Changes in Test Methods for Internationalization in the Japanese Pharmacopoeia (Part 3): Establishment of a Quantitative Method for Sodium Cromoglicate and Trihexyphenidyl Hydrochloride Using HPLC Analysis
In this study, we synthesized the related impurities of sodium cromoglicate and trihexyphenidyl hydrochloride listed in the EP and determined their purities using quantitative NMR. The separation conditions of these compounds were examined using HPLC and simultaneous analyses were performed.PMID:36858562 | DOI:10.1248/yakushi.22-00188 (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 1, 2023 Category: Drugs & Pharmacology Authors: Genichiro Tsuji Takahito Ito Nahoko Uchiyama Junko Hosoe Yosuke Demizu Yukihiro Goda Source Type: research
Changes in Test Methods for Internationalization in the Japanese Pharmacopoeia (Part 3): Establishment of a Quantitative Method for Sodium Cromoglicate and Trihexyphenidyl Hydrochloride Using HPLC Analysis
In this study, we synthesized the related impurities of sodium cromoglicate and trihexyphenidyl hydrochloride listed in the EP and determined their purities using quantitative NMR. The separation conditions of these compounds were examined using HPLC and simultaneous analyses were performed.PMID:36858562 | DOI:10.1248/yakushi.22-00188 (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 1, 2023 Category: Drugs & Pharmacology Authors: Genichiro Tsuji Takahito Ito Nahoko Uchiyama Junko Hosoe Yosuke Demizu Yukihiro Goda Source Type: research
Phenobarbital in Status epilepticus - Rediscovery of an effective drug
Epilepsy Behav. 2023 Feb 18;141:109104. doi: 10.1016/j.yebeh.2023.109104. Online ahead of print.ABSTRACTPhenobarbital (PB) is one of the oldest Antiseizure Medicines (ASMs), which is in clinical use since 1912. Its value in the treatment of Status epilepticus is currently discussed controversially. Phenobarbital has fallen out of favor in many countries across Europe because of reports of hypotension, arrhythmias, and hypopnea. Phenobarbital has a strong antiseizure effect with remarkably little sedation. It exerts its clinical effects, through the increase of GABE-ergic inhibition and decrease of glutamatergic excitation ...
Source: Epilepsy and Behaviour - February 22, 2023 Category: Neurology Authors: Eugen Trinka Source Type: research
Phenobarbital in Status epilepticus - Rediscovery of an effective drug
Epilepsy Behav. 2023 Feb 18;141:109104. doi: 10.1016/j.yebeh.2023.109104. Online ahead of print.ABSTRACTPhenobarbital (PB) is one of the oldest Antiseizure Medicines (ASMs), which is in clinical use since 1912. Its value in the treatment of Status epilepticus is currently discussed controversially. Phenobarbital has fallen out of favor in many countries across Europe because of reports of hypotension, arrhythmias, and hypopnea. Phenobarbital has a strong antiseizure effect with remarkably little sedation. It exerts its clinical effects, through the increase of GABE-ergic inhibition and decrease of glutamatergic excitation ...
Source: Epilepsy and Behaviour - February 22, 2023 Category: Neurology Authors: Eugen Trinka Source Type: research
Clonazepam Treatment of Adolescent Catatonia in A Setting of Lorazepam-Related Hypotension
Journal of Child and Adolescent Psychopharmacology,Volume 33, Issue 1, Page 34-37, February 2023. (Source: Journal of Child and Adolescent Psychopharmacology)
Source: Journal of Child and Adolescent Psychopharmacology - February 14, 2023 Category: Pediatrics Authors: Dennis Valerstain Michelle Zaydlin Yasin Bez Barbara J. Coffey Source Type: research
