Letter from the Editor-in-Chief.
Authors: Mahantshetty U, Chicheł A PMID: 31523228 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - September 18, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Indian Brachytherapy Society Guidelines for radiotherapeutic management of cervical cancer with special emphasis on high-dose-rate brachytherapy.
Authors: Mahantshetty U, Gudi S, Singh R, Sasidharan A, Sastri SC, Gurram L, Sharma D, Ganeshrajah S, Mg J, Badakh D, Basu A, James F, Swamidas JV, Kuppuswamy T, Bhalavat R Abstract Brachytherapy (BT) for locally advanced cervical cancer is vital for optimal outcomes. There is heterogeneity in brachytherapy treatment practice for cervical cancer across India. In an attempt to standardize various processes involved in cervical cancer brachytherapy, the expert members of the Indian Brachytherapy Society (IBS) developed a document related to radiation therapy treatment of cervical cancer with special emphasis on brach...
Source: Journal of Contemporary Brachytherapy - September 18, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Magnetic resonance image-based 3D volume interstitial brachytherapy using polyether ether ketone catheters in advanced cervical cancer - a feasibility study.
Conclusions: When the facilities for MR-compatible applicators are not available, MR-based ISBT is feasible with PEEK catheters using available resources for advanced cervical cancer. Doses to HR-CTV and IR-CTV were achieved, restricting doses to OARs as per GEC-ESTRO guidelines. PMID: 31523230 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - September 18, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Second breast conserving therapy after ipsilateral breast tumor recurrence - a 10-year experience of re-irradiation.
Conclusions: In case of small, low-risk IBTR, adjuvant re-irradiation using multi-catheter brachytherapy is a feasible, safe, and effective treatment method after repeated lumpectomy, and an alternative to mastectomy. PMID: 31523231 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - September 18, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Treatment patterns of high-dose-rate and low-dose-rate brachytherapy as monotherapy for prostate cancer.
Conclusions: We observed an overall decrease in brachytherapy (BT) monotherapy use since 2004 for localized prostate cancer. Despite similar survival outcomes, the use of HDR monotherapy declined relative to LDR. PMID: 31523232 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - September 18, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Treatment of hepatic pancreatic ductal adenocarcinoma metastases with high-dose-rate image-guided interstitial brachytherapy: a single center experience.
Conclusions: Overall, iBT is a safe procedure, which enables excellent rates of local tumor control and presents a viable anti-neoplastic treatment option as a salvage therapy for metastatic PDAC patients. PMID: 31523233 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - September 18, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Individual multi-catheter mould technique in high-dose-rate brachytherapy - personalized approach in treating multifocal angiosarcoma of the face.
Conclusions: HDR brachytherapy may be a valuable option for angiosarcoma treatment. Difficult lesion location may yield non-radical surgery. Surface IMM HDR provides highly conformal plan and allow adjusting the dose to individual clinical situation. PMID: 31523234 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - September 18, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Image-guided high-dose-rate interstitial brachytherapy for recurrent rectal cancer after salvage surgery: a case report.
Authors: Yanping B, Murakami N, Shima S, Takahashi K, Inaba K, Okuma K, Igaki H, Nakayama Y, Itami J Abstract Treatment options for patients with recurrent rectal cancer in pelvis represent a significant challenge because the balance of efficiency and toxicity needs to be pursued. This case report illustrates a treatment effect of image-guided high-dose-rate interstitial brachytherapy (HDR-ISBT) for locally relapsed rectal cancer after salvage surgery. A 61-year-old male who underwent laparoscopic high anterior resection (LAP-HAR) with D3 lymph node dissection as a primary treatment for rectal cancer (pT3N0M0, well...
Source: Journal of Contemporary Brachytherapy - September 18, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Experience in multicatheter interstitial high-dose-rate breast brachytherapy: dose-volume histogram analysis of the first results.
Conclusions: This study is the first stage of the dosimetric evaluation of a new method. The analysis allows treating complex localizations of the breast cancer, for example, in a close position to the skin or ribs. In order to minimize the toxic effects, it is necessary to consider patient selection, catheter administration, and dose optimization. PMID: 31523236 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - September 18, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Placement of 131Cs permanent brachytherapy seeds in a large combined cavity of two resected brain metastases in one setting: case report and technical note.
We report a 57-year-old male patient, with metastatic hypopharyngeal brain cancer. The patient presented with two metastases in the right frontal and right parietal lobes. Post-resection of these lesions resulted in a large total combined cavity diameter of 5.3 cm, which was implanted with 131Cs seeds. The patient tolerated the procedure well, with 100% local control and 0% radiation necrosis. This case is unique in demonstrating that the 131Cs isotope was not only a convenient option of treating two resected brain metastases in one setting, but also that this treatment option offered excellent long-term LC and minimal tox...
Source: Journal of Contemporary Brachytherapy - September 18, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Addition of magnetic resonance imaging to real time trans-rectal ultrasound-based treatment planning for prostate implants.
Conclusions: The MRI-TRUS image fusion is a feasible tool for the visualization of the prostate gland, particularly at the apex and base of the gland. Tumor identification presents the potential for dose escalation using fusion, especially for anteriorly located tumors. PMID: 31523238 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - September 18, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Hypofractionated 192Ir source stereotactic ablative brachytherapy with coplanar template assistance in the primary treatment of peripheral lung cancer.
In this study, we reported the safety and efficacy of hypofractionated 192Ir source stereotactic ablative brachytherapy (SABT) with coplanar template assistance for peripheral lung cancer, and compared the dosimetric parameters between SABT and stereotactic body radiotherapy (SBRT). Material and methods: Thirty-three peripheral lung cancer patients, with the gross lung tumor volume (GTVL) 0.05); the remaining dosimetric parameters were significantly lower in SABT than in SBRT (all p
Source: Journal of Contemporary Brachytherapy - September 18, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Dosimetric comparison of graphical optimization and inverse planning simulated annealing for brachytherapy of cervical cancer.
Conclusions: In 3D brachytherapy of cervical cancer, GO and IPSA optimizations do not present a significant difference in target dose coverage; nevertheless, IPSA may reduce the maximum dose to normal tissue when compared with GO. PMID: 31523240 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - September 18, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

End-to-end test and MOSFET in vivo skin dosimetry for 192Ir high-dose-rate brachytherapy of chronic psoriasis.
Conclusions: We demonstrated achievable HDR-BT for our first case of nail bed psoriasis. The end-to-end exercise was an efficient methodology to evaluate new feasibility for this technique. Real-time dose monitoring using MOSFET was an effective and reliable tool to ensure treatment quality and patient safety. PMID: 31523241 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - September 18, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Complications and adverse events of plaque brachytherapy for ocular melanoma.
This article reviews complications and adverse events of plaque brachytherapy, including scleral necrosis, strabismus, cataract, glaucoma, and retinopathies as well as management of these conditions. For practicing oncologists and ophthalmologists, these complications are important to understand, identify, and treat. Additionally, an understanding of common complications of brachytherapy should influence the decision of pursuing it as a treatment option. PMID: 31523242 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - September 18, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Carotid dosimetry after re-irradiation with 131Cs permanent implant brachytherapy in recurrent, resected head and neck cancer.
Conclusions: Carotid artery doses from 131Cs are reported. Vascularized tissue flaps should be considered when planning 131Cs brachytherapy. PMID: 31447900 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - August 27, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Letter from the Editor-in-Chief.
Authors: Chicheł A PMID: 31435424 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Prospective four years of evaluation of erectile function after low-dose-rate prostate brachytherapy using baseline IIEF-5 > 16.
Conclusions: During the first 4 years after BT, more than half of patients maintained an IIEF-5> 16, and EF results remained stable. Severe erectile dysfunction (ED) was very rare. PMID: 31435425 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Whole-gland salvage treatment for recurrent prostate cancer after initial definitive radiotherapy: A case series of 125I brachytherapy and robot-assisted radical prostatectomy.
Conclusions: Whole-gland salvage BT is an effective treatment with an acceptable toxicity profile. The pathology findings from RARP imply that there is a room for improvement in diagnoses made by MRI in the pre-salvage setting. PMID: 31435426 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

A prospective comparison of subjective and objective assessments of cosmetic outcomes following breast brachytherapy.
Authors: Wadasadawala T, Sinha S, Verma S, Parmar V, Kannan S, Pathak R, Sarin R, Gaikar M Abstract Purpose: We evaluated agreement between subjective and objective methods of cosmesis scoring in an accelerated partial breast irradiation (APBI) cohort. Material and methods: Consecutive women treated with APBI using interstitial brachytherapy reported for clinical follow-up every 6 months. Single cross-sectional assessment of the breast cosmesis was done by a radiation oncologist (subjective method) using Harvard scale and by photographic assessment using BCCT.core (Breast Cancer Conservative Treatment. Cosmetic...
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Interstitial high-dose-rate brachytherapy in the primary treatment of inoperable glioblastoma multiforme.
Conclusions: For patients with inoperable GBM, IRT HDR BRT alone or in combination with EBRT is a safe and effective irradiation method providing palliation without excessive toxicity. PMID: 31435428 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Single institution implementation of permanent 131Cs interstitial brachytherapy for previously irradiated patients with resectable recurrent head and neck carcinoma.
Conclusions: Cesium-131 interstitial brachytherapy is feasible and does not pose major radiation safety concerns; it should be considered as a treatment option for previously irradiated patients with recurrent, resectable HNC. PMID: 31435429 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Dosimetry verification of 3D-printed individual template based on CT-MRI fusion for radioactive 125I seed implantation in recurrent high-grade gliomas.
Conclusions: 3D-PIT based on the CT-MRI fusion images can result in good accuracy for positioning and dose distribution in radioactive seed implantation for treatment of rHGG. PMID: 31435430 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Fibre-optic endoscope-guided three-dimensional high-dose-rate interstitial brachytherapy for residual nasopharyngeal carcinoma after conventional external beam radiotherapy.
Conclusions: Fibre-optic endoscope-guided 3D HDR ISBT boost could be an additional treatment strategy for locoregional residual NPC after radical EBRT, especially for deep invasive lesion. PMID: 31435431 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Image-guided high-dose-rate brachytherapy for prostate cancer patients with previous rectal resection and pelvic irradiation: feasibility study.
Conclusions: Fluoroscopy and 3D CT image-guided interstitial brachytherapy is feasible and appears to be a suitable treatment technique for patients with clinically localized prostate cancer after previous rectal resection and external beam radiation therapy. PMID: 31435432 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Influence of dwell time homogeneity error weight parameter on treatment plan quality in inverse optimized high-dose-rate cervix brachytherapy using SagiPlan.
This study, for the first time, aims to quantify the impact of modulation restriction on plan quality indices in inverse optimization for cervix high-dose-rate (HDR) brachytherapy using the BEBIG SagiPlan treatment planning system. Material and methods: Ten cervical cancer patient plans were optimized for treatment with a BEBIG SagiNova 60Co HDR afterloader using the min/max inverse planning method, with dwell time homogeneity error weight (DTHEW) parameter values of 0 to 10. Dwell time homogeneity and gradients as well as various plan quality indices were analyzed. Results: For DTHEW = 0, min/max-based optimizatio...
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Hybrid optimization based on non-coplanar needles for brachytherapy dose planning.
Conclusions: The hybrid inverse optimization method achieved high conformity in the clinical practice. The non-coplanar needle can help to achieve a better dose distribution than the coplanar needle. PMID: 31435434 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Treatment planning considerations for 125I eye plaque brachytherapy.
Authors: Miguel D, de Frutos JM, López-Lara F, Alonso P, Diezhandino P, Saornil MA, García C Abstract Effective cancer brachytherapy requires a treatment plan that delivers high-dose to tumor, while minimizing the dose to critical normal tissues. Therefore, an accurate knowledge of the sources and magnitude of the techniques is essential for producing robust and well optimized-plans. The purpose of this technical note is to establish general procedures and strategies for optimization and customization of the plaques loaded with radioactive seeds, particularly focusing on the definition of useful tacti...
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Treatment of locally advanced cervical cancer in a patient with a bicornuate uterus with MRI-guided intracavitary/interstitial brachytherapy.
Conclusions: We found that the use of the hybrid applicator allowed for adequate target coverage in a patient with unusual anatomy. The patient tolerated treatment well and demonstrated favorable response on follow-up exam and imaging. The long-term curative result needs to be further evaluated. PMID: 31435436 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Letter from the Editor-in-Chief.
Authors: Chicheł A PMID: 31149018 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - June 4, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Second breast-conserving therapy with interstitial brachytherapy (APBI) as a salvage treatment in ipsilateral breast tumor recurrence: a retrospective study of 40 patients.
Conclusions: Second BCT with APBI as a salvage treatment in ipsilateral breast recurrence achieves good local disease control, with a satisfactory toxicity profile compared to mastectomy. This approach seems to be safe and effective, although more data from randomized trials are needed. PMID: 31139217 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 31, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Catheter-based delineation of lumpectomy cavity for accurate target definition in partial-breast irradiation with multicatheter interstitial brachytherapy.
Authors: Sato K, Shimo T, Fuchikami H, Takeda N, Kato M, Okawa T Abstract Purpose: In partial-breast irradiation (PBI), accurate lumpectomy cavity (LC) delineation is critical. Seroma-based delineation (SBD) using computed tomography (CT) with clips remains uncertain, causing an expansion of the LC and planning target volume (PTV). In catheter-based delineation (CBD), the implanted catheters were used as reference markers for LC delineation in multicatheter interstitial brachytherapy (MIB). Material and methods: Between October 2008 and October 2018, 513 patients who underwent MIB-PBI were examined. In CBD, ana...
Source: Journal of Contemporary Brachytherapy - May 31, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Adjuvant interstitial three-dimensional pulse-dose-rate-brachytherapy for lip squamous cell carcinoma after surgical resection.
Conclusions: PDR-BT in the adjuvant treatment of the lip cancer yields high local control with low toxicity. Even patients with close margins after surgery (
Source: Journal of Contemporary Brachytherapy - May 31, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

The impact of inter-fraction changes for perineal template-based interstitial gynecologic brachytherapy implants.
Conclusions: The implementation of perineal template-based ISBT treatment without inter-fraction adaptive planning can be delivered to comply with the ABS normal tissue dose guidelines and EMBRACE II limits for prescribed dose. PMID: 31139220 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 31, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Development and assessment of 3D-printed individual applicators in gynecological MRI-guided brachytherapy.
Authors: Logar HBZ, Hudej R, Šegedin B Abstract Purpose: To evaluate the clinical use of 3D printing technology for the modelling of individual applicators for advanced gynecological tumors in magnetic resonance imaging (MRI)-based brachytherapy (BT). Material and methods: We tested individually designed 3D-printed applicators in nine patients with advanced gynecological cancer. Before BT was performed, all patients were treated with external beam radiotherapy (EBRT). The most common indication for individualized BT was advanced gynecological tumors where the use of standard BT applicators was not feasib...
Source: Journal of Contemporary Brachytherapy - May 31, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Assessment of the anatomical position of point B and the relationship between point B dose and the dose delivered to pelvic lymph nodes in CT-based high-dose-rate brachytherapy for uterine cervical cancer.
Authors: Matsukawa H, Sasaki T, Hirayama R, Hirose TA, Fukunaga JI Abstract Purpose: To examine the anatomical position of point B and the relationship between the dose at point B and the dose delivered to the pelvic lymph nodes in computed tomography (CT)-based brachytherapy for cervical cancer. Material and methods: Forty-nine cervical cancer patients were treated at Kyushu University Hospital. For all cases, planning CT images obtained after the applicator insertion were imported to an Oncentra Brachy (Elekta AB, Stockholm, Sweden), and points A (dose prescription, 6 Gy) and points B were set according to th...
Source: Journal of Contemporary Brachytherapy - May 31, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

High-dose-rate brachytherapy for high-grade vaginal intraepithelial neoplasia: a dosimetric analysis.
Conclusions: Patients with VAIN3 seemed to benefit from BT. It is generally assumed that the vagina is radio-resistant, and no constraints have yet been set, but sexual dysfunction after BT is an important cause of long-term distress. Finding applicable dose limits to the vagina could improve patients' quality of life. PMID: 31139223 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 31, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

First report on extended distance between tumor lesion and adjacent organs at risk using interventionally applied balloon catheters: a simple procedure to optimize clinical target volume covering effective isodose in interstitial high-dose-rate brachytherapy of liver malignomas.
Conclusions: The distancing of the adjacent OARs allows a higher D100 value of CTV, therefore allowing for more efficient local control. PMID: 31139224 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 31, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Template-assisted 192Ir-based stereotactic ablative brachytherapy as a neoadjuvant treatment for operable peripheral non-small cell lung cancer: a phase I clinical trial.
Authors: Shi XX, Pang HW, Ren PR, Sun XY, Wu JB, Lin S Abstract Purpose: To evaluate safety, feasibility, and efficacy of template-assisted 192Ir-based stereotactic ablative brachytherapy (SABT), combined with surgery for peripheral non-small cell lung cancer (NSCLC). Material and methods: Patients with pathologically confirmed operable peripheral NSCLC, who underwent template-assisted SABT (30 Gy delivered in one fraction) and were scheduled for tumor resection 4-6 weeks after SABT were included in this study. The perioperative adverse reactions of SABT were recorded to evaluate safety and feasibility of SABT ...
Source: Journal of Contemporary Brachytherapy - May 31, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Comparative study for CT-guided 125I seed implantation assisted by 3D printing coplanar and non-coplanar template in peripheral lung cancer.
Conclusions: The dose distributions of the two 3DPCT plans were similar. 3DPNCT plan had a higher dose in target volume margin, with fewer needles and fewer breaks to the ribs. PMID: 31139226 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 31, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

A novel approach for salvage treatment of non-small-cell lung cancer: percutaneous CT fluoroscopy-guided permanent seed brachytherapy for salvage treatment of lung cancer: long-term results of a case series.
Conclusions: Percutaneous CT fluoroscopy-guided permanent seed brachytherapy is a safe, efficacious, and cost effective primary and salvage treatment for lung cancer. CT-fluoroscopy resources are readily available in the community and are an effective alternative to stereotactic body radiation therapy (SBRT), intensity-modulated radiation therapy (IMRT)/proton beam, radiofrequency ablation (RFA), and cryoablation (CA). Percutaneous CT fluoroscopy-guided permanent seed brachytherapy has an equivalent or better local control rate, a lower resource cost, and a far lower integral radiation dose than other therapies. We believe...
Source: Journal of Contemporary Brachytherapy - May 31, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Concurrent chemoradiotherapy for locally advanced squamous cell carcinoma of the cervix in a uterus didelphys with vaginal septum.
Authors: Kaneyasu Y, Koh I, Fujiwara H, Hirata E, Kudo Y, Arihiro K, Miharu N, Nakagawa T, Takahashi I, Takeuchi Y, Imano N, Nishibuchi I, Nakashima T, Kawahara D, Ohno Y, Nagata Y Abstract In November 2011, a 61-year-old woman was diagnosed with squamous cell carcinoma (SCC) of the cervix in a uterus didelphys with vaginal septum. The patient was diagnosed with Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) stage IIB because of infiltration to the left parametrium without infiltration to the pelvic wall. The patient was treated with external-beam radiotherapy (EBRT) an...
Source: Journal of Contemporary Brachytherapy - May 31, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Impact of different dose prescription schedules on EQD2 in high-dose-rate intracavitary brachytherapy of carcinoma cervix.
Conclusions: EQD2 of bladder, rectum, sigmoid, D90 CTVHR, and point A were similar with 5.5 Gy × 5 fractions, 6.5 Gy × 4 fractions, and 7 Gy × 4 fractions, whereas EQD2 of 9 Gy × 2 fractions was significantly unfavorable compared to other schedules. Further clinical studies are recommended to observe clinical outcomes. PMID: 31139229 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 31, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Hyaluronic gel injection into the vesicovaginal septum for high-dose-rate brachytherapy of uterine cervical cancer: an effective approach for bladder dose reduction.
Conclusions: HGI in the VVS can be performed safely and can effectively reduce the bladder dose in BT for uterine cervical cancer patients. PMID: 30911303 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - March 28, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Improving rectal dosimetry for patients with intermediate and high-risk prostate cancer undergoing combined high-dose-rate brachytherapy and external beam radiotherapy with hydrogel space.
Conclusions: Insertion of HS in prostate cancer patients receiving combined HDR and EBRT is safe and has resulted in a significant radiation dose reduction to the rectum, resulting in significantly less acute GI toxicity and a trend towards less late GI toxicity. PMID: 30911304 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - March 28, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Subdermal injection of hyaluronic acid to decrease skin toxicity from radiation delivered with low-dose-rate brachytherapy for cancer patients.
Authors: Yuan Y, Ying Z, Jianjian D, Qi L, Ruicai X, Baocheng G, Mingyong H Abstract Purpose: To study the feasibility of hyaluronic acid (HA) injection to increase the distance between skin and radioactive sources, and dose reduction of skin during low-dose-rate (LDR) brachytherapy.Material and methods: A total of 11 patients with subdermal malignant tumors were enrolled in this study. HA was injected after I-125 seed implantation, and dosimetric parameters were calculated by a brachytherapy treatment planning system (BTPS). The distance of the new space between radioactive sources and skin was measured on compute...
Source: Journal of Contemporary Brachytherapy - March 28, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Long-term results of chemoradiation plus pulsed-dose-rate brachytherapy boost in anal canal carcinoma: A mono-institutional retrospective analysis.
Conclusions: The role of BRT boost in ACC remains unclear since the outcomes were not clearly different compared to CCRT alone. However, further improvement of clinical results in ACC treatment is needed, and therefore prospective trials based on advanced (image-guided/adapted) BRT techniques are warranted. PMID: 30911306 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - March 28, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Five-year outcome of ultrasound-guided interstitial permanent 125I seeds implantation for local head and neck recurrent tumors: a single center retrospective study.
Conclusions: Interstitial permanent implantation of 125I seeds under ultrasound guidance is feasible, efficacious, and safe for refractory head and neck metastasis or recurrence. PMID: 30911307 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - March 28, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

How many times 125I seed implantation brachytherapy can be repeated for pulmonary metastases: clinical efficacy and complications.
Conclusions: ISB for RPM is safe and efficacious. RPM treatment seems not to be limited by number of times ISB could be repeated; at least up to 8 times for different sites of lung. PMID: 30911308 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - March 28, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Changes in magnetic resonance T2-weighted imaging signal intensity correlate with concurrent chemoradiotherapy response in cervical cancer.
This study is aimed to compare magnetic resonance imaging (MRI) parameters and clinical pathological factors (CPF) of residual tumor group with non-residual tumor group in cervical cancer (CC) patients during concurrent chemoradiotherapy (CCRT), and thus to establish a biomarker for individualized treatment strategy. Material and methods: From May 2014 to November 2015, 164 CC patients were included in this retrospective study. T2-weighted MRI was performed at pre-treatment (week-0), the completion of external radiotherapy (RT) (week-4), and one month after the completion of CCRT, using 3.0T MR scanner with regular pel...
Source: Journal of Contemporary Brachytherapy - March 28, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research