Performance evaluation of a staggered 3-layer DOI PET detector using a 1 mm LYSO pitch with PETsys TOFPET2 ASIC: comparison of HAMAMATSU and KETEK SiPMs
In conclusion, the performance of the staggered 3-layer DOI detector with 1 mm LYSO pitch and 19.8 mm total crystal thickness was fully characterized. The feasibility of a highly performing readout of a high resolution DOI PET detector via SiPM arrays from KETEK and HAMAMATSU employing the PETsys TOFPET v2c ASIC could be demonstrated.PMID:33906179 | DOI:10.1088/1361-6560/abfbf3 (Source: Physics in Medicine and Biology)
Source: Physics in Medicine and Biology - April 27, 2021 Category: Physics Authors: Tim Maximilian Binder Han Gyu Kang Munetaka Nitta Florian Roland Schneider Taiga Yamaya Katia Parodi Florian Wiest Peter G Thirolf Source Type: research
Performance evaluation of a staggered 3-layer DOI PET detector using a 1 mm LYSO pitch with PETsys TOFPET2 ASIC: comparison of HAMAMATSU and KETEK SiPMs
In conclusion, the performance of the staggered 3-layer DOI detector with 1 mm LYSO pitch and 19.8 mm total crystal thickness was fully characterized. The feasibility of a highly performing readout of a high resolution DOI PET detector via SiPM arrays from KETEK and HAMAMATSU employing the PETsys TOFPET v2c ASIC could be demonstrated.PMID:33906179 | DOI:10.1088/1361-6560/abfbf3 (Source: Physics in Medicine and Biology)
Source: Physics in Medicine and Biology - April 27, 2021 Category: Physics Authors: Tim Maximilian Binder Han Gyu Kang Munetaka Nitta Florian Roland Schneider Taiga Yamaya Katia Parodi Florian Wiest Peter G Thirolf Source Type: research
Placentitis and abortion caused by a multidrug resistant strain of Campylobacter fetus subspecies fetus in a sheep in Uruguay
We describe a case of abortion caused by a multidrug resistant strain of Cff in a sheep in Uruguay. In August 2017, 3/57 pregnant ewes (5.3%) aborted whithin one week. Histopathologic examination of the placenta of an aborted ewe revealed severe neutrophilic and fibrinonecrotizing placentitis with vasculitis and thrombosis of the chorionic arterioles. Cff was isolated on microaerobic culture in Skirrow agar, and further confirmed by 16S rDNA PCR amplification and sequencing, and endpoint and real time PCR assays. Antimicrobial sensitivity testing revealed resistance to tetracyclines, nalidixic acid, telithromycin and clind...
Source: Revista Argentina de Microbiologia - April 20, 2021 Category: Microbiology Authors: Mat ías A Dorsch Mar ía L Casaux Luc ía Calleros Virginia Ar áoz Rub én D Caffarena Cecilia Monesiglio Maila Barcellos Caroline da Silva Silveira Yisell Perdomo Georgget Banchero Francisco A Uzal Mart ín Fraga Federico Giannitti Source Type: research
The Antibacterial and Antibiofilm Activity of Telithromycin Against Enterococcus spp. Isolated From Patients in China
In conclusion, these results revealed that telithromycin significantly decreased the planktonic cells of both E. faecalis and E. faecium. In addition, the data further demonstrated that telithromycin has the robust ability to inhibit E. faecalis biofilms and the combination of telithromycin and ampicillin improved antibiofilm activity. These in vitro antibacterial and antibiofilm activities suggest that telithromycin could be a potential candidate for the treatment of enterococcal infections. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - January 14, 2021 Category: Microbiology Source Type: research
Assessment of the in vitro cytochrome P450 (CYP) inhibition potential of Nafithromycin, a next generation lactone ketolide antibiotic.
Abstract
Nafithromycin is a next generation lactone ketolide antibiotic slated to enter phase III clinical development in India for the treatment of CABP as a shorter 800mg-OD X3 day therapeutic regimen. Nafithromycin exhibits potent activity against MDR Streptococcus pneumoniae including erythromycin and telithromycin-resistant resistant strains. Older macrolides/ketolides are reported to be potent inhibitors of CYP3A4/5. To facilitate comparative assessment of drug-drug interaction potential, CYP inhibitory activities of nafithromycin was evaluated in comparison with clarithromycin, telithromycin, ceth...
Source: Xenobiotica - October 20, 2020 Category: Research Authors: Chavan RP, Zope VS, Chavan NN, Patil K, Yeole RD, Bhagwat SB, Patel MV Tags: Xenobiotica Source Type: research
Delirium associated with the use of macrolide antibiotics: a review.
CONCLUSIONS: Considering that these drugs may be a possible cause of delirium, clinicians should be aware that timely recognition of this possible side effect can lead to earlier discontinuation of the culprit drug, reduce time spent in a delirious state and improve patients' outcomes. KEY POINTS Cases of delirium which satisfied inclusion criteria were found for clarithromycin, azithromycin, erythromycin and telithromycin. Cases of delirium were described in patients of various age groups, including children. Drug-drug interactions may have contributed to the occurrence of delirium in some of the cases. Time to onset of d...
Source: International Journal of Psychiatry in Clinical Practice - October 8, 2020 Category: Psychiatry Tags: Int J Psychiatry Clin Pract Source Type: research
A Review: Effects of macrolides on CYP450 enzymes.
This article summarizes some published applications of the influence of macrolides on CYP450 and the DDIs of macrolides caused by CYP450. And the article may subsequently guides the use drugs of rationally in clinical trials. To a certain extent, poisoning caused by adverse drug interactions can be avoided. Unreasonable use of macrolide antibiotics may cause the residue of macrolide antibiotics in animal-origin food. It is unhealthy for people to eat food with macrolide antibiotic residues. So it is of great significance to guarantee the food safety and the health of consumers by the rational use of macrolides. This review...
Source: Current Drug Metabolism - August 16, 2020 Category: Drugs & Pharmacology Authors: Zhang L, Xu X, Badawy S, Ihsan A, Liu Z, Xie C, Wang X, Tao Y Tags: Curr Drug Metab Source Type: research
In Vitro ADME, Preclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of RBx14255, a Novel Ketolide with Pharmacodynamics Against Multidrug-Resistant Bacterial Pathogens.
CONCLUSION: RBx14255 displayed significantly better pharmacodynamics which correlates with the pharmacokinetic properties against S. pneumoniae and H. influenzae as compared to telithromycin. The predicted human efficacious doses are in the range of 124-226 mg, making it amenable to oral dosage form drug in human. This could be a promising clinical candidate for future studies.
PMID: 32574140 [PubMed - as supplied by publisher] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - June 24, 2020 Category: Drugs & Pharmacology Authors: Chaira T, Barman T, Samuel Raj V Tags: J Pharm Pharm Sci Source Type: research
[Intrapulmonary Pharmacokinetics and Drug Distribution Characteristics for the Treatment of Respiratory Diseases].
This study was designed to clarify the intrapulmonary pharmacokinetics and distribution characteristics of drugs in order to develop better therapies for respiratory diseases, including respiratory infections and pulmonary fibrosis. The distribution characteristics of three macrolide antimicrobial agents-clarithromycin, azithromycin, and telithromycin-in plasma, lung epithelial lining fluid (ELF), and alveolar macrophages (AMs), were examined for the optimization of antimicrobial therapy. The time course of the uptake of these agents in ELF and AMs, following oral administration to rats, resulted in markedly higher concent...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 4, 2020 Category: Drugs & Pharmacology Authors: Togami K Tags: Yakugaku Zasshi Source Type: research
Solution conformations explain the chameleonic behaviour of macrocyclic drugs.
Abstract
It has been hypothesized that drugs in the chemical space beyond the rule of 5 (bRo5) must behave as molecular chameleons to combine otherwise conflicting properties, including aqueous solubility, cell permeability and target binding. Evidence for this has, however, been limited to the cyclic peptide cyclosporin A. Herein we show that the non-peptidic and macrocyclic drugs roxithromycin, telithromycin and spiramycin behave as molecular chameleons, with rifampicin showing a less pronounced behavior. In particular roxithromycin, telithromycin and spiramycin display a marked, yet limited flexibility ...
Source: Chemistry - February 5, 2020 Category: Chemistry Authors: Danelius E, Poongavanam V, Peintner S, Wieske L, Erdelyi M, Kihlberg J Tags: Chemistry Source Type: research
In vitro activities of telithromycin against Staphylococcus aureus biofilms compared with azithromycin, clindamycin, vancomycin and daptomycin.
Conclusions. Telithromycin is more effective than azithromycin, clindamycin, vancomycin, or daptomycin against S. aureus biofilms.
PMID: 31916929 [PubMed - as supplied by publisher] (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - January 8, 2020 Category: Microbiology Authors: Zheng JX, Tu HP, Sun X, Xu GJ, Chen JW, Deng QW, Yu ZJ, Qu D Tags: J Med Microbiol Source Type: research
Cytotoxic comparison of macrolide antibiotics and their chlorinated disinfection byproduct mixtures.
In this study, the Jurkat cell line was used to compare the toxicities of the disinfection byproduct mixtures and their precursor compounds. The cell viability results indicated that the toxicity of ERY-M may not be enhanced after disinfection by chlorination. In contrast, at the same concentrations, AZI-M and TEL-M induced more significant inhibitory effects on cell viability than their parent compounds. Additionally, the total antioxidant capacity (T-AOC) and cell cytokine release (including interleukin-2, interleukin-8 and tumor necrosis factor-α) analyses of AZI-M and TEL-M further verified these results. Our findings...
Source: Ecotoxicology and Environmental Safety - July 8, 2019 Category: Environmental Health Authors: Feng Y, Guo Q, Shao B Tags: Ecotoxicol Environ Saf Source Type: research
Performance comparison of depth-encoding detectors based on dual-ended readout and different SiPMs for high-resolution PET applications.
Abstract
Silicon photomultipliers (SiPMs) are widely used in positron emission tomography (PET), however, SiPMs from different vendors vary in their performance characteristics. In addition, the specifications provided by the manufacturers are measured under different operating conditions and using different test setups, making it difficult to choose the optimal device for a specific application using the published specifications. In this work, we evaluated four state-of-the-art 8 × 8 arrays of ~ 3 mm × 3 mm SiPMs from SensL, KETEK, and Hamamatsu for high-resolution dual-ended readout detectors using the...
Source: Physics in Medicine and Biology - April 23, 2019 Category: Physics Authors: Du J, Bai X, Cherry SR Tags: Phys Med Biol Source Type: research
