A 13-week subchronic toxicity study of an Eriobotrya japonica leaf extract in rats
ConclusionUnder the present experimental conditions, the no-observed-adverse-effect level of EJE was>1000 mg/kg/day in both sexes and no target organs were identified. The results suggest that the EJE is a safe traditional medicine for clinical applications at proper dose.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 24, 2018 Category: Drugs & Pharmacology Source Type: research
Label-free visualization of fruit lignification: Raman molecular imaging of loquat lignified cells
Flesh lignification, leading to increased fruit firmness, has been reported in several kinds of fruit. Understanding the mechanisms underlying fruit lignification is important to optimize the postharvest stora... (Source: Plant Methods)
Source: Plant Methods - July 13, 2018 Category: Biology Authors: Nan Zhu, Di Wu and Kunsong Chen Tags: Methodology Source Type: research
Herbal medicine Eriobotrya japonica formula for acne vulgaris: A systematic review
Publication date: March 2018Source: Journal of Herbal Medicine, Volume 11Author(s): Suzi Shu Yi Mansu, Meaghan Coyle, Kaiyi Wang, Brian May, Anthony Lin Zhang, Charlie Chang Li XueAbstractAcne vulgaris is a common inflammatory skin condition characterized by comedones. Current pharmacotherapies are effective but are associated with adverse events (AEs) such as mood disorders and antibiotic resistance. The Eriobotrya japonica Formula (EJF) contains six herbs commonly used in traditional Chinese medicine clinical practice. This paper evaluates the experimental evidence and clinical efficacy of EJF for acne vulgaris.Searches ...
Source: Journal of Herbal Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research
Antitussive and expectorant properties of growing and fallen leaves of loquat (Eriobotrya japonica)
ABSTRACT Folium Eriobotryae, the dried leaves of loquat (Eriobotrya japonica, (Thunb.) Lindl., Rosaceae), is a traditional Chinese medicine used to treat cough with phlegm in China. Fallen and growing loquat leaves were tested for their effect on coughing and expectoration in mice. HPLC-ELSD and HPLC-MS analyses of aqueous and ethanol extracts of fallen or growing leaves were used to identify the chemical components responsible for this effect. Both the aqueous and ethanol extracts of growing and fallen leaves of loquat contained antitussive and expectorant activities. Moreover, an aqueous extract of growing loquat leaves ...
Source: Revista Brasileira de Farmacognosia - June 11, 2018 Category: Drugs & Pharmacology Source Type: research
Comparison of structural and functional properties of starches from five fruit kernels
Publication date: 15 August 2018 Source:Food Chemistry, Volume 257 Author(s): Ke Guo, Lingshang Lin, Xiaoxu Fan, Long Zhang, Cunxu Wei Starch was isolated from the kernels of jackfruit, longan, loquat, litchi, and mango fruits, which contained approximately 56, 59, 71, 53, and 64% starch, respectively, indicating that these fruit kernels are good starch sources. The structural and functional properties of these isolated starches were investigated and compared. The starches had irregular, truncated, spherical, and elliptical shapes with central hila and exhibited different sizes, with mango starch being the largest a...
Source: Food Chemistry - March 8, 2018 Category: Food Science Source Type: research
A novel sesquiterpene glycoside from Loquat leaf alleviates oleic acid-induced steatosis and oxidative stress in HepG2 cells.
In this study, both SG1 and TSG were found to significantly reduce the lipid deposition in the cell model. They could also decrease total cholesterol (TC), triglyceride (TG) and intracellular free fatty acid (FFA) contents. Compared with OA-treated cells, the superoxide dismutase (SOD) level increased, and the malondialdehyde (MDA) and 4-hydroxynonenal levels respectively decreased after the administration of SG1 or TSG. The high dose of SG1 (140 μg/mL) displayed a similar therapeutic effect as TSG at 200 μg/mL. Both SG1 and TSG were found to suppress the expression of cytochrome P450 2E1 (CYP2E1) and the phosphoryl...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 9, 2017 Category: Drugs & Pharmacology Authors: Jian T, Wu Y, Ding X, Lv H, Ma L, Zuo Y, Ren B, Zhao L, Tong B, Chen J, Li W Tags: Biomed Pharmacother Source Type: research
Herbal Medicine Eriobotrya japonica Formula for Acne Vulgaris: A Systematic Review
Publication date: Available online 9 September 2017 Source:Journal of Herbal Medicine Author(s): Suzi Shu Yi Mansu, Meaghan Coyle, Kaiyi Wang, Brian May, Anthony Lin Zhang, Charlie Chang Li Xue Acne vulgaris is a common inflammatory skin condition characterized by comedones. Current pharmacotherapies are effective but are associated with adverse events (AEs) such as mood disorders and antibiotic resistance. The Eriobotrya japonica Formula (EJF) contains six herbs commonly used in traditional Chinese medicine clinical practice. This paper evaluates the experimental evidence and clinical efficacy of EJF for acne vulg...
Source: Journal of Herbal Medicine - September 10, 2017 Category: Complementary Medicine Source Type: research
Volatile metabolite profiling reveals the changes in the volatile compounds of new spontaneously generated loquat cultivars
Publication date: October 2017 Source:Food Research International, Volume 100, Part 1 Author(s): C. Besada, G. Sanchez, R. Gil, A. Granell, A. Salvador In recent years, the advantageous traits of three new loquat cultivars have drawn the attention of breeders and growers. All three have spontaneously arisen from the ‘Algerie’ cultivar: the new ‘Xirlero’ cultivar is a bud mutant of ‘Algerie’, while ‘Amadeo’ and ‘Raúl’ arose as chance seedlings. Following a non-targeted approach based on HS-SPME-GC–MS, the volatile compounds profile of the fruits from the new cultivars were obtained and compared...
Source: Food Research International - September 2, 2017 Category: Food Science Source Type: research
Anti-hyperglycemic effect of loquat leaf extract is associated with the redistribution of glucose carbon to its metabolites: a 13 C-tracing study in HepG2 cells
ConclusionOur study demonstrates the utility of isotopomer matrix in summarizing metabolic actions of LLE on the balance of fluxes occurring within the central glucose metabolism in HepG2 cells.13C carbon tracing (tracer-based metabolomics) is a useful systems biology tool to elucidate glucose metabolic pathways affected by diabetes and its treatment. (Source: Metabolomics)
Source: Metabolomics - June 23, 2017 Category: Biology Source Type: research
Metabolic and transcriptional elucidation of the carotenoid biosynthesis pathway in peel and flesh tissue of loquat fruit during on-tree development
Carotenoids are the main colouring substances found in orange-fleshed loquat fruits. The aim of this study was to unravel the carotenoid biosynthetic pathway of loquat fruit (cv. ‘Obusa’) in peel and flesh tis... (Source: BMC Plant Biology)
Source: BMC Plant Biology - June 14, 2017 Category: Biology Authors: Margarita Hadjipieri, Egli C. Georgiadou, Alicia Marin, Huertas M. Diaz-Mula, Vlasios Goulas, Vasileios Fotopoulos, Francisco A. Tom ás-Barberán and George A. Manganaris Source Type: research
Molecules, Vol. 22, Pages 830: Protective Effects of Tormentic Acid, a Major Component of Suspension Cultures of Eriobotrya japonica Cells, on Acetaminophen-Induced Hepatotoxicity in Mice
An acetaminophen (APAP) overdose can cause hepatotoxicity and lead to fatal liver damage. The hepatoprotective effects of tormentic acid (TA) on acetaminophen (APAP)-induced liver damage were investigated in mice. TA was intraperitoneally (i.p.) administered for six days prior to APAP administration. Pretreatment with TA prevented the elevation of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (T-Bil), total cholesterol (TC), triacylglycerol (TG), and liver lipid peroxide levels in APAP-treated mice and markedly reduced APAP-induced histological alterations in liver tissues. Additio...
Source: Molecules - May 18, 2017 Category: Chemistry Authors: Wen-Ping Jiang Shyh-Shyun Huang Yoshikazu Matsuda Hiroshi Saito Naoto Uramaru Hui-Ya Ho Jin-Bin Wu Guan-Jhong Huang Tags: Article Source Type: research
Footprints of domestication revealed by RAD-tag resequencing in loquat: SNP data reveals a non-significant domestication bottleneck and a single domestication event
The process of crop domestication has long been a major area of research to gain insights into the history of human civilization and to understand the process of evolution. Loquat (Eriobotrya japonica Lindl.) is ... (Source: BMC Genomics)
Source: BMC Genomics - May 6, 2017 Category: Genetics & Stem Cells Authors: Yunsheng Wang, Muhammad Qasim Shahid, Shunquan Lin, Chengjie Chen and Chen Hu Source Type: research
Some physicochemical properties and mineral contents of stirred yoghurts containing different fruit marmalades
In this study chemical properties and mineral levels of yoghurts containing different fruit marmalades were investigated. Cherry laurel, loquat fruit and kiwi marmalade were used to make the stirred yoghurts, and the calcium, phosphorus, sodium, magnesium, manganese, iron, zinc, copper, boron, lead, nickel, molybdenum, chromium, cadmium, cobalt levels were determined by an inductively coupled plasma optical emission spectrometer (ICP–OES). The total solid, fat, ash, pH, viscosity and syneresis contents of the yoghurt samples changed between 13.85–21.02%, 2.45–2.90%, 0.82–0.94%, 4.11–4.22, 2104–2454 cP and 42.0...
Source: International Journal of Dairy Technology - May 1, 2017 Category: Nutrition Authors: Hasan Temiz, Zekai Tarak çı, Tarik Yarilgaç, Beşir Dağ Tags: Short Communication Source Type: research
Total sesquiterpene glycosides from Loquat (Eriobotrya japonica) leaf alleviate high-fat diet induced non-alcoholic fatty liver disease through cytochrome P450 2E1 inhibition
Publication date: July 2017 Source:Biomedicine & Pharmacotherapy, Volume 91 Author(s): Tunyu Jian, Xiancan Ao, YueXian Wu, Han Lv, Li Ma, Lei Zhao, Bei Tong, Bingru Ren, Jian Chen, Weilin Li Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by hepatic steatosis, which affects 20–40% of the population in the world. Loquat (Eriobotrya japonica) Leaf possesses several pharmacological actions. Many sesquiterpene glycosides were reported to be isolated exclusively from the Loquat Leaf, however, their biological activity has been rarely investigated. The present study was de...
Source: Biomedicine and Pharmacotherapy - April 29, 2017 Category: Drugs & Pharmacology Source Type: research
