BZPs degraded in artificial gastric juice, none could be restored, despite increasing the storage pH, implying that the degradation reaction was irreversible. As for LMZ, we discussed the ...
Source: Chemical and Pharmaceutical Bulletin - April 2, 2023 Category: Drugs & Pharmacology Authors: Rie Ito Chisa Takemura Hiroshi Akiyama Koichi Saito Source Type: research
Elucidation of Degradation Behavior of Hydroxy Group-Containing Benzodiazepines in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (III)
Chem Pharm Bull (Tokyo). 2023;71(4):312-317. doi: 10.1248/cpb.c22-00911.ABSTRACTThe degradation behavior of three benzodiazepines (BZPs)-lormetazepam (LMZ), lorazepam, and oxazepam-with hydroxy groups on the diazepine ring in artificial gastric juice and the effect of storage pH conditions on drug degradability were monitored using an LC/photodiode array detector (PDA) to estimate their pharmacokinetics in the stomach. Although the three BZPs degraded in artificial gastric juice, none could be restored, despite increasing the storage pH, implying that the degradation reaction was irreversible. As for LMZ, we discussed the ...
Source: Chemical and Pharmaceutical Bulletin - April 2, 2023 Category: Drugs & Pharmacology Authors: Rie Ito Chisa Takemura Hiroshi Akiyama Koichi Saito Source Type: research
Elucidation of Degradation Behavior of Hydroxy Group-Containing Benzodiazepines in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (III)
Chem Pharm Bull (Tokyo). 2023;71(4):312-317. doi: 10.1248/cpb.c22-00911.ABSTRACTThe degradation behavior of three benzodiazepines (BZPs)-lormetazepam (LMZ), lorazepam, and oxazepam-with hydroxy groups on the diazepine ring in artificial gastric juice and the effect of storage pH conditions on drug degradability were monitored using an LC/photodiode array detector (PDA) to estimate their pharmacokinetics in the stomach. Although the three BZPs degraded in artificial gastric juice, none could be restored, despite increasing the storage pH, implying that the degradation reaction was irreversible. As for LMZ, we discussed the ...
Source: Chemical and Pharmaceutical Bulletin - April 2, 2023 Category: Drugs & Pharmacology Authors: Rie Ito Chisa Takemura Hiroshi Akiyama Koichi Saito Source Type: research
Elucidation of Degradation Behavior of Hydroxy Group-Containing Benzodiazepines in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (III)
Chem Pharm Bull (Tokyo). 2023;71(4):312-317. doi: 10.1248/cpb.c22-00911.ABSTRACTThe degradation behavior of three benzodiazepines (BZPs)-lormetazepam (LMZ), lorazepam, and oxazepam-with hydroxy groups on the diazepine ring in artificial gastric juice and the effect of storage pH conditions on drug degradability were monitored using an LC/photodiode array detector (PDA) to estimate their pharmacokinetics in the stomach. Although the three BZPs degraded in artificial gastric juice, none could be restored, despite increasing the storage pH, implying that the degradation reaction was irreversible. As for LMZ, we discussed the ...
Source: Chemical and Pharmaceutical Bulletin - April 2, 2023 Category: Drugs & Pharmacology Authors: Rie Ito Chisa Takemura Hiroshi Akiyama Koichi Saito Source Type: research
Elucidation of Degradation Behavior of Hydroxy Group-Containing Benzodiazepines in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (III)
Chem Pharm Bull (Tokyo). 2023;71(4):312-317. doi: 10.1248/cpb.c22-00911.ABSTRACTThe degradation behavior of three benzodiazepines (BZPs)-lormetazepam (LMZ), lorazepam, and oxazepam-with hydroxy groups on the diazepine ring in artificial gastric juice and the effect of storage pH conditions on drug degradability were monitored using an LC/photodiode array detector (PDA) to estimate their pharmacokinetics in the stomach. Although the three BZPs degraded in artificial gastric juice, none could be restored, despite increasing the storage pH, implying that the degradation reaction was irreversible. As for LMZ, we discussed the ...
Source: Chemical and Pharmaceutical Bulletin - April 2, 2023 Category: Drugs & Pharmacology Authors: Rie Ito Chisa Takemura Hiroshi Akiyama Koichi Saito Source Type: research
Elucidation of Degradation Behavior of Hydroxy Group-Containing Benzodiazepines in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (III)
Chem Pharm Bull (Tokyo). 2023;71(4):312-317. doi: 10.1248/cpb.c22-00911.ABSTRACTThe degradation behavior of three benzodiazepines (BZPs)-lormetazepam (LMZ), lorazepam, and oxazepam-with hydroxy groups on the diazepine ring in artificial gastric juice and the effect of storage pH conditions on drug degradability were monitored using an LC/photodiode array detector (PDA) to estimate their pharmacokinetics in the stomach. Although the three BZPs degraded in artificial gastric juice, none could be restored, despite increasing the storage pH, implying that the degradation reaction was irreversible. As for LMZ, we discussed the ...
Source: Chemical and Pharmaceutical Bulletin - April 2, 2023 Category: Drugs & Pharmacology Authors: Rie Ito Chisa Takemura Hiroshi Akiyama Koichi Saito Source Type: research
Elucidation of Degradation Behavior of Hydroxy Group-Containing Benzodiazepines in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (III)
Chem Pharm Bull (Tokyo). 2023;71(4):312-317. doi: 10.1248/cpb.c22-00911.ABSTRACTThe degradation behavior of three benzodiazepines (BZPs)-lormetazepam (LMZ), lorazepam, and oxazepam-with hydroxy groups on the diazepine ring in artificial gastric juice and the effect of storage pH conditions on drug degradability were monitored using an LC/photodiode array detector (PDA) to estimate their pharmacokinetics in the stomach. Although the three BZPs degraded in artificial gastric juice, none could be restored, despite increasing the storage pH, implying that the degradation reaction was irreversible. As for LMZ, we discussed the ...
Source: Chemical and Pharmaceutical Bulletin - April 2, 2023 Category: Drugs & Pharmacology Authors: Rie Ito Chisa Takemura Hiroshi Akiyama Koichi Saito Source Type: research
Elucidation of Degradation Behavior of Hydroxy Group-Containing Benzodiazepines in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (III)
Chem Pharm Bull (Tokyo). 2023;71(4):312-317. doi: 10.1248/cpb.c22-00911.ABSTRACTThe degradation behavior of three benzodiazepines (BZPs)-lormetazepam (LMZ), lorazepam, and oxazepam-with hydroxy groups on the diazepine ring in artificial gastric juice and the effect of storage pH conditions on drug degradability were monitored using an LC/photodiode array detector (PDA) to estimate their pharmacokinetics in the stomach. Although the three BZPs degraded in artificial gastric juice, none could be restored, despite increasing the storage pH, implying that the degradation reaction was irreversible. As for LMZ, we discussed the ...
Source: Chemical and Pharmaceutical Bulletin - April 2, 2023 Category: Drugs & Pharmacology Authors: Rie Ito Chisa Takemura Hiroshi Akiyama Koichi Saito Source Type: research
Elucidation of Degradation Behavior of Hydroxy Group-Containing Benzodiazepines in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (III)
Chem Pharm Bull (Tokyo). 2023;71(4):312-317. doi: 10.1248/cpb.c22-00911.ABSTRACTThe degradation behavior of three benzodiazepines (BZPs)-lormetazepam (LMZ), lorazepam, and oxazepam-with hydroxy groups on the diazepine ring in artificial gastric juice and the effect of storage pH conditions on drug degradability were monitored using an LC/photodiode array detector (PDA) to estimate their pharmacokinetics in the stomach. Although the three BZPs degraded in artificial gastric juice, none could be restored, despite increasing the storage pH, implying that the degradation reaction was irreversible. As for LMZ, we discussed the ...
Source: Chemical and Pharmaceutical Bulletin - April 2, 2023 Category: Drugs & Pharmacology Authors: Rie Ito Chisa Takemura Hiroshi Akiyama Koichi Saito Source Type: research
Elucidation of Degradation Behavior of Hydroxy Group-Containing Benzodiazepines in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (III)
Chem Pharm Bull (Tokyo). 2023;71(4):312-317. doi: 10.1248/cpb.c22-00911.ABSTRACTThe degradation behavior of three benzodiazepines (BZPs)-lormetazepam (LMZ), lorazepam, and oxazepam-with hydroxy groups on the diazepine ring in artificial gastric juice and the effect of storage pH conditions on drug degradability were monitored using an LC/photodiode array detector (PDA) to estimate their pharmacokinetics in the stomach. Although the three BZPs degraded in artificial gastric juice, none could be restored, despite increasing the storage pH, implying that the degradation reaction was irreversible. As for LMZ, we discussed the ...
Source: Chemical and Pharmaceutical Bulletin - April 2, 2023 Category: Drugs & Pharmacology Authors: Rie Ito Chisa Takemura Hiroshi Akiyama Koichi Saito Source Type: research
