Effect of travoprost, latanoprost and bimatoprost PGF2 α treatments on the biomechanical properties of in-vivo rabbit cornea
Exp Eye Res. 2022 Jan 7;215:108920. doi: 10.1016/j.exer.2022.108920. Online ahead of print.ABSTRACTProstaglandin F2α analogues (PGF2α), one of the most commonly prescribed classes of hypotensive agents, could decrease collagen fibril density and remodel the extracellular matrix in cornea. We hypothesized that PGF2α's would induce corneal softening, reduce the accuracy of intraocular pressure (IOP) measurement and lead to uncertainty in the effectiveness of the therapy. We determined the stress-strain behavior of rabbit cornea after PGF2α usage and evaluated the effect of biomechanical changes associated with PGF2α tre...
Source: Experimental Eye Research - January 10, 2022 Category: Opthalmology Authors: JunJie Wang YiPing Zhao AYong Yu Jie Wu ManMan Zhu MuChen Jiang Xuefei Li DaTian Zhu PeiPei Zhang XiaoBo Zheng FangJun Bao Ahmed Elsheikh Source Type: research
Correction to: Evaluation of physical properties and dose equivalency of generic versus branded latanoprost formulations
(Source: International Ophthalmology)
Source: International Ophthalmology - December 27, 2021 Category: Opthalmology Source Type: research
Brimonidine/latanoprost
(Source: Reactions Weekly)
Source: Reactions Weekly - December 1, 2021 Category: Drugs & Pharmacology Source Type: research
Optic Disc Cupping Due to Dolichoectatic Internal Carotid Artery Optic Nerve Compression
Conclusions:
Significant compression of the optic nerve by a normal, tortuous, or dolichoectatic ICA may result in an optic neuropathy with optic disc cupping that resembles glaucoma. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - November 22, 2021 Category: Opthalmology Tags: Original Contribution Source Type: research
Ophthalmic Drugs: In vitro paraoxonase 1 inhibition and molecular docking studies
This study was tested some ophthalmic drugs used to treat the diseases, such as glaucoma and allergic conjunctivitis, mentioned above, travoprost, latanoprost, ketotifen, emedastine, and olopatadine, for their inhibition activities against PON1. These drugs displayed the potent inhibition effect with IC50 values ranging between 14.95 ± 0.15 and 299.60 ± 4.07 μM and KI constants ranging from 9.71 ± 2.63 to 261.50 ± 59.98 μM. Besides, the molecular docking analyses of the competitive inhibitors, travoprost, emedastine, and olopatadine, were performed to understand the binding interactions on the enzyme's binding site. ...
Source: Biotechnology and Applied Biochemistry - November 17, 2021 Category: Biochemistry Authors: B üşra Çalışkan,
Yeliz Demir,
Cüneyt Türkeş Tags: Original Article Source Type: research
Structure/function/treatment in glaucoma: progress over the last 10 years
Ophthalmologe. 2021 Oct 5. doi: 10.1007/s00347-021-01505-2. Online ahead of print.ABSTRACTSince the 1990s several so-called landmark studies were carried out, which played an important role in the management of glaucoma patients due to their multicenter, randomized and masked structure. The Ocular Hypertension Treatment Study (OHTS) and the Collaborative Initial Treatment Glaucoma Study (CIGTS) and their follow-up studies are especially important in the conservative glaucoma management and in the evaluation of structure and function. The OHTS examined if lowering of the intraocular pressure (IOP) treatment reduces the prog...
Source: Der Ophthalmologe - October 5, 2021 Category: Opthalmology Authors: Frances Meier-Gibbons Marc T öteberg-Harms Source Type: research
Structure/function/treatment in glaucoma: progress over the last 10 years
Ophthalmologe. 2021 Oct 5. doi: 10.1007/s00347-021-01505-2. Online ahead of print.ABSTRACTSince the 1990s several so-called landmark studies were carried out, which played an important role in the management of glaucoma patients due to their multicenter, randomized and masked structure. The Ocular Hypertension Treatment Study (OHTS) and the Collaborative Initial Treatment Glaucoma Study (CIGTS) and their follow-up studies are especially important in the conservative glaucoma management and in the evaluation of structure and function. The OHTS examined if lowering of the intraocular pressure (IOP) treatment reduces the prog...
Source: Der Ophthalmologe - October 5, 2021 Category: Opthalmology Authors: Frances Meier-Gibbons Marc T öteberg-Harms Source Type: research
Structure/function/treatment in glaucoma: progress over the last 10 years
Ophthalmologe. 2021 Oct 5. doi: 10.1007/s00347-021-01505-2. Online ahead of print.ABSTRACTSince the 1990s several so-called landmark studies were carried out, which played an important role in the management of glaucoma patients due to their multicenter, randomized and masked structure. The Ocular Hypertension Treatment Study (OHTS) and the Collaborative Initial Treatment Glaucoma Study (CIGTS) and their follow-up studies are especially important in the conservative glaucoma management and in the evaluation of structure and function. The OHTS examined if lowering of the intraocular pressure (IOP) treatment reduces the prog...
Source: Der Ophthalmologe - October 5, 2021 Category: Opthalmology Authors: Frances Meier-Gibbons Marc T öteberg-Harms Source Type: research
The Effects of Topical Timolol and Latanoprost on Calculated Ocular Perfusion Pressure in Nonglaucomatous Volunteers
Journal of Ocular Pharmacology and Therapeutics, Ahead of Print. (Source: Journal of Ocular Pharmacology and Therapeutics)
Source: Journal of Ocular Pharmacology and Therapeutics - October 4, 2021 Category: Opthalmology Authors: Ajay Kolli Carol B. Toris David M. Reed Jesse Gilbert Arthur J. Sit Vikas Gulati Arash Kazemi Shan Fan David C. Musch Sayoko E. Moroi Source Type: research
Ocular Surface Disease in Glaucoma Patients Randomized to Benzalkonium Chloride-Containing Latanoprost and Preservative-Free Bimatoprost
Journal of Ocular Pharmacology and Therapeutics, Ahead of Print. (Source: Journal of Ocular Pharmacology and Therapeutics)
Source: Journal of Ocular Pharmacology and Therapeutics - October 4, 2021 Category: Opthalmology Authors: Jo-Hsuan Wu Tsing-Hong Wang Jehn-Yu Huang Chien-Chia Su Source Type: research
Comparative Study between Generic versus Brand Latanoprost in treatment of Open Angle Glaucoma Patients
ConclusionOriginal latanoprost has a tendency of better efficacy and tolerability with low incidence of conjunctival hyperaemia and ocular irritation compared with the generic latanoprost in management of open angle glaucoma patient. (Source: QJM)
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research
