Total sesquiterpene glycosides from Loquat (Eriobotrya japonica) leaf alleviate high-fat diet induced non-alcoholic fatty liver disease through cytochrome P450 2E1 inhibition.
Abstract
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by hepatic steatosis, which affects 20-40% of the population in the world. Loquat (Eriobotrya japonica) Leaf possesses several pharmacological actions. Many sesquiterpene glycosides were reported to be isolated exclusively from the Loquat Leaf, however, their biological activity has been rarely investigated. The present study was designed to evaluate the pharmacological effect of total sesquiterpene glycosides (TSG) in high-fat diet (HFD) induced NAFLD mice with its related mechanisms of action. Mice were fed with a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 27, 2017 Category: Drugs & Pharmacology Authors: Jian T, Ao X, Wu Y, Lv H, Ma L, Zhao L, Tong B, Ren B, Chen J, Li W Tags: Biomed Pharmacother Source Type: research
Acute and Subacute Oral Toxicity Evaluation of Eriobotrya japonica Leaf Triterpene Acids in ICR Mice.
Authors: Li F, Li Y, Li Q, Shi X, Guo Y
Abstract
The interest focusing on Eriobotrya japonica leaf triterpene acid (ELTA) has increased recently because of its beneficial effects on health. However, there has been a lack of experimental data on its toxicity. The present study therefore was conducted to evaluate its toxicity in ICR mice. The results showed that ELTA produced neither mortality nor toxicity of the main organs in ICR male and female mice in both acute (0.30, 0.65, 1.39, and 3.00 g·kg(-1) body weight) and subacute (150, 300, and 600 mg·kg(-1) BW) 28-day toxicity studies. Because of lack...
Source: Evidence-based Complementary and Alternative Medicine - April 14, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Triterpenoid-rich loquat leaf extract induces growth inhibition and apoptosis of pancreatic cancer cells through altering key flux ratios of glucose metabolism
ConclusionMetabolic homeostasis (balance of fluxes) in cancer cells is maintained through the regulation of metabolic fluxes by oncogenes and tumor-suppressor genes. Treatment of MIA PaCa-2 cells by LLE, UA and metformin likely altered key metabolic flux ratios affecting metabolic homeostasis required for energy and macromolecular production in tumor growth. (Source: Metabolomics)
Source: Metabolomics - February 22, 2017 Category: Biology Source Type: research
Effect of Loquat Leaf Extract on Muscle Strength, Muscle Mass, and Muscle Function in Healthy Adults: A Randomized, Double-Blinded, and Placebo-Controlled Trial.
We examined the peak torque/body weight at 60°/s knee extension, handgrip strength, skeletal muscle mass, physical performance, and metabolic parameters at baseline, as well as after 4 and 12 weeks of intervention. Either 500 mg of LLE (50.94 mg of UA) or a placebo was administered to fifty-four healthy adults each day for 12 weeks; no differences in muscle strength, muscle mass, and physical performance were observed between the two groups. However, the right-handgrip strength of female subjects in the LLE group was found to be significantly better than that of subjects in the control group (P = 0.047). Further studi...
Source: Evidence-based Complementary and Alternative Medicine - December 22, 2016 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Characterization of an O-methyltransferase specific to guaiacol-type benzenoids from the flowers of loquat (Eriobotrya japonica)
Publication date: Available online 26 July 2016 Source:Journal of Bioscience and Bioengineering Author(s): Takao Koeduka, Mami Kajiyama, Takumi Furuta, Hideyuki Suzuki, Tomohiko Tsuge, Kenji Matsui Volatile benzenoids, including methyl p-methoxybenzoate, p-anisaldehyde, and p-anisalcohol, are responsible for the sweet and characteristic fragrance of loquat (Eriobotrya japonica, Rosaceae) flowers. Although the full pathway of volatile benzenoid synthesis has yet to be elucidated, their chemical structures suggest that O-methyltransferases are present in loquat and function in the methylation of the para-OH g...
Source: Journal of Bioscience and Bioengineering - July 26, 2016 Category: Biomedical Science Source Type: research
Study on the mechanisms of the bronchodilator effects of Folium Eriobotryae and the selected active ingredient on isolated guinea pig tracheal strips.
CONCLUSION: These results suggest that bronchodilator activities of EFE were related to activation of β-adrenoceptor and NO/cGMP pathway. Blockage of Ca(2+ )channels and inhibition of IP3R-mediated internal Ca(2+ )release were also involved. Additionally, UA produced relaxant effects by the NO/cGMP pathway.
PMID: 27251608 [PubMed - as supplied by publisher] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - June 3, 2016 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Molecules, Vol. 21, Pages 722: Eriobotrya japonica Water Extract Characterization: An Inducer of Interferon-Gamma Production Mainly by the JAK-STAT Pathway
In conclusion, these polar compounds in the EJ extract are responsible for inducing IFN-γ production. Further chemical elucidation is warranted to lead to a specific IFN-γ inducer and an immunomodulator in polarizing immune cells and balancing immune responses in certain diseases. (Source: Molecules)
Source: Molecules - June 1, 2016 Category: Chemistry Authors: Khalid MatalkaNada AbdulridhaMujtaba BadrKenza MansoorNidal QinnaFadi Qadan Tags: Article Source Type: research
Characteristics of Subcritical Water Extraction and Kinetics of Pentacyclic Triterpenoids from Dry Loquat (Eriobotrya japonica) Leaves
Authors: Mlyuka, Erasto / Zhang, Shuang / Wang, Linxiang / Zheng, Zongping / Chen, Jie (Source: International Journal of Food Engineering)
Source: International Journal of Food Engineering - May 4, 2016 Category: Food Science Source Type: research
Effects of Standardized Eriobotrya japonica Extract in LP-BM5 Murine Leukemia Viruses-Induced Murine Immunodeficiency Syndrome.
In this study, we investigated the immunomodulatory effects of leaves from LEJ water extracts (LEJE) in LP-BM5 murine leukemia viruses (MuLV)-induced immune-deficient animal model. Dietary supplementation of LEJE (100, 300, 500 mg/kg) began on the day of LP-BM5 MuLV infection and continued for 12 weeks. Dietary supplementation of LEJE inhibited LP-BM5 MuLV-induced splenomegaly and lymphadenopathy. Moreover, LEJE attenuated reductions of T- and B-cell proliferation and Th1/Th2 cytokine imbalance in LP-BM5. We found that dietary supplements of LEJE suppressed the hypergammaglobulinemia by ameliorating LP-BM5 MuLV infection-i...
Source: Immunological Investigations - February 17, 2016 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
A New Sesquiterpene Glycoside from the Leaves of Eriobotrya japonica
A new sesquiterpene glycoside, namely β-monocyclonerolidol-3-O-α-L-rhamnopyranosyl-(1→4)-α-Lrhamnopyranosyl-( 1→2)-[α-L-rhamnopyranosyl-(1→6)]-β-D-glucopyranoside (1), was isolated from the leaves of Eriobotrya japonica. Its structure was characterized by chemical and spectroscopic methods. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - November 9, 2015 Category: Chemistry Source Type: research
New Sesquiterpene Glycosides from the Leaves of Eriobotrya japonica.
Authors: Zhaoa L, Li H, Rena B, Wub H, Chen J, Lia W
Abstract
One new sesquiterpene glycoside, named nerolidol-3-O-α-L-rhamnopyranosyl-(1 --> 6)-β-D-glucopyranoside (1), along with one novel natural product nerolidol-3-O-α-L-rhamnopyranosyl-(1 --> 2)-[α-L-rhamnopyranosyl-(1 --> 6)]-β-D-glucopyranoside (2) and two known sesquiterpene glycosides (3-4), were isolated from the leaves of Eriobotrya japonica (Thunb.) Lindl.. Their structures were elucidated on the basis of 1D, 2D NMR and HR-MS data. The chemotaxonomic significance of this type of constituents was discussed.
PMID: 26410996 [...
Source: Natural Product Communications - September 30, 2015 Category: Biochemistry Tags: Nat Prod Commun Source Type: research
Loquat leaf extract enhances myogenic differentiation, improves muscle function and attenuates muscle loss in aged rats.
Abstract
A main characteristic of aging is the debilitating, progressive and generalized impairment of biological functions, resulting in an increased vulnerability to disease and death. Skeletal muscle comprises approximately 40% of the human body; thus, it is the most abundant tissue. At the age of 30 onwards, 0.5‑1% of human muscle mass is lost each year, with a marked acceleration in the rate of decline after the age of 65. Thus, novel strategies that effectively attenuate skeletal muscle loss and enhance muscle function are required to improve the quality of life of older subjects. The aim of th...
Source: International Journal of Molecular Medicine - July 15, 2015 Category: Molecular Biology Authors: Sung B, Hwang SY, Kim MJ, Kim M, Jeong JW, Kim CM, Chung HY, Kim ND Tags: Int J Mol Med Source Type: research
Anti-Obesity Effects of the Mixture of Eriobotrya japonica and Nelumbo nucifera in Adipocytes and High-Fat Diet-Induced Obese Mice.
In conclusion, the MIX of EJ and NN extract may strongly regulate BW gain than EJ or NN alone, and its anti-obesity effect is associated with the control of lipid metabolism, including adipogenesis and lipogenesis.
PMID: 26133751 [PubMed - as supplied by publisher] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - July 1, 2015 Category: Complementary Medicine Authors: Sharma BR, Oh J, Kim HA, Kim YJ, Jeong KS, Rhyu DY Tags: Am J Chin Med Source Type: research
Ursolic acid and oleanolic acid from Eriobotrya fragrans inhibited the viability of A549 cells.
Authors: Yuan Y, Gao Y, Song G, Lin S
Abstract
Loquat {Eriobotrya japonica (Lindl.)}, a kind of Chinese herb, has many efficacies such as anti-inflammatory, antimicrobial and curing chronic bronchitis. However, reports on the pharmacological action of wild loquat extract are limited. In this work, the A549 cell line was selected to study the inhibitory effect of ursolic acid and oleanolic acid (UA, OA) from the leaves of E. fragrans. Results showed that UA/OA inhibited A549 cell viability and induced apoptosis in a dose and time dependent manner. The cell fraction in the G0/G1 phase dramatically increased ...
Source: Natural Product Communications - June 17, 2015 Category: Biochemistry Tags: Nat Prod Commun Source Type: research
