Elucidation of Degradation Behavior of Hydroxy Group-Containing Benzodiazepines in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (III)
Chem Pharm Bull (Tokyo). 2023;71(4):312-317. doi: 10.1248/cpb.c22-00911.ABSTRACTThe degradation behavior of three benzodiazepines (BZPs)-lormetazepam (LMZ), lorazepam, and oxazepam-with hydroxy groups on the diazepine ring in artificial gastric juice and the effect of storage pH conditions on drug degradability were monitored using an LC/photodiode array detector (PDA) to estimate their pharmacokinetics in the stomach. Although the three BZPs degraded in artificial gastric juice, none could be restored, despite increasing the storage pH, implying that the degradation reaction was irreversible. As for LMZ, we discussed the ...
Source: Chemical and Pharmaceutical Bulletin - April 2, 2023 Category: Drugs & Pharmacology Authors: Rie Ito Chisa Takemura Hiroshi Akiyama Koichi Saito Source Type: research
Elucidation of Degradation Behavior of Hydroxy Group-Containing Benzodiazepines in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (III)
Chem Pharm Bull (Tokyo). 2023;71(4):312-317. doi: 10.1248/cpb.c22-00911.ABSTRACTThe degradation behavior of three benzodiazepines (BZPs)-lormetazepam (LMZ), lorazepam, and oxazepam-with hydroxy groups on the diazepine ring in artificial gastric juice and the effect of storage pH conditions on drug degradability were monitored using an LC/photodiode array detector (PDA) to estimate their pharmacokinetics in the stomach. Although the three BZPs degraded in artificial gastric juice, none could be restored, despite increasing the storage pH, implying that the degradation reaction was irreversible. As for LMZ, we discussed the ...
Source: Chemical and Pharmaceutical Bulletin - April 2, 2023 Category: Drugs & Pharmacology Authors: Rie Ito Chisa Takemura Hiroshi Akiyama Koichi Saito Source Type: research
Comparison of Droperidol and Midazolam Versus Haloperidol and Lorazepam for Acute Agitation Management in the Emergency Department
CONCLUSION AND RELEVANCE: IM D+M resulted in a lower rate of repeat doses of acute agitation medication compared with IM H+L, though this was not statistically significant. Both therapies were safe, and the adverse event rate was low.PMID:36999520 | DOI:10.1177/10600280231163192 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 31, 2023 Category: Drugs & Pharmacology Authors: Patrick J Allen Kendra E Johanson Kelly R Reveles Luke A Neff Ashley E Lock Source Type: research
Comparison of Droperidol and Midazolam Versus Haloperidol and Lorazepam for Acute Agitation Management in the Emergency Department
CONCLUSION AND RELEVANCE: IM D+M resulted in a lower rate of repeat doses of acute agitation medication compared with IM H+L, though this was not statistically significant. Both therapies were safe, and the adverse event rate was low.PMID:36999520 | DOI:10.1177/10600280231163192 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 31, 2023 Category: Drugs & Pharmacology Authors: Patrick J Allen Kendra E Johanson Kelly R Reveles Luke A Neff Ashley E Lock Source Type: research
Feasibility of outpatient hybrid brachytherapy for cervical cancer with minimal sedation: Results from a single-institutional protocol
CONCLUSIONS: In our series, the treatment of HBT for cervical cancer with minimal sedation was feasible at a high percentage (96.8%). The ability to perform HBT without GA or CS could be a reasonable option to provide image-guided adaptive brachytherapy (IGABT) with limited resources, allowing for more widespread use. Further investigations using this technique are warranted.PMID:36970442 | PMC:PMC10034729 | DOI:10.5114/jcb.2023.125527 (Source: Cancer Control)
Source: Cancer Control - March 27, 2023 Category: Cancer & Oncology Authors: Subhakar Mutyala Gabriella Smith Hayden Ansinelli Nitika Thawani Source Type: research
Feasibility of outpatient hybrid brachytherapy for cervical cancer with minimal sedation: Results from a single-institutional protocol
CONCLUSIONS: In our series, the treatment of HBT for cervical cancer with minimal sedation was feasible at a high percentage (96.8%). The ability to perform HBT without GA or CS could be a reasonable option to provide image-guided adaptive brachytherapy (IGABT) with limited resources, allowing for more widespread use. Further investigations using this technique are warranted.PMID:36970442 | PMC:PMC10034729 | DOI:10.5114/jcb.2023.125527 (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - March 27, 2023 Category: Cancer & Oncology Authors: Subhakar Mutyala Gabriella Smith Hayden Ansinelli Nitika Thawani Source Type: research
