Cytotoxic comparison of macrolide antibiotics and their chlorinated disinfection byproduct mixtures.

In this study, the Jurkat cell line was used to compare the toxicities of the disinfection byproduct mixtures and their precursor compounds. The cell viability results indicated that the toxicity of ERY-M may not be enhanced after disinfection by chlorination. In contrast, at the same concentrations, AZI-M and TEL-M induced more significant inhibitory effects on cell viability than their parent compounds. Additionally, the total antioxidant capacity (T-AOC) and cell cytokine release (including interleukin-2, interleukin-8 and tumor necrosis factor-α) analyses of AZI-M and TEL-M further verified these results. Our findings demonstrate that the cytotoxicity of AZI and TEL was enhanced during the chlorination disinfection process. This investigation will provide substantial new details related to the toxicity of the mixed disinfection byproducts (DBPs) of ERY, AZI and TEL generated in the chlorination disinfection process.
PMID: 31299471 [PubMed - as supplied by publisher]

Source: Ecotoxicology and Environmental Safety - July 8, 2019 Category: Environmental Health Authors: Feng Y, Guo Q, Shao B Tags: Ecotoxicol Environ Saf Source Type: research