Corosolic acid delivered by exosomes from Eriobotrya japonica decreased pancreatic cancer cell proliferation and invasion by inducing SAT1-mediated ferroptosis
CONCLUSION: The data suggested that corosolic acid delivered by exosomes from Eriobotrya japonica decreased pancreatic cancer cell proliferation and invasion by inducing SAT1-mediated ferroptosis.PMID:38608471 | DOI:10.1016/j.intimp.2024.111939 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Mingming Jin Jingjing Li Liying Zheng Mi Huang Yue Wu Qingqing Huang Gang Huang Source Type: research

Genes, Vol. 15, Pages 23: Genome-Wide Identification and Expression Analysis of the SBP-Box Gene Family in Loquat Fruit Development
In this study, we identified 28 EjSBP genes in the loquat genome, which were unevenly distributed on 12 chromosomes. We also systematically investigated the phylogenetic relationship, collinearity, gene structure, conserved motifs, and cis-elements of EjSBP proteins. Most EjSBP genes showed high expression in the root, stem, leaf, and inflorescence, while only five EjSBP genes were highly expressed in the fruit. Gene expression analysis revealed eight differentially expressed EjSBP genes between yellow- and white-fleshed fruits, suggesting that the EjSBP genes play important roles in loquat fruit development at the breaker...
Source: Genes - December 23, 2023 Category: Genetics & Stem Cells Authors: Haiyan Song Ke Zhao Guoliang Jiang Shuxia Sun Jing Li Meiyan Tu Lingli Wang Hongjiang Xie Dong Chen Tags: Article Source Type: research

Characteristics of physicochemical properties, structure and in vitro digestibility of seed starches from five loquat cultivars
This study delved into the variations in the physicochemical properties, structure attributes and in vitro digestibility of seed starches extracted from five distinct loquat cultivars (Eriobotrya japonica L.). The starch extraction yield of loquat seeds was found to be 45.2 % as an average. Loquat seed starches were designated as having high-amylose starch (>50 %). The starch granules exhibited similar shapes, but granular size significantly varied across the cultivars. Loquat starches presented a C-type crystalline pattern with relative crystallinity from 17.14 % to 21.06 %. The short-range ordered structure of the sta...
Source: International Journal of Biological Macromolecules - September 3, 2023 Category: Biochemistry Authors: Xiangli Kong Weidong Yang Youming Zuo Muhammad Dawood Zirui He Source Type: research

Polyphenol-rich extract from loquat fruit peel prevents hyperlipidemia and hepato-nephrotoxicity in mice: < em > in vivo < /em > study and < em > in silico < /em > prediction of possible mechanisms involving identified polyphenols and/or their circulating metabolites
This study aims to evaluate the preventive effect of loquat fruit peel extract (PE) against tyloxapol-induced hyperlipidemia and related tissue lipotoxicity in mice. The in vivo study was conducted on mice injected daily with tyloxapol at 100 mg per kg B.W. and treated simultaneously with the PE at concentrations of 100 and 200 mg kg-1 or fenofibrate for 28 days. Plasma and tissue lipid biochemical analyses were undertaken using enzymatic methods. The antioxidative stress was revealed by measuring the malondialdehyde content and activities of superoxide dismutase and catalase as well as the scavenging activity against lipo...
Source: Atherosclerosis - July 27, 2023 Category: Cardiology Authors: Imane Mokhtari Chakib Mokhtari Mohammadine Moumou Mohamed Harnafi Dragan Milenkovic Souliman Amrani Abdelmalek Hakmaoui Hicham Harnafi Source Type: research

Polyphenol-rich extract from loquat fruit peel prevents hyperlipidemia and hepato-nephrotoxicity in mice: < em > in vivo < /em > study and < em > in silico < /em > prediction of possible mechanisms involving identified polyphenols and/or their circulating metabolites
This study aims to evaluate the preventive effect of loquat fruit peel extract (PE) against tyloxapol-induced hyperlipidemia and related tissue lipotoxicity in mice. The in vivo study was conducted on mice injected daily with tyloxapol at 100 mg per kg B.W. and treated simultaneously with the PE at concentrations of 100 and 200 mg kg-1 or fenofibrate for 28 days. Plasma and tissue lipid biochemical analyses were undertaken using enzymatic methods. The antioxidative stress was revealed by measuring the malondialdehyde content and activities of superoxide dismutase and catalase as well as the scavenging activity against lipo...
Source: Atherosclerosis - July 27, 2023 Category: Cardiology Authors: Imane Mokhtari Chakib Mokhtari Mohammadine Moumou Mohamed Harnafi Dragan Milenkovic Souliman Amrani Abdelmalek Hakmaoui Hicham Harnafi Source Type: research

Molecules, Vol. 28, Pages 5612: Dried Loquat Fruit Extract Containing Chlorogenic Acid Prevents Depressive-like Behaviors Induced by Repeated Corticosteroid Injections in Mice
In this study, we evaluated the antidepressant-like effects of E. japonica fruit extract (EJFE) in a mouse model of corticosterone (CORT)-induced depression. An HPLC analysis revealed that chlorogenic acid (CGA) is the major compound in EJFE. Male ICR mice (5weeks-old) were injected with CORT (40 mg/kg, intraperitoneally) once daily for 21 days to induce depressive-like behaviors. Various behavioral tests, including the open field test, rotarod test, elevated plus maze (EPM), passive avoidance test (PAT), tail suspension test (TST), and forced swim test (FST), were conducted 1 h after the oral administration of EJFE at dif...
Source: Molecules - July 24, 2023 Category: Chemistry Authors: Dong Wook Lim Guijae Yoo Changho Lee Tags: Communication Source Type: research

The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
Biomed Pharmacother. 2023 Jul 7;165:115132. doi: 10.1016/j.biopha.2023.115132. Online ahead of print.ABSTRACTEllagic acid (EA) is a kind of polyphenol compound extracted from a variety of herbs, such as paeoniae paeoniae, raspberry, Chebule, walnut kernel, myrrh, loquat leaf, pomegranate bark, quisquite, and fairy herb. It has anti-tumor, anti-oxidation, anti-inflammatory, anti-mutation, anti-bacterial, anti-allergic and multiple pharmacological properties. Studies have shown its anti-tumor effect in gastric cancer, liver cancer, pancreatic cancer, breast cancer, colorectal cancer, lung cancer and other malignant tumors, m...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 9, 2023 Category: Drugs & Pharmacology Authors: Guangying Lu Xuezhen Wang Ming Cheng Shijun Wang Ke Ma Source Type: research

Ultrasound-assisted acid/enzymatic hydrolysis preparation of loquat kernel porous starch: A carrier with efficient palladium loading capacity
Int J Biol Macromol. 2023 Jul 7:125676. doi: 10.1016/j.ijbiomac.2023.125676. Online ahead of print.ABSTRACTPorous starch, with excellent renewal and thermodynamic stability characteristics, could be utilized as a novel carrier for metals. In this research, starch was obtained from wasted loquat kernel (LKS) and converted into loquat kernel porous starch (LKPS) through ultrasound-assisted acid/enzymatic hydrolysis. Then, LKS and LKPS were utilized for loading with palladium. The porous structures of LKPS were evaluated by the results of water/oil absorption rate and N2 adsorption analysis, and the physicochemical properties...
Source: International Journal of Biological Macromolecules - July 9, 2023 Category: Biochemistry Authors: Jing Li Junwei Fan Fei Hu Source Type: research

The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
Biomed Pharmacother. 2023 Jul 7;165:115132. doi: 10.1016/j.biopha.2023.115132. Online ahead of print.ABSTRACTEllagic acid (EA) is a kind of polyphenol compound extracted from a variety of herbs, such as paeoniae paeoniae, raspberry, Chebule, walnut kernel, myrrh, loquat leaf, pomegranate bark, quisquite, and fairy herb. It has anti-tumor, anti-oxidation, anti-inflammatory, anti-mutation, anti-bacterial, anti-allergic and multiple pharmacological properties. Studies have shown its anti-tumor effect in gastric cancer, liver cancer, pancreatic cancer, breast cancer, colorectal cancer, lung cancer and other malignant tumors, m...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 9, 2023 Category: Drugs & Pharmacology Authors: Guangying Lu Xuezhen Wang Ming Cheng Shijun Wang Ke Ma Source Type: research

Ultrasound-assisted acid/enzymatic hydrolysis preparation of loquat kernel porous starch: A carrier with efficient palladium loading capacity
Int J Biol Macromol. 2023 Jul 7:125676. doi: 10.1016/j.ijbiomac.2023.125676. Online ahead of print.ABSTRACTPorous starch, with excellent renewal and thermodynamic stability characteristics, could be utilized as a novel carrier for metals. In this research, starch was obtained from wasted loquat kernel (LKS) and converted into loquat kernel porous starch (LKPS) through ultrasound-assisted acid/enzymatic hydrolysis. Then, LKS and LKPS were utilized for loading with palladium. The porous structures of LKPS were evaluated by the results of water/oil absorption rate and N2 adsorption analysis, and the physicochemical properties...
Source: International Journal of Biological Macromolecules - July 9, 2023 Category: Biochemistry Authors: Jing Li Junwei Fan Fei Hu Source Type: research

Loquat seed starch - Emerging source of non-conventional starch: Structure, properties, and novel applications
Int J Biol Macromol. 2023 Jun 8:125230. doi: 10.1016/j.ijbiomac.2023.125230. Online ahead of print.ABSTRACTRecently, non-conventional sources of starch have attracted attention due to their potential to provide cost-effective alternatives to traditional starch. Among non-conventional starches, loquat (Eriobotrya japonica) seed starch is an emerging source of starch consisting of the amount of starch (nearly 20 %). Due to its unique structure, functional properties, and novel applications, it could be utilized as a potential ingredient. Interestingly, this starch has similar properties as commercial starches including high ...
Source: International Journal of Biological Macromolecules - June 10, 2023 Category: Biochemistry Authors: Mansuri M Tosif Aarti Bains Pardeep Kumar Sadh Prakash Kumar Sarangi Ravinder Kaushik Sunitha Venkata Seshamamba Burla Prince Chawla Kandi Sridhar Source Type: research

Loquat seed starch - Emerging source of non-conventional starch: Structure, properties, and novel applications
Int J Biol Macromol. 2023 Jun 8:125230. doi: 10.1016/j.ijbiomac.2023.125230. Online ahead of print.ABSTRACTRecently, non-conventional sources of starch have attracted attention due to their potential to provide cost-effective alternatives to traditional starch. Among non-conventional starches, loquat (Eriobotrya japonica) seed starch is an emerging source of starch consisting of the amount of starch (nearly 20 %). Due to its unique structure, functional properties, and novel applications, it could be utilized as a potential ingredient. Interestingly, this starch has similar properties as commercial starches including high ...
Source: International Journal of Biological Macromolecules - June 10, 2023 Category: Biochemistry Authors: Mansuri M Tosif Aarti Bains Pardeep Kumar Sadh Prakash Kumar Sarangi Ravinder Kaushik Sunitha Venkata Seshamamba Burla Prince Chawla Kandi Sridhar Source Type: research

996 Targeting the whole of rosacea symptoms with the combination of eriobotrya japonica and myrtus communis leaf extracts
Rosacea is a chronic skin condition that mainly affects the face. It characterizes by a symptomatic pattern, involving exacerbated reactivity and impaired microcirculation of the facial dermis. Sudden variations in temperature, food or microbiota can then trigger flushes. Demodex sp. and Substance P (SP) are both specific contributors to the physiopathology of Rosaceae and are involved in inflammatory response and neurovascular dysregulation. The aim of this work was to assess the soothing and anti-redness properties of a combination of dermo-cosmetic ingredients in several in vitro models. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: F. Lestienne, C. Michel, S. Bessou-Touya, V. Mengeaud, H. Duplan Source Type: research

Bacterial cellulose production by a strain of Komagataeibacter rhaeticus isolated from residual loquat
In this study, loquat extract was selected as a promising substrate for bacterial cellulose (BC) production. A new BC-producing bacterial strain was isolated from residual loquat and identified as Komagataeibacter rhaeticus. BC production with different carbon sources and with loquat extract was investigated. Among all tested carbon sources, glucose was demonstrated to be the best substrate for BC production by K. rhaeticus, with up to 7.89 g/L dry BC obtained under the optimal initial pH (5.5) and temperature (28 °C) with 10 days of fermentation. The total sugar and individual sugars were investigated in different loquat...
Source: Applied Microbiology and Biotechnology - February 1, 2023 Category: Microbiology Authors: Jianbin Ye Jianqing Li Qiuhui Wang Xiangjiang Wang Shouan Wang Honglin Wang Jia Xu Source Type: research

Bacterial cellulose production by a strain of Komagataeibacter rhaeticus isolated from residual loquat
In this study, loquat extract was selected as a promising substrate for bacterial cellulose (BC) production. A new BC-producing bacterial strain was isolated from residual loquat and identified as Komagataeibacter rhaeticus. BC production with different carbon sources and with loquat extract was investigated. Among all tested carbon sources, glucose was demonstrated to be the best substrate for BC production by K. rhaeticus, with up to 7.89 g/L dry BC obtained under the optimal initial pH (5.5) and temperature (28 °C) with 10 days of fermentation. The total sugar and individual sugars were investigated in different loquat...
Source: Applied Microbiology and Biotechnology - February 1, 2023 Category: Microbiology Authors: Jianbin Ye Jianqing Li Qiuhui Wang Xiangjiang Wang Shouan Wang Honglin Wang Jia Xu Source Type: research