Distribution of emm, superantigen and other virulence genotypes and detection of phylogenetic relationships in group A streptococcal isolates
Acta Microbiol Immunol Hung. 2022 Nov 11. doi: 10.1556/030.2022.01740. Online ahead of print.ABSTRACTGroup A streptococci are important pathogens with various virulence factors, such as M protein, superantigens, hemolysins, deoxyribonuclease, and proteases. The aims of this study are to investigate the detection of emm genotypes and other virulence genes, such as SAgs, DNase, protease, antibiotic resistance, and phylogenetic relationships in GAS strains isolated from clinical samples.Test strains were obtained from Çukurova University Balcalı Hospital and regional hospitals in Adana province. The M proteins were detected...
Source: Acta Microbiologica et Immunologica Hungarica - November 12, 2022 Category: Microbiology Authors: Suna K ızılyıldırım Fatih K öksal Cansu Önlen Güneri Source Type: research
Distribution of emm, superantigen and other virulence genotypes and detection of phylogenetic relationships in group A streptococcal isolates
Acta Microbiol Immunol Hung. 2022 Nov 11. doi: 10.1556/030.2022.01740. Online ahead of print.ABSTRACTGroup A streptococci are important pathogens with various virulence factors, such as M protein, superantigens, hemolysins, deoxyribonuclease, and proteases. The aims of this study are to investigate the detection of emm genotypes and other virulence genes, such as SAgs, DNase, protease, antibiotic resistance, and phylogenetic relationships in GAS strains isolated from clinical samples.Test strains were obtained from Çukurova University Balcalı Hospital and regional hospitals in Adana province. The M proteins were detected...
Source: Acta Microbiologica et Immunologica Hungarica - November 12, 2022 Category: Microbiology Authors: Suna K ızılyıldırım Fatih K öksal Cansu Önlen Güneri Source Type: research
Distribution of emm, superantigen and other virulence genotypes and detection of phylogenetic relationships in group A streptococcal isolates
Acta Microbiol Immunol Hung. 2022 Nov 11. doi: 10.1556/030.2022.01740. Online ahead of print.ABSTRACTGroup A streptococci are important pathogens with various virulence factors, such as M protein, superantigens, hemolysins, deoxyribonuclease, and proteases. The aims of this study are to investigate the detection of emm genotypes and other virulence genes, such as SAgs, DNase, protease, antibiotic resistance, and phylogenetic relationships in GAS strains isolated from clinical samples.Test strains were obtained from Çukurova University Balcalı Hospital and regional hospitals in Adana province. The M proteins were detected...
Source: Acta Microbiologica et Immunologica Hungarica - November 12, 2022 Category: Microbiology Authors: Suna K ızılyıldırım Fatih K öksal Cansu Önlen Güneri Source Type: research
Distribution of emm, superantigen and other virulence genotypes and detection of phylogenetic relationships in group A streptococcal isolates
Acta Microbiol Immunol Hung. 2022 Nov 11. doi: 10.1556/030.2022.01740. Online ahead of print.ABSTRACTGroup A streptococci are important pathogens with various virulence factors, such as M protein, superantigens, hemolysins, deoxyribonuclease, and proteases. The aims of this study are to investigate the detection of emm genotypes and other virulence genes, such as SAgs, DNase, protease, antibiotic resistance, and phylogenetic relationships in GAS strains isolated from clinical samples.Test strains were obtained from Çukurova University Balcalı Hospital and regional hospitals in Adana province. The M proteins were detected...
Source: Acta Microbiologica et Immunologica Hungarica - November 12, 2022 Category: Microbiology Authors: Suna K ızılyıldırım Fatih K öksal Cansu Önlen Güneri Source Type: research
Distribution of emm, superantigen and other virulence genotypes and detection of phylogenetic relationships in group A streptococcal isolates
Acta Microbiol Immunol Hung. 2022 Nov 11. doi: 10.1556/030.2022.01740. Online ahead of print.ABSTRACTGroup A streptococci are important pathogens with various virulence factors, such as M protein, superantigens, hemolysins, deoxyribonuclease, and proteases. The aims of this study are to investigate the detection of emm genotypes and other virulence genes, such as SAgs, DNase, protease, antibiotic resistance, and phylogenetic relationships in GAS strains isolated from clinical samples.Test strains were obtained from Çukurova University Balcalı Hospital and regional hospitals in Adana province. The M proteins were detected...
Source: Acta Microbiologica et Immunologica Hungarica - November 12, 2022 Category: Microbiology Authors: Suna K ızılyıldırım Fatih K öksal Cansu Önlen Güneri Source Type: research
Distribution of emm, superantigen and other virulence genotypes and detection of phylogenetic relationships in group A streptococcal isolates
Acta Microbiol Immunol Hung. 2022 Nov 11. doi: 10.1556/030.2022.01740. Online ahead of print.ABSTRACTGroup A streptococci are important pathogens with various virulence factors, such as M protein, superantigens, hemolysins, deoxyribonuclease, and proteases. The aims of this study are to investigate the detection of emm genotypes and other virulence genes, such as SAgs, DNase, protease, antibiotic resistance, and phylogenetic relationships in GAS strains isolated from clinical samples.Test strains were obtained from Çukurova University Balcalı Hospital and regional hospitals in Adana province. The M proteins were detected...
Source: Acta Microbiologica et Immunologica Hungarica - November 12, 2022 Category: Microbiology Authors: Suna K ızılyıldırım Fatih K öksal Cansu Önlen Güneri Source Type: research
The efficacy and tolerability of antibiotics in scrub typhus: An updated network meta-analysis of randomized controlled trials
Abbreviation: Azi: azithromycin; Chl: chloramphenicol; CI: confidence interval; Dox: doxycycline; ES: effect size; Min: minocycline; NMA: network meta-analysis; PRISMA: preferred reporting items for systematic reviews and meta-analyses; Qui: second-generation quinolone; RCT: randomized controlled trial; Rif: rifampicin; RR: rate ratio; SMD: standardized mean difference; SUCRA: surface under the cumulative ranking curve; Tel: telithromycin; Ttr: tetracycline (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - June 17, 2022 Category: Infectious Diseases Authors: Bing-Syuan Zeng, Bing-Yan Zeng, Chao-Ming Hung, Hung-Chang Kuo, Yen-Wen Chen, Mein-Woei Suen, Yow-Ling Shiue, Ping-Tao Tseng, Chang-Hua Chen Source Type: research
Design and Synthesis of Novel Macrolones Bridged with Linkers from 11,12-Positions of Macrolides
Bioorg Med Chem Lett. 2022 Apr 25:128761. doi: 10.1016/j.bmcl.2022.128761. Online ahead of print.ABSTRACTResistance to telithromycin and off-target effects associated with the metabolic instability present serious and challenging problems for the development of novel macrolides. Herein, studies of hybrids of macrolides and quinolones (termed macrolones) bridged with linkers from 11,12-cyclic carbamate of macrolides revealed different structure-activity relationships from the previously reported macrolones bridged with linkers derived from 6-, 9- and 4''-positions of macrolides. The optimized macrolone 34g with a longer and...
Source: Bioorganic and Medicinal Chemistry Letters - April 28, 2022 Category: Chemistry Authors: Xie-Peng Liu Wei Lv Fei Zhao Jing Ding Jue-Ru Zhang Feng Xue Jian-Zhong Zhang Li-Yong Liu Mark Cushman Yun Li Jian-Hua Liang Source Type: research
Design and Synthesis of Novel Macrolones Bridged with Linkers from 11,12-Positions of Macrolides
Bioorg Med Chem Lett. 2022 Apr 25:128761. doi: 10.1016/j.bmcl.2022.128761. Online ahead of print.ABSTRACTResistance to telithromycin and off-target effects associated with the metabolic instability present serious and challenging problems for the development of novel macrolides. Herein, studies of hybrids of macrolides and quinolones (termed macrolones) bridged with linkers from 11,12-cyclic carbamate of macrolides revealed different structure-activity relationships from the previously reported macrolones bridged with linkers derived from 6-, 9- and 4''-positions of macrolides. The optimized macrolone 34g with a longer and...
Source: Bioorganic and Medicinal Chemistry Letters - April 28, 2022 Category: Chemistry Authors: Xie-Peng Liu Wei Lv Fei Zhao Jing Ding Jue-Ru Zhang Feng Xue Jian-Zhong Zhang Li-Yong Liu Mark Cushman Yun Li Jian-Hua Liang Source Type: research
Design and Synthesis of Novel Macrolones Bridged with Linkers from 11,12-Positions of Macrolides
Bioorg Med Chem Lett. 2022 Apr 25:128761. doi: 10.1016/j.bmcl.2022.128761. Online ahead of print.ABSTRACTResistance to telithromycin and off-target effects associated with the metabolic instability present serious and challenging problems for the development of novel macrolides. Herein, studies of hybrids of macrolides and quinolones (termed macrolones) bridged with linkers from 11,12-cyclic carbamate of macrolides revealed different structure-activity relationships from the previously reported macrolones bridged with linkers derived from 6-, 9- and 4''-positions of macrolides. The optimized macrolone 34g with a longer and...
Source: Bioorganic and Medicinal Chemistry Letters - April 28, 2022 Category: Chemistry Authors: Xie-Peng Liu Wei Lv Fei Zhao Jing Ding Jue-Ru Zhang Feng Xue Jian-Zhong Zhang Li-Yong Liu Mark Cushman Yun Li Jian-Hua Liang Source Type: research
A Rapid Assessment Model for Liver Toxicity of Macrolides and an Integrative Evaluation for Azithromycin Impurities
This study provides a theoretical basis for improvement of the quality of macrolide antibiotics. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 4, 2022 Category: Drugs & Pharmacology Source Type: research
Alternative approaches utilizing click chemistry to develop next-generation analogs of solithromycin
Eur J Med Chem. 2022 Feb 24;233:114213. doi: 10.1016/j.ejmech.2022.114213. Online ahead of print.ABSTRACTThe marked rise in bacterial drug resistance has created an urgent need for novel antibacterials belonging to new drug classes and ideally possessing new mechanisms of action. The superior biological activity of solithromycin against streptococci and other bacteria causative of community-acquired pneumonia pathogens, compared to telithromycin and other macrolides encouraged us to extensively explore this class of antibiotics. We, thus, present the design and synthesis of a novel series of solithromycin analogs. Three ma...
Source: European Journal of Medicinal Chemistry - March 3, 2022 Category: Chemistry Authors: Samer S Daher Miseon Lee Xiao Jin Christiana N Teijaro Pamela R Barnett Joel S Freundlich Rodrigo B Andrade Source Type: research
Alternative approaches utilizing click chemistry to develop next-generation analogs of solithromycin
Eur J Med Chem. 2022 Feb 24;233:114213. doi: 10.1016/j.ejmech.2022.114213. Online ahead of print.ABSTRACTThe marked rise in bacterial drug resistance has created an urgent need for novel antibacterials belonging to new drug classes and ideally possessing new mechanisms of action. The superior biological activity of solithromycin against streptococci and other bacteria causative of community-acquired pneumonia pathogens, compared to telithromycin and other macrolides encouraged us to extensively explore this class of antibiotics. We, thus, present the design and synthesis of a novel series of solithromycin analogs. Three ma...
Source: European Journal of Medicinal Chemistry - March 3, 2022 Category: Chemistry Authors: Samer S Daher Miseon Lee Xiao Jin Christiana N Teijaro Pamela R Barnett Joel S Freundlich Rodrigo B Andrade Source Type: research
Systematic Evaluation of Whole-Genome Sequencing Based Prediction of Antimicrobial Resistance in Campylobacter jejuni and C. coli
This study evaluated the use of whole-genome sequencing (WGS) to predict AMR in Campylobacter jejuni and C. coli. A panel of 271 isolates recovered from Canadian poultry was used to compare AMR genotype to antimicrobial susceptibility testing (AST) results (azithromycin, ciprofloxacin, erythromycin, gentamicin, tetracycline, florfenicol, nalidixic acid, telithromycin, and clindamycin). The presence of antibiotic resistance genes (ARGs) was determined for each isolate using five computational approaches to evaluate the effect of: ARG screening software, input data (i.e., raw reads, draft genome assemblies), genome coverage ...
Source: Frontiers in Microbiology - November 16, 2021 Category: Microbiology Source Type: research
Prevalence, antibiotic resistance, and enterotoxin production of Staphylococcus aureus isolated from retail raw beef, sheep, and lamb meat in Turkey
Int J Food Microbiol. 2021 Oct 29;361:109461. doi: 10.1016/j.ijfoodmicro.2021.109461. Online ahead of print.ABSTRACTThe main objective of this study was to isolate and identify Staphylococcus aureus from retail raw red meat samples and evaluate their enterotoxin gene and antibiotic resistance profiles. A total of 452 retail raw meat samples, including beef (n = 200), sheep (n = 125), and lamb (n = 127) randomly purchased from various supermarkets and butchers in Ankara between July 2019 and November 2020, were tested for the prevalence of S. aureus. The S. aureus strain was identified using morphological and molecular (16S...
Source: International Journal of Food Microbiology - November 6, 2021 Category: Food Science Authors: P ınar Şanlıbaba Source Type: research
