Ruthenium brachytherapy for intraocular growth of a conjunctival squamous cell carcinoma: a case report.
Authors: Rospond-Kubiak I, Adamski W, Sosnowska K, Kociȩcki J, Marszałek A Abstract The aim of this study is to report the use of ruthenium brachytherapy as an adjunctive treatment in the management of an intraocular extension of the conjunctival squamous cell carcinoma (SCC). In 2013, a 73-year-old man presented with a tumor blocking the angle and infiltrating corneal endothelium. The patient was treated with iridectomy, and after one month, ruthenium brachytherapy was applied. 4.5 years post-irradiation, the treated eye is painless, and no recurrence was noted. We advocate the use of ruthenium brachytherapy as ...
Source: Journal of Contemporary Brachytherapy - May 29, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Advantages of intraoperative implant for interstitial brachytherapy for accelerated partial breast irradiation either frail patients with early-stage disease or in locally recurrent breast cancer.
Conclusions: This technique, although time-consuming, achieves good local disease control with a satisfactory toxicity profile in both early-stage and local recurrent breast cancer patients. It may be especially suitable for frail patients. PMID: 29789758 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 27, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Combined external beam radiotherapy and vaginal brachytherapy versus vaginal brachytherapy in stage I, intermediate- and high-risk cases of endometrium carcinoma.
Conclusions: VBT alone is as effective as EBRT+VBT in ensuring loco-regional control and achieving comparable survival rates, with fewer toxic effects for patients with stage I intermediate- and high-risk endometrial carcinoma. The dose escalation did not make a difference in the survival rates and was like in the other major trials (PORTEC-2). PMID: 29789759 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 27, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

High-dose-rate brachytherapy in treatment of non-melanoma skin cancer of head and neck region: preliminary results of a prospective single institution study.
Conclusions: With appropriate patient selection and choosing as lowest dose per fraction as possible, HDR brachytherapy with customized surface molds yields good oncological and cosmetic results for the treatment of localized skin BCC and SCC. PMID: 29789760 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 27, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Visual outcome after posterior uveal melanoma episcleral brachytherapy including radiobiological doses.
Conclusions: Visual acuity changes can be modeled by an exponential function for the first 5 years after treatment. No relation between VA loss and BED has been found; nevertheless, apical height, plaque size, juxtapapillary localization, and dose to fovea were found as statistical significant variables. PMID: 29789761 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 27, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Percutaneous computed tomography-guided permanent 125I implantation as therapy for pulmonary metastasis.
Authors: Huo X, Huo B, Wang H, Wang L, Cao Q, Zheng G, Wang J, Chai S, Zhang Z, Yang K, Niu Y, Wang H Abstract Purpose: To evaluate intermediate-term outcomes after computed tomography (CT)-guided radioactive 125I seed implantation (CTRISI), and to determine prognostic variables associated with outcomes in patients with pulmonary metastases. Material and methods: Thoracic surgeons evaluated and performed implantation of 125I radioactive seeds under CT guidance or combined with surgical resection. Patients were monitored in the thoracic surgery clinic for recurrence and survival. Results: Fifty patients (31 ...
Source: Journal of Contemporary Brachytherapy - May 27, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Verification of high-dose-rate brachytherapy treatment planning dose distribution using liquid-filled ionization chamber array.
Conclusion: The dosimetric properties of IA 2.5-5 mm showed the applicability of liquid-filled ionization chamber array as a potential QA device for HDR brachytherapy treatment planning systems. PMID: 29789763 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 27, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

A single institution analysis of low-dose-rate brachytherapy: 5-year reported survival and late toxicity outcomes.
Conclusions: LDR brachytherapy is an effective treatment option in low- to intermediate-risk prostate cancer patients. We observed low biochemical relapse rates and minimal GU toxicities several years after treatment in patients with or without TURP. However, a small risk of urinary retention was observed in some patients. PMID: 29789764 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 27, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Successful salvage treatment of refractory recurrence of maxillary sinus carcinoma using image-guided high-dose-rate interstitial brachytherapy.
Authors: Zhang Y, Wu N, Zhao Z, Chen Q, Cheng G Abstract This case report illustrates a treatment effect of image-guided high-dose-rate (HDR) interstitial brachytherapy for refractory recurrence of maxillary sinus carcinoma. A 61-year-old male was previously admitted to another hospital and received surgery because of left maxillary sinus squamous cell carcinoma (SCC) 6 years ago. Tumor regrowth was noted 2 years after the initial radical surgery. The patient accepted local excision again for the recurrence, followed by external beam radiotherapy. Despite salvage treatment with surgery and external irradiation...
Source: Journal of Contemporary Brachytherapy - May 27, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Salvage high-dose-rate brachytherapy for prostate cancer persistence after brachytherapy: repeated use of a polyethylene glycol hydrogel spacer.
Conclusions: The use of a hydrogel prior to salvage HDR-BT in a patient previously treated with HDR-BT is feasible and could help reduce the rectal exposure in the salvage setting. PMID: 29789766 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 27, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Don't forget the bladder!
Authors: Oosterveld BJ, van der Steen-Banasik EM, Smits GA PMID: 29789767 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 27, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Radiological and clinical findings following rectal contact X-ray brachytherapy (Papillon technique) - how to assess response.
Conclusions: MR scans should be used in combination with endoluminal mucosal assessment (and digital rectal examination) to determine response following Papillon radiotherapy. This is the first paper to describe both the endoscopic and imaging findings following Papillon radiotherapy. PMID: 29789768 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 27, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Time to PSA rise differentiates the PSA bounce after HDR and LDR brachytherapy of prostate cancer.
Conclusions: HDR-BT and LDR-BT for low and intermediate risk prostate cancer had similar PB rate. The PB occurred earlier after HDR-BT than after LDR-BT. ADT and higher Gleason score decreased, and higher PSA nadir and longer time to PSA nadir increased the risk of PB after HDR-BT. PMID: 29619050 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - April 7, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

A cold spot compensation technique using a combination of trans-rectal ultrasonography and intraoperative computed tomography for interstitial permanent prostate brachytherapy: a single-arm prospective trial.
Authors: Ishiyama H, Tsumura H, Kawakami S, Satoh T, Sekiguchi A, Tabata KI, Iwamura M, Hayakawa K Abstract Purpose: To evaluate the efficacy of a cold spot compensation technique using a combination of trans-rectal ultrasonography (TRUS) and computed tomography (CT) for permanent interstitial prostate brachytherapy. Material and methods: Sixty-five patients were treated with the cold spot compensation technique using TRUS-CT fusion. The prescribed dose was set at 145 Gy. The dose to 90% of prostate volume (D90) was planned to be within 195 Gy (134%) and 205 Gy (141%). After implantation using the conventional ...
Source: Journal of Contemporary Brachytherapy - April 7, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Impact of brachytherapy technique (2D versus 3D) on outcome following radiotherapy of cervical cancer.
Authors: Derks K, Steenhuijsen JLG, van den Berg HA, Houterman S, Cnossen J, van Haaren P, Jaeger K Abstract Purpose: The purpose of this study was to analyze the effect of 2D conventional brachytherapy (CBT) compared to 3D MRI-guided brachytherapy (IGBT) with and without the use of interstitial needles on local control, overall survival, and toxicity in patients treated for cervical cancer with radiation or chemoradiation. Material and methods: A retrospective analysis was performed of biopsy-proven FIGO IB-IVA cervical cancer patients, treated with primary radiation or chemoradiation, followed by brachytherap...
Source: Journal of Contemporary Brachytherapy - April 7, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Clinical analysis of speculum-based vaginal packing for high-dose-rate intracavitary tandem and ovoid brachytherapy in cervical cancer.
Conclusions: In patients with conducive anatomy, SBVP is a cost-efficient packing method that is associated with improved bladder sparing and comparable rectal sparing relative to gauze packing during HDR-ICB without general anesthesia. PMID: 29619054 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - April 7, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Late G2 vagina toxicity in post-operative endometrial carcinoma is associated with a 68 Gy dose equivalent to 2 Gy per fraction( α/β=3Gy) at 2 cm3 of vagina.
Conclusions: More than 68 Gy EQD2(α/β=3Gy) at 2 cm3 was related to G2 toxicity in P-EC-VBT. Further studies including larger number of patients are needed to confirm these results. Patients receiving these doses should be informed of the risk of toxicity, with individualized treatment planning and follow-up to reduce G2 toxicity. PMID: 29619055 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - April 7, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Should molecular subtype be recommended as one of the selection criteria for accelerated partial breast irradiation? Preliminary results from an Asian cohort.
Conclusions: None of the mentioned APBI guidelines predicted local or locoregional recurrence risk in our study population. Additional follow-up will be needed to recommend inclusion of molecular subtype (or at least HER2 receptor status) in the patient selection criteria for APBI. PMID: 29619056 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - April 7, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Accelerated partial breast irradiation in a single 18 Gy fraction with high-dose-rate brachytherapy: preliminary results.
Conclusions: This is the first report in the medical literature that focuses on feasibility and acute and chronic toxicity, with a median follow-up of 24 months (range, 20-40). The protocol is viable and convenient. However, a longer follow-up is needed to know chronic toxicity and oncologic outcomes. PMID: 29619057 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - April 7, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Long-term outcome of high-dose-rate brachytherapy and perioperative brachytherapy in early mobile tongue cancer.
Conclusions: HDR-BT alone gives acceptable loco-regional control in T1 tumors. T2 stage tumors should not be treated by brachytherapy alone in view of high failure rates in nodal regions and should undergo either neck dissection or nodal irradiation. Perioperative brachytherapy is investigational and can be considered in patients who are at high-risk for local recurrence in patients undergoing surgery alone. PMID: 29619058 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - April 7, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

A comparative assessment of inhomogeneity and finite patient dimension effects in 60Co and 192Ir high-dose-rate brachytherapy.
Conclusions: The magnitude of differences observed between TG-43 based and MC dosimetry and their smaller dispersion relative to 192Ir, suggest that 60Co HDR sources are more amenable to the TG-43 assumptions in clinical treatment planning dosimetry. PMID: 29619059 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - April 7, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Reduction of applicator displacement in MR/CT-guided cervical cancer HDR brachytherapy by the use of patient hover transport system.
Conclusions: This study indicates that the hover transport system is effectively reducing displacement between tandem and patient bony anatomy during patient transports. The potential improvement in dosimetric accuracy due to this reduction warrants further study. PMID: 29619060 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - April 7, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

The effect of tandem-ovoid titanium applicator on points A, B, bladder, and rectum doses in gynecological brachytherapy using 192Ir.
Conclusions: According to the results, applicator attenuation has no significant effect on the calculated points dose, the superposition method, adding the dose of each source obtained by the MC simulation, can estimate the dose to points A, B, bladder, and rectum with good accuracy. PMID: 29619061 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - April 7, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Is an Interventional Oncology Center an advantage in the service of cancer patients or in the education? The Gemelli Hospital and INTERACTS experience.
Authors: Kovács G, Tagliaferri L, Valentini V PMID: 29441092 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - February 16, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Correlations of post-implant regional dosimetric parameters at 24 hours and one month, with clinical results of low-dose-rate brachytherapy for localized prostate cancer.
Conclusions: Post-implant D90 of PSQ is significantly associated with BFFS for localized prostate cancer not only at 1 month, but also at 24 hours. D90 of PSQ at 1 month is also a significant factor for rectal hemorrhage. PMID: 29441093 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - February 16, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Artificial neural network based gynaecological image-guided adaptive brachytherapy treatment planning correction of intra-fractional organs at risk dose variation.
Conclusions: There are semi-automatic and fast responding models that can be used in the routine clinical workflow to reduce individually IGABT uncertainties. These models can be more validated by more patients' plans to be able to serve as a clinical tool. PMID: 29441094 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - February 16, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Off-line magnetic resonance imaging navigation of cervix cancer brachytherapy in patients with risk factors for uterine perforation.
Authors: Al-Hammadi NM, Chandramouli SH, Hammoud R, Petric P Abstract Purpose: There are no reports on pre-insertion identification of cervix cancer patients at risk for uterine perforation during brachytherapy (BT). Our aim was to assess the incidence of risk factors in our patient cohort, and assess feasibility of a novel technique of magnetic resonance imaging (MRI)-guided navigation for applicator insertion (NAI) in high-risk cases. Material and methods: All patients with locally advanced cervical cancer, treated with image guided adaptive BT at our department between October 2013 and June 2017 were conside...
Source: Journal of Contemporary Brachytherapy - February 16, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Implantation of computed tomography-guided Iodine-125 seeds in combination with chemotherapy for the treatment of stage III non-small cell lung cancer.
Conclusions: CT-guided 125I seed implantation combined with chemotherapy is an effective, minimally invasive method for the treatment of stage III NSCLC. Furthermore, hemoglobin levels before treatment, D100, and the maximum diameter of the tumor may be prognostic factors in patients with NSCLC treated sequentially with radiotherapy and chemotherapy. PMID: 29441096 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - February 16, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

The feasibility of using ultrasound during follow-up for superficial non-melanoma skin cancers after electronic brachytherapy.
Conclusions: US is an objective imaging modality that may be able to assess NMSC response after eBT. Based on follow-up imaging, further treatment or observation may be recommended. Although this study is hypothesis generating, larger studies with pathologic confirmation of recurrences would be needed to validate US use for follow-up, avoiding possible painful and scarring biopsies in case of low suspicion of recurrence. PMID: 29441097 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - February 16, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Nomogram for predicting radiation maculopathy in patients treated with Ruthenium-106 plaque brachytherapy for uveal melanoma.
Authors: Tagliaferri L, Pagliara MM, Masciocchi C, Scupola A, Azario L, Grimaldi G, Autorino R, Gambacorta MA, Laricchiuta A, Boldrini L, Valentini V, Blasi MA Abstract Purpose: To develop a predictive model and nomogram for maculopathy occurrence at 3 years after 106Ru/106Rh plaque brachytherapy in uveal melanoma. Material and methods: Clinical records of patients affected by choroidal melanoma and treated with 106Ru/106Rh plaque from December 2006 to December 2014 were retrospectively reviewed. Inclusion criteria were: dome-shaped melanoma, distance to the fovea> 1.5 mm, tumor thickness> 2 mm, and follo...
Source: Journal of Contemporary Brachytherapy - February 16, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Ruthenium brachytherapy for uveal melanoma - single institution experience.
Conclusions: 106Ru brachytherapy is an effective, globe sparing treatment that provides good tumor control and a high rate of survival. However, some ocular complications tend to appear late post-treatment, and therefore long-term follow-up is advised. PMID: 29441099 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - February 16, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Dose-volume analysis of target volume and critical structures in computed tomography image-based multicatheter high-dose-rate interstitial brachytherapy for head and neck cancer.
Conclusions: Using conformal treatment planning, it was desirable to keep the dose to the mandible, spinal cord, and salivary glands at an acceptable level. The quantitative plan evaluation may help us find correlations between dosimetric parameters and clinical outcome, which may lead to improve the quality of the treatment, but it requires longer follow-up and results from other studies. PMID: 29441100 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - February 16, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

High-dose-rate brachytherapy in the treatment of skin Kaposi sarcoma.
Conclusions: HDR brachytherapy could be a good option of treatment for these types of lesions, especially in elderly patients, or when cosmetic results are not good after surgery. Brachytherapy with the Valencia applicator, using hypofractionated regimen provides excellent results in terms of cosmetic and local control, and furthermore, facilitates treatment compliance, which is very relevant in elderly patients. HDR brachytherapy offers a simple, safe, quick, and attractive non-surgical treatment option. PMID: 29441101 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - February 16, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Dosimetric analysis of rib interference of the CTV during interstitial brachytherapy of lung tumors.
This study evaluated the change in dose to the target by comparing the dose between the actual interstitial brachytherapy plan (AIBP, what is deliverable due to anatomic constraints), and the virtual interstitial brachytherapy plan (VIBP, pretreatment-modified dose distribution). Material and methods: AIBPs and VIBPs were designed for 20 lung tumors. The VIBP was designed with uniform spacing between needles, regardless of the presence of ribs. The prescription dose was 30 Gy. The percentage of normal ipsilateral lung volume that received a dose ≥ 5 Gy (V5), conformity index (COIN), incremental dose percentage (IDP)...
Source: Journal of Contemporary Brachytherapy - February 16, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Complete response in a patient with gynecological hidradenocarcinoma treated with exclusive external beam radiotherapy and brachytherapy: a case report.
Authors: Giannelli F, Chiola I, Belgioia L, Garelli S, Pastorino A, Marcenaro M, Mammoliti S, Costantini S, Bizzarri N, Vellone V, Barra S, Corvò R Abstract Hidradenocarcinoma (HC) is a very rare disease. This case report illustrates a successful treatment of a 60-year-old woman with vulvo-vaginal localization of hidradenocarcinoma treated with external beam radiotherapy delivered by helical tomotherapy with a simultaneous integrated boost (SIB), followed by brachytherapy. External beam radiotherapy dose prescription was 50.4 Gy in 28 fractions, five fractions per week to whole pelvis (planning target volume...
Source: Journal of Contemporary Brachytherapy - February 16, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Current status of brachytherapy in cancer treatment - short overview.
Authors: Skowronek J Abstract Cancer incidence and mortality depend on a number of factors, including age, socio-economic status and geographical location, and its prevalence is growing around the world. Most of cancer treatments include external beam radiotherapy or brachytherapy. Brachytherapy, a type of radiotherapy with energy from radionuclides inserted directly into the tumor, is increasingly used in cancer treatment. For cervical and skin cancers, it has become a standard therapy for more than 100 years as well as an important part of the treatment guidelines for other malignancies, including head and neck, ...
Source: Journal of Contemporary Brachytherapy - February 16, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Radiation treatment of prostate cancers - the contemporary role of modern brachytherapy techniques.
Authors: Pellizzon ACA PMID: 29204158 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

What pelvic radiation disease symptoms are experienced by patients receiving external beam radiotherapy and a high-dose-rate brachytherapy boost for prostate cancer?
Conclusions: Patients receiving EBRT plus HDR brachytherapy to the prostate experienced mild pelvic radiation disease symptoms. Determining the proportion of patients with symptoms provided the most meaningful data. PMID: 29204159 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Does supplemental external beam radiation therapy impact urinary, bowel, and erectile function following permanent prostate brachytherapy?: results of two prospective randomized trials.
Conclusions: Supplemental EBRT did not significantly effect catheter dependency, IPSS resolution, urethral stricture rate, the need for post-implant TURP, bowel, or erectile function. Careful attention to brachytherapy dose distributions appears to be most important in minimizing post-brachytherapy morbidity. PMID: 29204160 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Dosimetry advantages of intraoperatively built custom-linked seeds compared with loose seeds in permanent prostate brachytherapy.
This study included 74 prostate cancer patients who were treated with permanent prostate brachytherapy (PPB) using IBCL (n = 37) or LS (n = 37) between July 2014 and June 2016. Dose-volume histogram (DVH) parameters, seed migration, and operation time were compared between the IBCL and LS groups. In addition to the standard target volume of the whole prostate gland, DVH parameters for prostate plus a 3 mm margin (CTV) were evaluated. Results: In intraoperative planning, prostate V150 was lower (54.8% vs. 59.6%, p = 0.027), and CTV V100 (88.1% vs. 85.6%, p = 0.019) and D90 (98.5% vs. 92.6%, p = 0.0033) were higher in th...
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Treatment plan dosimetric impact after catheter stretch during multi-catheter interstitial breast brachytherapy.
Authors: Boman E, Paterson D, Huang J, Pearson S, Johnson C Abstract Purpose: Nylon 6/6 interstitial brachytherapy catheters may stretch when exposed to moisture, mechanical tension, and body temperature. The purpose of this study is to evaluate the magnitude of catheter stretch during a course of multi-catheter interstitial breast brachytherapy for nylon 6/6 treatment catheters, and to assess the impact this has on treatment plan dosimetry. Material and methods: Catheters were exposed to water at 37°C for six days and the internal catheter length change (ΔL_W) was measured daily. Additionally, the me...
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Efficacy of single-stage breast-conserving treatment using multicatheter partial breast brachytherapy evaluated by GEC-ESTRO phase 3 trial.
Conclusions: Single-stage BCT using MCB-PBI offered similar tumor control rates compering to WBI. However, further research is needed to define the benefit for patients with an exclusion criteria. PMID: 29204163 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Comparison of dose volume parameters evaluated using three forward planning - optimization techniques in cervical cancer brachytherapy involving two applicators.
Conclusions: Fletcher applicator generates higher dose to both CTV and organs at risk (2 cc volumes) after all optimization techniques. Dose restriction to rectum is possible using graphical optimization only during selected HDR fractionation schedules. Bladder always receives dose higher than recommended, and 2 cc sigmoid colon always gets permissible dose. Contrarily, graphical optimization with ring applicators fulfills all dose volume objectives in all HDR fractionations practiced. PMID: 29204164 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Throwing the dart blind-folded: comparison of computed tomography versus magnetic resonance imaging-guided brachytherapy for cervical cancer with regard to dose received by the 'actual' targets and organs at risk.
Conclusions: MRI-based IGBT remains the gold standard. CT planning may compromise HRCTVmriD90 or increase OARmriD2cc, which could decrease local control or increase treatment toxicity. PMID: 29204165 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Patterns of care and survival outcomes after treatment for uveal melanoma in the post-coms era (2004-2013): a surveillance, epidemiology, and end results analysis.
Authors: Rao YJ, Sein J, Badiyan S, Schwarz JK, DeWees T, Grigsby P, Rao PK Abstract Purpose: The Collaborative Ocular Melanoma Study (COMS) established modern treatment recommendations for uveal melanoma. We aim to evaluate patterns of care and survival outcomes in the time after COMS. Material and methods: The retrospective study population includes 2,611 patients in the SEER database treated for uveal melanoma between 2004-2013. Patients stage were T1-4N0M0. Data analyzed included age, clinical stage, tumor size, race, and treatment. Treatments included enucleation (EN) and globe preserving therapy (GPT), wh...
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Interstitial brachytherapy for orbital soft tissue sarcoma: an innovative technique.
Conclusions: Interstitial brachytherapy for orbit using this innovative technique is a safe and effective modality of local treatment for appropriately selected orbital soft tissue tumors. Brachytherapy resulted in excellent disease control with significant reduction of dose to surrounding ocular structures compared to EBRT. PMID: 29204167 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Pre-plan technique feasibility in multi-interstitial/endocavitary perineal gynecological brachytherapy.
Conclusions: We describe a virtual pre-planning technique using a multi-interstitial and endocavitary perineal template. It is based on a virtual work with MRI images. This procedure has shown to be feasible and efficient in clinical practice by facilitating the work of specialists, and reducing uncertainties of the application. PMID: 29204168 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Independent assessment of source position for gynecological applicator in high-dose-rate brachytherapy.
Conclusions: In HDR brachytherapy, an effectiveness of independent source position assessment could be demonstrated. The 95% confidence limit was 2.1 mm for a tandem-ovoids applicator. PMID: 29204169 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Locally advanced squamous cell cervical cancer in a patient with septate uterus.
Authors: Yavas G, Yavas C, Inan G Abstract A 33-year-old premenopausal multiparous woman with the history of septate uterus was referred to the hospital with menorrhagia and inter-menstrual bleeding occurring for the last 6 months. Work-up revealed a stage IIB cervical cancer. The patient underwent curative chemo/radiotherapy. The patient's septate uterus presented several difficulties during application. Brachytherapy was applied using standard computed tomography-compatible tandem and ovoids. The high-risk clinical target volume (HR-CTV), intermediate risk CTV, and organs at risk were contoured according to the G...
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Magnetic resonance imaging metal artifact reduction for eye plaque patient with dental braces.
Conclusions: T2-weighted MRI with metal artifact reduction was successfully applied to minimize artifacts in the orbits resulting from the dental braces, thus allowing the MRIs to be used in 3D brachytherapy treatment planning. PMID: 29204171 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - December 6, 2017 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research