Nanostructured lipid carriers loaded with an association of minoxidil and latanoprost for targeted topical therapy of alopecia
Eur J Pharm Biopharm. 2022 Feb 7:S0939-6411(22)00024-8. doi: 10.1016/j.ejpb.2022.02.003. Online ahead of print.ABSTRACTAlopecia is a condition associated with different etiologies, ranging from hormonal changes to chemotherapy, that affects over 80 million people in the USA. Nevertheless, there are currently few FDA-approved drugs for topical treatment, and existing formulations still present skin irritation issues, compromising treatment adherence. This work aimed to develop a safe formulation based on nanostructured lipid carriers (NLC) that entrap an association of minoxidil and latanoprost and target drug delivery to t...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 10, 2022 Category: Drugs & Pharmacology Authors: Paula M Oliveira Thuany Alencar-Silva Felipe Q Pires Marcilio Cunha-Filho Tais Gratieri Juliana Lott Carvalho Guilherme M Gelfuso Source Type: research
Effect of Latanoprostene Bunod on Optic Nerve Head Blood Flow
This study aimed to evaluate the effect of topical latanoprostene bunod on optic nerve blood volume and oxygen saturation in a population of healthy participants.
METHODS
In this prospective double-blind crossover study, 23 healthy participants aged from 21 to 62 years were recruited. Optic nerve head capillary blood volume (ONHvol) and oxygen saturation (ONHSaO2) baselines were measured over a period of 2 hours using multichannel spectroscopic reflectometry and were remeasured after a 7-day once-daily instillation regimen of either latanoprost 0.005% or latanoprostene bunod 0.024%. After a 30-day washout period, pa...
Source: Optometry and Vision Science - February 1, 2022 Category: Opthalmology Tags: ORIGINAL INVESTIGATIONS Source Type: research
Sustained release glaucoma therapies: Novel modalities for overcoming key treatment barriers associated with topical medications
Ann Med. 2022 Dec;54(1):343-358. doi: 10.1080/07853890.2021.1955146.ABSTRACTGlaucoma is a progressive optic neuropathy and a leading cause of irreversible blindness. The disease has conventionally been characterized by an elevated intraocular pressure (IOP); however, recent research has built the consensus that glaucoma is not only dependent on IOP but rather represents a multifactorial optic neuropathy. Although many risk factors have been identified ranging from demographics to co-morbidities to ocular structural predispositions, IOP is currently the only modifiable risk factor, most often treated by topical IOP-lowering...
Source: Annals of Medicine - January 25, 2022 Category: Internal Medicine Authors: Aditya Belamkar Alon Harris Ryan Zukerman Brent Siesky Francesco Oddone Alice Verticchio Vercellin Thomas A Ciulla Source Type: research
Effect of Prostaglandin E2 Agonist Omidenepag on the Expression of Matrix Metalloproteinase in Trabecular Meshwork Cells
CONCLUSIONS: In TM cells, prostaglandin E2 agonist OMD did not increase the permeability through the TM cell monolayer, and the protein levels of MMPs. These suggest that the direct effect on the trabecular outflow by OMD may be limited.PMID:35067026 | DOI:10.3341/kjo.2021.0169 (Source: Korean Journal of Ophthalmology : KJO)
Source: Korean Journal of Ophthalmology : KJO - January 24, 2022 Category: Opthalmology Authors: Jeong Yeub Kim Jae Woo Kim Source Type: research
