On the Horizon: Biologics and Nutrients for Neurotrophic Keratitis
Abstract: Neurotrophic keratitis (NK), a potentially sight-threatening corneal disease, still does not have a specific treatment. The reduction or complete loss of corneal sensation, the most important factor in its pathogenesis, is one of the most important factors that complicate the treatment of corneal wound healing. In addition, the visual outcome may be adversely affected because of aggressive stromal fibrosis in severe NK cases. Basically, the current management of NK aims to accelerate wound healing and prevent the progression. However, new therapeutic agents, particularly developed depending on cell type-speci...
Source: Eye and Contact Lens: Science and Clinical Practice - February 24, 2021 Category: Opthalmology Tags: Review Source Type: research

Surgical Management of the Ocular Surface in Neurotrophic Keratopathy: Amniotic Membrane, Conjunctival Grafts, Lid Surgery, and Neurotization
Conclusion: A variety of surgical options exist to manage neurotrophic keratopathy when medical treatments alone fail to resolve epitheliopathy. Ongoing protection and optimization of the ocular surface health remains crucial to prevent recurrent epithelial breakdown. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - February 24, 2021 Category: Opthalmology Tags: Review Article Source Type: research

Scleral Lens Use in Neurotrophic Keratopathy: A Review of Current Concepts and Practice
Conclusions: Scleral lenses may be effective in reducing the need for surgical intervention and improving the quality of life in patients with NK. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - February 24, 2021 Category: Opthalmology Tags: Review Article Source Type: research

Overview of Neurotrophic Keratopathy and a Stage-Based Approach to Its Management
Abstract: Neurotrophic keratopathy (NK) occurs because of disruption of corneal sensory innervation. There are many etiologies that can lead to NK, such as infection, trauma, topical medication use, cornea surgery, and intracranial tumors among others. We review the current available treatment options and provide a stage-based approach to its management. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - February 24, 2021 Category: Opthalmology Tags: Review Article Source Type: research

Neurotrophic Keratopathy: Ophthalmology's Diabetic Foot Problem
This article summarizes key elements of the 2020 Harold A. Stein Lecture presented at the Eye and Contact Lens Special Symposium “Healing the Ocular Surface: What's New for Neurotrophic Keratitis.” The major point that I made in this talk is that we need to think about neurotrophic keratopathy as ophthalmology's diabetic foot problem; as a chronic condition that is, often best managed by prevention. Neurotrophic keratopathy is not primarily an inflammatory condition, as suggested by the term ‟neurotrophic keratitis.” The epitheliopathy in this condition is a consequence of the dysregulated epithelial ce...
Source: Eye and Contact Lens: Science and Clinical Practice - February 24, 2021 Category: Opthalmology Tags: Review Article Source Type: research

Neurotrophic Keratitis: Do Not Be Insensitive
No abstract available (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - February 24, 2021 Category: Opthalmology Tags: Editorial Source Type: research

Deposition of Fluorescently Tagged Lysozyme on Contact Lenses in a Physiological Blink Model
Purpose: To visualize the deposition of fluorescein isothiocyanate (FITC) lysozyme on daily disposable contact lenses (CLs) using a novel blink model. Methods: Three daily disposable conventional hydrogel CLs (etafilcon A, omafilcon A, and nelfilcon A) and three silicone hydrogel CLs (delefilcon A, senofilcon A, and somofilcon A) were evaluated in the study. The CLs were mounted onto a novel blink model and exposed to an artificial tear solution containing FITC lysozyme for 2 and 10 hr. The flow rate and blink speed were set to 1 μL/min and 6 blinks/min, respectively. After the incubation period, a 5-mm-diame...
Source: Eye and Contact Lens: Science and Clinical Practice - January 30, 2021 Category: Opthalmology Tags: Article Source Type: research

Risk Factors for Contact Lens–Related Microbial Keratitis and Associated Vision Loss in a South Indian Population
Conclusions: Identification of these risk factors may help inform safe contact lens wear habits and management strategies. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - January 30, 2021 Category: Opthalmology Tags: Article Source Type: research

Effect of Bandage Contact Lens Exchange on Pain and Healing After Photorefractive Keratectomy—A Randomized Control Trial
Objective: To evaluate the corneal re-epithelialization and patient-perceived pain after bandage contact lens (BCL) exchange on day one, after photorefractive keratectomy (PRK). Methods: A randomized controlled trial, of all patients who underwent bilateral transepithelial-PRK (trans-PRK) or bilateral alcohol debridement and PRK (A-PRK), between March and October 2019. One eye of each patient was randomly assigned to BCL exchange on the first postoperative day (exchange group) and the BCL was not exchanged in the fellow eye (control group). Patients were evaluated daily until healing was complete. At each visit,...
Source: Eye and Contact Lens: Science and Clinical Practice - January 30, 2021 Category: Opthalmology Tags: Article Source Type: research

The Myopic Shift in Aphakic Eyes in the Infant Aphakia Treatment Study After 10 Years of Follow-up
Conclusions: The RE in aphakic eyes decreased by 44% from infancy to age 10.5 years. About two-thirds of children who remained aphakic at age 10.5 years continued to wear a contact lens. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - January 30, 2021 Category: Opthalmology Tags: Article Source Type: research

Axial Length Elongation in Japanese Youth With Myopia
Objectives: To investigate the correlation between the annual axial length (AL) elongation and associated factors in Japanese youth with myopia. Methods: This retrospective study enrolled patients aged 7 to 21 years with myopia. Axial length was measured using ocular biometry. Refractive errors and curvature radius (CR) were measured using an open-field Binocular Auto Ref/Keratometer without cycloplegia. Subjects were divided into five groups using 3-year age intervals, and the relationship between annual AL elongation and age, spherical equivalent (SE), corneal CR, and sex was evaluated. Results: Four hu...
Source: Eye and Contact Lens: Science and Clinical Practice - January 30, 2021 Category: Opthalmology Tags: Article Source Type: research

The Efficacy of Atropine Combined With Orthokeratology in Slowing Axial Elongation of Myopia Children: A Meta-Analysis
Conclusions: This meta-analysis demonstrates atropine combined with orthokeratology is effective in slowing axial elongation in myopia children. This effect may be superior to that of the orthokeratology alone. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - January 30, 2021 Category: Opthalmology Tags: Article Source Type: research

Should Overnight Orthokeratology Patients Wear Their Lenses During Their Afternoon Nap?
Purpose: The purpose of this study was to evaluate changes in visual acuity, corneal curvature, elevation, pachymetry, and objective quality of vision of experienced orthokeratology patients using their contact lenses during a simulated 30-min afternoon nap. Method: Twelve patients aged 30.8±8.3 years were recruited for the study, with a history of overnight orthokeratology of 27.4±23.0 months. Patients were instructed to close their eyes for 30 min while wearing their contact lenses or without lenses. Anterior corneal curvature, elevation, and corneal pachymetry were assessed with the Pentacam Sch...
Source: Eye and Contact Lens: Science and Clinical Practice - January 30, 2021 Category: Opthalmology Tags: Article Source Type: research

Corneal Elevation, Power, and Astigmatism to Assess Toric Orthokeratology Lenses in Moderate-to-High Astigmats
Objectives: Fitting philosophies for toric orthokeratology are based on elevation or corneal astigmatism, but it is unclear which is more effective. The purpose of this analysis was to further understand corneal shape and the relationship between peripheral elevation and central astigmatism in moderate-to-high astigmats. Methods: Corneal tomography was measured three times on the right eyes of 25 moderate-to-high refractive myopic astigmatic adults. Corneal astigmatism and elevation were calculated at 4-, 6-, and 8-mm chords. Subjects were fitted with toric orthokeratology lenses following the manufacturer's gui...
Source: Eye and Contact Lens: Science and Clinical Practice - January 30, 2021 Category: Opthalmology Tags: Article Source Type: research

Comparison of Administration of 0.02% Atropine and Orthokeratology for Myopia Control
Conclusion: Within the limits of this study design, orthokeratology seems to be a better method for controlling AL elongation compared with administration of 0.02% atropine in children with higher myopia over a treatment period of 2 years. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - January 30, 2021 Category: Opthalmology Tags: Article Source Type: research

Treating Uncomfortable Contact Lens Wear With Orthokeratology
Conclusions: Although not all symptomatic soft CL wearers were able to be refit into orthokeratology, subjects who were wearing orthokeratology at 3 months had a significant and clinically meaningful improvement in ocular symptoms. Additional work is needed to determine the mechanism leading to improved comfort because few clinical signs were changed after switching to orthokeratology. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - January 30, 2021 Category: Opthalmology Tags: Article Source Type: research

Acanthamoeba Keratitis in Minors With Orthokeratology (OK) Lens Use: A Case Series
Conclusions: The proportion of orthokeratology cases among AK minors (13%) in our case series exceeds the expected proportion of orthokeratology cases expected based on orthokeratology market penetrance (1%). Results from this case series suggest a potential increased risk of AK in orthokeratology users compared with other lens modalities. In the context of the current myopia epidemic and concerns for halting myopia progression in minors, caution should be exercised when selecting appropriate treatment options to minimize the risk of AK. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - January 30, 2021 Category: Opthalmology Tags: Article Source Type: research

Is Overnight Orthokeratology OK for Kids?
No abstract available (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - January 30, 2021 Category: Opthalmology Tags: Editorial Source Type: research

Simple Oral Mucosal Epithelial Transplantation in a Patient With Bilateral Limbal Stem Cell Deficiency
Conclusions: This report showed that SOMET seems to be an alternative technique in LSCD. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - December 22, 2020 Category: Opthalmology Tags: Case Report Source Type: research

Prevalence of Ocular Demodex Infestation in Children: An Epidemiological Survey in South China
Objectives: To investigate the prevalence of and risk factors for Demodex mite infestation of the eyelashes in Chinese children. Methods: A total of 1,575 children were surveyed from June 2017 to January 2019 and stratified into two age groups: 3 to 6 and 7 to 14 years. All subjects underwent routine eye examination and lash epilation for Demodex mite identification and counting using microscopy. Demographic data and lifestyle habits were also recorded. Results: Demodex mites were detected in 189 of 1,575 (12.0%) children, including Demodex folliculorum (D. folliculorum) in 180 (11.4%), Demodex brevis (D....
Source: Eye and Contact Lens: Science and Clinical Practice - December 22, 2020 Category: Opthalmology Tags: Article Source Type: research

Efficacy of Azithromycin Eyedrops for Individuals With Meibomian Gland Dysfunction–Associated Posterior Blepharitis
Conclusion: Azithromycin eyedrops improved eyelid inflammation, the quality and quantity of the lipid layer of the tear film, and tear film stability. Such eyedrops thus seem to be a safe and effective treatment for MGD-associated posterior blepharitis. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - December 22, 2020 Category: Opthalmology Tags: Article Source Type: research

The Efficacy of Intense Pulsed Light Combined With Meibomian Gland Expression for the Treatment of Dry Eye Disease Due to Meibomian Gland Dysfunction: A Multicenter, Randomized Controlled Trial
Objectives: To compare the efficacy of intense pulsed light (IPL) combined with Meibomian gland expression (MGX), and instant warm compresses combined with MGX, for treatment of dry eye disease (DED) due to meibomian gland dysfunction (MGD). Methods: In a prospective, multicenter, interventional study, 120 subjects with DED due to MGD were randomized 1:1 to an IPL arm or a control arm. Each subject was treated 3 times at 3-week intervals. The primary outcome measure was the tear break up time (TBUT). Tear break up time and a few additional outcome measures were evaluated at the baseline and at 3 weeks after the ...
Source: Eye and Contact Lens: Science and Clinical Practice - December 22, 2020 Category: Opthalmology Tags: Article Source Type: research

A Retrospective Study of Treatment Outcomes and Prognostic Factors of Intense Pulsed Light Therapy Combined With Meibomian Gland Expression in Patients With Meibomian Gland Dysfunction
Conclusions: Improved dry eye symptoms, TBUT, corneal staining, and meibomian gland secretion were observed in MGD patients after IPL/MGX. Patients in the early stages of MGD maybe benefited most from IPL/MGX treatment. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - December 22, 2020 Category: Opthalmology Tags: Article Source Type: research

Ocular Surface Changes in Hashimoto's Thyroiditis Without Thyroid Ophthalmopathy
Objective: We sought to evaluate ocular surface changes in patients with Hashimoto's thyroiditis without thyroid ophthalmopathy and elucidate the relationship between dry eye syndrome and meibomian gland dysfunction (MGD) in cases of Hashimoto's thyroiditis. Methods: This prospective study included 105 patients with Hashimoto's thyroiditis and 105 age- and sex-matched controls. The 12-item Ocular Surface Disease Index (OSDI) questionnaire was administered to all patients. Both eyes affected by Hashimoto's thyroiditis and normal eyes were evaluated and compared with regard to the following parameters: Hertel exop...
Source: Eye and Contact Lens: Science and Clinical Practice - December 22, 2020 Category: Opthalmology Tags: Article Source Type: research

Association Between Dry Eye and Polycystic Ovary Syndrome: Subclinical Inflammation May Be Part of the Process
Purpose: To evaluate the changes in tear function in patients with polycystic ovary syndrome (PCOS) and establish whether there is a correlation between hormonal levels, novel hematologic biomarkers, and dry eye parameters. Material and Method: Forty-seven patients with PCOS and 43 age-matched patients with unexplained infertility were included in the control group. Follicle-stimulating hormone, luteinizing hormone, estradiol, thyroid-stimulating hormone, prolactin, dehydroepiandrosterone sulfate (DHEA-S), 17-OH progesterone, fasting and postprandial glucose, fasting insulin, and cholesterol metabolites were eva...
Source: Eye and Contact Lens: Science and Clinical Practice - December 22, 2020 Category: Opthalmology Tags: Article Source Type: research

The Early Effects of Alcohol Consumption on Functional Visual Acuity, Tear Functions, and the Ocular Surface
Purpose: We investigated the early effects of alcohol intake on tear functions and ocular surface health in this prospective controlled study. Methods: Forty-four eyes of 22 subjects (17 males, 5 females; mean age: 35.3 years) who drank 200 mL of 25% Japanese vodka and 44 eyes of age- and sex-matched 22 control subjects who drank water were investigated. Subjects were requested to refrain from alcohol consumption from the previous day and food ingestion 6 hr before the study. Each subject consumed exactly the same order prepared dinner and same quantity of alcohol over the same time frame. Subjects underwent bre...
Source: Eye and Contact Lens: Science and Clinical Practice - December 22, 2020 Category: Opthalmology Tags: Article Source Type: research

Simplified Classification of Tear Film Break-Up Patterns and Their Clinicopathological Correlations in Patients With Dry Eye Disease
Conclusions: We were able to clearly classify patients with DED with different TBUPs into two groups, and each group had different clinical and pathophysiological characteristics. In patients with the dot break-up pattern, the disease was strongly associated with ocular surface inflammation, as opposed to that in patients without this pattern. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - December 22, 2020 Category: Opthalmology Tags: Article Source Type: research

Development of a Questionnaire for Detecting Changes in Dry Eye Disease–Related Symptoms
Conclusions: CDES-Q can be a useful tool for the evaluation of changes in DED-related symptoms. It is simple and better discriminates patients without changes from those who suffered a worsening than SANDE II. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - December 22, 2020 Category: Opthalmology Tags: Article Source Type: research

Associations Between Systemic Omega-3 Fatty Acid Levels With Moderate-to-Severe Dry Eye Disease Signs and Symptoms at Baseline in the Dry Eye Assessment and Management Study
Conclusion: Previous studies have found varying results on the role of n-3 supplementation with the signs and symptoms of DED. Among patients with DED enrolled in the DREAM Study, lower systemic n-3 levels were not associated with worse symptoms and most signs of DED. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - December 22, 2020 Category: Opthalmology Tags: Article Source Type: research

Marching Ahead Online and Leaving the Print Behind
No abstract available (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - December 22, 2020 Category: Opthalmology Tags: Editorial Source Type: research

Dematiaceous Fungal Colonization of the Bandage Contact Lens in a Patient Lost to Follow-up During the COVID-19 Crisis
We report a rare case of dematiaceous fungus colonization in the therapeutic bandage contact lens (BCL), in an eye with peripheral ulcerative keratitis. Bandage contact lens removal and appropriate treatment resulted in improvement of the visual acuity and prevented the spread of fungus to the underlying ocular structures. Microbiological evaluation of the BCL showed dematiaceous fungal filaments, and the fungus was identified as Bipolaris species. In patients with pigmented plaque-like lesions, with BCL in situ, dematiaceous fungus on the undersurface of the BCL should be kept in mind. Patient education regarding the impo...
Source: Eye and Contact Lens: Science and Clinical Practice - October 28, 2020 Category: Opthalmology Tags: Case Report Source Type: research

Arthrographis kalrae Keratitis Complicated by Endophthalmitis: A Case Report With Literature Review
Conclusions: A. kalrae keratitis is an exceptionally rare clinical entity that poses significant therapeutic challenges. MALDI-TOF-MS serves as a useful diagnostic technique in identifying this rare organism. Although the literature suggested that A. kalrae keratitis may sometimes be controlled with antifungal medical treatment alone, this approach was proven to be futile in our immunocompromised patient with pre-existing neurotrophic keratopathy, suggesting that early surgical intervention such as therapeutic keratoplasty may be required in these cases. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - October 28, 2020 Category: Opthalmology Tags: Case Report Source Type: research

Epithelial Inclusion Cyst of the Bulbar Conjunctiva Secondary to Scleral Lens Impingement Managed With a MicroVault
Abstract: Acquired epithelial inclusion conjunctival bulbar cyst is a reported complication of scleral contact lens impingement commonly corrected with a diameter change or notch of the scleral contact lens. This case discusses an acquired epithelial inclusion conjunctival bulbar cyst due to microtrauma caused by prolonged scleral contact lens wear and corrected with a MicroVault. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - October 28, 2020 Category: Opthalmology Tags: Case Report Source Type: research

Clinical Findings and Ocular Symptoms Over 1 Year in a Sample of Scleral Lens Wearers
Purpose: To report the fitting aspects, clinical findings, and symptoms over 12 months of scleral lens (SL) wear. Methods: Sixty-nine patients with irregular cornea due to ectasia or surgical procedures (IC group) or regular corneas with high ametropia (RC group) completed the 12-month prospective follow-up period. Patients were evaluated at baseline, lens dispensing visit, 1 month, 3 months, 6 months, and 12 months for assessment of comfort, fitting aspects, and slitlamp findings. Comfort was assessed with the Ocular Surface Disease Index (OSDI) questionnaire and Dry Eye Questionnaire. Slitlamp evaluations comprised ...
Source: Eye and Contact Lens: Science and Clinical Practice - October 28, 2020 Category: Opthalmology Tags: Article Source Type: research

Intrasession Repeatability of the Contact Angle Measured Using the Captive Bubble Method and Agreement Assessed Between Different Analysis Software Programs
Objectives: The material biocompatibility of hydrogel and silicone hydrogel (SiHy) contact lens (CL) is of paramount importance in CL wear because a decrease in CL wettability reduces wearer comfort and increases wearer dropout. The aim of this study is to report on the repeatability and agreement between two different software programs that measure the contact angle with the captive bubble method in marketed CLs, which will help to translate this information into clinical practice. Methods: The contact angle of 23 different CLs was measured with the captive bubble method using 2 software programs: FTÅ200 and Im...
Source: Eye and Contact Lens: Science and Clinical Practice - October 28, 2020 Category: Opthalmology Tags: Article Source Type: research

Rigid Gas-Permeable Contact Lenses Fitting Philosophy for Unilateral Aphakic Infants
Purpose: To provide fitting guidelines with suggested powers and base curves (BCs) and diameters for initial rigid gas-permeable (RGP) contact lenses (CLs) selection for unilateral aphakic infants based on age. Methods: Records of 52 children (52 eyes) with RGP CLs to unilateral aphakia between 2014 and 2019 were evaluated. Refractive status was assessed by standard retinoscopy. The original BC and diameter were determined by keratometric readings and fluorescein pattern under sedation. Correlation analysis was performed between age and CLs parameters. Linear regression analysis was used to develop a model for estimat...
Source: Eye and Contact Lens: Science and Clinical Practice - October 28, 2020 Category: Opthalmology Tags: Article Source Type: research

Effect of Orthokeratology Lens on Contrast Sensitivity Function and High-Order Aberrations in Children and Adults
Conclusion: Our study revealed that OOK lenses decrease CSF to a greater extent in adults than that in children despite no significant differences in the change of ocular HOAs between both subject groups. We proposed children may have better neural adaptation to compensate for optical aberrations induced by OOK lens use. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - October 28, 2020 Category: Opthalmology Tags: Article Source Type: research

Regional Variations in Postlens Tear Layer Thickness During Scleral Lens Wear
Conclusions: The PLTL was thickest temporally and thinnest nasally in healthy eyes fitted with rotationally symmetric scleral lenses, most likely because of regional differences in underlying scleral elevation, eyelid forces, and lens centration. Postlens tear layer asymmetries diminished with lens wear, and stabilization occurred more rapidly in regions with less corneal clearance immediately after lens insertion. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - October 28, 2020 Category: Opthalmology Tags: Article Source Type: research

Prevalence of Ocular Surface Disease and Corneal Irregularity and Outcomes in Patients Using Therapeutic Scleral Lenses at a Tertiary Care Center
Conclusions: Ocular surface disease was common in this tertiary referral patient population and was a primary or secondary indication for ScCL evaluation in 85.7% (n=114) of patients evaluated for ScCL. Scleral contact lenses improved visual outcomes in patients with both primary diagnoses of CI and OSD. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - October 28, 2020 Category: Opthalmology Tags: Article Source Type: research

Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) for Visual Rehabilitation in Limbal Stem Cell Deficiency
Objectives: To evaluate the clinical outcomes of patients with limbal stem cell deficiency (LSCD) who were fitted with the Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) scleral device. Methods: In this retrospective, interventional case series, we reviewed the charts of 31 eyes of 19 consecutive patients clinically diagnosed with LSCD who were evaluated for the PROSE device. Clinical data were reviewed before PROSE evaluation and at the last available follow-up. The main outcomes measures were best-corrected distance visual acuity (CDVA) and modified ocular involvement score (OIS), graded using a prev...
Source: Eye and Contact Lens: Science and Clinical Practice - October 28, 2020 Category: Opthalmology Tags: Article Source Type: research

Impact of Changes in the Optical Density of Postlens Fluid on the Clinical Performance of Miniscleral Lenses
Purpose: To determine the impact of optical density changes in postlens fluid on clinical performance and to quantify these changes over time during miniscleral lens wear. Methods: Twenty-three eyes of 13 patients with keratoconus were fitted with a miniscleral lens (scleral Misa lenses; Microlens Contactlens Technology, Arnhem, Netherlands). The lens fit was evaluated using the fluorescein pattern and also through anterior segment optical coherence tomography imaging. The optical density changes were measured using Scheimpflug tomography at 30 min, 1, 2, 3, and 4 hr. High- and low-contrast visual acuity (VA), subject...
Source: Eye and Contact Lens: Science and Clinical Practice - October 28, 2020 Category: Opthalmology Tags: Article Source Type: research

Outcomes of Scleral Contact Lens Use in Veteran Population
Objectives: To document outcomes associated with use of scleral contact lenses (SL) in the veteran population and analyze the medical and demographic factors that affect these outcomes, specifically those involved in contact lens discontinuation. Methods: A retrospective study of consecutive patients first fitted with Jupiter Scleral lenses at the Michael E. DeBakey Veterans Affairs Medical Center between 2010 and 2018. The primary outcome was continuation of SL use at 1 year. Demographic factors and variables such as presence of comorbid diseases, improvement in visual acuity, and daily lens wear time were compared. ...
Source: Eye and Contact Lens: Science and Clinical Practice - October 28, 2020 Category: Opthalmology Tags: Article Source Type: research

Effect of Scleral Lens Wear on Central Corneal Thickness and Intraocular Pressure in Patients With Ocular Surface Disease
Conclusion: There was a statistically significant increase in CCT after scleral lens wear in subjects with ocular surface disease, which may be attributed to subclinical hypoxic conditions created by scleral lens wear. No significant relationship was found between scleral lens wear and IOP. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - October 28, 2020 Category: Opthalmology Tags: Article Source Type: research

A Systematic Review of Emerging Therapeutic Strategies in the Management of Chemical Injuries of the Ocular Surface
Conclusion: Recent advances and understanding in various novel therapeutic methods for corneal epithelial chemical injuries should provide potential alternatives to current standard treatment regimens and help reduce risks of complications, hence improve patient outcomes. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - October 28, 2020 Category: Opthalmology Tags: Review Article Source Type: research

Contact Lens–Related Microbial Keratitis and Host Genetics
No abstract available (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - October 28, 2020 Category: Opthalmology Tags: Editorial Source Type: research

A New Perspective on Dry Eye Classification: Proposal by the Asia Dry Eye Society: Erratum
No abstract available (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - August 25, 2020 Category: Opthalmology Tags: Erratum Source Type: research

Epipremnum aureum Keratopathy: Case Report and Review of the Literature
Conclusion: Epipremnum aureum toxicity is a rare cause of keratitis. It can mimic acanthamoeba keratitis or anesthetic abuse and should be considered in cases of culture negative nonhealing corneal ulcerations. Eliciting a history of plant sap exposure can facilitate appropriate supportive care for this toxic keratitis. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - August 25, 2020 Category: Opthalmology Tags: Case Report Source Type: research

Corneal Endotheliitis as a Presentation of Acanthamoeba Keratitis
Conclusions: Corneal endotheliitis, although uncommon, may be a manifestation of AK. We must have high-index suspicion for AK in all contact lens users, particularly before making a diagnosis of HSV keratitis. Accurate diagnosis and prompt treatment can result in a favorable prognosis for AK. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - August 25, 2020 Category: Opthalmology Tags: Case Report Source Type: research

Tear Levels of IGFBP-3: A Potential Biomarker for Diabetic Nerve Changes in the Cornea
Conclusions: Overwhelming evidence supports the use of in vivo confocal microscopy as a tool to evaluate corneal nerve and epithelial changes induced by diabetes in research settings. The newly identified relationship between morphological changes in the corneal subbasal nerve plexus in diabetes and the increase in tear levels of IGFBP-3 suggest that this protein may represent an innovative new biomarker to assess risk of ocular and nonocular complications in type 2 diabetes mellitus. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - August 25, 2020 Category: Opthalmology Tags: Review Article Source Type: research

Comparative Evaluation of Visual Outcomes After Bilateral Implantation of a Diffractive Trifocal Intraocular Lens and an Extended Depth of Focus Intraocular Lens
Conclusions: Trifocal IOL had a clear advantage over EDOF IOLs in near VA, while both IOLs showed excellent performance in distance and intermediate VA. Both IOLs provided high percentage of spectacle independence and patient satisfaction with minimal level of disturbing photic phenomena. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - August 25, 2020 Category: Opthalmology Tags: Article Source Type: research