Dp412e: a novel human embryonic dystrophin isoform induced by BMP4 in early differentiated cells
Duchenne muscular dystrophy (DMD) is a devastating X-linked recessive genetic myopathy. DMD physiopathology is still not fully understood and a prenatal onset is suspected but difficult to address. (Source: Skeletal Muscle)
Source: Skeletal Muscle - November 14, 2015 Category: Research Authors: Emmanuelle Massouridès, Jérôme Polentes, Philippe-Emmanuel Mangeot, Virginie Mournetas, Juliette Nectoux, Nathalie Deburgrave, Patrick Nusbaum, France Leturcq, Linda Popplewell, George Dickson, Nicolas Wein, Kevin M. Flanigan, Marc Peschanski, Jamel Ch Source Type: research
Differential myofiber-type transduction preference of adeno-associated virus serotypes 6 and 9
Gene therapy strategies are promising therapeutic options for monogenic muscular dystrophies, with several currently underways. The adeno-associated viral (AAV) vector is among the most effective gene delivery... (Source: Skeletal Muscle)
Source: Skeletal Muscle - November 10, 2015 Category: Research Authors: Muhammad Riaz, Yotam Raz, Elizabeth B. Moloney, Maaike van Putten, Yvonne D. Krom, Silvere M. van der Maarel, Joost Verhaagen and Vered Raz Source Type: research
Differential myofiber-type transduction preference of adeno-associated virus serotypes 6 and 9
Conclusions:
Our findings identify differences between AAV6 and AAV9 for myofiber-type preferences, which could be an underlying factor for mosaic transduction of skeletal muscle. Adjusting AAV serotype for specific muscle conditions can therefore improve transduction efficacy in clinical applications. (Source: Skeletal Muscle)
Source: Skeletal Muscle - November 10, 2015 Category: Research Authors: Muhammad RiazYotam RazElizabeth MoloneyMaaike van PuttenYvonne D. KromSilvere van der MaarelJoost VerhaagenVered Raz Source Type: research
Pax3-induced expansion enables the genetic correction of dystrophic satellite cells
Satellite cells (SCs) are indispensable for muscle regeneration and repair; however, due to low frequency in primary muscle and loss of engraftment potential after ex vivo expansion, their use in cell therapy ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - October 26, 2015 Category: Research Authors: Antonio Filareto, Fabrizio Rinaldi, Robert W. Arpke, Radbod Darabi, Joseph J. Belanto, Erik A. Toso, Auston Z. Miller, James M. Ervasti, R. Scott McIvor, Michael Kyba and Rita CR Perlingeiro Source Type: research
Pax3-induced expansion enables the genetic correction of dystrophic satellite cells
Conclusion:
These results demonstrate that Pax3 is able to promote the ex vivo expansion of SCs while maintaining their stem cell regenerative properties. (Source: Skeletal Muscle)
Source: Skeletal Muscle - October 26, 2015 Category: Research Authors: Antonio FilaretoFabrizio RinaldiRobert ArpkeRadbod DarabiJoseph BelantoErik TosoAuston MillerJames ErvastiR. McIvorMichael KybaRita Perlingeiro Source Type: research
Genetic characterization and improved genotyping of the dysferlin-deficient mouse strain Dysf tm1Kcam
Mouse models of dysferlinopathies are valuable tools with which to investigate the pathomechanisms underlying these diseases and to test novel therapeutic strategies. One such mouse model is the Dysf ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - October 13, 2015 Category: Research Authors: Tatiana Wiktorowicz, Jochen Kinter, Kazuhiro Kobuke, Kevin P. Campbell and Michael Sinnreich Source Type: research
Genetic characterization and improved genotyping of the dysferlin-deficient mouse strain Dysf tm1Kcam
Conclusion:
Our work will make the Dysf tm1Kcam
mouse model more attractive for animal studies of dysferlinopathies. (Source: Skeletal Muscle)
Source: Skeletal Muscle - October 13, 2015 Category: Research Authors: Tatiana WiktorowiczJochen KinterKazuhiro KobukeKevin CampbellMichael Sinnreich Source Type: research
Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice
Conclusions:
We show that specific myostatin antagonism with the human antibody REGN1033 enhanced muscle mass and function in young and aged mice and had beneficial effects in models of skeletal muscle atrophy. (Source: Skeletal Muscle)
Source: Skeletal Muscle - October 9, 2015 Category: Research Authors: Esther LatresJeffrey PangilinanLawrence MiloscioRoy BauerleinErqian NaTerra PotockyYing HuangMark EckersdorffAshique RafiqueJason MastaitisCalvin LinAndrew MurphyGeorge YancopoulosJesper GromadaTrevor Stitt Source Type: research
A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging
Background:
Although high-throughput studies of gene expression have generated large amounts of data, most of which is freely available in public archives, the use of this valuable resource is limited by computational complications and non-homogenous annotation. To address these issues, we have performed a complete re-annotation of public microarray data from human skeletal muscle biopsies and constructed a muscle expression compendium consisting of nearly 3000 samples. The created muscle compendium is a publicly available resource including all curated annotation. Using this data set, we aimed to elucidate the molecular m...
Source: Skeletal Muscle - October 9, 2015 Category: Research Authors: Jing SuCarl EkmanNikolay OskolkovLeo LahtiKristoffer StrömAlvis BrazmaLeif GroopJohan RungOla Hansson Source Type: research
Skeletal muscle interleukin 15 promotes CD8 + T-cell function and autoimmune myositis
Conclusions:
These findings together indicate that skeletal muscle IL-15 directly regulates immune effector cells but not muscle cells and thus presents a potential therapeutic target for myositis. (Source: Skeletal Muscle)
Source: Skeletal Muscle - September 28, 2015 Category: Research Authors: Po-Lin HuangMau-Sheng HouSzu-Wen WangChin-Ling ChangYae-Huei LiouNan-Shih Liao Source Type: research
Erratum to: Increased microenvironment stiffness in damaged myofibers promotes myogenic progenitor cell proliferation
No description available (Source: Skeletal Muscle)
Source: Skeletal Muscle - September 17, 2015 Category: Research Authors: Frédéric TrenszFabrice LucienVanessa CoutureThomas SöllraldGeneviève DrouinAndré-Jean RouleauClaire DuboisMichel GrandboisGregory LacrazGuillaume Grenier Source Type: research
Syntaxin 4 regulates the surface localization of a promyogenic receptor Cdo thereby promoting myogenic differentiation
Conclusions:
Stx4 promotes myoblast differentiation through interaction with Cdo and stimulation of its surface translocation. Both Cdo and Stx4 are required for GLUT4 translocation to cell surface and glucose uptake in myoblast differentiation. (Source: Skeletal Muscle)
Source: Skeletal Muscle - September 7, 2015 Category: Research Authors: Miran YooBok-Geon KimSang-Jin LeeHyeon-Ju JeongJong ParkDong-Wan SeoYong KimHoi LeeJeung-Whan HanJong-Sun KangGyu-Un Bae Source Type: research
