Netarsudil-Induced Corneal Flattening in a Child with Secondary Open-Angle Glaucoma
We report a case of a child with secondary open-angle glaucoma who developed 6.5 diopters (D) of corneal flattening upon the addition of Rhopressa (0.02% netarsudil dimesylate solution) eye drops to a preexisting treatment regimen of timolol and latanoprost. This change in corneal power reversed after netarsudil, a rho-kinase inhibitor, was discontinued and replaced with Vyzulta (0.024% latanoprostene bunod ophthalmic solution). The 4-year-old female patient presented with bilateral secondary open-angle glaucoma from Paired Box 6 (PAX6)-related aniridia, aphakia, and persistent fetal vasculature. She was started on netarsu...
Source: Case Reports in Ophthalmology - May 2, 2022 Category: Opthalmology Source Type: research
Short-term efficacy of latanoprostene bunod for the treatment of open-angle glaucoma and ocular hypertension: a systematic literature review and a network meta-analysis
Conclusion
LBN was significantly more effective than the PGA unoprostone and most of the beta-blockers. Compared with the most widely used PGAs, LBN numerically outperformed latanoprost and travoprost and was similar to bimatoprost 0.01%. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - April 21, 2022 Category: Opthalmology Authors: Harasymowycz, P., Royer, C., Cui, A. X., Barbeau, M., Jobin-Gervais, K., Mathurin, K., Lachaine, J., Beauchemin, C. Tags: Open access Original articles - Clinical science Source Type: research
Bilateral Severe Herpes Simplex Endotheliitis with a Possible Association with Latanoprost
CONCLUSION: Bilateral simultaneous HSV endotheliitis is a rare condition and positive PCR test can help rule in the diagnosis. HSV keratitis is a known adverse event with Latanoprost use and can present atypically.PMID:35442856 | DOI:10.1080/09273948.2022.2065310 (Source: Herpes)
Source: Herpes - April 20, 2022 Category: Infectious Diseases Authors: Arundhati Dvivedi Somasheila I Murthy Chandrasekhar Garudadri Esther Sheba Savitri Sharma Source Type: research
Bilateral Severe Herpes Simplex Endotheliitis with a Possible Association with Latanoprost
CONCLUSION: Bilateral simultaneous HSV endotheliitis is a rare condition and positive PCR test can help rule in the diagnosis. HSV keratitis is a known adverse event with Latanoprost use and can present atypically.PMID:35442856 | DOI:10.1080/09273948.2022.2065310 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 20, 2022 Category: Allergy & Immunology Authors: Arundhati Dvivedi Somasheila I Murthy Chandrasekhar Garudadri Esther Sheba Savitri Sharma Source Type: research
Noninferiority Study Comparing Latanoprost 0.005% Without Versus With Benzalkonium Chloride in Open-Angle Glaucoma or Ocular Hypertension
Conclusions:
Latanoprost without BAK did not meet two of three criteria for noninferiority and showed a similar safety profile relative to latanoprost with BAK. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - March 22, 2022 Category: Opthalmology Tags: Article Source Type: research
Macular Fluid in a Patient With a Reported History of Normal-Tension Glaucoma
A patient with a history of normal-tension glaucoma and 5 years of latanoprost treatment for an enlarged cup-disc ratio presented with a blurred spot in the central vision of the right eye. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - March 1, 2022 Category: Opthalmology Source Type: research
SCD1-Fatty Acid Desaturase Inhibitor MF-438 Alleviates Latent Inflammation Induced by Preservative-Free Prostaglandin Analog Eye Drops
CONCLUSION: Inhibition of SCD1 in monocytes prevents their transformation into macrophages after exposure to saturated fatty acid derivatives contained in eye drops, which may contribute to the limitation of latent inflammation within ocular adnexa and could possibly translate into better tolerability of the topical treatment.PMID:35173454 | PMC:PMC8840838 | DOI:10.2147/JIR.S347784 (Source: Cell Research)
Source: Cell Research - February 17, 2022 Category: Cytology Authors: Anna Pacwa Joanna Machowicz Alicja Wojtyniak Marita Pietrucha-Dutczak Elisa Toropainen Ali Koskela Ewa Mrukwa-Kominek Joanna Lewin-Kowalik Adrian Smedowski Source Type: research
Nanostructured lipid carriers loaded with an association of minoxidil and latanoprost for targeted topical therapy of alopecia
Eur J Pharm Biopharm. 2022 Feb 7:S0939-6411(22)00024-8. doi: 10.1016/j.ejpb.2022.02.003. Online ahead of print.ABSTRACTAlopecia is a condition associated with different etiologies, ranging from hormonal changes to chemotherapy, that affects over 80 million people in the USA. Nevertheless, there are currently few FDA-approved drugs for topical treatment, and existing formulations still present skin irritation issues, compromising treatment adherence. This work aimed to develop a safe formulation based on nanostructured lipid carriers (NLC) that entrap an association of minoxidil and latanoprost and target drug delivery to t...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 10, 2022 Category: Drugs & Pharmacology Authors: Paula M Oliveira Thuany Alencar-Silva Felipe Q Pires Marcilio Cunha-Filho Tais Gratieri Juliana Lott Carvalho Guilherme M Gelfuso Source Type: research
