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Radiation treatment of prostate cancers - the contemporary role of modern brachytherapy techniques.
Authors: Pellizzon ACA PMID: 29204158 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

What pelvic radiation disease symptoms are experienced by patients receiving external beam radiotherapy and a high-dose-rate brachytherapy boost for prostate cancer?
Conclusions: Patients receiving EBRT plus HDR brachytherapy to the prostate experienced mild pelvic radiation disease symptoms. Determining the proportion of patients with symptoms provided the most meaningful data. PMID: 29204159 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Does supplemental external beam radiation therapy impact urinary, bowel, and erectile function following permanent prostate brachytherapy?: results of two prospective randomized trials.
Conclusions: Supplemental EBRT did not significantly effect catheter dependency, IPSS resolution, urethral stricture rate, the need for post-implant TURP, bowel, or erectile function. Careful attention to brachytherapy dose distributions appears to be most important in minimizing post-brachytherapy morbidity. PMID: 29204160 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Dosimetry advantages of intraoperatively built custom-linked seeds compared with loose seeds in permanent prostate brachytherapy.
This study included 74 prostate cancer patients who were treated with permanent prostate brachytherapy (PPB) using IBCL (n = 37) or LS (n = 37) between July 2014 and June 2016. Dose-volume histogram (DVH) parameters, seed migration, and operation time were compared between the IBCL and LS groups. In addition to the standard target volume of the whole prostate gland, DVH parameters for prostate plus a 3 mm margin (CTV) were evaluated. Results: In intraoperative planning, prostate V150 was lower (54.8% vs. 59.6%, p = 0.027), and CTV V100 (88.1% vs. 85.6%, p = 0.019) and D90 (98.5% vs. 92.6%, p = 0.0033) were higher in th...
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Treatment plan dosimetric impact after catheter stretch during multi-catheter interstitial breast brachytherapy.
Authors: Boman E, Paterson D, Huang J, Pearson S, Johnson C Abstract Purpose: Nylon 6/6 interstitial brachytherapy catheters may stretch when exposed to moisture, mechanical tension, and body temperature. The purpose of this study is to evaluate the magnitude of catheter stretch during a course of multi-catheter interstitial breast brachytherapy for nylon 6/6 treatment catheters, and to assess the impact this has on treatment plan dosimetry. Material and methods: Catheters were exposed to water at 37°C for six days and the internal catheter length change (ΔL_W) was measured daily. Additionally, the me...
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Efficacy of single-stage breast-conserving treatment using multicatheter partial breast brachytherapy evaluated by GEC-ESTRO phase 3 trial.
Conclusions: Single-stage BCT using MCB-PBI offered similar tumor control rates compering to WBI. However, further research is needed to define the benefit for patients with an exclusion criteria. PMID: 29204163 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Comparison of dose volume parameters evaluated using three forward planning - optimization techniques in cervical cancer brachytherapy involving two applicators.
Conclusions: Fletcher applicator generates higher dose to both CTV and organs at risk (2 cc volumes) after all optimization techniques. Dose restriction to rectum is possible using graphical optimization only during selected HDR fractionation schedules. Bladder always receives dose higher than recommended, and 2 cc sigmoid colon always gets permissible dose. Contrarily, graphical optimization with ring applicators fulfills all dose volume objectives in all HDR fractionations practiced. PMID: 29204164 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Throwing the dart blind-folded: comparison of computed tomography versus magnetic resonance imaging-guided brachytherapy for cervical cancer with regard to dose received by the 'actual' targets and organs at risk.
Conclusions: MRI-based IGBT remains the gold standard. CT planning may compromise HRCTVmriD90 or increase OARmriD2cc, which could decrease local control or increase treatment toxicity. PMID: 29204165 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Patterns of care and survival outcomes after treatment for uveal melanoma in the post-coms era (2004-2013): a surveillance, epidemiology, and end results analysis.
Authors: Rao YJ, Sein J, Badiyan S, Schwarz JK, DeWees T, Grigsby P, Rao PK Abstract Purpose: The Collaborative Ocular Melanoma Study (COMS) established modern treatment recommendations for uveal melanoma. We aim to evaluate patterns of care and survival outcomes in the time after COMS. Material and methods: The retrospective study population includes 2,611 patients in the SEER database treated for uveal melanoma between 2004-2013. Patients stage were T1-4N0M0. Data analyzed included age, clinical stage, tumor size, race, and treatment. Treatments included enucleation (EN) and globe preserving therapy (GPT), wh...
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Interstitial brachytherapy for orbital soft tissue sarcoma: an innovative technique.
Conclusions: Interstitial brachytherapy for orbit using this innovative technique is a safe and effective modality of local treatment for appropriately selected orbital soft tissue tumors. Brachytherapy resulted in excellent disease control with significant reduction of dose to surrounding ocular structures compared to EBRT. PMID: 29204167 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Pre-plan technique feasibility in multi-interstitial/endocavitary perineal gynecological brachytherapy.
Conclusions: We describe a virtual pre-planning technique using a multi-interstitial and endocavitary perineal template. It is based on a virtual work with MRI images. This procedure has shown to be feasible and efficient in clinical practice by facilitating the work of specialists, and reducing uncertainties of the application. PMID: 29204168 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Independent assessment of source position for gynecological applicator in high-dose-rate brachytherapy.
Conclusions: In HDR brachytherapy, an effectiveness of independent source position assessment could be demonstrated. The 95% confidence limit was 2.1 mm for a tandem-ovoids applicator. PMID: 29204169 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Locally advanced squamous cell cervical cancer in a patient with septate uterus.
Authors: Yavas G, Yavas C, Inan G Abstract A 33-year-old premenopausal multiparous woman with the history of septate uterus was referred to the hospital with menorrhagia and inter-menstrual bleeding occurring for the last 6 months. Work-up revealed a stage IIB cervical cancer. The patient underwent curative chemo/radiotherapy. The patient's septate uterus presented several difficulties during application. Brachytherapy was applied using standard computed tomography-compatible tandem and ovoids. The high-risk clinical target volume (HR-CTV), intermediate risk CTV, and organs at risk were contoured according to the G...
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Magnetic resonance imaging metal artifact reduction for eye plaque patient with dental braces.
Conclusions: T2-weighted MRI with metal artifact reduction was successfully applied to minimize artifacts in the orbits resulting from the dental braces, thus allowing the MRIs to be used in 3D brachytherapy treatment planning. PMID: 29204171 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Prostate cancer-specific death in brachytherapy treated high-risk patients stratified by pre-treatment PSA.
CONCLUSIONS: High-risk prostate cancer treated with permanent prostate brachytherapy and supplemental external beam radiotherapy resulted in excellent long-term biochemical control and PCSM. Overall, PCSM was low in all cohorts but highest in the intermediate PSA group (10.1-20 ng/ml). PMID: 28951747 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - September 29, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Is intraoperative real-time dosimetry in prostate seed brachytherapy predictive of biochemical outcome?
CONCLUSIONS: Although improving the IO preimplant and postimplant dosimetry improved dosimetry on Day 30, the BR-free rate was not dependent on any dosimetric parameter. Unpredictable factors such as intraprostatic seed migration and IO factors, prevented the accurate prediction of Day 30 dosimetry. PMID: 28951748 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - September 29, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Evaluation of intraoperative magnetic resonance imaging/ultrasound fusion optimization for low-dose-rate prostate brachytherapy.
CONCLUSIONS: The MRI/US fusion demonstrated greater prostate volume compared to standard CT/US based planning likely due to the better resolution of the prostate apex. Furthermore, rectal dose was underestimated with CT vs. MRI based planning. Additional study is required to assess long-term clinical implications of disease control and effects on long-term toxicity, especially as related to the rectum and urinary sphincter. MRI/US intraoperative fusion may improve prostate dosimetry while sparing the rectum and urethra, potentially impacting disease control and late toxicity. PMID: 28951749 [PubMed] (Source: Journal of...
Source: Journal of Contemporary Brachytherapy - September 29, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Comparison of prostate contours between conventional stepping transverse imaging and Twister-based sagittal imaging in permanent interstitial prostate brachytherapy.
Authors: Kawakami S, Ishiyama H, Satoh T, Tsumura H, Sekiguchi A, Takenaka K, Tabata KI, Iwamura M, Hayakawa K Abstract PURPOSE: To compare prostate contours on conventional stepping transverse image acquisitions with those on twister-based sagittal image acquisitions. MATERIAL AND METHODS: Twenty prostate cancer patients who were planned to have permanent interstitial prostate brachytherapy were prospectively accrued. A transrectal ultrasonography probe was inserted, with the patient in lithotomy position. Transverse images were obtained with stepping movement of the transverse transducer. In the same patient,...
Source: Journal of Contemporary Brachytherapy - September 29, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Adjuvant high-dose-rate brachytherapy in the management of oral cavity cancers: 5 years of experience in Iran.
CONCLUSIONS: HDR-IBT as a monotherapy or in combination with EBRT is an appropriate option for the management of oral cavity squamous cell carcinomas, and supports the improvement in treatment outcomes and toxicity profiles in adjuvant settings. PMID: 28951751 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - September 29, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

External beam radiation and high-dose-rate brachytherapy for elderly patients with gastroesophageal junction adenocarcinoma.
CONCLUSIONS: The clinical data indicated that NBT in combination with EBRT produced favorable local control and long-term survival rates for elderly patients with GEJAC, and that the side effects were tolerable. The patient's age could be used to select the appropriate treatment in an elderly patient. PMID: 28951752 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - September 29, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Comparison of electronic brachytherapy and Mohs micrographic surgery for the treatment of early-stage non-melanoma skin cancer: a matched pair cohort study.
CONCLUSIONS: This matched-pair cohort study supports the use of EBT as an effective non-surgical treatment option for NMSC with equivalent recurrence rates and cosmetic outcomes to MMS in appropriately-selected patients with early stage NMSC at extended follow-up. PMID: 28951753 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - September 29, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Assessing dose contribution to pelvic lymph nodes in intracavitary brachytherapy for cervical cancer.
CONCLUSIONS: Our study demonstrates that pelvic lymph nodes receive substantial dose contributions from HDR brachytherapy in cervical cancer. This should be taken into account by the radiation oncologist during EBRT planning, and adequate external beam boost doses calculated to achieve cumulative tumoricidal doses to pelvic nodal disease. PMID: 28951754 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - September 29, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Automated calculation of point A coordinates for CT-based high-dose-rate brachytherapy of cervical cancer.
Authors: Kang H, Padilla L, Hasan Y, Al-Hallaq H Abstract PURPOSE: The goal is to develop a stand-alone application, which automatically and consistently computes the coordinates of the dose calculation point recommended by the American Brachytherapy Society (i.e., point A) based solely on the implanted applicator geometry for cervical cancer brachytherapy. MATERIAL AND METHODS: The application calculates point A coordinates from the source dwell geometries in the computed tomography (CT) scans, and outputs the 3D coordinates in the left and right directions. The algorithm was tested on 34 CT scans of 7 patient...
Source: Journal of Contemporary Brachytherapy - September 29, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Inflatable multichannel rectal applicator for adaptive image-guided endoluminal high-dose-rate rectal brachytherapy: design, dosimetric characteristics, and first clinical experiences.
CONCLUSION: The use of the applicator was clinically feasible, and resulted in a stable and reproducible dose distribution. First clinical results are promising. PMID: 28951756 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - September 29, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Oncological outcome, complications, lower urinary tract symptoms, and health-related quality of life after low-dose-rate salvage brachytherapy for recurrent prostate cancer following primary radiotherapy: a report of 8 cases.
CONCLUSIONS: The present study is our experiment of eight patients undergoing salvage brachytherapy, suggesting that this modality is noninvasive, safe, and an effective salvage local treatment in selected patients. To our knowledge, this is the first study to evaluate lower urinary tract symptoms and health-related quality of life in the post-treatment period in prostate cancer patients. PMID: 28951757 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - September 29, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Robot-assisted brachytherapy of the bladder with long distance support using video conferencing.
CONCLUSIONS: The previously reported good rates of tumor control and survival, and the excellent tolerance and low morbidity support RALB as a promising approach for selected groups of patients with localized MIBC. This case illustrates the ability to expand efficiently this technique, particularly among inexperienced medical teams. PMID: 28951758 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - September 29, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Focal therapy for prostate cancer: the technical challenges.
This article provides an overview of the technical considerations for the implementation of a clinical service, and discusses related topics that should be considered in the design of clinical trials to ensure precise and accurate methods are applied for focal brachytherapy treatments. PMID: 28951759 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - September 29, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Focal application of low-dose-rate brachytherapy for prostate cancer: a pilot study.
CONCLUSIONS: Low-dose-rate brachytherapy is a favorable ablation option for focal treatment of prostate cancer, requiring minimal modification to the standard (whole gland) LDR-PB treatment, and appears to have a more favorable side effect profile. Further investigation, in the form of a larger study, is needed to assess the methods used and the long-term outcomes of focal LDR-PB. PMID: 28725242 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - July 21, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Outcomes of salvage high-dose-rate brachytherapy with or without external beam radiotherapy for isolated vaginal recurrence of endometrial cancer.
This study was designed to retrospectively analyze outcomes of high-dose-rate (HDR) brachytherapy, with or without external beam radiotherapy (EBRT), in patients with vaginal recurrence of endometrial carcinoma, and to identify factors prognostic of patient outcomes. MATERIAL AND METHODS: The medical records of all patients who underwent HDR brachytherapy for initial recurrence in the vagina of endometrial cancer after definitive surgery between 1992 and 2014 were retrospectively reviewed. All patients underwent either intracavitary brachytherapy (ICBT) or interstitial brachytherapy (ISBT) with or without EBRT. Late to...
Source: Journal of Contemporary Brachytherapy - July 21, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Optimal perioperative anesthesia management for gynecologic interstitial brachytherapy.
CONCLUSIONS: Interstitial gynecologic brachytherapy requires a multidisciplinary effort for optimal perioperative management. Our study outlines the appropriate preoperative, intraoperative, and postoperative anesthesia clinical care pathway. Decreased narcotic use during hospitalization and utilization of a patient-directed infusion may decrease side effects and allow for a more efficient hospital discharge. PMID: 28725244 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - July 21, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

The usefulness of fleet rectal enemas on high-dose-rate intracavitary cervical cancer brachytherapy. A prospective trial.
CONCLUSIONS: Our rectal enemas protocol prior to HDR-BT was ineffective in significantly modifying rectal DVH parameters. No differences were observed according to the type of applicator used. PMID: 28725245 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - July 21, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Effects of vaginal cylinder position on dose distribution in patients with endometrial carcinoma in treatment of vaginal cuff brachytherapy.
CONCLUSIONS: Vaginal cuff brachytherapy in the P and A positions is significantly superior to that in the N position in terms of rectum dosimetry. The bladder dose in the N position is considerably lower than that in the other positions. PMID: 28725246 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - July 21, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Novel anesthetic technique for combined intracavitary and interstitial brachytherapy for cervix cancer in an outpatient setting.
CONCLUSIONS: Outpatient combined intracavitary and interstitial brachytherapy for cervix cancer with sedation and local anesthesia is feasible and safe. This could potentially lead to significant cost savings. PMID: 28725247 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - July 21, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Clinical outcomes with high-dose-rate surface mould brachytherapy for intra-oral and skin malignancies involving head and neck region.
We report our institutional experience of SMB for such tumours. MATERIAL AND METHODS: Thirty-five patients with malignant localized early T1/T2, N0 (21 intra-oral and 14 skin) tumours treated with SMB during 2008-2014 were analyzed. Treatment was delivered using HDR (192)Ir source to a median dose of 49 Gy (range, 38.5-52.5 Gy) as radical brachytherapy and 18 Gy (range, 15.5-30 Gy) as boost with 3-4 Gy/fraction twice daily using customized surface mould. RESULTS: Median follow-up was 52 months (range, 6 to 98 months). Local control (LC) for skin tumours and intra-oral malignancies at 5 years were 92% and 76%, respe...
Source: Journal of Contemporary Brachytherapy - July 21, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Two years results of electronic brachytherapy for basal cell carcinoma.
CONCLUSIONS: This work is special, since the equipment's treatment voltage was 69.5 kV, and this is the first prospective study with long term follow-up with Esteya(®). These preliminary report show excellent results with less toxicity and excellent cosmesis. While surgery has been the treatment of choice, certain patients might benefit from eBT treatment. These are elderly patients with comorbidities or undergoing anticoagulant treatment as well as those who simply refuse surgery or might have other contraindications. PMID: 28725249 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - July 21, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Adjuvant radiotherapy with brachytherapy boost in soft tissue sarcomas.
CONCLUSIONS: The combination of BRT and EBRT was able to achieve satisfactory results even in a patients population with intermediate-high risk STS. Patients with recurrent or other than lower limb sited tumors show a worse LC. PMID: 28725250 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - July 21, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Custom-made micro applicators for high-dose-rate brachytherapy treatment of chronic psoriasis.
CONCLUSIONS: The first HDR brachytherapy treatment of psoriasis of the nail bed is presented. The initial experience revealed that brachytherapy treatment was well-tolerated and resulted in adequate control of the disease. A larger cohort of patients will be required for additional conclusions related to the long-term clinical benefits. PMID: 28725251 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - July 21, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Individualized 3D scanning and printing for non-melanoma skin cancer brachytherapy: a financial study for its integration into clinical workflow.
CONCLUSIONS: As the present project demonstrates, through the application of 3D printing technologies, the costs and time spent during the process in the clinical workload in brachytherapy treatment are reduced. Overall, 3D printing is a promising technique for brachytherapy that might be well received in the community. PMID: 28725252 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - July 21, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Computed tomography-based treatment planning for high-dose-rate brachytherapy using the tandem and ring applicator: influence of applicator choice on organ dose and inter-fraction adaptive planning.
Authors: Dumane VA, Yuan Y, Sheu RD, Gupta V Abstract Three dimensional planning for high-dose-rate (HDR) brachytherapy in cervical cancer has been highly recommended by consensus guidelines such as the American Brachytherapy Society (ABS) and the Groupe Européen de Curiethérapie - European Society for Radiotherapy and Oncology (GEC-ESTRO). In this document, we describe our experience with computed tomography (CT)-based planning using the tandem/ring applicator. We discuss the influence of applicator geometry on doses to organs at risk (OARs), namely the bladder, rectum, and sigmoid. Through example c...
Source: Journal of Contemporary Brachytherapy - July 21, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

INTERACTS (INTErventional Radiotherapy ACtive Teaching School) guidelines for quality assurance in choroidal melanoma interventional radiotherapy (brachytherapy) procedures.
Authors: Tagliaferri L, Pagliara MM, Boldrini L, Caputo CG, Azario L, Campitelli M, Gambacorta MA, Smaniotto D, Frascino V, Deodato F, Morganti AG, Kovács G, Valentini V, Blasi MA Abstract Eye plaque brachytherapy represents a safe and effective therapeutic approach for choroidal melanoma, combining clinical outcomes with an eye and visual preservation. As it represents a complex procedure, a specific quality assurance program is strongly suggested to improve patients and operators safety, and to reduce possible complications linked to surgical procedure and radiation exposure. The aim of this paper is to de...
Source: Journal of Contemporary Brachytherapy - July 21, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Parameters predicting for prostate specific antigen response rates at one year post low-dose-rate intraoperative prostate brachytherapy.
Authors: Martell K, Meyer T, Sia M, Angyalfi S, Husain S Abstract PURPOSE: To develop a model for prostate specific antigen (PSA) values at one year among patients treated with intraoperatively planned (125)I prostate brachytherapy (IOPB). MATERIAL AND METHODS: Four hundred and deven patients treated with IOPB for prostate adenocarcinoma were divided into four groups: those with PSA values ≥ 3 ng/ml;
Source: Journal of Contemporary Brachytherapy - May 25, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

High-dose-rate interstitial brachytherapy for accelerated partial breast irradiation - trial results of Azerbaijan National Center of Oncology.
CONCLUSIONS: Accelerated partial breast irradiation using multicatheter brachytherapy with 32 Gy/8 fractions and 35 Gy/7 fractions for early breast cancer seems to be similar in terms of late side effects. According to our findings, APBI was also feasible for intermediate-risk of early breast cancer patients. PMID: 28533797 [PubMed - in process] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 25, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Optimal bladder filling during high-dose-rate intracavitary brachytherapy for cervical cancer: a dosimetric study.
CONCLUSIONS: Bladder filling protocol with 50 ml and 100 ml was well tolerated and achieved a reasonably reproducible bladder volume during cervical brachytherapy. In our analysis so far, there is no significant impact of bladder filling on DVH parameters, although larger bladders tend to have higher doses. Small bowel doses are lesser with higher bladder volumes. Further evaluation and validation are necessary. PMID: 28533798 [PubMed - in process] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 25, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Definitive three-dimensional high-dose-rate brachytherapy for inoperable endometrial cancer.
CONCLUSIONS: Although some limitations of our analysis (relatively few number of patients recruited, retrospective evaluation, and consequent suboptimal patient selection), it confirms effectiveness and safety of definitive HDR-BT for medically inoperable stage I-III endometrial cancer. The best LC was obtained in stage I low-risk histology. PMID: 28533799 [PubMed - in process] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 25, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

High-dose-rate interstitial brachytherapy in head and neck cancer: do we need a look back into a forgotten art - a single institute experience.
CONCLUSIONS: The overall outcome was good with implementation of HDR-BRT used alone or as boost, and shows DFS as better when the dose received is more than the median BED and median EQD2. The role of HDR-BRT in HNC is a proven, effective, and safe treatment method with excellent long term outcome as seen in this study, which reflects the need for reviving the forgotten art and science of interstitial brachytherapy in HNC. PMID: 28533800 [PubMed - in process] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 25, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Computed tomography-guided implantation of (125)I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results.
CONCLUSIONS: CT-guided (125)I brachytherapy is a safe and effective treatment for multiple pulmonary metastatic tumors, and can achieve good short-term local control, so long as the radiation dose is sufficient. PMID: 28533801 [PubMed - in process] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 25, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Interobserver variations of target volume delineation and its impact on irradiated volume in accelerated partial breast irradiation with intraoperative interstitial breast implant.
Authors: Upreti RR, Budrukkar A, Wadasadawala T, Misra S, Gurram L, Pathak R, Deshpande DD Abstract PURPOSE: To investigate the interobserver variations in delineation of lumpectomy cavity (LC) and clinical target volume (CTV), and its impact on irradiated volume in accelerated partial breast irradiation using intraoperative multicatheter brachytherapy. MATERIAL AND METHODS: Delineation of LC and CTV was done by five radiation oncologists on planning computed tomography (CT) scans of 20 patients with intraoperative interstitial breast implant. Cavity visualization index (CVI), four-point index ranging from (0 =...
Source: Journal of Contemporary Brachytherapy - May 25, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Use of ultrasound in image-guided high-dose-rate brachytherapy: enumerations and arguments.
Authors: Banerjee S, Kataria T, Gupta D, Goyal S, Bisht SS, Basu T, Abhishek A Abstract Inherently, brachytherapy is the most conformal radiotherapeutic technique. As an aid to brachytherapy, ultrasonography (USG) serves as a portable, inexpensive, and simple to use method allowing for accurate, reproducible, and adaptive treatments. Some newer brachytherapy planning systems have incorporated USG as the sole imaging modality. Ultrasonography has been successfully used to place applicator and dose planning for prostate, cervix, and anal canal cancers. It can guide placement of brachytherapy catheters for all other s...
Source: Journal of Contemporary Brachytherapy - May 25, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

The use of trans-applicator intracavitary ultrasonography in brachytherapy for cervical cancer: phantom study of a novel approach to 3D image-guided brachytherapy.
CONCLUSIONS: Three-dimensional reconstructed trans-applicator intracavitary ultrasonographic images clearly depicted meat tissue within the phantom, and could thus be used for brachytherapy planning. This study proves the concept of trans-applicator intracavitary ultrasonography for intracavitary brachytherapy. Further research such as development of intracavitary ultrasonography system, 3D reconstruction method, ultrasonography-compatible applicators, and ultrasonography-based target concept is warranted to assess the potential clinical application. PMID: 28533804 [PubMed - in process] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 25, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Electronic brachytherapy management of atypical fibroxanthoma: report of 8 lesions.
CONCLUSIONS: To our knowledge, this is the first report in the literature on the use of radiation therapy as curative primary treatment for AFX. No contraindication to the use of radiations is found in the literature, with surgery being the sole treatment for AFX noted. Our recurrence rate is 0% for debulked lesions. Risk of recurrence is mitigated with surgical debulking prior to brachytherapy. Electronic brachytherapy appears to be a safe and effective treatment for debulked AFX. Multiple excisions, skin grafting, and wound care can be avoided in elderly patients by the use of electronic brachytherapy. PMID: 28533805...
Source: Journal of Contemporary Brachytherapy - May 25, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research