Impact of vutrisiran on exploratory cardiac parameters in hereditary transthyretin ‐mediated amyloidosis with polyneuropathy
ConclusionsVutrisiran demonstrated evidence of potential benefit on cardiac manifestations in patients with ATTRv amyloidosis with polyneuropathy, with an acceptable safety profile. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - February 7, 2024 Category: Cardiology Authors: Pablo Garcia ‐Pavia, Martha Grogan, Parag Kale, John L. Berk, Mathew S. Maurer, Isabel Conceição, Marcelo Di Carli, Scott D. Solomon, Chongshu Chen, Elena Yureneva, John Vest, Julian D. Gillmore Tags: Research Article Source Type: research
Elevated Southern Hemisphere moisture availability during glacial periods
Nature, Published online: 07 February 2024; doi:10.1038/s41586-023-06989-3Contrary to expectations from pollen and dust records, Southern Hemisphere subtropical regions experienced the greatest climatic moisture during glacial periods of the Late Pleistocene, which may not have been an obstacle to movement and expansion of animals and plants. (Source: Nature AOP)
Source: Nature AOP - February 7, 2024 Category: Research Authors: Rieneke Weij J. M. Kale Sniderman Jon D. Woodhead John C. Hellstrom Josephine R. Brown Russell N. Drysdale Elizabeth Reed Steven Bourne Jay Gordon Source Type: research
Molecules, Vol. 29, Pages 754: Free Fatty Acid Determination in Broccoli Tissues Using Liquid Chromatography & ndash;High-Resolution Mass Spectrometry
Molecules, Vol. 29, Pages 754: Free Fatty Acid Determination in Broccoli Tissues Using Liquid Chromatography–High-Resolution Mass Spectrometry
Molecules doi: 10.3390/molecules29040754
Authors:
Christiana Mantzourani
Irene-Dimitra Mesimeri
Maroula G. Kokotou
Broccoli (Brassica oleracea L. var. italica Plenck) is a widely consumed vegetable, very popular due to its various nutritional and bioactive components. Since studies on the lipid components of broccoli have been limited so far, the aim of the present work was the study of free fatty acids (FFAs) present in different broccoli parts, aerial and und...
Source: Molecules - February 6, 2024 Category: Chemistry Authors: Christiana Mantzourani Irene-Dimitra Mesimeri Maroula G. Kokotou Tags: Article Source Type: research
Map-based cloning and functional analysis of a major quantitative trait locus, BolC.Pb9.1, controlling clubroot resistance in a wild Brassica relative (Brassica macrocarpa)
In this study, we constructed populations using B2013 and broccoli line 90196. CR in B2013 is quantitatively inherited, and a major QTL, BolC.Pb9.1, was identified on C09 using QTL-seq and linkage analysis. The BolC.Pb9.1 was finely mapped to a 56 kb genomic region using F2:3 populations. From the target region, the candidate BoUGT76C2 showed nucleotide variations between the parents, and was inducible in response to P. brassicae infection. We generated BoUGT76C2 overexpression lines in the 90196 background, which showed significantly enhanced resistance to P. brassicae compared to the WT line, suggesting that BoUGT76C2 co...
Source: TAG. Theoretical and Applied Genetics - February 2, 2024 Category: Genetics & Stem Cells Authors: Xiaoli Zhang Fengqing Han Zhansheng Li Zhenghua Wen Wenjuan Cheng Xiaozheng Shan Deling Sun Yumei Liu Source Type: research
Determining the association of inflammatory markers, cell-adhesion molecules, and endothelial dysfunction biomarkers with ACS in Indian population
Indian Heart J. 2024 Jan 30:S0019-4832(24)00017-8. doi: 10.1016/j.ihj.2024.01.016. Online ahead of print.ABSTRACTThe observational study aims to evaluate inflammatory markers, cell adhesion molecules (CAM) and endothelial dysfunction markers as biomarkers in Indian ACS patients with no conventional risk factors. The study population included 110 healthy individuals and 102 ACS patients without any history of conventional risk factors, except smoking and alcoholism, were included. Patient history, biochemical parameters and levels of biomarkers were estimated. ACS patients had a significant elevation in the circulatory leve...
Source: Indian Heart J - February 1, 2024 Category: Cardiology Authors: Keshav Kale Harshad Rajage Kane G R Source Type: research
Granulomatous Lymphocytic Interstitial Lung Disease in Common Variable Deficiency: A Retrospective Cohort Study
This study sought to determine key features, evaluation and therapy in a retrospective cohort encompassing patients seen by Pulmonology and Immunology at the University of Michigan from 2018-2022. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Fatema Mollah, Angeline Massett, Kale Bongers, Kristine Konopka, Bonnie Wang, David O'Dwyer, Anna Kovalszki Source Type: research
Genetic Polymorphisms of XPC, XPD, XPG Genes and their Association with Radiotherapy Induced Toxicity among Head and Neck Cancer Patients: A Hospital Based Study from Maharashtra
CONCLUSION: The results obtained in this study concluded that the SNPs rs2228001of XPC, rs238406, rs13181 SNPs of XPD and rs17655 SNP of XPG are not associated with normal tissue toxicity in HNC patients treated with radiotherapy. Radiotherapy with high radiation dose was significantly associated with oral mucositis in response to radiotherapy.PMID:38285784 | DOI:10.31557/APJCP.2024.25.1.191 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - January 29, 2024 Category: Cancer & Oncology Authors: Anand K Gudur Shivani R Kale Rashmi A Gudur Suresh J Bhosale Kailas D Datkhile Source Type: research
Author Correction: Frustration- and doping-induced magnetism in a Fermi–Hubbard simulator
Nature, Published online: 29 January 2024; doi:10.1038/s41586-024-07072-1Author Correction: Frustration- and doping-induced magnetism in a Fermi–Hubbard simulator (Source: Nature AOP)
Source: Nature AOP - January 29, 2024 Category: Research Authors: Muqing Xu Lev Haldar Kendrick Anant Kale Youqi Gang Geoffrey Ji Richard T. Scalettar Martin Lebrat Markus Greiner Source Type: research
Genes, Vol. 15, Pages 184: Involvement of Alfin-Like Transcription Factors in Plant Development and Stress Response
g
Juan Wang
Alfin-like (AL) proteins are an important class of transcription factor (TF) widely distributed in eukaryotes and play vital roles in many aspects of plant growth and development. AL proteins contain an Alfin-like domain and a specific PHD-finger structure domain at the N-terminus and C-terminus, respectively. The PHD domain can bind to a specific (C/A) CAC element in the promoter region and affect plant growth and development by regulating the expression of functional genes. This review describes a variety of AL transcription factors that have been isolated and characterized in Arabidopsis thaliana, Bras...
Source: Genes - January 29, 2024 Category: Genetics & Stem Cells Authors: Ruixin Jin Haitao Yang Tayeb Muhammad Xin Li Diliaremu Tuerdiyusufu Baike Wang Juan Wang Tags: Review Source Type: research
